Semantic memory is impaired in both dementia with Lewy Bodies (DLB) and dementia of Alzheimer's type (DAT): a comparative neuropsychological study and literature review

OBJECTIVE---To test the hypothesis that semantic impairment is present in both patients with dementia with Lewy bodies (DLB) and those with dementia of Alzheimer's type (DAT). METHODS---A comprehensive battery of neuropsychological tasks designed to assess semantic memory, visuoperceptual function, verbal fluency, and recognition memory was given to groups of patients with DLB (n=10), DAT (n=10) matched pairwise for age and mini mental state examination (MMSE), and age matched normal controls (n=15). RESULTS---Both DLB and DAT groups exhibited impaired performance across the range of tasks designed to assess semantic memory. Whereas patients with DAT showed equivalent comprehension of written words and picture stimuli, patients with DLB demonstrated more severe semantic deficits for pictures than words. As in previous studies, patients with DLB but not those with DAT were found to have impaired visuoperceptual functioning. Letter and category fluency were equally reduced for the patients with DLB whereas performance on letter fluency was significantly better in the DAT group. Recognition memory for faces and words was impaired in both groups. CONCLUSIONS---Semantic impairment is not limited to patients with DAT. Patients with DLB exhibit particular problems when required to access meaning from pictures that is most likely to arise from a combination of semantic and visuoperceptual impairments

Use of novel sensors combining local positioning and acceleration to measure feeding behavior differences associated with lameness in dairy cattle

Time constraints for dairy farmers are an important factor contributing to the under-detection of lameness, resulting in delayed or missed treatment of lame cows within many commercial dairy herds. Hence, a need exists for flexible and affordable cow-based sensor systems capable of monitoring behaviors such as time spent feeding, which may be affected by the onset of lameness. In this study a novel neck-mounted mobile sensor system that combines local positioning and activity (acceleration) was tested and validated on a commercial UK dairy farm. Position and activity data were collected over 5 consecutive days for 19 high-yield dairy cows (10 lame, 9 non-lame) that formed a subset of a larger (120 cow) management group housed in a freestall barn. A decision tree algorithm that included sensor-recorded position and accelerometer data was developed to classify a cow as doing 1 of 3 categories of behavior: (1) feeding, (2) not feeding, and (3) out of pen for milking. For each classified behavior the mean number of bouts, the mean bout duration, and the mean total duration across all bouts was determined on a daily basis, and also separately for the time periods in between milking (morning = 0630–1300 h; afternoon = 1430–2100 h; night = 2230–0500 h). A comparative analysis of the classified cow behaviors was undertaken using a Welch -test with Benjamini-t Hochberg post-hoc correction under the null hypothesis of no differences in the number or duration of behavioral bouts between the 2 test groups of lame and nonlame cows. Analysis showed that mean total daily feeding duration was significantly lower for lame cows compared with non-lame cows. Behavior was also affected by time of day with significantly lower mean total duration of feeding and higher total duration of nonfeeding in the afternoons for lame cows compared with nonlame cows. The results demonstrate how sensors that measure both position and acceleration are capable of detecting differences in feeding behavior that may be associated with lameness. Such behavioral differences could be used in the development of predictive algorithms for the prompt detection of lameness as part of a commercially viable automated behavioral monitoring system

The Relationship between Behavioural Changes, Cognitive Symptoms, and Functional Disability in Primary Progressive Aphasia: A Longitudinal Study

Background: The contribution of behavioural changes to functional decline is yet to be explored in primary progressive aphasia (PPA). Objectives: (1) investigate functional changes in two PPA variants [semantic (svPPA) and non-fluent (nfvPPA)], at baseline and after 12 months; (2) investigate baseline differences in behavioural changes between groups, and (3) explore predictors of functional decline after a 12-month period. Methods: A longitudinal study involving 29 people with PPA (18 svPPA; 11 nfvPPA) seen annually in Sydney/Australia was conducted. A total of 114 functional and behavioural assessments were included for within-group (repeated-measures ANOVA; annual rate of change; multiple regression analyses) and between-group analyses (pairwise comparisons). Results: Functional profiles in svPPA and nfvPPA were similar in people with up to 5 years of disease duration. Behavioural changes were marked in svPPA patients (stereotypical behaviour and apathy) but did not predict annual rate of change of functional abilities; global cognitive scores at baseline did. Despite mild behavioural changes in nfvPPA (disinhibition, apathy), these were significant predictors of annual rate of functional change. Conclusions: The presentation and interplay of behavioural changes and functional disability differ in svPPA and nfvPPA. These varying factors should be taken into account when considering prognosis, disease management, and selection of outcome measures for interventions

Understanding the neural basis of episodic amnesia in logopenic progressive aphasia: A multimodal neuroimaging study.

