Tourism Innovation: Integrating Ginseng into Spa Development: A Case Study of Sunmore Ginseng Health Spa in Kamloops, BC, Canada

Although innovation research has built a solid ground in the realms of nature science and technology, for examples, innovation study in the field of engineering looks at the development of new processes; innovation study in the field of medicine focuses on the development of new devices, drugs and practices, it has not obtained its proper respect as a critical topic in social science, particularly in tourism research. Innovation study in tourism is surprisingly limited and still in a phase of infancy. The purpose of this study is to further explore the notion of innovation in the context of tourism based on earlier scholars’ research. To provide more practical and industrial insights into the understanding of how innovation works in tourism, our researchers conduct a case study of Sunmore Ginseng Health Spa to examine its application of the established innovation concepts and paradigms, as well as the fitness for Abernathy and Clark’s innovation model. Sunmore Ginseng Spa, a health spa in Canada, is located in Kamloops, BC. It is operated as a day spa. The spa is characterized by four functioned suites with the themes from Chinese ancient philosophy: Gold, Wood, Water and Fire. The services offered at Sunmore spa include Swedish massage, aromatherapy massage, reflexology, body wrap, salt glow, facials, and ginseng steaming and sauna. The study found Sunmore Ginseng Health Spa fits well the right upper quadrant of the model which is named ‘architectural innovation’. In line with the ‘experience economy’, Sunmore Ginseng Health Spa may also be considered a good example of ‘experience innovation’. In addition, the research also identified several emergent themes from tourism innovations such as service differentiation, ‘high-tech. and high- touch’, and experience innovation in the experience economy. Future research should further look into the main drivers of tourism innovation, the relationship between innovation and entrepreneurship, the development of innovation models for specific service sub-sectors, as well as the roles of innovation in the experience economy

Isotopic biases for actinide-only burnup credit

The primary purpose of this paper is to present the new methodology for establishing bias and uncertainty associated with isotopic prediction in spent fuel assemblies for burnup credit analysis. The analysis applies to the design of criticality control systems for spent fuel casks. A total of 54 spent fuel samples were modeled and analyzed using the Shielding Analyses Sequence (SAS2H). Multiple regression analysis and a trending test were performed to develop isotopic correction factors for 10 actinide burnup credit isotopes. 5 refs., 1 tab

Nonlinear Dynamic Phenomena in Macroscopic Tunneling

Numerical simulations of the NLSE (or GPE) are presented demonstrating emission of short pulses of the matter (light) density formed in the course of tunneling in wave-guided light and/or trapped BEC. The phenomenon is observed under various conditions, for nonlinearities of different signs, zero nonlinearity included. We study, both numerically and analytically, pulsations of matter (light) remaining within the trap and use the results in order to induce emission of sequential pulses by properly narrowing the trap. This allows us to propose a mechanism for a realization of Atom Pulse Laser.Comment: 14 pages, 6 figure

Large-Scale Patterns of Green Turtle Trophic Ecology in the Eastern Pacific Oceans

