595 research outputs found
Non-uniform interpolatory subdivision schemes with improved smoothness
Subdivision schemes are used to generate smooth curves or surfaces by iteratively refining an initial control polygon or mesh. We focus on univariate, linear, binary subdivision schemes, where the vertices of the refined polygon are computed as linear combinations of the current neighbouring vertices. In the classical stationary setting, there are just two such subdivision rules, which are used throughout all subdivision steps to construct the new vertices with even and odd indices, respectively. These schemes are well understood and many tools have been developed for deriving their properties, including the smoothness of the limit curves. For non-stationary schemes, the subdivision rules are not fixed and can be different in each subdivision step. Non-uniform schemes are even more general, as they allow the subdivision rules to be different for every new vertex that is generated by the scheme. The properties of non-stationary and non-uniform schemes are usually derived by relating the scheme to a corresponding stationary scheme and then exploiting the fact that the properties of the stationary scheme carry over under certain proximity conditions. In particular, this approach can be used to show that the limit curves of a non-stationary or non-uniform scheme are as smooth as those of a corresponding stationary scheme. In this paper we show that non-uniform subdivision schemes have the potential to generate limit curves that are smoother than those of stationary schemes with the same support size of the subdivision rule. For that, we derive interpolatory 2-point and 4-point schemes that generate C-1 and C-2 limit curves, respectively. These values of smoothness exceed the smoothness of classical interpolating schemes with the same support size by one. (C) 2022 The Author(s). Published by Elsevier B.V
PolyCube-Maps
Standard texture mapping of real-world meshes suffers from the presence of seams that need to be introduced in order to avoid excessive distortions and to make the topology of the mesh compatible to the one of the texture domain. In contrast, cube maps provide a mechanism that could be used for seamless texture mapping with low distortion, but only if the object roughly resembles a cube. We extend this concept to arbitrary meshes by using as texture domain the surface of a polycube whose shape is similar to that of the given mesh. Our approach leads to a seamless texture mapping method that is simple enough to be implemented in currently available graphics hardware
Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma
Glioblastoma are the most frequent and malignant human brain tumors, having a very poor prognosis. The enhanced radio- and chemoresistance of glioblastoma and the glioblastoma stem cells might be the main reason why conventional therapies fail. The second messenger cyclic AMP (cAMP) controls cell proliferation, differentiation, and apoptosis. Downregulation of cAMP sensitizes tumor cells for anti-cancer treatment. Opioid receptor agonists triggering opioid receptors can activate inhibitory Gi proteins, which, in turn, block adenylyl cyclase activity reducing cAMP. In this study, we show that downregulation of cAMP by opioid receptor activation improves the effectiveness of anti-cancer drugs in treatment of glioblastoma. The µ-opioid receptor agonist D,L-methadone sensitizes glioblastoma as well as the untreatable glioblastoma stem cells for doxorubicin-induced apoptosis and activation of apoptosis pathways by reversing deficient caspase activation and deficient downregulation of XIAP and Bcl-xL, playing critical roles in glioblastomas' resistance. Blocking opioid receptors using the opioid receptor antagonist naloxone or increasing intracellular cAMP by 3-isobutyl-1-methylxanthine (IBMX) strongly reduced opioid receptor agonist-induced sensitization for doxorubicin. In addition, the opioid receptor agonist D,L-methadone increased doxorubicin uptake and decreased doxorubicin efflux, whereas doxorubicin increased opioid receptor expression in glioblastomas. Furthermore, opioid receptor activation using D,L-methadone inhibited tumor growth significantly in vivo. Our findings suggest that opioid receptor activation triggering downregulation of cAMP is a promising strategy to inhibit tumor growth and to improve the effectiveness of anti-cancer drugs in treatment of glioblastoma and in killing glioblastoma stem cells
