The Ursinus Weekly, January 11, 1960

Christmas in Africa • Officer selection team to visit Ursinus College • Band concert is slated for second semester • EEP offers many programs in many countries in 1960 • W.A.A. variety show is scheduled for Feb. 26 • Unique is success • Prof. Armstrong addresses meeting • Debating Club in match at St. Joseph\u27s tonight • Dean Pettit to speak at PSEA session Tuesday • Courbet exhibit at Museum of Art until Feb. 14 • Spirit Committee square dance planned for Friday • Editorial: Purpose • Letters to the editor • Making movies • Reminiscing • Grapplers victorious in match with Fords, 19-15 • Football honors awarded Petersen and Wiest for MAC • Bears defeat Haverford, conquer Swarthmore to total six U.C. wins • Ecumenical conference • Annual Lorelei dance set for Friday, February 12https://digitalcommons.ursinus.edu/weekly/1353/thumbnail.jp

Spatiotemporal heterogeneity of water flowpaths controls dissolved organic carbon sourcing in a snow-dominated, headwater catchment

The non-uniform distribution of water in snowdrift-driven systems can lead to spatial heterogeneity in vegetative communities and soil development, as snowdrifts may locally increase weathering. The focus of this study is to understand the coupled hydrological and biogeochemical dynamics in a heterogeneous, snowdrift-dominated headwater catchment (Reynolds Mountain East, Reynolds Creek Critical Zone Observatory, Idaho, USA). We determine the sources and fluxes of stream water and dissolved organic carbon (DOC) at this site, deducing likely flowpaths from hydrometric and hydrochemical signals of soil water, saprolite water, and groundwater measured through the snowmelt period and summer recession. We then interpret flowpaths using end-member mixing analysis in light of inferred subsurface structure derived from electrical resistivity and seismic velocity transects. Streamwater is sourced primarily from groundwater (averaging 25% of annual streamflow), snowmelt (50%), and water traveling along the saprolite/bedrock boundary (25%). The latter is comprised of the prior year\u27s soil water, which accumulates DOC in the soil matrix through the summer before flushing to the saprolite during snowmelt. DOC indices suggest that it is sourced from terrestrial carbon, and derives originally from soil organic carbon (SOC) before flushing to the saprolite/bedrock boundary. Multiple subsurface regions in the catchment appear to contribute differentially to streamflow as the season progresses; sources shift from the saprolite/bedrock interface to deeper bedrock aquifers from the snowmelt period into summer. Unlike most studied catchments, lateral flow of soil water during the study year is not a primary source of streamflow. Instead, saprolite and groundwater act as integrators of soil water that flows vertically in this system. Our results do not support the flushing hypothesis as observed in similar systems and instead indicate that temporal variation in connectivity may cause the unexpected dilution behavior displayed by DOC in this catchment

Global Water Governance and Climate Change: Identifying Innovative Arrangements for Adaptive Transformation

A convoluted network of different water governance systems exists around the world. Collectively, these systems provide insight into how to build sustainable regimes of water use and management. We argue that the challenge is not tomake the systemless convoluted, but rather to support positive and promising trends in governance, creating a vision for future environmental outcomes. In this paper, we analyse nine water case studies from around the world to help identify potential ‘innovative arrangements’ for addressing existing dilemmas. We argue that such arrangements can be used as a catalyst for crafting new global water governance futures. The nine case studies were selected for their diversity in terms of location, scale and water dilemma, and through an examination of their contexts, structures and processes we identify key themes to consider in the milieu of adaptive transformation. These themes include the importance of acknowledging socio-ecological entanglements, understanding the political dimensions of environmental dilemmas, the recognition of different constructions of the dillema, and the importance of democratized processes.The research for this paper is a part of the “CADWAGO: Climate change adaptation and water governance—reconciling food security, renewable energy and the provision of multiple ecosystem services” project funded as part of the “Europe and Global Challenges programme” by Compagnia di San Paolo, VolkswagenStiftung and Riksbankens Jubileumsfond.https://www.mdpi.com/2073-4441/10/1/2

Enhancing emotional experiences to dance through music: the role of valence and arousal in the cross-modal bias

It is well established that emotional responses to stimuli presented to one perceptive modality (e.g., visual) are modulated by the concurrent presentation of affective information to another modality (e.g., auditory)-an effect known as the cross-modal bias. However, the affective mechanisms mediating this effect are still not fully understood. It remains unclear what role different dimensions of stimulus valence and arousal play in mediating the effect, and to what extent cross-modal influences impact not only our perception and conscious affective experiences, but also our psychophysiological emotional response. We addressed these issues by measuring participants' subjective emotion ratings and their Galvanic Skin Responses (GSR) in a cross-modal affect perception paradigm employing videos of ballet dance movements and instrumental classical music as the stimuli. We chose these stimuli to explore the cross-modal bias in a context of stimuli (ballet dance movements) that most participants would have relatively little prior experience with. Results showed (i) that the cross-modal bias was more pronounced for sad than for happy movements, whereas it was equivalent when contrasting high vs. low arousal movements; and (ii) that movement valence did not modulate participants' GSR, while movement arousal did, such that GSR was potentiated in the case of low arousal movements with sad music and when high arousal movements were paired with happy music. Results are discussed in the context of the affective dimension of neuroentrainment and with regards to implications for the art community

Late style and speaking out: J A Symonds's In the Key of Blue

This article examines In the Key of Blue (1893)—an essay collection by John Addington Symonds—as a case study in queer public utterance during the early 1890s. Viewed through the critical lens of late style, as theorised by Edward Said, the evolution of this project, from compilation through to reader reception, reveals Symonds's determination to “speak out” on the subject of homosexuality. Paradoxically, In the Key of Blue was thus a timely and untimely work: it belonged to a brief period of increased visibility and expressiveness when dealing with male same-sex desire, spearheaded by a younger generation of Decadent writers, but it also cut against the grain of nineteenth-century social taboo and legal repression. Symonds's essay collection brought together new and previously unpublished work with examples of his writing for the periodical press. These new combinations, appearing together for the first time, served to facilitate new readings and new inferences, bringing homosexual themes to the fore. This article traces the dialogic structure of In the Key of Blue , its strategies for articulating homosexual desire, and examines the response of reviewers, from the hostile to celebratory

Integrated genomic characterization of pancreatic ductal adenocarcinoma

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations. Protein profiling identified a favorable prognosis subset with low epithelial-mesenchymal transition and high MTOR pathway scores. Associations of non-coding RNAs with tumor-specific mRNA subtypes were also identified. Our integrated multi-platform analysis reveals a complex molecular landscape of PDAC and provides a roadmap for precision medicine

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH -Mutant Molecular Profiles

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme. We identified an IDH mutant-enriched subtype with distinct molecular features including low expression of chromatin modifiers, elevated expression of mitochondrial genes, and increased mitochondrial DNA copy number. Leveraging the multi-platform data, we observed that ARID1A exhibited DNA hypermethylation and decreased expression in the IDH mutant subtype. More broadly, we found that IDH mutations are associated with an expanded histological spectrum of liver tumors with molecular features that stratify with CCA. Our studies reveal insights into the molecular pathogenesis and heterogeneity of cholangiocarcinoma and provide classification information of potential therapeutic significance

Integrated genomic characterization of oesophageal carcinoma

Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies