Blockout: Dynamic Model Selection for Hierarchical Deep Networks

Most deep architectures for image classification--even those that are trained to classify a large number of diverse categories--learn shared image representations with a single model. Intuitively, however, categories that are more similar should share more information than those that are very different. While hierarchical deep networks address this problem by learning separate features for subsets of related categories, current implementations require simplified models using fixed architectures specified via heuristic clustering methods. Instead, we propose Blockout, a method for regularization and model selection that simultaneously learns both the model architecture and parameters. A generalization of Dropout, our approach gives a novel parametrization of hierarchical architectures that allows for structure learning via back-propagation. To demonstrate its utility, we evaluate Blockout on the CIFAR and ImageNet datasets, demonstrating improved classification accuracy, better regularization performance, faster training, and the clear emergence of hierarchical network structures

Sets of visible points

We say that two lattice points are visible from one another if there is no lattice point on the open line segment joining them. If Q is a subset of the n-dimensional integer lattice L^n, we write VQ for the set of points which can see every point of Q, and we call a set S a set of visible points if S = VQ for some set Q. In the first section we study the elementary properties of the operator V and of certain associated operators. A typical result is that Q is a set of visible points if and only if Q = V(VQ). In the second and third sections we study sets of visible points in greater detail. In particular we show that if Q is a finite subset of L^n, then VQ has a "density" which is given by the Euler product ^π_p (1 – r_p(Q)/p_n) where the numbers r_p (Q) are certain integers determined by the set Q and the primes p. And if Q is an infinite subset of L^ n, we give necessary and sufficient conditions on the set Q such that VQ has a density which is given by this or other related products. In the final section we compute the average values of a certain class of functions defined on L^n, and we show that the resulting formula may be used to compute the density of a set of visible points VQ generated by a finite set Q

The Kinesin-Related Protein, Hset, Opposes the Activity of Eg5 and Cross-Links Microtubules in the Mammalian Mitotic Spindle

We have prepared antibodies specific for HSET, the human homologue of the KAR3 family of minus end-directed motors. Immuno-EM with these antibodies indicates that HSET frequently localizes between microtubules within the mammalian metaphase spindle consistent with a microtubule cross-linking function. Microinjection experiments show that HSET activity is essential for meiotic spindle organization in murine oocytes and taxol-induced aster assembly in cultured cells. However, inhibition of HSET did not affect mitotic spindle architecture or function in cultured cells, indicating that centrosomes mask the role of HSET during mitosis. We also show that (acentrosomal) microtubule asters fail to assemble in vitro without HSET activity, but simultaneous inhibition of HSET and Eg5, a plus end-directed motor, redresses the balance of forces acting on microtubules and restores aster organization. In vivo, centrosomes fail to separate and monopolar spindles assemble without Eg5 activity. Simultaneous inhibition of HSET and Eg5 restores centrosome separation and, in some cases, bipolar spindle formation. Thus, through microtubule cross-linking and oppositely oriented motor activity, HSET and Eg5 participate in spindle assembly and promote spindle bipolarity, although the activity of HSET is not essential for spindle assembly and function in cultured cells because of centrosomes

Orbital symmetry control in the nitrone-oxaziridine system. Nitrone photostationary states

Recent the orbital symmetry rules have been shown to apply to hetero-atom systems such as nitrone thermal cycloaddition reactions and the thermal and photochemical aziridine ring cleavage at the C-C bond. The concerted photocyclization is disrotatory and the reverse thermal cleavage is conrotatory in these molecules with four {pi} electrons. In contrast to the azomethine ylide-aziridine system, the stereochemistry of the nitrone photocyclization to oxaziridine can only be observed on carbon and nitrogen atoms because the oxygen atom has lone pair electrons instead of substituents. For the reverse thermal ring opening of oxaziridine to the nitrone, the two possible conrotatory motions of C-O bond cleavage should result in a mixture of the cis and trans-isomers of the nitrone, in contrast to the photoclosure which should be stereospecific

The Grand Tour of the Ruby-East Humboldt Metamorphic Core Complex, Northeastern Nevada: Part 1-Introduction & Road Log

The purpose of this geological excursion is to provide an overview of the multiphase developmental history of the Ruby Mountains and East Humboldt Range, northeastern Nevada. Although these mountain ranges are commonly cited as a classic example of a Cordilleran metamorphic core complex developed through large-magnitude, mid-Tertiary crustal extension, a preceding polyphase Mesozoic contractional history is also well preserved in the ranges. An early phase of this history involved Late Jurassic two-mica granitic magmatism, high-temperature but relatively low-pressure metamorphism, and polyphase deformation in the central Ruby Mountains. In the northern Ruby Mountains and East Humboldt Range, a Late Cretaceous history of crustal shortening, metamorphism, and magmatism is manifested by fold-nappes (involving Archean basement rocks in the northern East Humboldt Range), widespread migmatization, injection of monzogranitic and leucogranitic magmas, all coupled with sillimanite-grade metamorphism. Following Late Cretaceous contraction, a protracted extensional deformation partially overprinted these areas during the Cenozoic. This extensional history may have begun as early as the Late Cretaceous or as late as the mid-Eocene. Late Eocene and Oligocene magmatism occurred at various levels in the crust yielding mafic to felsic orthogneisses in the deep crust, a composite granitic pluton in the upper crust, and volcanic rocks at the surface. Movement along a west-rooted, extensional shear zone in the Oligocene and early Miocene led to core-complex exhumation. The shear zone produced mylonitic rocks about 1 km thick at deep crustal levels, and an overprint of brittle detachment faulting at shallower levels as unroofing proceeded. Megabreccias and other synextensional sedimentary deposits are locally preserved in a tilted, upper Eocene through Miocene stratigraphic sequence. Neogene magmatism included the emplacement of basalt dikes and eruption of rhyolitic rocks. Subsequent Basin and Range normal faulting, as young as Holocene, records continued tectonic extension