Cell death sensitization of leukemia cells by opioid receptor activation
Cyclic AMP (cAMP) regulates a number of cellular processes and modulates cell death induction. cAMP levels are altered upon stimulation of specific G-protein-coupled receptors inhibiting or activating adenylyl cyclases. Opioid receptor stimulation can activate inhibitory Gi-proteins which in turn block adenylyl cyclase activity reducing cAMP. Opioids such as D,L-methadone induce cell death in leukemia cells. However, the mechanism how opioids trigger apoptosis and activate caspases in leukemia cells is not understood. In this study, we demonstrate that downregulation of cAMP induced by opioid receptor activation using the opioid D,L-methadone kills and sensitizes leukemia cells for doxorubicin treatment. Enhancing cAMP levels by blocking opioid-receptor signaling strongly reduced D,L-methadone-induced apoptosis, caspase activation and doxorubicin-sensitivity. Induction of cell death in leukemia cells by activation of opioid receptors using the opioid D,L-methadone depends on critical levels of opioid receptor expression on the cell surface. Doxorubicin increased opioid receptor expression in leukemia cells. In addition, the opioid D,L-methadone increased doxorubicin uptake and decreased doxorubicin efflux in leukemia cells, suggesting that the opioid D,L-methadone as well as doxorubicin mutually increase their cytotoxic potential. Furthermore, we found that opioid receptor activation using D,L-methadone alone or in addition to doxorubicin inhibits tumor growth significantly in vivo. These results demonstrate that opioid receptor activation via triggering the downregulation of cAMP induces apoptosis, activates caspases and sensitizes leukemia cells for doxorubicin treatment. Hence, opioid receptor activation seems to be a promising strategy to improve anticancer therapies
Ecdysteroid 7,9(11)-dien-6-ones as potential photoaffinity labels for ecdysteroid binding proteins
Three ecdysteroid 7,9(11)-dien-7-ones (dacryhainansterone, 25-hydroxydacryhainansterone and kaladasterone) were prepared by dehydration of the corresponding 11a-hydroxy ecdysteroids (ajugasterone C, turkesterone and muristerone A, respectively). The biological activities of the dienones in the Drosophila melanogaster B(II) cell bioassay, which reflect the affinity for the ecdysteroid receptor complex, showed that the dienones retain high biological activity. Irradiation at 350 nm of the ecdysteroid dienones (100 nM) with bacterially-expressed dipteran and lepidopteran ecdysteroid receptor proteins (DmEcR/DmUSP or CfEcR/CfUSP), followed by loading with [(3)H]ponasterone A revealed that irradiation of dacryhainansterone or kaladasterone resulted in blocking of >70% of the specific binding sites. Thus, ecdysteroid dienones show considerable potential as photoaffinity analogues for ecdysteroid binding proteins
Iterative Methods for Visualization of Implicit Surfaces on GPU
The original publication is available at www.springerlink.comInternational audienceThe ray-casting of implicit surfaces on GPU has been explored in the last few years. However, until recently, they were restricted to second degree (quadrics). We present an iterative solution to ray cast cubics and quartics on GPU. Our solution targets efficient implementation, obtaining interactive rendering for thousands of surfaces per frame. We have given special attention to torus rendering since it is a useful shape for multiple CAD models. We have tested four different iterative methods, including a novel one, comparing them with classical tessellation solution
Aberrant computational mechanisms of social learning and decision-making in schizophrenia and borderline personality disorder