Trophic position and niche width are fundamental components of a species\u27 ecology, reflecting resource use, and influencing key demographic parameters such as somatic growth, maturation, and survival. Concepts about a species\u27 trophic niche space have important implications for local management and habitat protection, and can shed light about resilience to changing climate for species occurring over broad spatial scales. For elusive marine animals such as sea turtles, trophic niche is challenging to study, and researchers often rely on other metrics, such as isotopic niche, as a proxy. Here, stable isotope analysis (delta C-13 and delta N-15 values) was conducted on bulk skin tissue of 718 green turtles (Chelonia mydas) distributed among 16 foraging areas in the eastern Pacific from the USA to Chile, a range spanning similar to 10,000 km. Compound-specific nitrogen isotope analysis of amino acids (CSIA-AA) was applied to 21 turtles among seven sites. Isotopic niche space was determined via Bayesian ellipse area (BEA) and convex hull area (CHA) analyses of bulk isotope values, which were also used along with amino acid delta N-15 values to determine trophic position (TP). Substantial variability in bulk tissue delta C-13 and delta N-15 values was found within and among sites, and amino acid delta N-15 values confirmed this was largely due to spatial differences in baseline nitrogen isotopic compositions, but also to a lesser extent from TP differences among the green turtle foraging populations. Isotope niche space varied among sites, influenced by the diversity of prey types and relative input of terrestrial- vs. marine-derived nutrients; BEAs were the most suitable measurement of isotopic niche space due to the larger influence of outlying values with the CHA approach. Amino acid isotope-derived TP estimates that accounted for local habitat conditions (e.g., mixed seagrass/macroalgae diet) performed the best among several approaches; TP ranged from 2.3 to 3.6, which indicates an omnivorous diet for most populations. In addition to providing additional spatial resolution for delta C-13 and delta N-15 isoscapes in the eastern Pacific, especially in coastal habitats, this study further establishes CSIA-AA as an effective tool to study the trophic ecology of sea turtles across a variety of food webs and habitats

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy

BACKGROUND: A few tau immunotherapies are now in clinical trials with several more likely to be initiated in the near future. A priori, it can be anticipated that an antibody which broadly recognizes various pathological tau aggregates with high affinity would have the ideal therapeutic properties. Tau antibodies 4E6 and 6B2, raised against the same epitope region but of varying specificity and affinity, were tested for acutely improving cognition and reducing tau pathology in transgenic tauopathy mice and neuronal cultures. RESULTS: Surprisingly, we here show that one antibody, 4E6, which has low affinity for most forms of tau acutely improved cognition and reduced soluble phospho-tau, whereas another antibody, 6B2, which has high affinity for various tau species was ineffective. Concurrently, we confirmed and clarified these efficacy differences in an ex vivo model of tauopathy. Alzheimer’s paired helical filaments (PHF) were toxic to the neurons and increased tau levels in remaining neurons. Both toxicity and tau seeding were prevented by 4E6 but not by 6B2. Furthermore, 4E6 reduced PHF spreading between neurons. Interestingly, 4E6’s efficacy relates to its high affinity binding to solubilized PHF, whereas the ineffective 6B2 binds mainly to aggregated PHF. Blocking 4E6's uptake into neurons prevented its protective effects if the antibody was administered after PHF had been internalized. When 4E6 and PHF were administered at the same time, the antibody was protective extracellularly. CONCLUSIONS: Overall, these findings indicate that high antibody affinity for solubilized PHF predicts efficacy, and that acute antibody-mediated improvement in cognition relates to clearance of soluble phospho-tau. Importantly, both intra- and extracellular clearance pathways are in play. Together, these results have major implications for understanding the pathogenesis of tauopathies and for development of immunotherapies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13024-016-0126-z) contains supplementary material, which is available to authorized users

Underground railroads: citizen entitlements and unauthorized mobility in the antebellum period and today

In recent years, some scholars and prominent political figures have advocated the deepening of North American integration on roughly the European Union model, including the creation of new political institutions and the free movement of workers across borders. The construction of such a North American Union, if it included even a very thin trans-state citizenship regime, could represent the most significant expansion of individual entitlements in the region since citizenship was extended to former slaves in the United States. With such a possibility as its starting point, this article explores some striking parallels between the mass, legally prohibited movement across boundaries by fugitive slaves in the pre-Civil War period, and that by current unauthorized migrants to the United States. Both were, or are, met on their journeys by historically parallel groups of would-be helpers and hinderers. Their unauthorized movements in both periods serve as important signals of incomplete entitlements or institutional protections. Most crucially, moral arguments for extending fuller entitlements to both groups are shown here to be less distinct than may be prima facie evident, reinforcing the case for expanding and deepening the regional membership regime

AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity.

