A disk census for the nearest group of young stars: Mid-infrared observations of the TW Hydrae Association

A group of young, active stars in the vicinity of TW Hydrae has recently been identified as a possible physical association with a common origin. Given its proximity ($\sim$50 pc), age ($\sim$10 Myr) and abundance of binary systems, the TW Hya Association is ideally suited to studies of diversity and evolution of circumstellar disks. Here we present mid-infrared observations of 15 candidate members of the group, 11 of which have no previous flux measurements at wavelengths longer than 2$\mu$m. We report the discovery of a possible 10$\mu$m excess in CD -33$^{\circ}$7795, which may be due to a circumstellar disk or a faint, as yet undetected binary companion. Of the other stars, only TW Hya, HD 98800, Hen 3-600A, and HR 4796A -- all of which were detected by IRAS -- show excess thermal emission. Our 10$\mu$m flux measurements for the remaining members of the Association are consistent with photospheric emission, allowing us to rule out dusty inner disks. In light of these findings, we discuss the origin and age of the TW Hya Association as well as implications for disk evolution timescales.Comment: 10 pages and 1 PostScript figure, accepted for publication in The Astrophysical Journal Letter

Mid-infrared imaging of the young binary star Hen 3-600: Evidence for a dust disk around the primary

We present high-resolution mid-infrared observations of the nearby late-type young binary system Hen 3-600. The binary, at a distance of $\sim$ 50 pc, could be a member of the TW Hydrae Association, the nearest known group of young stars, with an age of a few million years. Our images make it possible for the first time to determine which star in the pair, separated by 1.4'', harbors the mid-infrared excess detected by IRAS. In the near-infrared, where the radiation is primarily photospheric, Hen 3-600A (M3) and Hen 3-600B (M3.5) have a flux ratio of 1.6. At 4.8$\mu$m, 10.8$\mu$m, and 18.2$\mu$m, the primary becomes increasingly dominant over the secondary, suggesting that most of the circumstellar dust in the system resides around Hen 3-600A. Comparison of the spectral energy distribution (SED) of Hen 3-600A to the median SED of classical T Tauri stars suggests that its disk may be truncated by the secondary and provides tentative evidence for a central disk hole. The distribution of dust in the Hen 3-600 system may provide important clues to the formation and evolution of protoplanetary disks in close binaries.Comment: 9 pages, 2 PostScript figures, accepted for publication in The Astrophysical Journal Letter

Adapting CALIPSO Climate Measurements for Near Real Time Analyses and Forecasting

The Cloud-Aerosol Lidar and Infrared Pathfinder satellite Observations (CALIPSO) mission was originally conceived and designed as a climate measurements mission, with considerable latency between data acquisition and the release of the level 1 and level 2 data products. However, the unique nature of the CALIPSO lidar backscatter profiles quickly led to the qualitative use of CALIPSO?s near real time (i.e., ? expedited?) lidar data imagery in several different forecasting applications. To enable quantitative use of their near real time analyses, the CALIPSO project recently expanded their expedited data catalog to include all of the standard level 1 and level 2 lidar data products. Also included is a new cloud cleared level 1.5 profile product developed for use by operational forecast centers for verification of aerosol predictions. This paper describes the architecture and content of the CALIPSO expedited data products. The fidelity and accuracy of the expedited products are assessed via comparisons to the standard CALIPSO data products

Proposal for the development of 3D Vertically Integrated Pattern Recognition Associative Memory (VIPRAM)

Future particle physics experiments looking for rare processes will have no choice but to address the demanding challenges of fast pattern recognition in triggering as detector hit density becomes significantly higher due to the high luminosity required to produce the rare process. The authors propose to develop a 3D Vertically Integrated Pattern Recognition Associative Memory (VIPRAM) chip for HEP applications, to advance the state-of-the-art for pattern recognition and track reconstruction for fast triggering

Stop! In the name of transforming growth factor-β: keeping estrogen receptor-α-positive mammary epithelial cells from proliferating

Recent genetic and cell biological studies illustrate the importance of active transforming growth factor-β signaling in preventing the proliferation of estrogen receptor-positive cells in the normal mammary gland, and suggest how the loss of this inhibition may be important in early breast cancer progression

Financial Sector Liberalisation: Should the Poor Applaud?