Psychiatric disorders are ubiquitously characterized by debilitating social impairments. These difficulties are thought to emerge from aberrant social inference. In order to elucidate the underlying computational mechanisms, patients diagnosed with major depressive disorder (N = 29), schizophrenia (N = 31), and borderline personality disorder (N = 31) as well as healthy controls (N = 34) performed a probabilistic reward learning task in which participants could learn from social and nonsocial information. Patients with schizophrenia and borderline personality disorder performed more poorly on the task than healthy controls and patients with major depressive disorder. Broken down by domain, borderline personality disorder patients performed better in the social compared to the non-social domain. In contrast, controls and MDD patients showed the opposite pattern and SCZ patients showed no difference between domains. In effect, borderline personality disorder patients gave up a possible overall performance advantage by concentrating their learning in the social at the expense of the non-social domain. We used computational modeling to assess learning and decision-making parameters estimated for each participant from their behavior. This enabled additional insights into the underlying learning and decision-making mechanisms. Patients with borderline personality disorder showed slower learning from social and non-social information and an exaggerated sensitivity to changes in environmental volatility, both in the non-social and the social domain, but more so in the latter. Regarding decision-making the modeling revealed that compared to controls and major depression patients, patients with borderline personality disorder and schizophrenia showed a stronger reliance on social relative to non-social information when making choices. Depressed patients did not differ significantly from controls in this respect. Overall, our results are consistent with the notion of a general interpersonal hypersensitivity in borderline personality disorder and schizophrenia based on a shared computational mechanism characterized by an over-reliance on beliefs about others in making decisions and by an exaggerated need to make sense of others during learning specifically in borderline personality disorder
Differential cross section measurements for the production of a W boson in association with jets in proton-proton collisions at root s=7 TeV
Citation: Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., . . . Collaboration, C. M. S. (2015). Differential cross section measurements for the production of a W boson in association with jets in proton-proton collisions at root s=7 TeV. Physics Letters B, 741, 12-37. doi:10.1016/j.physletb.2014.12.003Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (p(T)) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (H-T), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb (1). The measured cross sections are compared to predictions from Monte Carlo generators, MADGRAPH + PYTHIA and SHERPA, and to next-to-leading-order calculations from BLACKHAT + SHERPA. The differential cross sections are found to be in agreement with the predictions, apart from the p(T) distributions of the leading jets at high p(T) values, the distributions of the H-T at high-H-T and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).Additional Authors: Kiesenhofer, W.;Knunz, V.;Krammer, M.;Kratschmer, I.;Liko, D.;Mikulec, I.;Rabady, D.;Rahbaran, B.;Rohringer, H.;Schofbeck, R.;Strauss, J.;Taurok, A.;Treberer-Treberspurg, W.;Waltenberger, W.;Wulz, C. E.;Mossolov, V.;Shumeiko, N.;SuarezGonzalez, J.;Alderweireldt, S.;Bansal, M.;Bansal, S.;Cornelis, T.;De Wolf, E. A.;Janssen, X.;Knutsson, A.;Luyckx, S.;Ochesanu, S.;Roland, B.;Rougny, R.;Van De Klundert, M.;Van Haevermaet, H.;Van Mechelen, P.;Van Remortel, N.;Van Spilbeeck, A.;Blekman, F.;Blyweert, S.;D'Hondt, J.;Daci, N.;Heracleous, N.;Kalogeropoulos, A.;Keaveney, J.;Kim, T. J.;Lowette, S.;Maes, M.;Olbrechts, A.;Python, Q.;Strom, D.;Tavernier, S.;Van Doninck, W.;Van Mulders, P.;Van Onsem, G. P.;Villella, I.;Caillol, C.;Clerbaux, B.;De Lentdecker, G.;Dobur, D.;Favart, L.;Gay, A. P. R.;Grebenyuk, A.;Leonard, A.;Mohammadi, A.;Pernie, L.;Reis, T.;Seva, T.;Thomas, L.;Vander Velde, C.;Vanlaer, P.;Wang, J.;Adler, V.;Beernaert, K.;Benucci, L.;Cimmino, A.;Costantini, S.;Crucy, S.;Dildick, S.;Fagot, A.;Garcia, G.;Klein, B.;McCartin, J.;Rios, A. A. O.;Ryckbosch, D.;Diblen, S. S.;Sigamani, M.;Strobbe, N.;Thyssen, F.;Tytgat, M.;Yazgan, E.;Zaganidis, N.;Basegmez, S.;Beluffi, C.;Bruno, G.;Castello, R.;Caudron, A.;Ceard, L.;Da Silveira, G. G.;Delaere, C.;du