Antiquity at the National Memorial Arboretum

This is an Accepted Manuscript of an article published by Taylor & Francis in International Journal of Heritage Studies on 16/1/2013 available online: http://wwww.tandfonline.com/10.1080/13527258.2012.757556The paper explores the use of ancient and historic material cultures and architectures within the recent resurgence in public commemoration in the UK. Using the case study of the National Memorial Arboretum (Staffordshire), the study focuses on how ancient designs (including prehistoric, classical and medieval styles and forms) interleave with the arboreal, geological and celestial themes of the memorial gardens. Together these designs serve to create a multitude of temporal poises by which auras of commemorative perpetuity and regeneration are projected and sustained. The paper proposes that archaeologists can bring their expertise to bear on the investigation of the complex, varied allusions to the past within contemporary landscapes of memory.This book chapter was submitted to the RAE2014 for the University of Chester - Geography, Environmental Studies and Archaeology

Negative Experiences in Television Programming : A View from the Other Side

Many professional archaeologists will engage with television. There seems to be little guidance- other than trial and error and personal communications - for navigating interactions with media production companies. Here, through a series of informal questions and answers, I present some issues with which one might be confronted in such engagements. I base my discussions on personal experience, literature, and conversations with experienced colleagues. A key point is that media production companies' agendas and priorities often differ from those of archaeologists. While the article draws on experiences from Europe and North America, it has relevance for archaeologists working with television everywhere.Peer reviewe

Heritage Futures - Comparative Approaches to Natural and Cultural Heritage Practices

This is the final version. Available on open access from UCL Press via the DOI in this recordWe present the book as a co-authored monograph because we acknowledge the collective contributions to the arguments developed within it, and the collaborative nature of the work. This has in itself been an experiment in finding a format in which diverse voices and views could productively speak to one another, while also acknowledging and foregrounding the diversity and range of different views, academic traditions and writing styles of contributors. As principal investigator, Harrison acted as the lead and coordinating author of the book, taking overall responsibilities for its editing and production. The co-investigators (DeSilvey, Holtorf, Macdonald) shared with Harrison editorial responsibilities for the individual thematic parts they each led, and for shaping the intellectual agenda of the book as a whole. However, we also felt it important to indicate the main authors of individual chapters within the book, to make clear specific contributions to the text and its arguments, and to highlight which named individuals were responsible for the empirical work that underpins them. Preservation of natural and cultural heritage is often said to be something that is done for the future, or on behalf of future generations, but the precise relationship of such practices to the future is rarely reflected upon. Heritage Futures draws on research undertaken over four years by an interdisciplinary, international team of 16 researchers and more than 25 partner organisations to explore the role of heritage and heritage-like practices in building future worlds. Engaging broad themes such as diversity, transformation, profusion and uncertainty, Heritage Futures aims to understand how a range of conservation and preservation practices across a number of countries assemble and resource different kinds of futures, and the possibilities that emerge from such collaborative research for alternative approaches to heritage in the Anthropocene. Case studies include the cryopreservation of endangered DNA in frozen zoos, nuclear waste management, seed biobanking, landscape rewilding, social history collecting, space messaging, endangered language documentation, built and natural heritage management, domestic keeping and discarding practices, and world heritage site management.Arts and Humanities Research Council (AHRC

Heritage, endangerment and participation: alternative futures in the Lake District

Cultural heritage policy in the UK puts a high value on participation, and heritage agencies often encourage that participation through appealing to the endangered status of the landscapes, sites and monuments in their care. Participation takes many forms, and can involve influencing policy, contributing to cultural outputs and enjoying cultural activities. This paper critically examines the literature and discourse underpinning the endangerment/participation axis and presents a case study of heritage participation in the English Lake District. In order to ground critique in empirical investigation, the case study focusses on the practice of a particular fell shepherd, whose participation in heritage is not motivated by endangerment. The paper then explores the implications of this research for wider thinking about heritage and public life, arguing for the importance of moving beyond endangerment narratives for the creation of resilient heritage futures

Effectiveness of Compounded Bioidentical Hormone Replacement Therapy: An Observational Cohort Study

