Innovation and all that jazz: an exploration of jazz as a medium for learning about innovation

The research study discussed in this paper is centrally concerned with perception and understanding of innovation and association with the concept in small and medium-sized enterprises (SMEs). lt is with particular reference to jazz, as a metaphor for innovation, that the concept is examined and an exploration of the effectiveness of the jazz metaphor therefore represents a core focus for this study. lt is within the overarching 'Year of Innovation' programme delivered by the University of Gloucestershire during 2004-5, that this study is located. The 'Innovation through Jazz' component of this programme involved the use of live jazz within interactive workshops delivered with Gloucestershire SMEs. The author was involved in the design and delivery of these workshops and these engagements provided a useful forum for exploration of innovation and the jazz metaphor. The author approached this study from an interpretivist worldview, adopting a primarily qualitative methodological approach for this essentially exploratory study. The author used mixed methods in her research, making particular use of semi-structured interviews, observation and questionnaires. The resultant data set incorporated data of both a qualitative and quantitative nature, triangulated to provide rich insight into perceptions and understanding of innovation and the effectiveness of the jazz metaphor as well as into a number of issues around employment relations in small firms. Given the diversity of small firms as well as of the individuals within them, the author does not attempt to make generalisations from her findings. This exploratory study does however provide new insight into the effectiveness of the jazz metaphor, applied in the specific context of small firm innovation

The Networked Recluse

The image is so well known it is practically iconic: The reclusive poet, feminine and fragile, weaving verse of beguiling complexity from the room in which she kept herself sequestered from the world. The Belle of Amherst, the distinctive American voice, the singer of the soul’s mysteries: Emily Dickinson. Yet that image scarcely captures the fullness and vitality of Dickinson’s life, most notably her many connections—to family, to friends, to correspondents, to the literary tastemakers of her day, even to the unnamed, and perhaps unknowable, “Master” to whom she addressed three of her most breathtaking works of prose. Through an exploration of a relatively small group of items from Dickinson’s vast literary remains, this volume—an accompaniment to an exhibition on Dickinson mounted at The Morgan Library & Museum in New York—demonstrates the complex ways in which these often humble objects came into conversation with other people, places, and events in the poet’s life. Seeing the network of connections and influences that shaped Dickinson’s life presents us with a different understanding of this most enigmatic yet elegiac poet in American letters, and allows us more fully to appreciate both her uniqueness and her humanity. The materials collected here make clear that the story of Dickinson’s manuscripts, her life, and her work is still unfolding. While the image of Dickinson as the reclusive poet dressed only in white remains a popular myth, details of Dickinson’s life continue to emerge. Several items included both in the exhibit and in this volume were not known to exist until the present century. The scrap of biographical intelligence recorded by Sarah Tuthill in a Mount Holyoke catalogue, or the concern about Dickinson’s salvation expressed by Abby Wood in a private letter to Abiah Root, were acquired by Amherst College in the last fifteen years. What additional pieces of evidence remain to be uncovered and identified in the attics and basements of New England? Published to accompany The Morgan Library & Museum’s pathbreaking exhibit I’m Nobody! Who are You? The Life and Poetry of Emily Dickinson—part of a series of exhibits at the Morgan celebrating and exploring the creative lives of significant women authors—The Networked Recluse offers the reader an account of the exhibit itself, together with a series of contributions by curators, scholars of Dickinson, and poets whose own work her words have influenced

The Pulse of War: Writing a Response

Introduction and a series of articles and poetry concerning the war on terror being imposed by the U.S., and more. Writes Kevin Bowen: One year into the war in Iraq, the ugliness of the undertaking has become more and more inescapable. If anything, the experience has reaffirmed a few simple facts that deserve reiteration. There is no such thing as an easily winnable war. There is no such thing as a humane war. In every war, long after the fighting ends, peace will remain elusive, and memories of suffering will endure through generations. Of course we knew all this before. Writers have been trying to tell us such things for centuries. The writings that follow illustrate ways contemporary writers confront these truths. From Tony Aiello\u27s memories of the First Gulf War, a war that Colin Powell told us was conducted more humanely than any war in history through Almira El-Zein\u27s incredible evocation of mortality in Is this Desolation for Me Alone ; through Carolyn Forche\u27s testimony to the role of writers; Chris Agee\u27s meditation on conflicts in Bosnia and Rwanda to present-day Iraq; Fred Marchant\u27s essay on war poetry and Fanny Howe\u27s beautiful understated testiment we are reminded of the ways good writers take the complicated pulse of war and why now, more than ever, we need their voices

Exploring the Roles of Spectral Detail and Intonation Contour in Speech Intelligibility:An fMRI Study