Pree, T.;Favart, D.;Forthomme, L.;Giammanco, A.;Hollar, J.;Jez, P.;Komm, M.;Lemaitre, V.;Liao, J.;Nuttens, C.;Pagano, D.;Perrini, L.;Pin, A.;Piotrzkowski, K.;Popov, A.;Quertenmont, L.;Selvaggi, M.;Marono, M. V.;Garcia, J. M. V.;Beliy, N.;Caebergs, T.;Daubie, E.;Hammad, G. H.;Alda, W. L.;Alves, G. A.;Martins, M. C.;Martins, T. D.;Pol, M. E.;Carvalho, W.;Chinellato, J.;Custodio, A.;Da Costa, E. M.;Damiao, D. D.;Martins, C. D.;De Souza, S. F.;Malbouisson, H.;Malek, M.;Figueiredo, D. M.;Mundim, L.;Nogima, H.;Da Silva, W. L. P.;Santaolalla, J.;Santoro, A.;Sznajder, A.;Manganote, E. J. T.;Pereira, A. V.;Bernardes, C. A.;Dias, F. A.;Tomei, Trfp;Gregores, E. M.;Mercadante, P. G.;Novaes, S. F.;Padula, S. S.;Aleksandrov, A.;Genchev, V.;Iaydjiev, P.;Marinov, A.;Piperov, S.;Rodozov, M.;Sultanov, G.;Vutova, M.;Dimitrov, A.;Glushkov, I.;Hadjiiska, R.;Kozhuharov, V.;Litov, L.;Pavlov, B.;Petkov, P.;Bian, J. G.;Chen, G. M.;Chen, H. S.;Chen, M.;Du, R.;Jiang, C. H.;Liang, D.;Liang, S.;Plestina, R.;Tao, J.;Wang, X.;Wang, Z.;Asawatangtrakuldee, C.;Ban, Y.;Guo, Y.;Li, Q.;Li, W.;Liu, S.;Mao, Y.;Qian, S. J.;Wang, D.;Zhang, L.;Zou, W.;Avila, C.;Sierra, L. F. C.;Florez, C.;Gomez, J. P.;Moreno, B. G.;Sanabria, J. C.;Godinovic, N.;Lelas, D.;Polic, D.;Puljak, I.;Antunovic, Z.;Kovac, M.;Brigljevic, V.;Kadija, K.;Luetic, J.;Mekterovic, D.;Sudic, L.;Attikis, A.;Mavromanolakis, G.;Mousa, J.;Nicolaou, C.;Ptochos, F.;Razis, P. A.;Bodlak, M.;Finger, M.;Finger, M.;Assran, Y.;Kamel, A. E.;Mahmoud, M. A.;Radi, A.;Kadastik, M.;Murumaa, M.;Raidal, M.;Tiko, A.;Eerola, P.;Fedi, G.;Voutilainen, M.;Harkonen, J.;Karimaki, V.;Kinnunen, R.;Kortelainen, M. J.;Lampen, T.;Lassila-Perini, K.;Lehti, S.;Linden, T.;Luukka, P.;Maenpaa, T.;Peltola, T.;Tuominen, E.;Tuominiemi, J.;Tuovinen, E.;Wendland, L.;Tuuva, T.;Besancon, M.;Couderc, F.;Dejardin, M.;Denegri, D.;Fabbro, B.;Faure, J. L.;Favaro, C.;Ferri, F.;Ganjour, S.;Givernaud, A.;Gras, P.;de Monchenault, G. H.;Jarry, P.;Locci, E.;Malcles, J.;Rander, J.;Rosowsky, A.;Titov, M.;Baffioni, S.;Beaudette, F.;Busson, P.;Charlot, C.;Dahms, T.;Dalchenko, M.;Dobrzynski, L.;Filipovic, N.;Florent, A.;de Cassagnac, R. G.;Mastrolorenzo, L.;Mine, P.;Mironov, C.;Naranjo, I. N.;Nguyen, M.;Ochando, C.;Paganini, P.;Salerno, R.;Sauvan, J. B.;Sirois, Y.;Veelken, C.;Yilmaz, Y.;Zabi, A.;Agram, J. L.;Andrea, J.;Aubin, A.;Bloch, D.;Brom, J. M.;Chabert, E. C.;Collard, C.;Conte, E.;Fontaine, J. C.;Gele, D.;Goerlach, U.;Goetzmann, C.;Le Bihan, A. C.;Van Hove, P.;Gadrat, S.;Beauceron, S.;Beaupere, N.;Boudoul, G.;Brochet, S.;Montoya, C. A. C.;Chasserat, J.;Chierici, R.;Contardo, D.;Depasse, P.;El Mamouni, H.;Fan, J.;Fay, J.;Gascon, S.;Gouzevitch, M.;Ille, B.;Kurca, T.;Lethuillier, M.;Mirabito, L.;Perries, S.;Alvarez, J. D. R.;Sabes, D.;Sgandurra, L.;Sordini, V.;Donckt, M.;Verdier, P.;Viret, S.;Xiao, H.;Tsamalaidze, Z.;Autermann, C.;Beranek, S.;Bontenackels, M.;Edelhoff, M.;Feld, L.;Hindrichs, O.;Klein, K.;Ostapchuk, A.;Perieanu, A.;Raupach, F.;Sammet, J.;Schael, S.;Sprenger, D.;Weber, H.;Wittmer, B.;Zhukov, V.;Ata, M.;Dietz-Laursonn, E.;Duchardt, D.;Erdmann, M.;Fischer, R.;Guth, A.;Hebbeker, T.;Heidemann, C.;Hoepfner, K.;Klingebiel, D.;Knutzen, S.;Kreuzer, P.;Merschmeyer, M.;Meyer, A.;Olschewski, M.;Padeken, K.;Papacz, P.;Reithler, H.;Schmitz, S. A.;Sonnenschein, L.;Teyssier, D.;Thuer, S.;Weber, M.;Cherepanov, V.;Erdogan, Y.;Flugge, G.;Geenen, H.;Geisler, M.;Ahmad, W. H.;Hoehle, F.;Kargoll, B.;Kress, T.;Kuessel, Y.;Lingemann, J.;Nowack, A.;Nugent, I. M.;Perchalla, L.;Pooth, O.;Stahl, A.;Asin, I.;Bartosik, N.;Behr, J.;Behrenhoff, W.;Behrens, U.;Bell, A. J.;Bergholz, M.;Bethani, A.;Borras, K.;Burgmeier, A.;Cakir, A.;Calligaris, L.;Campbell, A.;Choudhury, S.;Costanza, F.;Pardos, C. D.;Dooling, S.;Dorland, T.;Eckerlin, G.;Eckstein, D.;Eichhorn, T.;Flucke, G.;Garcia, J. G.;Geiser, A.;Gunnellini, P.;Hauk, J.;Hellwig, G.;Hempel, M.;Horton, D.;Jung, H.;Kasemann, M.;Katsas, P.;Kieseler, J.;Kleinwort, C.;Krucker, D.;Lange, W.;Leonard, J.;Lipka, K.;Lobanov, A.;Lohmann, W.;Lutz, B.;Mankel, R.;Marfin, I.;Melzer-Pellmann, I. A.;Meyer, A. B.;Mnich, J.;Mussgiller, A.;Naumann-Emme, S.;Nayak, A.;Novgorodova, O.;Nowak, F.;Ntomari, E.;Perrey, H.;Pitzl, D.;Placakyte, R.;Raspereza, A.;RibeiroCipriano, P. M.;Ron, E.;Sahin, M. O.;Salfeld-Nebgen, J.;Saxena, P.;Schmidt, R.;Schoerner-Sadenius, T.;Schroder, M.;Spannagel, S.;Trevino, Adrv;Walsh, R.;Wissing, C.;Martin, M. A.;Blobel, V.;Vignali, M. C.;Erfle, J.;Garutti, E.;Goebel, K.;Gorner, M.;Gosselink, M.;Haller, J.;Hoffmann, M.;Hoing, R. S.;Kirschenmann, H.;Klanner, R.;Kogler, R.;Lange, J.;Lapsien, T.;Lenz, T.;Marchesini, I.;Ott, J.;Peiffer, T.;Pietsch, N.;Rathjens, D.;Sander, C.;Schettler, H.;Schleper, P.;Schlieckau, E.;Schmidt, A.;Seidel, M.;Sibille, J.;Sola, V.;Stadie, H.;Steinbruck, G.;Troendle, D.;Usai, E.;Vanelderen, L.;Barth, C.;Baus, C.;Berger, J.;Boser, C.;Butz, E.;Chwalek, T.;De