18 research outputs found
Connections between stratospheric ozone and climate: Radiative forcing, climate variability, and change
Effect of temperature, light intensity and dilution rate on the cellular composition of red alga Porphyridium cruentum in light-limited chemostat cultures
10.1007/BF01301953MIRCEN Journal of Applied Microbiology and Biotechnology42231-23
Current Evidence for the Use of Laminar Flow in Reducing Infection Rates in Total Joint Arthroplasty
Suckling Rat Brain Regional Distribution of Na+,K+-ATPase Activity in the In Vitro Galactosaemia: The Effect of L-Cysteine and Glutathione
Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily
We have determined the crystal structures of three homologous proteins from the pathogenic protozoans Leishmania donovani, Leishmania major, and Trypanosoma cruzi. We propose that these proteins represent a new subfamily within the isochorismatase superfamily (CDD classification cd004310). Their overall fold and key active site residues are structurally homologous both to the biochemically well-characterized N-carbamoylsarcosine-amidohydrolase, a cysteine hydrolase, and to the phenazine biosynthesis protein PHZD (isochorismase), an aspartyl hydrolase. All three proteins are annotated as mitochondrial-associated ribonuclease Mar1, based on a previous characterization of the homologous protein from L. tarentolae. This would constitute a new enzymatic activity for this structural superfamily, but this is not strongly supported by the observed structures. In these protozoan proteins, the extended active site is formed by inter-subunit association within a tetramer, which implies a distinct evolutionary history and substrate specificity from the previously characterized members of the isochorismatase superfamily. The characterization of the active site is supported crystallographically by the presence of an unidentified ligand bound at the active site cysteine of the T. cruzi structure
Spatial distribution and synoptic conditions of snow accumulation in the Russian Arctic
Snow accumulation and associated synoptic conditions in the Russian Arctic are analysed based on snow depth data from 1950 to 2013 from the All-Russian Research Institute of Hydrometeorological Information—World Data Centre data set. The mean duration of snow coverage in the Russian Arctic is approximately eight to nine months. While the period of snowmelt is usually very short (one or two months), snow accumulates during most of the cold season (October–May). Snow accumulation is associated with negative anomalies of sea level pressure and positive anomalies of air temperature, which means increased cyclonic activity over the analysed region. The cyclones differ in intensity and localization, depending on the area of snowfall. In the western part of the Russian Arctic the cyclones and air masses that bring snowfall may originate from the North Atlantic, while in the eastern part they originate from the Bering Sea, Okhotsk Sea or the North Pacific. The cyclones that bring snowfall may also form locally along the zonal border between two different air masses: the very cold, polar, continental air originating from the Siberian High and the Arctic air from the north, which is often warmer and always more humid than the continental air