Winter storm risk of residential structures ? model development and application to the German state of Baden-Württemberg

International audienceThe derivation of probabilities of high wind speeds and the establishment of risk curves for storm damage is of prime importance in natural hazard risk analysis. Risk curves allow the assessment of damage being exceeded at a given level of probability. In this paper, a method for the assessment of winter storm damage risk is described in detail and applied to the German state of Baden-Württemberg. Based on meteorological observations of the years 1971?2000 and on damage information of 4 severe storm events, storm hazard and damage risk of residential buildings is calculated on the level of communities. For this purpose, highly resolved simulations of storm wind fields with the Karlsruher Atmospheric Mesoscale Model (KAMM) are performed and a storm damage model is developed. Risk curves including the quantification of the uncertainties are calculated for every community. Local differences of hazard and risk are presented in state-wide maps. An average annual winter storm damage to residential buildings of minimum 15 million Euro (reference year 2000) for Baden-Württemberg is expected

An approach to build an event set of European wind storms based on ECMWF EPS

The properties of European wind storms under present climate conditions are estimated on the basis of surface wind forecasts from the European Center of Medium-Range Weather Forecast (ECMWF) Ensemble Prediction System (EPS). While the EPS is designed to provide forecast information of the range of possible weather developments starting from the observed state of weather, we use its archive in a climatological context. It provides a large number of modifications of observed storm events, and includes storms that did not occur in reality. Thus it is possible to create a large sample of storm events, which entirely originate from a physically consistent model, whose ensemble spread represents feasible alternative storm realizations of the covered period. This paper shows that the huge amount of identifiable events in the EPS is applicable to reduce uncertainties in a wide range of fields of research focusing on winter storms. Wind storms are identified and tracked in this study over their lifetime using an algorithm, based on the local exceedance of the 98th percentile of instantaneous 10 m wind speed, calculating a storm severity measure. After removing inhomogeneities in the dataset arising from major modifications of the operational system, the distributions of storm severity, storm size and storm duration are computed. The overall principal properties of the homogenized EPS storm data set are in good agreement with storms from the ERA-Interim dataset, making it suitable for climatological investigations of these extreme events. A demonstrated benefit in the climatological context by the EPS is presented. It gives a clear evidence of a linear increase of maximum storm intensity and wind field size with storm duration. This relation is not recognizable from a sparse ERA-Interim sample for long lasting events, as the number of events in the reanalysis is not sufficient to represent these characteristics

Ultrafast optically induced spin transfer in ferromagnetic alloys

The vision of using light to manipulate electronic and spin excitations in materials on their fundamental time and length scales requires new approaches in experiment and theory to observe and understand these excitations. The ultimate speed limit for all-optical manipulation requires control schemes for which the electronic or magnetic subsystems of the materials are coherently manipulated on the time scale of the laser excitation pulse. In our work, we provide experimental evidence of such a direct, ultrafast, and coherent spin transfer between two magnetic subsystems of an alloy of Fe and Ni. Our experimental findings are fully supported by time-dependent density functional theory simulations and, hence, suggest the possibility of coherently controlling spin dynamics on subfemtosecond time scales, i.e., the birth of the research area of attomagnetism

Drosophila Sperm Swim Backwards in the Female Reproductive Tract and Are Activated via TRPP2 Ion Channels

Sperm have but one purpose, to fertilize an egg. In various species including Drosophila melanogaster female sperm storage is a necessary step in the reproductive process. Amo is a homolog of the human transient receptor potential channel TRPP2 (also known as PKD2), which is mutated in autosomal dominant polycystic kidney disease. In flies Amo is required for sperm storage. Drosophila males with Amo mutations produce motile sperm that are transferred to the uterus but they do not reach the female storage organs. Therefore Amo appears to be a mediator of directed sperm motility in the female reproductive tract but the underlying mechanism is unknown.Amo exhibits a unique expression pattern during spermatogenesis. In spermatocytes, Amo is restricted to the endoplasmic reticulum (ER) whereas in mature sperm, Amo clusters at the distal tip of the sperm tail. Here we show that flagellar localization of Amo is required for sperm storage. This raised the question of how Amo at the rear end of sperm regulates forward movement into the storage organs. In order to address this question, we used in vivo imaging of dual labelled sperm to demonstrate that Drosophila sperm navigate backwards in the female reproductive tract. In addition, we show that sperm exhibit hyperactivation upon transfer to the uterus. Amo mutant sperm remain capable of reverse motility but fail to display hyperactivation and directed movement, suggesting that these functions are required for sperm storage in flies.Amo is part of a signalling complex at the leading edge of the sperm tail that modulates flagellar beating and that guides a backwards path into the storage organs. Our data support an evolutionarily conserved role for TRPP2 channels in cilia

