2,455 research outputs found
Numerical modelling and simulation in sheet metal forming
The application of numerical modelling and simulation in manufacturing technologies is looking back over about a 20–30 years history. In recent years, the role of modelling and simulation in engineering and in manufacturing industry has been continuously increasing. It is well known that during manufacturing processes simultaneous the effect of many different parameters can be observed. This is the reason why in former years, detailed analysis of manufacturing processes could have been done only by time-consuming and expensive trial-and-error methods. Due to the recent developments in the methods of modelling and simulation, as well as in computational facilities, modelling and simulation has become an everyday tool in engineering practice. Besides the aforementioned facts, the emerging role of modelling and simulation can also be explained by the growing globalisation and competition of the world market requiring shorter lead times and more cost effective solutions. In spite the enormous development of hardware and software facilities, the exclusive use of numerical modelling still seems to be very time- and cost consuming, and there is still often a high scepticism about the results among industrialists. Therefore, the purpose of this paper is to overview the present situation of numerical modelling and simulation in sheet metal forming, mainly from the viewpoint of scientific research and industrial applications
Large QCD at non-zero chemical potential
The general issue of large QCD at nonzero chemical potential is
considered with a focus on understanding the difference between large QCD
with an isospin chemical potential and large QCD with a baryon chemical
potential. A simple diagrammatic analysis analogous to `t Hooft's analysis at
implies that the free energy with a given baryon chemical potential is
equal to the free energy with an isospin chemical potential of the same value
plus corrections. Phenomenologically, these two systems behave quite
differently. A scenario to explain this difference in light of the diagrammatic
analysis is explored. This scenario is based on a phase transition associated
with pion condensation when the isospin chemical potential exceeds ;
associated with this transition there is breakdown of the expansion--in
the pion condensed phase there is a distinct expansion including a
larger set of diagrams. While this scenario is natural, there are a number of
theoretical issues which at least superficially challenge it. Most of these can
be accommodated. However, the behavior of quenched QCD which raises a number of
apparently analogous issues cannot be easily understood completely in terms of
an analogous scenario. Thus, the overall issue remains open
A trait-based approach for predicting species responses to environmental change from sparse data : how well might terrestrial mammals track climate change?
Acknowledgements LS was supported by two STSMs by the COST Action ES1101 ”Harmonising Global Biodiversity Modelling“ (Harmbio), supported by COST (European Cooperation in Science and Technology). JMB and SMW were funded by CEH projects NEC05264 and NEC05100. JMJT and SCFP are grateful for the support of the Natural Environment Research Council UK (NE/J008001/1). LS, JAH and JMJT conceived the original idea. LS, JAH, JMB, TC & JMJT designed the study; LS collected the data; LS and TC performed the statistical analyses; LS conducted the integrodifference modelling assisted by JMB and SMW. LS conducted the individual-based modelling assisted by SCFP. LS led the writing supported by JMJT, JMB, SCFP, SMW, TC, JAH and GB.Peer reviewedPublisher PD
Dust sedimentation and self-sustained Kelvin-Helmholtz turbulence in protoplanetary disk mid-planes. I. Radially symmetric simulations
We perform numerical simulations of the Kelvin-Helmholtz instability in the
mid-plane of a protoplanetary disk. A two-dimensional corotating slice in the
azimuthal--vertical plane of the disk is considered where we include the
Coriolis force and the radial advection of the Keplerian rotation flow. Dust
grains, treated as individual particles, move under the influence of friction
with the gas, while the gas is treated as a compressible fluid. The friction
force from the dust grains on the gas leads to a vertical shear in the gas
rotation velocity. As the particles settle around the mid-plane due to gravity,
the shear increases, and eventually the flow becomes unstable to the
Kelvin-Helmholtz instability. The Kelvin-Helmholtz turbulence saturates when
the vertical settling of the dust is balanced by the turbulent diffusion away
from the mid-plane. The azimuthally averaged state of the self-sustained
Kelvin-Helmholtz turbulence is found to have a constant Richardson number in
the region around the mid-plane where the dust-to-gas ratio is significant.