Model-based autonomous system for performing dexterous, human-level manipulation tasks

This article presents a model based approach to autonomous dexterous manipulation, developed as part of the DARPA Autonomous Robotic Manipulation Software (ARM-S) program. Performing human-level manipulation tasks is achieved through a novel combination of perception in uncertain environments, precise tool use, forceful dual-arm planning and control, persistent environmental tracking, and task level verification. Deliberate interaction with the environment is incorporated into planning and control strategies, which, when coupled with world estimation, allows for refinement of models and precise manipulation. The system takes advantage of sensory feedback immediately with little open-loop execution, attempting true autonomous reasoning and multi-step sequencing that adapts in the face of changing and uncertain environments. A tire change scenario utilizing human tools, discussed throughout the article, is used to described the system approach. A second scenario of cutting a wire is also presented, and is used to illustrate system component reuse and generality.United States. Defense Advanced Research Projects Agency. Autonomous Robotic Manipulation Progra

Performance of a cryogenic test facility for 4 K interferometer delay line investigations

The next generation of space-borne instruments for far infrared astronomical spectroscopy will utilize large diameter, cryogenically cooled telescopes in order to achieve unprecedented sensitivities. Low background, ground-based cryogenic facilities are required for the cryogenic testing of materials, components and subsystems. The University of Lethbridge Test Facility Cryostat (TFC) is a large volume, closed cycle, 4 K cryogenic facility, developed for this purpose. This paper discusses the design and performance of the facility and associated metrology instrumentation, both internal and external to the TFC. Additionally, an apparatus for measuring the thermal and mechanical properties of carbon-fiber-reinforced polymers is presented

Powering the ABC multidrug exporter LmrA: How nucleotides embrace the ion-motive force.

LmrA is a bacterial ATP-binding cassette (ABC) multidrug exporter that uses metabolic energy to transport ions, cytotoxic drugs, and lipids. Voltage clamping in a Port-a-Patch was used to monitor electrical currents associated with the transport of monovalent cationic HEPES+ by single-LmrA transporters and ensembles of transporters. In these experiments, one proton and one chloride ion are effluxed together with each HEPES+ ion out of the inner compartment, whereas two sodium ions are transported into this compartment. Consequently, the sodium-motive force (interior negative and low) can drive this electrogenic ion exchange mechanism in cells under physiological conditions. The same mechanism is also relevant for the efflux of monovalent cationic ethidium, a typical multidrug transporter substrate. Studies in the presence of Mg-ATP (adenosine 5'-triphosphate) show that ion-coupled HEPES+ transport is associated with ATP-bound LmrA, whereas ion-coupled ethidium transport requires ATP binding and hydrolysis. HEPES+ is highly soluble in a water-based environment, whereas ethidium has a strong preference for residence in the water-repelling plasma membrane. We conclude that the mechanism of the ABC transporter LmrA is fundamentally related to that of an ion antiporter that uses extra steps (ATP binding and hydrolysis) to retrieve and transport membrane-soluble substrates from the phospholipid bilayer.This research was supported by the Biotechnology and Biological Sciences Research Council grants BB/R00224X/1, BB/I002383/1 and BB/K017713/1, and Medical Research Council grant G0401165 (to H.W.V.V.). We are also grateful for funding by the Human Frontier Science Program (grant RGP0034/2013), Strategic International Cooperative Program (Japan Science and Technology Agency, Japan) and Royal Society (UK) for collaborative research between H.W.V.V. and S.M. C.H.F.L. received a research studentship of Peterhouse, Cambridge. Y.S.K.K. received a Federal Training Award from the Ministry of Health in Malaysia. H.S. and S.R. were supported by the Cambridge Commonwealth, European and International Trust

Cyberinfrastructure for Preservation of Stream and River Ecology

2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio

The BLAST Survey of the Vela Molecular Cloud: Physical Properties of the Dense Cores in Vela-D

The Balloon-borne Large-Aperture Submillimeter Telescope (BLAST) carried out a 250, 350 and 500 micron survey of the galactic plane encompassing the Vela Molecular Ridge, with the primary goal of identifying the coldest dense cores possibly associated with the earliest stages of star formation. Here we present the results from observations of the Vela-D region, covering about 4 square degrees, in which we find 141 BLAST cores. We exploit existing data taken with the Spitzer MIPS, IRAC and SEST-SIMBA instruments to constrain their (single-temperature) spectral energy distributions, assuming a dust emissivity index beta = 2.0. This combination of data allows us to determine the temperature, luminosity and mass of each BLAST core, and also enables us to separate starless from proto-stellar sources. We also analyze the effects that the uncertainties on the derived physical parameters of the individual sources have on the overall physical properties of starless and proto-stellar cores, and we find that there appear to be a smooth transition from the pre- to the proto-stellar phase. In particular, for proto-stellar cores we find a correlation between the MIPS24 flux, associated with the central protostar, and the temperature of the dust envelope. We also find that the core mass function of the Vela-D cores has a slope consistent with other similar (sub)millimeter surveys.Comment: Accepted for publication in the Astrophysical Journal. Data and maps are available at http://blastexperiment.info