944 research outputs found

    Sensitivity analysis as an aid in modelling and control of (poorly-defined) ecological systems

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    A literature review of the use of sensitivity analyses in modelling nonlinear, ill-defined systems, such as ecological interactions is presented. Discussions of previous work, and a proposed scheme for generalized sensitivity analysis applicable to ill-defined systems are included. This scheme considers classes of mathematical models, problem-defining behavior, analysis procedures (especially the use of Monte-Carlo methods), sensitivity ranking of parameters, and extension to control system design

    Decoherence in a Talbot Lau interferometer: the influence of molecular scattering

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    We study the interference of C70 fullerenes in a Talbot-Lau interferometer with a large separation between the diffraction gratings. This permits the observation of recurrences of the interference contrast both as a function of the de Broglie wavelength and in dependence of the interaction with background gases. We observe an exponential decrease of the fringe visibility with increasing background pressure and find good quantitative agreement with the predictions of decoherence theory. From this we extrapolate the limits of matter wave interferometry and conclude that the influence of collisional decoherence may be well under control in future experiments with proteins and even larger objects.Comment: 8 pages, 5 figure

    PCN13 COST-EFFECTIVENESS OF RITUXIMAB IN DIFFUSE LARGE B CELL LYMPHOMA

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    Concept of an ionizing time-domain matter-wave interferometer

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    We discuss the concept of an all-optical and ionizing matter-wave interferometer in the time domain. The proposed setup aims at testing the wave nature of highly massive clusters and molecules, and it will enable new precision experiments with a broad class of atoms, using the same laser system. The propagating particles are illuminated by three pulses of a standing ultraviolet laser beam, which detaches an electron via efficient single photon-absorption. Optical gratings may have periods as small as 80 nm, leading to wide diffraction angles for cold atoms and to compact setups even for very massive clusters. Accounting for the coherent and the incoherent parts of the particle-light interaction, we show that the combined effect of phase and amplitude modulation of the matter waves gives rise to a Talbot-Lau-like interference effect with a characteristic dependence on the pulse delay time.Comment: 25 pages, 5 figure

    A ballistic motion disrupted by quantum reflections

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    I study a Lindblad dynamics modeling a quantum test particle in a Dirac comb that collides with particles from a background gas. The main result is a homogenization theorem in an adiabatic limiting regime involving large initial momentum for the test particle. Over the time interval considered, the particle would exhibit essentially ballistic motion if either the singular periodic potential or the kicks from the gas were removed. However, the particle behaves diffusively when both sources of forcing are present. The conversion of the motion from ballistic to diffusive is generated by occasional quantum reflections that result when the test particle's momentum is driven through a collision near to an element of the half-spaced reciprocal lattice of the Dirac comb.Comment: 54 pages. I rewrote the introduction and simplified some of the presentatio

    Spatial Degrees of Freedom in Everett Quantum Mechanics

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    Stapp claims that, when spatial degrees of freedom are taken into account, Everett quantum mechanics is ambiguous due to a "core basis problem." To examine an aspect of this claim I generalize the ideal measurement model to include translational degrees of freedom for both the measured system and the measuring apparatus. Analysis of this generalized model using the Everett interpretation in the Heisenberg picture shows that it makes unambiguous predictions for the possible results of measurements and their respective probabilities. The presence of translational degrees of freedom for the measuring apparatus affects the probabilities of measurement outcomes in the same way that a mixed state for the measured system would. Examination of a measurement scenario involving several observers illustrates the consistency of the model with perceived spatial localization of the measuring apparatus.Comment: 34 pp., no figs. Introduction, discussion revised. Material tangential to main point remove

    Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease

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    Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential diagnosis of dementia subtypes. Automated, observer-independent atlas-based MRI volumetry was applied to analyse 102 MRI data sets from 15 bvFTD, 14 AD, and 10 healthy elderly control participants with consecutive scans over at least 12 months. Anatomically defined targets were chosen a priori as brain structures of interest. Groups were compared regarding volumes at clinic presentation and annual change rates. Baseline volumes, especially of grey matter compartments, were significantly reduced in bvFTD and AD patients. Grey matter volumes of the caudate and the gyrus rectus were significantly smaller in bvFTD than AD. The bvFTD group could be separated from AD on the basis of caudate volume with high accuracy (79% cases correct). Annual volume decline was markedly larger in bvFTD and AD than controls, predominantly in white matter of temporal structures. Decline in grey matter volume of the lateral orbitofrontal gyrus separated bvFTD from AD and controls. Automated longitudinal MRI volumetry discriminates bvFTD from AD. In particular, greater reduction of orbitofrontal grey matter and temporal white matter structures after 12 months is indicative of bvFTD

    Lithium atom interferometer using laser diffraction : description and experiments

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    We have built and operated an atom interferometer of the Mach-Zehnder type. The atomic wave is a supersonic beam of lithium seeded in argon and the mirrors and beam-splitters for the atomic wave are based on elastic Bragg diffraction on laser standing waves at 671 nm. We give here a detailed description of our experimental setup and of the procedures used to align its components. We then present experimental signals, exhibiting atomic interference effects with a very high visibility, up to 84.5 %. We describe a series of experiments testing the sensitivity of the fringe visibility to the main alignment defects and to the magnetic field gradient.Comment: 8 avril 200
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