Nevertheless the dust density has a strong non-axisymmetric component. We
identify a powerful clumping mechanism, caused by the dependence of the
rotation velocity of the dust grains on the dust-to-gas ratio, as the source of
the non-axisymmetry. Our simulations confirm recent findings that the critical
Richardson number for Kelvin-Helmholtz instability is around unity or larger,
rather than the classical value of 1/4Comment: Accepted for publication in ApJ. Some minor changes due to referee
report, most notably that the clumping mechanism has been identified as the
streaming instability of Youdin & Goodman (2005). Movies of the simulations
are still available at http://www.mpia.de/homes/johansen/research_en.ph
Exploring the role of formal bodies of knowledge in defining a profession - The case of project management
Since the mid 1970s, project management associations around the world have made serious attempts to conduct themselves as professional associations. Traditional professions distinguished themselves by emphasising standards such as service to the public and competence in their field, and by ensuring that their membership meets these standards. An important element of a profession is ownership of a body of knowledge that is distinctive to the professional group. Project management associations have spent considerable time and effort in developing Bodies of Knowledge (BOKs) and their associated certification programs, and indeed the popularity of these has been notable. Yet there are problems, some relating to the broader issue of whether the project management associations really are equipped to act as professional bodies, others related to the specific challenge of agreeing the 'distinctive body of knowledge' and to the value of certification. This paper draws on insights from the rethinking project management EPSRC project as well as several separate research programs to explore the development of project management as a profession and the role of the formal BOKs in this professionalization, and to suggest a research agenda for critiquing, contributing to, and maintaining both the formal BOKs and the more general body of knowledge relevant to the needs of the discipline. © 2006
Four-year clinical experience with Ad Hoc fractional flow reserve measurement to guide ravascularization strategy
Early Kidney Damage in a Population Exposed to Cadmium and Other Heavy Metals
BACKGROUND: Exposure to heavy metals may cause kidney damage. The population living near the Avonmouth zinc smelter has been exposed to cadmium and other heavy metals for many decades. OBJECTIVES: We aimed to assess Cd body burden and early signs of kidney damage in the Avonmouth population. METHODS: We used dispersion modeling to assess exposure to Cd. We analyzed urine samples from the local population (n = 180) for Cd (U-Cd) to assess dose (body burden) and for three biomarkers of early kidney damage [N-acetyl-β-d-glucosaminidase (U-NAG), retinol-binding protein, and α-1-microglobulin]. We collected information on occupation, intake of homegrown vegetables, smoking, and medical history by questionnaire. RESULTS: Median U-Cd concentrations were 0.22 nmol/mmol creatinine (nonsmoking 0.18/smoking 0.40) and 0.34 nmol/mmol creatinine (nonsmoking 0.31/smoking 0.46) in non-occupationally exposed men and women, respectively. There was a significant dose–response relationship between U-Cd and the prevalence of early renal damage—defined as U-NAG > 0.22 IU/mmol—with odds ratios of 2.64 [95% confidence interval (95% CI), 0.70–9.97] and 3.64 (95% CI, 0.98–13.5) for U-Cd levels of 0.3 to < 0.5 and levels ≥ 0.5 nmol/mmol creatinine, respectively (p for trend = 0.045). CONCLUSION: U-Cd concentrations were close to levels where kidney and bone effects have been found in other populations. The dose–response relationship between U-Cd levels and prevalence of U-NAG above the reference value support the need for measures to reduce environmental Cd exposure
Sea ice led to poleward-shifted winds at the Last Glacial Maximum: the influence of state dependency on CMIP5 and PMIP3 models
Latitudinal shifts in the Southern Ocean westerly wind jet could drive changes in the glacial to interglacial ocean CO2 inventory. However, whilst CMIP5 model results feature consistent future-warming jet shifts, there is considerable disagreement in deglacial-warming jet shifts. We find here that the dependence of pre-industrial (PI) to Last Glacial Maximum (LGM) jet shifts on PI jet position, or state dependency, explains less of the shifts in jet simulated by the models for the LGM compared with future-warming scenarios. State dependence is also weaker for intensity changes, compared to latitudinal shifts in the jet. Winter sea ice was considerably more extensive during the LGM. Changes in surface heat fluxes, due to this sea ice change, probably had a large impact on the jet. Models that both simulate realistically large expansions in sea ice and feature PI jets which are south of 50° S show an increase in wind speed around 55° S and can show a poleward shift in the jet between the PI and the LGM. However, models with the PI jet positioned equatorwards of around 47° S do not show this response: the sea ice edge is too far from the jet for it to respond. In models with accurately positioned PI jets, a +1° difference in the latitude of the sea ice edge tends to be associated with a −0.85° shift in the 850 hPa jet. However, it seems that around 5° of expansion of LGM sea ice is necessary to hold the jet in its PI position. Since the Gersonde et al. (2005) data support an expansion of more than 5°, this result suggests that a slight poleward shift and intensification was the most likely jet change between the PI and the LGM. Without the effect of sea ice, models simulate poleward-shifted westerlies in warming climates and equatorward-shifted westerlies in colder climates. However, the feedback of sea ice counters and reverses the equatorward trend in cooler climates so that the LGM winds were more likely to have also been shifted slightly poleward
Lack of antigenic diversification of major outer membrane proteins during clonal waves of Neisseria meningitidis serogroup A colonization and disease
In particular in the ‘meningitis belt' of sub-Saharan Africa, epidemic meningococcal meningitis is a severe public health problem. In the past decades, serogroup A lineages have been the dominant etiologic agents, but also other serogroups have caused outbreaks. A comprehensive vaccine based on subcapsular outer membrane proteins (OMPs) is not available. Here, we have investigated whether meningococcal populations overcome herd immunity by changing antigenic properties of their OMPs. Meningococcal isolates were collected in the context of longitudinal studies in Ghana between 2002 and 2008 and in Burkina Faso between 2006 and 2007. Serogroup A strains isolated during two clonal waves of colonization and disease showed no diversification in the genes encoding their PorA, PorB, and FetA proteins. However, we detected occasional allelic exchange of opa genes, as well as wide variation in the number of intragenic tandem repeats, showing that phase variation of Opa protein expression is a frequent event. Altogether we observed a remarkable antigenic stability of the PorA, PorB and FetA proteins over years. Our results indicate that while herd immunity may be responsible for the disappearance of meningococcal clones over time, it is not a strong driving force for antigenic diversification of the major OMPs analyzed her
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