1,744 research outputs found
Evidence for field change in oral cancer based on cytokeratin expression.
It was hypothesised that one may be able to visualise field changes, which are proposed to exist around tumours, as alterations in keratin intermediate filament protein expression. Standard immunohistochemical analysis using a panel of monoclonal anti-keratin antibodies was applied to fresh tissue sections to look for subtle changes in epithelial differentiation not visible in H&E sections. Such changes were observed in clinically normal epithelium from oral cancer patients, involving primarily substantial expression of keratins K8/K7 (using CAM 5.2) in the basal cells of 12 out of 34 biopsies, and also a trend towards a reduction in the complexity of keratin differentiation. Monitoring such changes may prove to be a valuable adjunct to conventional H&E staining if found to have prognostic and diagnostic significance
A novel sputtering technique: Inductively Coupled Impulse Sputtering (ICIS)
Sputtering magnetic materials with magnetron based systems has the disadvantage of field quenching and variation of alloy composition with target erosion. The advantage of eliminating magnetic fields in the chamber is that this enables sputtered particles to move along the electric field more uniformly. Inductively coupled impulse sputtering (ICIS) is a form of high power impulse magnetron sputtering (HIPIMS) without a magnetic field where a high density plasma is produced by a high power radio frequency (RF) coil in order to sputter the target and ionise the metal vapour. In this emerging technology, the effects of power and pressure on the ionisation and deposition process are not known. The setup comprises of a 13.56 MHz pulsed RF coil pulsed with a duty cycle of 25 %. A pulsed DC voltage of 1900 V was applied to the cathode to attract Argon ions and initiate sputtering. Optical emission spectra (OES) for Cu and Ti neutrals and ions at constant pressure show a linear intensity increase for peak RF powers of 500 W â 3400 W and a steep drop of intensity for a power of 4500 W. Argon neutrals show a linear increase for powers of 500 W â 2300 W and a saturation of intensity between 2300 W â 4500 W. The influence of pressure on the process was studied at a constant peak RF power of 2300 W. With increasing pressure the ionisation degree increased. The microstructure of the coatings shows globular growth at 2.95Ă10â2 mbar and large-grain columnar growth at 1.2Ă10â1 mbar. Bottom coverage of unbiased vias with a width of 0.360 ÎŒm and aspect ratio of 2.5:1 increased from 15 % to 20 % for this pressure range. The current work has shown that the concept of combining a RF powered coil with a magnet-free high voltage pulsed DC powered cathode is feasible and produces very stable plasma. The experiments have shown a significant influence of power and pressure on the plasma and coating microstructure
Transfer of motor and perceptual skills from basketball to darts
The quiet eye is a perceptual skill associated with expertise and superior performance; however, little is known about the transfer of quiet eye across domains. We attempted to replicate previous skill-based differences in quiet eye and investigated whether transfer of motor and perceptual skills occurs between similar tasks. Throwing accuracy and quiet eye duration for skilled and less-skilled basketball players were examined in basketball free throw shooting and the transfer task of dart throwing. Skilled basketball players showed significantly higher throwing accuracy and longer quiet eye duration in the basketball free throw task compared to their less-skilled counterparts. Further, skilled basketball players showed positive transfer from basketball to dart throwing in accuracy but not in quiet eye duration. Our results raise interesting questions regarding the measurement of transfer between skills
Calibration of the Herschel SPIRE Fourier Transform Spectrometer
The Herschel SPIRE instrument consists of an imaging photometric camera and
an imaging Fourier Transform Spectrometer (FTS), both operating over a
frequency range of 450-1550 GHz. In this paper, we briefly review the FTS
design, operation, and data reduction, and describe in detail the approach
taken to relative calibration (removal of instrument signatures) and absolute
calibration against standard astronomical sources. The calibration scheme
assumes a spatially extended source and uses the Herschel telescope as primary
calibrator. Conversion from extended to point-source calibration is carried out
using observations of the planet Uranus. The model of the telescope emission is
shown to be accurate to within 6% and repeatable to better than 0.06% and, by
comparison with models of Mars and Neptune, the Uranus model is shown to be
accurate to within 3%. Multiple observations of a number of point-like sources
show that the repeatability of the calibration is better than 1%, if the
effects of the satellite absolute pointing error (APE) are corrected. The
satellite APE leads to a decrement in the derived flux, which can be up to ~10%
(1 sigma) at the high-frequency end of the SPIRE range in the first part of the
mission, and ~4% after Herschel operational day 1011. The lower frequency range
of the SPIRE band is unaffected by this pointing error due to the larger beam
size. Overall, for well-pointed, point-like sources, the absolute flux
calibration is better than 6%, and for extended sources where mapping is
required it is better than 7%.Comment: 20 pages, 18 figures, accepted for publication in MNRA
Systematic characterisation of the Herschel SPIRE Fourier Transform Spectrometer
A systematic programme of calibration observations was carried out to monitor
the performance of the SPIRE FTS instrument on board the Herschel Space
Observatory. Observations of planets (including the prime point-source
calibrator, Uranus), asteroids, line sources, dark sky, and cross-calibration
sources were made in order to monitor repeatability and sensitivity, and to
improve FTS calibration. We present a complete analysis of the full set of
calibration observations and use them to assess the performance of the FTS.