Boer, W.;Descroix, A.;Dierlamm, A.;Feindt, M.;Frensch, F.;Giffels, M.;Hartmann, F.;Hauth, T.;Husemann, U.;Katkov, I.;Kornmayer, A.;Kuznetsova, E.;Pardo, P. L.;Mozer, M. U.;Muller, T.;Nurnberg, A.;Quast, G.;Rabbertz, K.;Ratnikov, F.;Rocker, S.;Simonis, H. J.;Stober, F. M.;Ulrich, R.;Wagner-Kuhr, J.;Wayand, S.;Weiler, T.;Wolf, R.;Anagnostou, G.;Daskalakis, G.;Geralis, T.;Giakoumopoulou, V. A.;Kyriakis, A.;Loukas, D.;Markou, A.;Markou, C.;Psallidas, A.;Topsis-Giotis, I.;Panagiotou, A.;Saoulidou, N.;Stiliaris, E.;Aslanoglou, X.;Evangelou, I.;Flouris, G.;Foudas, C.;Kokkas, P.;Manthos, N.;Papadopoulos, I.;Paradas, E.;Bencze, G.;Hajdu, C.;Hidas, P.;Horvath, D.;Sikler, F.;Veszpremi, V.;Vesztergombi, G.;Zsigmond, A. J.;Beni, N.;Czellar, S.;Karancsi, J.;Molnar, J.;Palinkas, J.;Szillasi, Z.;Raics, P.;Trocsanyi, Z. L.;Ujvari, B.;Swain, S. K.;Beri, S. B.;Bhatnagar, V.;Dhingra, N.;Gupta, R.;Kalsi, A. K.;Kaur, M.;Mittal, M.;Nishu, N.;Singh, J. B.;Kumar, A.;Kumar, A.;Ahuja, S.;Bhardwaj, A.;Choudhary, B. C.;Kumar, A.;Malhotra, S.;Naimuddin, M.;Ranjan, K.;Sharma, V.;Banerjee, S.;Bhattacharya, S.;Chatterjee, K.;Dutta, S.;Gomber, B.;Jain, S.;Jain, S.;Khurana, R.;Modak, A.;Mukherjee, S.;Roy, D.;Sarkar, S.;Sharan, M.;Abdulsalam, A.;Dutta, D.;Kailas, S.;Kumar, V.;Mohanty, A. K.;Pant, L. M.;Shukla, P.;Topkar, A.;Aziz, T.;Banerjee, S.;Chatterjee, R. M.;Dewanjee, R. K.;Dugad, S.;Ganguly, S.;Ghosh, S.;Guchait, M.;Gurtu, A.;Kole, G.;Kumar, S.;Maity, M.;Majumder, G.;Mazumdar, K.;Mohanty, G. B.;Parida, B.;Sudhakar, K.;Wickramage, N.;Bakhshiansohi, H.;Behnamian, H.;Etesami, S. M.;Fahim, A.;Goldouzian, R.;Jafari, A.;Khakzad, M.;Najafabadi, M. M.;Naseri, M.;Mehdiabadi, S. P.;Safarzadeh, B.;Zeinali, M.;Felcini, M.;Grunewald, M.;Abbrescia, M.;Barbone, L.;Calabria, C.;Chhibra, S. S.;Colaleo, A.;Creanza, D.;De Filippis, N.;De Palma, M.;Fiore, L.;Iaselli, G.;Maggi, G.;Maggi, M.;My, S.;Nuzzo, S.;Pompili, A.;Pugliese, G.;Radogna, R.;Selvaggi, G.;Silvestris, L.;Singh, G.;Venditti, R.;Verwilligen, P.;Zito, G.;Abbiendi, G.;Benvenuti, A. C.;Bonacorsi, D.;Braibant-Giacomelli, S.;Brigliadori, L.;Campanini, R.;Capiluppi, P.;Castro, A.;Cavallo, F. R.;Codispoti, G.;Cuffiani, M.;Dallavalle, G. M.;Fabbri, F.;Fanfani, A.;Fasanella, D.;Giacomelli, P.;Grandi, C.;Guiducci, L.;Marcellini, S.;Masetti, G.;Montanari, A.;Navarria, F. L.;Perrotta, A.;Primavera, F.;Rossi, A. M.;Rovelli, T.;Siroli, G. P.;Tosi, N.;Travaglini, R.;Albergo, S.;Cappello, G.;Chiorboli, M.;Costa, S.;Giordano, F.;Potenza, R.;Tricomi, A.;Tuve, C.;Barbagli, G.;Ciulli, V.;Civinini, C.;D'Alessandro, R.;Focardi, E.;Gallo, E.;Gonzi, S.;Gori, V.;Lenzi, P.;Meschini, M.;Paoletti, S.;Sguazzoni, G.;Tropiano, A.;Benussi, L.;Bianco, S.;Fabbri, F.;Piccolo, D.;Ferro, F.;Lo Vetere, M.;Robutti, E.;Tosi, S.;Dinardo, M. E.;Fiorendi, S.;Gennai, S.;Gerosa, R.;Ghezzi, A.;Govoni, P.;Lucchini, M. T.;Malvezzi, S.;Manzoni, R. A.;Martelli, A.;Marzocchi, B.;Menasce, D.;Moroni, L.;Paganoni, M.;Pedrini, D.;Ragazzi, S.;Redaelli, N.;de Fatis, T. T.;Buontempo, S.;Cavallo, N.;Di Guida, S.;Fabozzi, F.;Iorio, A. O. M.;Lista, L.;Meola, S.;Merola, M.;Paolucci, P.;Azzi, P.;Bacchetta, N.;Bellato, M.;Bisello, D.;Branca, A.;Carlin, R.;Checchia, P.;Dall'Osso, M.;Dorigo, T.;Galanti, M.;Gasparini, F.;Gasparini, U.;Giubilato, P.;Gozzelino, A.;Kanishchev, K.;Lacaprara, S.;Margoni, M.;Meneguzzo, A. T.;Pazzini, J.;Pozzobon, N.;Ronchese, P.;Sgaravatto, M.;Tosi, M.;Triossi, A.;Ventura, S.;Zucchetta, A.;Zumerle, G.;Ratti, S. P.;Riccardi, C.;Salvini, P.;Vitulo, P.;Biasini, M.;Bilei, G. M.;Ciangottini, D.;Fano, L.;Lariccia, P.;Mantovani, G.;Menichelli, M.;Romeo, F.;Saha, A.;Santocchia, A.;Spiezia, A.;Androsov, K.;Azzurri, P.;Bagliesi, G.;Bernardini, J.;Boccali, T.;Broccolo, G.;Castaldi, R.;Ciocci, M. A.;Dell'Orso, R.;Donato, S.;Fiori, F.;Foa, L.;Giassi, A.;Grippo, M. T.;Ligabue, F.;Lomtadze, T.;Martini, L.;Messineo, A.;Moon, C. S.;Palla, F.;Rizzi, A.;Savoy-Navarro, A.;Serban, A. T.;Spagnolo, P.;Squillacioti, P.;Tenchini, R.;Tonelli, G.;Venturi, A.;Verdini, P. G.;Vernieri, C.;Barone, L.;Cavallari, F.;Del