<p>Abstract</p> <p>Background</p> <p>Bioidentical Hormone Replacement Therapy (BHRT) is believed it to be a safer and equally effective alternative to Conventional Hormone Therapy for the relief of menopausal symptoms; however, data are needed to support these claims. The objective of this study is to evaluate the effectiveness of compounded BHRT provided in six community pharmacies.</p> <p>Methods</p> <p>This was an observational cohort study of women between the ages of 18-89 who received a compounded BHRT product from January 1, 2003 to April 30, 2010 in six community pharmacies. Data included patient demographics, comorbidities, therapeutic outcomes, and hormone therapies. Women self-rated menopausal symptoms as absent, mild, moderate, or severe. Descriptive statistics were used to characterize the patient population, BHRT use, and adverse events. Patient symptom severity was compared at baseline and 3 to 6 months follow-up using the Wilcoxon signed-rank test.</p> <p>Results</p> <p>Women (n = 296) receiving BHRT at Oakdell Pharmacy had a mean (standard deviation) age of 52 (9) years. The most common BHRT dosage forms utilized were topical (71%) and oral (43%). Compounded BHRT regimens were generally initiated at low doses regardless of route. Women experienced a 25% decrease in emotional lability (p < 0.01), a 25% decrease in irritability (p < 0.01), and a 22% reduction in anxiety (p = 0.01) within 3 to 6 months. These women also experienced a 14% reduction in night sweats (p = 0.09) and a 6% reduction in hot flashes (p = 0.50).</p> <p>Conclusions</p> <p>This study demonstrates that compounded BHRT improves mood symptoms. Larger studies are needed to examine the impact on vasomotor symptoms, myocardial infarction and breast cancer.</p

Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats

<p>Abstract</p> <p>Background</p> <p>Pyrrolizidine alkaloids (PAs) are probably the most common plant constituents that poison livestock, wildlife, and humans worldwide. Riddelliine is isolated from plants grown in the western United States and is a prototype of genotoxic PAs. Riddelliine was used to investigate the genotoxic effects of PAs via analysis of gene expression in the target tissue of rats in this study. Previously we observed that the mutant frequency in the liver of rats gavaged with riddelliine was 3-fold higher than that in the control group. Molecular analysis of the mutants indicated that there was a statistically significant difference between the mutational spectra from riddelliine-treated and control rats.</p> <p>Results</p> <p>Riddelliine-induced gene expression profiles in livers of Big Blue transgenic rats were determined. The female rats were gavaged with riddelliine at a dose of 1 mg/kg body weight 5 days a week for 12 weeks. Rat whole genome microarray was used to perform genome-wide gene expression studies. When a cutoff value of a two-fold change and a <it>P</it>-value less than 0.01 were used as gene selection criteria, 919 genes were identified as differentially expressed in riddelliine-treated rats compared to the control animals. By analysis with the Ingenuity Pathway Analysis Network, we found that these significantly changed genes were mainly involved in cancer, cell death, tissue development, cellular movement, tissue morphology, cell-to-cell signaling and interaction, and cellular growth and proliferation. We further analyzed the genes involved in metabolism, injury of endothelial cells, liver abnormalities, and cancer development in detail.</p> <p>Conclusion</p> <p>The alterations in gene expression were directly related to the pathological outcomes reported previously. These results provided further insight into the mechanisms involved in toxicity and carcinogenesis after exposure to riddelliine, and permitted us to investigate the interaction of gene products inside the signaling networks.</p

(Im)material Culture : Towards an Archaeology of Cybercrime

Cybercrime is ubiquitous. People now inhabit a digital environment comprising permanent risk, exponential threats, and multiple virtual/physical harms, forming a global community of malefactors and the criminally exploited. The purpose of this paper is two-fold. First, through an archaeological lens, to characterize the new materiality of cybercrime (including its artefacts and architecture alongside digital/virtual manifestations). And second, to explore the potential for new perspectives on cybercrime borne out of this archaeological approach. In short: what is the archaeology of cybercrime and can new understandings emerge from an archaeological perspective? In undertaking this research we also challenge the long-held presumption that non-physical traces cannot be studied archaeologically. It is our contention that they can

Cold War : a Transnational Approach to a Global Heritage

Although within living memory, many countries now consider their surviving Cold War architecture as part of their heritage. It can even be a priority for heritage managers given that significant buildings are often suitable for reuse while extensive ‘brownfield’ sites such as airfields can be used for large-scale redevelopment. In a number of countries whose work we refer to here (notably the United Kingdom and elsewhere in Europe), agencies responsible for managing their country’s heritage have approached this priority by creating national inventories of sites and buildings with a view to taking informed decisions on their future. This paper presents the argument that the wider international context of the Cold War provides a more appropriate (or additional, higher-level) framework for such decision making. Such a ‘transnational’ approach would allow the comparison of similar (e.g. European) sites not merely within national borders but across the full extent of their western NATO1 deployment in Europe and North America. Taking this approach would also allow comparison with related sites in countries that formed part of the eastern-bloc Warsaw Pact.2 After outlining some examples of how national agencies have approached their Cold War heritage, this paper presents the four stages of this transnational approach making provision for an improved understanding and management of Cold War heritage sites wherever they occur. With a specific focus on the direct comparison between England and Russia, and also referring to sites surviving elsewhere within the former NATO and Warsaw Pact regions, as well as the United States, we argue that this four-stage approach: provides new understandings of a complex archaeological and architectural record; gives fresh perspectives on significance; and (importantly in a time of geopolitical instability) does so in a spirit of cooperation and friendship