Particular care is taken to understand and separate out the effect of pointing
uncertainties, including the position of the internal beam steering mirror for
sparse observations in the early part of the mission. The repeatability of
spectral line centre positions is <5km/s, for lines with signal-to-noise ratios
>40, corresponding to <0.5-2.0% of a resolution element. For spectral line
flux, the repeatability is better than 6%, which improves to 1-2% for spectra
corrected for pointing offsets. The continuum repeatability is 4.4% for the SLW
band and 13.6% for the SSW band, which reduces to ~1% once the data have been
corrected for pointing offsets. Observations of dark sky were used to assess
the sensitivity and the systematic offset in the continuum, both of which were
found to be consistent across the FTS detector arrays. The average point-source
calibrated sensitivity for the centre detectors is 0.20 and 0.21 Jy [1 sigma; 1
hour], for SLW and SSW. The average continuum offset is 0.40 Jy for the SLW
band and 0.28 Jy for the SSW band.Comment: 41 pages, 37 figures, 32 tables. Accepted for publication in MNRA
Correcting the extended-source calibration for the <i>Herschel</i>-SPIRE Fourier-transform spectrometer
We describe an update to the Herschel-Spectral and Photometric Imaging Receiver (SPIRE) Fourier-transform spectrometer (FTS) calibration for extended sources, which incorporates a correction for the frequency-dependent far-field feedhorn efficiency, ηff. This significant correction affects all FTS extended-source calibrated spectra in sparse or mapping mode, regardless of the spectral resolution. Line fluxes and continuum levels are underestimated by factors of 1.3â2 in thespectrometer long wavelength band (447â1018 GHz; 671â294 ÎŒm) and 1.4â1.5 in the spectrometer short wavelength band (944â1568 GHz; 318â191 ÎŒm). The correction was implemented in the FTS pipeline version 14.1 and has also been described in the SPIRE Handbook since 2017 February. Studies based on extended-source calibrated spectra produced prior to this pipeline version should be critically reconsidered using the current products available in the Herschel Science Archive. Once the extended-source calibrated spectra are corrected for ηff, the synthetic photometry and the broad-band intensities from SPIRE photometer maps agree within 2â4âperâcent â similar levels to the comparison of point-source calibrated spectra and photometry from point-source calibrated maps. The two calibration schemes for the FTS are now self-consistent: the conversion between the corrected extended-source and point-source calibrated spectra can be achieved with the beam solid angle and a gain correction that accounts for the diffraction loss
Gender and Tahrir Square: contesting the state and imagining a new nation
This article argues that the concepts of âStateâ and âNationâ should be treated as separate from one another, hence, more than one image of the nation is possible at one given time. During the early days of the January 2011 Egyptian revolution, a contestation emerged between Mubarakâs state and the protesters in Tahrir Square over the image and notion of the Egyptian nation. Both the state and the protesters attempted to exclude one another from their respective discourse of the Egyptian nation. While reflecting back on a number of womenâs voices who joined the early days of the Tahrir Square protests and using qualitative fieldwork interviews with Cairo-based feminist and political activists, this article points to the complexity of a newly forged image of Egyptian nationhood. In Tahrir Square, this image appeared to be largely framed within gendered criteria where notions of manhood and hyper visible gender equality were intrinsically linked to the broader objective of removing Mubarak and his regime. This raises the question of whether new gender paradigms of equality can continue to exist beyond Tahrir Squareâs imagination of a ânewâ nation
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