Re, D.;Diemoza, M.;Grassi, M.;Jorda, C.;Longo, E.;Margaroli, F.;Meridiani, P.;Micheli, F.;Nourbakhsh, S.;Organtini, G.;Paramatti, R.;Rahatlou, S.;Rovelli, C.;Santanastasio, F.;Soffi, L.;Traczyk, P.;Amapane, N.;Arcidiacono, R.;Argiro, S.;Arneodo, M.;Bellan, R.;Biino, C.;Cartiglia, N.;Casasso, S.;Costa, M.;Degano, A.;Demaria, N.;Finco, L.;Mariotti, C.;Maselli, S.;Migliore, E.;Monaco, V.;Musich, M.;Obertino, M. M.;Ortona, G.;Pacher, L.;Pastrone, N.;Pelliccioni, M.;Angioni, G. L. P.;Potenza, A.;Romero, A.;Ruspa, M.;Sacchi, R.;Solano, A.;Staiano, A.;Tamponi, U.;Belforte, S.;Candelise, V.;Casarsa, M.;Cossutti, F.;Della Ricca, G.;Gobbo, B.;LaLicata, C.;Marone, M.;Montanino, D.;Schizzi, A.;Umer, T.;Zanetti, A.;Chang, S.;Kropivnitskaya, A.;Nam, S. K.;Kim, D. H.;Kim, G. N.;Kim, M. S.;Kong, D. J.;Lee, S.;Oh, Y. D.;Park, H.;Sakharov, A.;Son, D. C.;Kim, J. Y.;Song, S.;Choi, S.;Gyun, D.;Hong, B.;Jo, M.;Kim, H.;Kim, Y.;Lee, B.;Lee, K. S.;Park, S. K.;Roh, Y.;Choi, M.;Kim, H.;Kim, J. H.;Park, I. C.;Park, S.;Ryu, G.;Ryu, M. S.;Choi, Y.;Choi, Y. K.;Goh, J.;Kwon, E.;Lee, J.;Seo, H.;Yu, I.;Juodagalvis, A.;Komaragiri, J. R.;Castilla-Valdez, H.;De La Cruz-Burelo, E.;Heredia-de La Cruz, I.;Lopez-Fernandez, R.;Sanchez-Hernandez, A.;Moreno, S. C.;Valencia, F. V.;Pedraza, I.;Ibarguen, H. A. S.;Linares, E. C.;Pineda, A. M.;Krofcheck, D.;Butler, P. H.;Reucroft, S.;Ahmad, A.;Ahmad, M.;Hassan, Q.;Hoorani, H. R.;Khalid, S.;Khan, W. A.;Khurshid, T.;Shah, M. A.;Shoaib, M.;Bialkowska, H.;Bluj, M.;Boimska, B.;Frueboes, T.;Gorski, M.;Kazana, M.;Nawrocki, K.;Romanowska-Rybinska, K.;Szleper, M.;Zalewski, P.;Brona, G.;Bunkowski, K.;Cwiok, M.;Dominik, W.;Doroba, K.;Kalinowski, A.;Konecki, M.;Krolikowski, J.;Misiura, M.;Olszewski, M.;Wolszczak, W.;Bargassa, P.;Silva, Cbde;Faccioli, P.;Parracho, P. G. F.;Gallinaro, M.;Nguyen, F.;Antunes, J. R.;Seixas, J.;Varela, J.;Vischia, P.;Golutvin, I.;Karjavin, V.;Konoplyanikov, V.;Korenkov, V.;Kozlov, G.;Lanev, A.;Malakhov, A.;Matveev, V.;Mitsyn, V. V.;Moisenz, P.;Palichik, V.;Perelygin, V.;Shmatov, S.;Shulha, S.;Skatchkov, N.;Smirnov, V.;Tikhonenko, E.;Zarubin, A.;Golovtsov, V.;Ivanov, Y.;Kim, V.;Levchenko, P.;Murzin, V.;Oreshkin, V.;Smirnov, I.;Sulimov, V.;Uvarov, L.;Vavilov, S.;Vorobyev, A.;Vorobyev, A.;Andreev, Y.;Dermenev, A.;Gninenko, S.;Golubev, N.;Kirsanov, M.;Krasnikov, N.;Pashenkov, A.;Tlisov, D.;Toropin, A.;Epshteyn, V.;Gavrilov, V.;Lychkovskaya, N.;Popov, V.;Safronov, G.;Semenov, S.;Spiridonov, A.;Stolin, V.;Vlasov, E.;Zhokin, A.;Andreev, V.;Azarkin, M.;Dremin, I.;Kirakosyan, M.;Leonidov, A.;Mesyats, G.;Rusakov, S. V.;Vinogradov, A.;Belyaev, A.;Boos, E.;Dubinin, M.;Dudko, L.;Ershov, A.;Gribushin, A.;Klyukhin, V.;Kodolova, O.;Lokhtin, I.;Obraztsov, S.;Petrushanko, S.;Savrin, V.;Snigirev, A.;Azhgirey, I.;Bayshev, I.;Bitioukov, S.;Kachanov, V.;Kalinin, A.;Konstantinov, D.;Krychkine, V.;Petrov, V.;Ryutin, R.;Sobol, A.;Tourtchanovitch, L.;Troshin, S.;Tyurin, N.;Uzunian, A.;Volkov, A.;Adzic, P.;Dordevic, M.;Ekmedzic, M.;Milosevic, J.;Maestre, J. A.;Battilana, C.;Calvo, E.;Cerrada, M.;Llatas, M. C.;Colino, N.;De La Cruz, B.;Peris, A. D.;Vazquez, D. D.;Del Valle, A. E.;Bedoya, C. F.;Ramos, J. P. F.;Flix, J.;Fouz, M. C.;Garcia-Abia, P.;Lopez, O. G.;Lopez, S. G.;Hernandez, J. M.;Josa, M. I.;Merino, G.;De Martino, E. N.;Yzquierdo, A. P. C.;Pelayo, J. P.;Olmeda, A. Q.;Redondo, I.;Romero, L.;Soares, M. S.;Albajar, C.;de Troconiz, J. F.;Missiroli, M.;Brun, H.;Cuevas, J.;Menendez, J. F.;Folgueras, S.;Caballero, I. G.;Iglesias, L. L.;Cifuentes, J. A. B.;Cabrillo, I. J.;Calderon, A.;Campderros, J. D.;Fernandez, M.;Gomez, G.;Graziano, A.;Virto, A. L.;Marco, J.;Marco, R.;Rivero, C. M.;Matorras, F.;Sanchez, F. J. M.;Gomez, J. P.;Rodrigo, T.;Rodriguez-Marrero, A. Y.;Ruiz-Jimeno, A.;Scodellaro, L.;Vila, I.;Cortabitarte, R. V.;Abbaneo, D.;Auffray, E.;Auzinger, G.;Bachtis, M.;Baillon, P.;Ball, A. H.;Barney, D.;Benaglia, A.;Bendavid, J.;Benhabib, L.;Benitez, J. F.;Bernet, C.;Bianchi, G.;Bloch, P.;Bocci, A.;Bonato, A.;Bondu, O.;Botta, C.;Breuker, H.;Camporesi, T.;Cerminara, G.;Colafranceschi, S.;D'Alfonso, M.;d'Enterria, D.;Dabrowski, A.;David, A.;De Guio, F.;De Roeck, A.;De