A Monte Carlo study of two Compton camera’s first plane detectors

Purpose: The suitability of two possible detectors, silicon and germanium as the Compton camera’s first plane detector has been investigated using a robust Monte Carlo approach. Methods: The GEANT4 simulation software was used to simulate the radiation transport and interactions with matter. Investigations were first done by relating the impact of Doppler broadening on the Compton camera angular uncertainty, energy spectra and reconstructed source image. Then, the impact of geometry and interaction type on the Compton camera performance was evaluated as well. Results: Analyses suggest that silicon of about 1 cm thickness would be suitable as the Compton camera first plane detector. The choice of silicon is however not completely flawless, Doppler broadening for this detector material contributes as much as 7.3 mm and 2.4 mm to full-width-half-maximum image resolution at 140.5 keV and 511 keV respectively. Conclusions: It is envisioned that with improved reconstruction technique, silicon would be the best first plane detector for the Compton camera

Wide-bandwidth, tunable, multiple-pulse-width optical delays using slow light in cesium vapor

We demonstrate an all-optical delay line in hot cesium vapor that tunably delays 275 ps input pulses up to 6.8 ns and 740 input ps pulses up to 59 ns (group index of approximately 200) with little pulse distortion. The delay is made tunable with a fast reconfiguration time (hundreds of ns) by optically pumping out of the atomic ground states.Comment: 4 pages, 6 figure

Investigation of Alternative Return Strategies for Orion Trans-earth Injection Design Options

The purpose of this study is to investigate alternative return strategies for the Orion trans-Earth injection (TEI) phase. A dynamical systems analysis approach considers the structure of the stable and unstable Sun perturbed Earth-Moon manifolds near the Earth-Moon interface region. A hybrid approach, then, combines the results from this analysis with classical two-body methods in a targeting process that seeks to expand the window of return opportunities in a precision entry scenario. The resulting startup arcs can be used, for instance, to enhance the block set of solutions available onboard during an autonomous targeting process

Age and growth estimates of the winter skate (Leucoraja ocellata) in the western Gulf of Maine

Age and growth estimates for the winter skate (Leucoraja ocellata) were estimated from vertebral band counts on 209 fish ranging in size from 145 to 940 mm total length (TL). An index of average percent error (IAPE) of 5.8% suggests that our aging method represents a precise approach to the age assessment of L. ocellata. Marginal increments were significantly different between months (Kruskal-Wallis P<0.001) and a distinct trend of increasing monthly increment growth began in July. Estimates of von Bertalanffy growth parameters suggest that females attain a slightly larger asymptotic TL (L∞=1374 mm) than males (L∞=1218 mm) and grow more slowly (k=0.059 and 0.074, respectively). The oldest ages obtained for the winter skate were 19 years for males and 18 years for females, which corresponded to total lengths of 932 mm and 940 mm, respectively. The results indicate that the winter skate exhibits the characteristics that have made other elasmobranch populations highly susceptible to exploitation by commercial fisheries

Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer\u27s disease.

BACKGROUND: Molecular characterization of late-onset Alzheimer\u27s disease (LOAD), the leading cause of age-related dementia, has revealed transcripts, proteins, and pathway alterations associated with disease. Assessing these postmortem signatures of LOAD in experimental model systems can further elucidate their relevance to disease origins and progression. Model organisms engineered with human genetic factors further link these signatures to disease-associated variants, especially when studies are designed to leverage homology across species. Here we assess differential gene splicing patterns in aging mouse models carrying humanized APOE4 and/or the Trem2*R47H variant on a C57BL/6J background. We performed a differential expression of gene (DEG) and differential splicing analyses on whole brain transcriptomes at multiple ages. To better understand the difference between differentially expressed and differentially spliced genes, we evaluated enrichment of KEGG pathways and cell-type specific gene signatures of the adult brain from each alteration type. To determine LOAD relevance, we compared differential splicing results from mouse models with multiple human AD splicing studies. RESULTS: We found that differentially expressed genes in Trem2*R47H mice were significantly enriched in multiple AD-related pathways, including immune response, osteoclast differentiation, and metabolism, whereas differentially spliced genes were enriched for neuronal related functions, including GABAergic synapse and glutamatergic synapse. These results were reinforced by the enrichment of microglial genes in DEGs and neuronal genes in differentially spliced genes in Trem2*R47H mice. We observed significant overlap between differentially spliced genes in Trem2*R47H mice and brains from human AD subjects. These effects were absent in APOE4 mice and suppressed in APOE4.Trem2*R47H double mutant mice relative to Trem2*R47H mice. CONCLUSIONS: The cross-species observation that alternative splicing observed in LOAD are present in Trem2*R47H mouse models suggests a novel link between this candidate risk gene and molecular signatures of LOAD in neurons and demonstrates how deep molecular analysis of new genetic models links molecular disease outcomes to a human candidate gene