Summary Increasingly micro?finance is being encouraged to reformulate its primary focus from explicit antipoverty work to concentrate instead on financial sustainability. Much of this approach is predicated on neoclassical theory which calls for liberalisation of financial markets. It is asserted that, apart from prudential supervision, liberalised markets would create an enabling environment for better financial servicing of the poor; and it is time that micro?finance programmes became financially self?sustaining, and therefore free of subsidies. Empirical testing of these views remains inconclusive, indicating the underlying fact that in many cases financial markets, even after liberalisation, have not behaved entirely as modelled. Though pro?poor interventions in financial markets often have been unsuccessful, they were motivated by valid concerns about the poor being under?served. The main contention of this article is that the current wisdom overestimates what liberalisation can achieve for greater market competition in serving the poor. This is because of its exaggerated faith in the role of interest rates in market clearance, and its inadequate account of informal financial service providers. Stronger, rather than reduced, focus on the poor and poorest, even if via subsidised micro?finance programmes, would help develop financial markets. As in other areas of economic reform, selfish motives of the market may require a helping hand to sustain poor?friendly innovations in service provision

Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.

We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard bolus regimen of 5-FU and folinic acid (5-FU/FA) given for 6 months as adjuvant treatment in colorectal cancer. A total of 716 patients with curatively resected Dukes' B or C colorectal cancer were randomised to 5-FU/FA (5-FU 425 mg m(-2) i.v. and FA 20 mg m(-2) i.v. bolus days 1-5 every 28 days for 6 months) or to PVI 5-FU alone (300 mg m(-2) day for 12 weeks). With a median follow-up of 19.8 months, 133 relapses and 77 deaths have been observed. Overall survival did not differ significantly (log rank P=0.764) between patients receiving 5-FU/FA and PVI 5-FU (3-year survival 83.2 vs 87.9%, respectively). Patients in the 5-FU/FA group had significantly worse relapse-free survival (RFS, log rank P=0.023) compared to those receiving PVI 5-FU (3-year RFS, 68.6 vs 80%, respectively). Grades 3-4 neutropenia, diarrhoea, stomatitis and severe alopecia were significantly less (P<0.0001) and global quality of life scores significantly better (P&<0.001) for patients in the PVI 5-FU treatment arm. In conclusion, infused 5-FU given over 12 weeks resulted in similar survival to bolus 5-FU and FA over a 6 month period, but with significantly less toxicity

Megafaunal Community Structure of Andaman Seamounts Including the Back-Arc Basin – A Quantitative Exploration from the Indian Ocean

Species rich benthic communities have been reported from some seamounts, predominantly from the Atlantic and Pacific Oceans, but the fauna and habitats on Indian Ocean seamounts are still poorly known. This study focuses on two seamounts, a submarine volcano (cratered seamount – CSM) and a non-volcano (SM2) in the Andaman Back–arc Basin (ABB), and the basin itself. The main purpose was to explore and generate regional biodiversity data from summit and flank (upper slope) of the Andaman seamounts for comparison with other seamounts worldwide. We also investigated how substratum types affect the megafaunal community structure along the ABB. Underwater video recordings from TeleVision guided Gripper (TVG) lowerings were used to describe the benthic community structure along the ABB and both seamounts. We found 13 varieties of substratum in the study area. The CSM has hard substratum, such as boulders and cobbles, whereas the SM2 was dominated by cobbles and fine sediment. The highest abundance of megabenthic communities was recorded on the flank of the CSM. Species richness and diversity were higher at the flank of the CSM than other are of ABB. Non-metric multi-dimensional scaling (nMDS) analysis of substratum types showed 50% similarity between the flanks of both seamounts, because both sites have a component of cobbles mixed with fine sediments in their substratum. Further, nMDS of faunal abundance revealed two groups, each restricted to one of the seamounts, suggesting faunal distinctness between them. The sessile fauna corals and poriferans showed a significant positive relation with cobbles and fine sediments substratum, while the mobile categories echinoderms and arthropods showed a significant positive relation with fine sediments only

Challenges and Opportunities for Remote Sensing of Air Quality: Insights from DISCOVER-AQ

No abstract availabl