Visscher, S.;Dobson, M.;Dupont-Sagorin, N.;Elliott-Peisert, A.;Eugster, J.;Franzoni, G.;Funk, W.;Gigi, D.;Gill, K.;Giordano, D.;Girone, M.;Glege, F.;Guida, R.;Gundacker, S.;Guthoff, M.;Hammer, J.;Hansen, M.;Harris, P.;Hegeman, J.;Innocente, V.;Janot, P.;Kousouris, K.;Krajczar, K.;Lecoq, P.;Lourenco, C.;Magini, N.;Malgeri, L.;Mannelli, M.;Marrouche, J.;Masetti, L.;Meijers, F.;Mersi, S.;Meschi, E.;Moortgat, F.;Morovic, S.;Mulders, M.;Musella, P.;Orsini, L.;Pape, L.;Perez, E.;Perrozzi, L.;Petrilli, A.;Petrucciani, G.;Pfeiffer, A.;Pierini, M.;Pimia, M.;Piparo, D.;Plagge, M.;Racz, A.;Rolandi, G.;Rovere, M.;Sakulin, H.;Schafer, C.;Schwick, C.;Sekmen, S.;Sharma, A.;Siegrist, P.;Silva, P.;Simon, M.;Sphicas, P.;Spiga, D.;Steggemann, J.;Stieger, B.;Stoye, M.;Treille, D.;Tsirou, A.;Veres, G. I.;Vlimant, J. R.;Wardle, N.;Wohri, H. K.;Zeuner, W. D.;Bertl, W.;Deiters, K.;Erdmann, W.;Horisberger, R.;Ingram, Q.;Kaestli, H. C.;Konig, S.;Kotlinski, D.;Langenegger, U.;Renker, D.;Rohe, T.;Bachmair, F.;Bani, L.;Bianchini, L.;Bortignon, P.;Buchmann, M. A.;Casal, B.;Chanon, N.;Deisher, A.;Dissertori, G.;Dittmar, M.;Donega, M.;Dunser, M.;Eller, P.;Grab, C.;Hits, D.;Lustermann, W.;Mangano, B.;Marini, A. C.;del Arbol, P. M. R.;Meister, D.;Mohr, N.;Nageli, C.;Nef, P.;Nessi-Tedaldi, F.;Pandolfi, F.;Pauss, F.;Peruzzi, M.;Quittnat, M.;Rebane, L.;Ronga, F. J.;Rossini, M.;Starodumov, A.;Takahashi, M.;Theofilatos, K.;Wallny, R.;Weber, H. A.;Amsler, C.;Canelli, M. F.;Chiochia, V.;De Cosa, A.;Hinzmann, A.;Hreus, T.;Rikova, M. I.;Kilminster, B.;Mejias, B. M.;Ngadiuba, J.;Robmann, P.;Snoek, H.;Taroni, S.;Verzetti, M.;Yang, Y.;Cardaci, M.;Chen, K. H.;Ferro, C.;Kuo, C. M.;Lin, W.;Lu, Y. J.;Volpe, R.;Yu, S. S.;Chang, P.;Chang, Y. H.;Chang, Y. W.;Chao, Y.;Chen, K. F.;Chen, P. H.;Dietz, C.;Grundler, U.;Hou, W. S.;Kao, K. Y.;Lei, Y. J.;Liu, Y. F.;Lu, R. S.;Majumder, D.;Petrakou, E.;Tzeng, Y. M.;Wilken, R.;Asavapibhop, B.;Srimanobhas, N.;Suwonjandee, N.;Adiguzel, A.;Bakirci, M. N.;Cerci, S.;Dozen, C.;Dumanoglu, I.;Eskut, E.;Girgis, S.;Gokbulut, G.;Gurpinar, E.;Hos, I.;Kangal, E. E.;Topaksu, A. K.;Onengut, G.;Ozdemir, K.;Ozturk, S.;Polatoz, A.;Sogut, K.;Cerci, D. S.;Tali, B.;Topakli, H.;Vergili, M.;Akin, I. V.;Bilin, B.;Bilmis, S.;Gamsizkan, H.;Karapinar, G.;Ocalan, K.;Surat, U. E.;Yalvac, M.;Zeyrek, M.;Gulmez, E.;Isildak, B.;Kaya, M.;Kaya, O.;Bahtiyar, H.;Barlas, E.;Cankocak, K.;Vardarli, F. I.;Yucel, M.;Levchuk, L.;Sorokin, P.;Brooke, J. J.;Clement, E.;Cussans, D.;Flacher, H.;Frazier, R.;Goldstein, J.;Grimes, M.;Heath, G. P.;Heath, H. F.;Jacob, J.;Kreczko, L.;Lucas, C.;Meng, Z.;Newbold, D. M.;Paramesvaran, S.;Poll, A.;Senkin, S.;Smith, V. J.;Williams, T.;Bell, K. W.;Belyaev, A.;Brew, C.;Brown, R. M.;Cockerill, D. J. A.;Coughlan, J. A.;Harder, K.;Harper, S.;Olaiya, E.;Petyt, D.;Shepherd-Themistocleous, C. H.;Thea, A.;Tomalin, I. R.;Womersley, W. J.;Worm, S. D.;Baber, M.;Bainbridge, R.;Buchmuller, O.;Burton, D.;Colling, D.;Cripps, N.;Cutajar, M.;Dauncey, P.;Davies, G.;Della Negra, M.;Dunne, P.;Ferguson, W.;Fulcher, J.;Futyan, D.;Gilbert, A.;Hall, G.;Iles, G.;Jarvis, M.;Karapostoli, G.;Kenzie, M.;Lane, R.;Lucas, R.;Lyons, L.;Magnan, A. M.;Malik, S.;Mathias, B.;Nash, J.;Nikitenko, A.;Pela, J.;Pesaresi, M.;Petridis, K.;Raymond, D. M.;Rogerson, S.;Rose, A.;Seez, C.;Sharp, P.;Tapper, A.;Acosta, M. V.;Virdee, T.;Cole, J. E.;Hobson, P. R.;Khan, A.;Kyberd, P.;Leggat, D.;Leslie, D.;Martin, W.;Reid, I. D.;Symonds, P.;Teodorescu, L.;Turner, M.;Dittmann, J.;Hatakeyama, K.;Kasmi, A.;Liu, H.;Scarborough, T.;Charaf, O.;Cooper, S. I.;Henderson, C.;Rumerio, P.;Avetisyan, A.;Bose, T.;Fantasia, C.;Heister, A.;Lawson, P.;Richardson, C.;Rohlf, J.;Sperka, D.;John, J. S.;Sulak, L.;Alimena, J.;Bhattacharya, S.;Christopher, G.;Cutts, D.;Demiragli, Z.;Ferapontov, A.;Garabedian, A.;Heintz, U.;Jabeen, S.;Kukartsev, G.;Laird, E.;Landsberg, G.;Luk, M.;Narain, M.;Segala, M.;Sinthuprasith, T.;Speer, T.;Swanson, J.;Breedon, R.;Breto, G.;Sanchez, M. C. D.;Chauhan, S.;Chertok, M.;Conway, J.;Conway, R.;Cox, P. T.;Erbacher, R.;Gardner, M.;Ko, W.;Lander, R.;Miceli, T.;Mulhearn, M.;Pellett, D.;Pilot, J.;Ricci-Tam, F.;Searle, M.;Shalhout, S.;Smith, J.;Squires, M.;Stolp, D.;Tripathi, M.;Wilbur, S.;Yohay, R.;Cousins, R.;Everaerts, P.;Farrell, C.;Hauser, J.;Ignatenko, M.;Rakness, G.;Takasugi, E.;Valuev, V.;Weber, M.;Babb, J.;Clare, R.;Ellison, J.;Gary, J. W.;Hanson, G.;Heilman, J.;Jandir, P.;Kennedy, E.;Lacroix, F.;Liu, H.;Long, O. R.;Luthra, A.;Malberti, M.;Nguyen, H.;Shrinivas, A.;Sumowidagdo, S.;Wimpenny, S.;Andrews, W.;Branson, J. G.;Cerati, G. B.;Cittolin, S.;D'Agnolo, R. T.;Evans, D.;Holzner, A.;Kelley, R.;Klein, D.;Lebourgeois, M.;Letts, J.;Macneill, I.;Olivito, D.;Padhi, S.;Palmer, C.;Pieri, M.;Sani, M.;Sharma, V.;Simon, S.;Sudano, E.;Tadel, M.;Tu, Y.;Vartak, A.;Welke, C.;Wuerthwein, F.;Yagil, A.;Yoo, J.;Barge, D.;Bradmiller-Feld, J.;Campagnari, C.;Danielson, T.;Dishaw, A.;Flowers, K.;Sevilla, M. F.;Geffert, P.;George, C.;Golf, F.;Gouskos, L.;Incandela, J.;Justus, C.;McColl, N.;Richman, J.;Stuart, D.;To, W.;West, C.;Apresyan, A.;Bornheim, A.;Bunn, J.;Chen, Y.;Di