AKT is a kinase regulating numerous cellular processes in the brain, and mutations in AKT are known to affect brain function. AKT is indirectly implicated in synaptic plasticity, but its direct role has not been studied. Moreover, three highly related AKT isoforms are expressed in the brain, but their individual roles are poorly understood. We find in Mus musculus, each AKT isoform has a unique expression pattern in the hippocampus, with AKT1 and AKT3 primarily in neurons but displaying local differences, while AKT2 is in astrocytes. We also find isoform-specific roles for AKT in multiple paradigms of hippocampal synaptic plasticity in area CA1. AKT1, but not AKT2 or AKT3, is required for L-LTP through regulating activity-induced protein synthesis. Interestingly, AKT activity inhibits mGluR-LTD, with overlapping functions for AKT1 and AKT3. In summary, our studies identify distinct expression patterns and roles in synaptic plasticity for AKT isoforms in the hippocampus

Energy-aware simulation with DVFS

International audienceIn recent years, research has been conducted in the area of large systems models, especially distributed systems, to analyze and understand their behavior. Simulators are now commonly used in this area and are becoming more complex. Most of them provide frameworks for simulating application scheduling in various Grid infrastructures, others are specifically developed for modeling networks, but only a few of them simulate energy-efficient algorithms. This article describes which tools need to be implemented in a simulator in order to support energy-aware experimentation. The emphasis is on DVFS simulation, from its implementation in the simulator CloudSim to the whole methodology adopted to validate its functioning. In addition, a scientific application is used as a use case in both experiments and simulations, where the close relationship between DVFS efficiency and hardware architecture is highlighted. A second use case using Cloud applications represented by DAGs, which is also a new functionality of CloudSim, demonstrates that the DVFS efficiency also depends on the intrinsic middleware behavior

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

Background: The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr protein kinase that plays a pivotal role in multiple fundamental biological processes, including synaptic plasticity. We explored the relationship between the mTOR pathway and b-amyloid (Ab)-induced synaptic dysfunction, which is considered to be critical in the pathogenesis of Alzheimer’s disease (AD). Methodology/Principal Findings: We provide evidence that inhibition of mTOR signaling correlates with impairment in synaptic plasticity in hippocampal slices from an AD mouse model and in wild-type slices exposed to exogenous Ab1-42. Importantly, by up-regulating mTOR signaling, glycogen synthase kinase 3 (GSK3) inhibitors rescued LTP in the AD mouse model, and genetic deletion of FK506-binding protein 12 (FKBP12) prevented Ab-induced impairment in long-term potentiation (LTP). In addition, confocal microscopy demonstrated co-localization of intraneuronal Ab42 with mTOR. Conclusions/Significance: These data support the notion that the mTOR pathway modulates Ab-related synaptic dysfunctio

Pharmacogenetic inhibition of eIF4E-dependent <i>Mmp9</i> mRNA translation reverses fragile X syndrome-like phenotypes

SummaryFragile X syndrome (FXS) is the leading genetic cause of autism. Mutations in Fmr1 (fragile X mental retardation 1 gene) engender exaggerated translation resulting in dendritic spine dysmorphogenesis, synaptic plasticity alterations, and behavioral deficits in mice, which are reminiscent of FXS phenotypes. Using postmortem brains from FXS patients and Fmr1 knockout mice (Fmr1−/y), we show that phosphorylation of the mRNA 5′ cap binding protein, eukaryotic initiation factor 4E (eIF4E), is elevated concomitant with increased expression of matrix metalloproteinase 9 (MMP-9) protein. Genetic or pharmacological reduction of eIF4E phosphorylation rescued core behavioral deficits, synaptic plasticity alterations, and dendritic spine morphology defects via reducing exaggerated translation of Mmp9 mRNA in Fmr1−/y mice, whereas MMP-9 overexpression produced several FXS-like phenotypes. These results uncover a mechanism of regulation of synaptic function by translational control of Mmp-9 in FXS, which opens the possibility of new treatment avenues for the diverse neurological and psychiatric aspects of FXS