Wide-Bandwidth, Tunable, Multiple-Pulse-Width Optical Delays Using Slow Light in Cesium Vapor

We demonstrate an all-optical delay line in hot cesium vapor that tunably delays 275 ps input pulses up to 6.8 ns and 740 input ps pulses up to 59 ns (group index of approximately 200) with little pulse distortion. The delay is made tunable with a fast reconfiguration time (hundreds of ns) by optically pumping out of the atomic ground states

A model for the break-up of a tuft of fibers

A simple model for the forces acting on a single fiber as it is withdrawn from a tangled fiber assembly is proposed. Particular emphasis is placed on understanding the dynamics of the reptating fiber with respect to the entanglement of fibers within the tuft. The resulting two-parameter model captures the qualitative features of experimental simulation. The model is extended to describe the break-up of a tuft. The results show good agreement with experiment and indicate where a fiber is most likely to fracture based on the density of fiber end-points

The Kepler Follow-up Observation Program

The Kepler Mission was launched on March 6, 2009 to perform a photometric survey of more than 100,000 dwarf stars to search for terrestrial-size planets with the transit technique. Follow-up observations of planetary candidates identified by detection of transit-like events are needed both for identification of astrophysical phenomena that mimic planetary transits and for characterization of the true planets and planetary systems found by Kepler. We have developed techniques and protocols for detection of false planetary transits and are currently conducting observations on 177 Kepler targets that have been selected for follow-up. A preliminary estimate indicates that between 24% and 62% of planetary candidates selected for follow-up will turn out to be true planets.Comment: 12 pages, submitted to the Astrophysical Journal Letter

Insulin Responsiveness in Metabolic Syndrome after Eight Weeks of Cycle Training

Introduction Insulin resistance in obesity is decreased after successful diet and exercise. Aerobic exercise training alone was evaluated as an intervention in subjects with the metabolic syndrome. Methods Eighteen nondiabetic, sedentary subjects, 11 with the metabolic syndrome, participated in 8 wk of increasing intensity stationary cycle training. Results Cycle training without weight loss did not change insulin resistance in metabolic syndrome subjects or sedentary control subjects. Maximal oxygen consumption (V˙O2max), activated muscle AMP-dependent kinase, and muscle mitochondrial marker ATP synthase all increased. Strength, lean body mass, and fat mass did not change. The activated mammalian target of rapamycin was not different after training. Training induced a shift in muscle fiber composition in both groups but in opposite directions. The proportion of type 2x fibers decreased with a concomitant increase in type 2a mixed fibers in the control subjects, but in metabolic syndrome, type 2x fiber proportion increased and type 1 fibers decreased. Muscle fiber diameters increased in all three fiber types in metabolic syndrome subjects. Muscle insulin receptor expression increased in both groups, and GLUT4 expression increased in the metabolic syndrome subjects. The excess phosphorylation of insulin receptor substrate 1 (IRS-1) at Ser337 in metabolic syndrome muscle tended to increase further after training in spite of a decrease in total IRS-1. Conclusions In the absence of weight loss, the cycle training of metabolic syndrome subjects resulted in enhanced mitochondrial biogenesis and increased the expression of insulin receptors and GLUT4 in muscle but did not decrease the insulin resistance. The failure for the insulin signal to proceed past IRS-1 tyrosine phosphorylation may be related to excess serine phosphorylation at IRS-1 Ser337, and this is not ameliorated by 8 wk of endurance exercise training