Marco, E.;Duarte, J.;Mott, A.;Newman, H. B.;Pena, C.;Rogan, C.;Spiropulu, M.;Timciuc, V.;Wilkinson, R.;Xie, S.;Zhu, R. Y.;Azzolini, V.;Calamba, A.;Ferguson, T.;Iiyama, Y.;Paulini, M.;Russ, J.;Vogel, H.;Vorobiev, I.;Cumalat, J. P.;Drell, B. R.;Ford, W. T.;Gaz, A.;Lopez, E. L.;Nauenberg, U.;Smith, J. G.;Stenson, K.;Ulmer, K. A.;Wagner, S. R.;Alexander, J.;Chatterjee, A.;Chu, J.;Dittmer, S.;Eggert, N.;Hopkins, W.;Mirman, N.;Kaufman, G. N.;Patterson, J. R.;Ryd, A.;Salvati, E.;Skinnari, L.;Sun, W.;Teo, W. D.;Thom, J.;Thompson, J.;Tucker, J.;Weng, Y.;Winstrom, L.;Wittich, P.;Winn, D.;Abdullin, S.;Albrow, M.;Anderson, J.;Apollinari, G.;Bauerdick, L. A. T.;Beretvas, A.;Berryhill, J.;Bhat, P. C.;Burkett, K.;Butler, J. N.;Cheung, H. W. K.;Chlebana, F.;Cihangir, S.;Elvira, V. D.;Fisk, I.;Freeman, J.;Gao, Y.;Gottschalk, E.;Gray, L.;Green, D.;
Targeted treatment options for paediatric B-cell precursor acute lymphoblastic leukaemia patients with constitutional or somatic chromosome 21 alterations
Background: Chromosome 21 is affected in ∼60% of paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) patients and includes somatic and constitutional gains, intrachromosomal amplification of chromosome 21 (iAMP21), and the translocation t(12;21) resulting in the ETV6::RUNX1 gene fusion. Methods: Since these numeric and structural chromosome 21 alterations are not targetable, we studied the type and frequency of yet-proven targetable events co-occurring with chromosome 21 alterations.Results: Among 307 primary paediatric BCP-ALL cases, JAK/STAT pathway lesions were most frequent in patients with constitutional gain of chromosome 21 (Down syndrome ALL; 35/71, 49%) and iAMP21 (9/22, 41%). RAS pathway lesions were most frequent in high hyperdiploidy (62/108, 57%) and FLT3 lesions were most frequent in iAMP21 (7/22, 32%). Virtually all cases expressed CD19 and CD22 at the cell surface. Positivity for CD20 surface expression ranged from 67% in iAMP21 (8/12) to 20% in ETV6::RUNX1 (26/129). Conclusion: Activated JAK/STAT, RAS or FLT3 signalling, and CD marker surface expression may provide targetable treatment options for the majority of chromosome 21-altered BCP-ALL cases.</p
Autonomous multi-platform observations during the Salinity Processes in the Upper-ocean Regional Study
Author Posting. © The Oceanography Society, 2017. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 30, no. 2 (2017): 38–48, doi:10.5670/oceanog.2017.218.The Salinity Processes in the Upper-ocean Regional Study (SPURS) aims to understand the patterns and variability of sea surface salinity. In order to capture the wide range of spatial and temporal scales associated with processes controlling salinity in the upper ocean, research vessels delivered autonomous instruments to remote sites, one in the North Atlantic and one in the Eastern Pacific. Instruments sampled for one complete annual cycle at each of these two sites, which are subject to contrasting atmospheric forcing. The SPURS field programs coordinated sampling from many different platforms, using a mix of Lagrangian and Eulerian approaches. This article discusses the motivations, implementation, and first results of the SPURS-1 and SPURS-2 programs.SPURS is supported by multiple NASA grants, with
important additional contributions from the US
National Science Foundation, NOAA, and the Office
of Naval Research, as well as international agencies. SVP drifters are deployed with support
from NASA and the NOAA funded Global Drifter
Program at the Lagrangian Drifter Laboratory of
the Scripps Institution of Oceanography. SVP-S2
drifters are provided by NOAA-AOML and NASA.
PRAWLER mooring development is supported
by NOAA’s Office of Oceanic and Atmospheric
Research, Ocean Observing and Monitoring Division,
and by NOAA/PMEL
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