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

Optogenetic inhibition of the electrical activity of neurons enables the causal assessment of their contributions to brain functions. Red light penetrates deeper into tissue than other visible wavelengths. We present a red-shifted cruxhalorhodopsin, Jaws, derived from Haloarcula (Halobacterium) salinarum (strain Shark) and engineered to result in red light–induced photocurrents three times those of earlier silencers. Jaws exhibits robust inhibition of sensory-evoked neural activity in the cortex and results in strong light responses when used in retinas of retinitis pigmentosa model mice. We also demonstrate that Jaws can noninvasively mediate transcranial optical inhibition of neurons deep in the brains of awake mice. The noninvasive optogenetic inhibition opened up by Jaws enables a variety of important neuroscience experiments and offers a powerful general-use chloride pump for basic and applied neuroscience.McGovern Institute for Brain Research at MIT (Razin Fellowship)United States. Defense Advanced Research Projects Agency. Living Foundries Program (HR0011-12-C-0068)Harvard-MIT Joint Research Grants Program in Basic NeuroscienceHuman Frontier Science Program (Strasbourg, France)Institution of Engineering and Technology (A. F. Harvey Prize)McGovern Institute for Brain Research at MIT. Neurotechnology (MINT) ProgramNew York Stem Cell Foundation (Robertson Investigator Award)National Institutes of Health (U.S.) (New Innovator Award 1DP2OD002002)National Institute of General Medical Sciences (U.S.) (EUREKA Award 1R01NS075421)National Institutes of Health (U.S.) (Grant 1R01DA029639)National Institutes of Health (U.S.) (Grant 1RC1MH088182)National Institutes of Health (U.S.) (Grant 1R01NS067199)National Science Foundation (U.S.) (Career Award CBET 1053233)National Science Foundation (U.S.) (Grant EFRI0835878)National Science Foundation (U.S.) (Grant DMS0848804)Society for Neuroscience (Research Award for Innovation in Neuroscience)Wallace H. Coulter FoundationNational Institutes of Health (U.S.) (RO1 MH091220-01)Whitehall FoundationEsther A. & Joseph Klingenstein Fund, Inc.JPB FoundationPIIF FundingNational Institute of Mental Health (U.S.) (R01-MH102441-01)National Institutes of Health (U.S.) (DP2-OD-017366-01)Massachusetts Institute of Technology. Simons Center for the Social Brai

A Temporal -omic Study of Propionibacterium freudenreichii CIRM-BIA1T Adaptation Strategies in Conditions Mimicking Cheese Ripening in the Cold

Propionibacterium freudenreichii is used as a ripening culture in Swiss cheese manufacture. It grows when cheeses are ripened in a warm room (about 24°C). Cheeses with an acceptable eye formation level are transferred to a cold room (about 4°C), inducing a marked slowdown of propionic fermentation, but P. freudenreichii remains active in the cold. To investigate the P. freudenreichii strategies of adaptation and survival in the cold, we performed the first global gene expression profile for this species. The time-course transcriptomic response of P. freudenreichii CIRM-BIA1T strain was analyzed at five times of incubation, during growth at 30°C then for 9 days at 4°C, under conditions preventing nutrient starvation. Gene expression was also confirmed by RT-qPCR for 28 genes. In addition, proteomic experiments were carried out and the main metabolites were quantified. Microarray analysis revealed that 565 genes (25% of the protein-coding sequences of P. freudenreichii genome) were differentially expressed during transition from 30°C to 4°C (P<0.05 and |fold change|>1). At 4°C, a general slowing down was observed for genes implicated in the cell machinery. On the contrary, P. freudenreichii CIRM-BIA1T strain over-expressed genes involved in lactate, alanine and serine conversion to pyruvate, in gluconeogenesis, and in glycogen synthesis. Interestingly, the expression of different genes involved in the formation of important cheese flavor compounds, remained unchanged at 4°C. This could explain the contribution of P. freudenreichii to cheese ripening even in the cold. In conclusion, P. freudenreichii remains metabolically active at 4°C and induces pathways to maintain its long-term survival

Winter storm risk of residential structures &ndash; model development and application to the German state of Baden-Württemberg

The derivation of probabilities of high wind speeds and the establishment of risk curves for storm damage is of prime importance in natural hazard risk analysis. Risk curves allow the assessment of damage being exceeded at a given level of probability. <P> In this paper, a method for the assessment of winter storm damage risk is described in detail and applied to the German state of Baden-Württemberg. Based on meteorological observations of the years 1971&ndash;2000 and on damage information of 4 severe storm events, storm hazard and damage risk of residential buildings is calculated on the level of communities. For this purpose, highly resolved simulations of storm wind fields with the Karlsruher Atmospheric Mesoscale Model (KAMM) are performed and a storm damage model is developed. <P> Risk curves including the quantification of the uncertainties are calculated for every community. Local differences of hazard and risk are presented in state-wide maps. An average annual winter storm damage to residential buildings of minimum 15 million Euro (reference year 2000) for Baden-Württemberg is expected