The melodic contour of speech forms an important perceptual aspect of tonal and nontonal languages and an important limiting factor on the intelligibility of speech heard through a cochlear implant. Previous work exploring the neural correlates of speech comprehension identified a left-dominant pathway in the temporal lobes supporting the extraction of an intelligible linguistic message, whereas the right anterior temporal lobe showed an overall preference for signals clearly conveying dynamic pitch information. The current study combined modulations of overall intelligibility (through vocoding and spectral inversion) with a manipulation of pitch contour (normal vs. falling) to investigate the processing of spoken sentences in functional MRI. Our overall findings replicate and extend those of Scott et al., whereas greater sentence intelligibility was predominately associated with increased activity in the left STS, the greatest response to normal sentence melody was found right superior temporal gyrus. These data suggest a spatial distinction between brain areas associated with intelligibility and those involved in the processing of dynamic pitch information in speech. By including a set of complexity-matched unintelligible conditions created by spectral inversion, this is additionally the first study reporting a fully factorial exploration of spectrotemporal complexity and spectral inversion as they relate to the neural processing of speech intelligibility. Perhaps surprisingly, there was no evidence for an interaction between the two factors—we discuss the implications for the processing of sound and speech in the dorsolateral temporal lobes

Faecal immunochemical tests (FIT) versus colonoscopy for surveillance after screening and polypectomy: a diagnostic accuracy and cost-effectiveness study.

OBJECTIVE: The English Bowel Cancer Screening Programme (BCSP) recommends 3 yearly colonoscopy surveillance for patients at intermediate risk of colorectal cancer (CRC) postpolypectomy (those with three to four small adenomas or one ≥10 mm). We investigated whether faecal immunochemical tests (FITs) could reduce surveillance burden on patients and endoscopy services. DESIGN: Intermediate-risk patients (60-72 years) recommended 3 yearly surveillance were recruited within the BCSP (January 2012-December 2013). FITs were offered at 1, 2 and 3 years postpolypectomy. Invitees consenting and returning a year 1 FIT were included. Participants testing positive (haemoglobin ≥40 µg/g) at years one or two were offered colonoscopy early; all others were offered colonoscopy at 3 years. Diagnostic accuracy for CRC and advanced adenomas (AAs) was estimated considering multiple tests and thresholds. We calculated incremental costs per additional AA and CRC detected by colonoscopy versus FIT surveillance. RESULTS: 74% (5938/8009) of invitees were included in our study having participated at year 1. Of these, 97% returned FITs at years 2 and 3. Three-year cumulative positivity was 13% at the 40 µg/g haemoglobin threshold and 29% at 10 µg/g. 29 participants were diagnosed with CRC and 446 with AAs. Three-year programme sensitivities for CRC and AAs were, respectively, 59% and 33% at 40 µg/g, and 72% and 57% at 10 µg/g. Incremental costs per additional AA and CRC detected by colonoscopy versus FIT (40 µg/g) surveillance were £7354 and £180 778, respectively. CONCLUSIONS: Replacing 3 yearly colonoscopy surveillance in intermediate-risk patients with annual FIT could reduce colonoscopies by 71%, significantly cut costs but could miss 30%-40% of CRCs and 40%-70% of AAs. TRIAL REGISTRATION NUMBER: ISRCTN18040196; Results

Individual common variants exert weak effects on the risk for autism spectrum disorders.

While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest

The promise and peril of chemical probes

Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial

Background: Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding. Methods: We did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries. Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to 100 mL infusion bag of 0·9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h for 24 h, or placebo (sodium chloride 0·9%). Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable. This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124. Findings: Between July 4, 2013, and June 21, 2019, we randomly allocated 12 009 patients to receive tranexamic acid (5994, 49·9%) or matching placebo (6015, 50·1%), of whom 11 952 (99·5%) received the first dose of the allocated treatment. Death due to bleeding within 5 days of randomisation occurred in 222 (4%) of 5956 patients in the tranexamic acid group and in 226 (4%) of 5981 patients in the placebo group (risk ratio [RR] 0·99, 95% CI 0·82–1·18). Arterial thromboembolic events (myocardial infarction or stroke) were similar in the tranexamic acid group and placebo group (42 [0·7%] of 5952 vs 46 [0·8%] of 5977; 0·92; 0·60 to 1·39). Venous thromboembolic events (deep vein thrombosis or pulmonary embolism) were higher in tranexamic acid group than in the placebo group (48 [0·8%] of 5952 vs 26 [0·4%] of 5977; RR 1·85; 95% CI 1·15 to 2·98). Interpretation: We found that tranexamic acid did not reduce death from gastrointestinal bleeding. On the basis of our results, tranexamic acid should not be used for the treatment of gastrointestinal bleeding outside the context of a randomised trial