Logopenic progressive aphasia (LPA) is a neurodegenerative disorder characterised by profound naming and sentence repetition disturbances, attributable to disproportionately left-sided temporo-parietal atrophy. Accumulating evidence suggests, in addition to language impairments, the presence of stark verbal and nonverbal episodic memory dysfunction in LPA. The neurocognitive bases of such impairments, however, remain to be clarified. Here, we characterised episodic memory disruption and its corresponding grey and white matter correlates in the LPA syndrome. Nineteen LPA patients were contrasted with 23 matched typical Alzheimer's disease (AD) patients and 31 healthy Controls on standardized verbal and nonverbal episodic delayed recall measures. Participants further underwent structural magnetic resonance and diffusion-weighted imaging. Significant verbal memory deficits were evident in both patient groups, with LPA patients performing at an intermediate level to AD and Controls. For nonverbal memory, however, LPA performance was indistinguishable from that of AD, with both groups displaying marked impairments relative to Controls. Whole-brain voxel-based morphometry analyses revealed significant left temporo-parietal and left hippocampal atrophy in the LPA group. Covariate analyses showed that verbal and nonverbal amnesia in LPA correlated with grey matter integrity of bilateral frontoparietal and left medial temporal lobe regions. Notably, the common regions underpinning verbal and nonverbal memory dysfunction in LPA were the left orbitofrontal cortex and bilateral angular gyri in the inferior parietal cortex. The bilateral angular gyri, along with prefrontal and hippocampal regions further emerged as disease-general correlates of verbal and nonverbal memory performance. Alterations in mean diffusivity in structural connections between the left angular gyrus and medial temporal lobes were further associated with verbal memory performance in all participants. Our findings reveal, for the first time, the presence of pervasive memory impairments in LPA mediated by degeneration of a distributed prefrontal-hippocampal-parietal network, and disrupted parieto-hippocampal structural connectivity

"Object Categorization: Reversals and Explanations of the Basic-Level Advantage" (Rogers & Patterson, 2007): A simplicity account

T. T. Rogers and K. Patterson (2007), in their article “Object Categorization: Reversals and Explanations of the Basic-Level Advantage” (Journal of Experimental Psychology: General, 136, 451–469), reported an impressive set of results demonstrating a reversal of the highly robust basic-level advantage both in patients with semantic dementia and in healthy individuals engaged in a speeded categorization task. To explain their results, as well as the usual basic-level advantage seen in healthy individuals, the authors employed a parallel distributed processing theory of conceptual knowledge. In this paper, we introduce an alternative way of explaining the results of Rogers and Patterson, which is premised on a more restricted set of assumptions born from standard categorization theory. Specifically, we provide evidence that their results can be accounted for based on the predictions of the simplicity model of unsupervised categorization

A calibration method for broad-bandwidth cavity enhanced absorption spectroscopy performed with supercontinuum radiation

An efficient calibration method has been developed for broad-bandwidth cavity enhanced absorption spectroscopy. The calibration is performed using phase shift cavity ring-down spectroscopy, which is conveniently implemented through use of an acousto-optic tunable filter (AOTF). The AOTF permits a narrowband portion of the SC spectrum to be scanned over the full high-reflectivity bandwidth of the cavity mirrors. After calibration the AOTF is switched off and broad-bandwidth CEAS can be performed with the same light source without any loss of alignment to the set-up. We demonstrate the merits of the method by probing transitions of oxygen molecules O-2 and collisional pairs of oxygen molecules (O-2)(2) in the visible spectral range

Topological Defects as Seeds for Eternal Inflation

We investigate the global structure of inflationary universe both by analytical methods and by computer simulations of stochastic processes in the early Universe. We show that the global structure of the universe depends crucially on the mechanism of inflation. In the simplest models of chaotic inflation the Universe looks like a sea of thermalized phase surrounding permanently self-reproducing inflationary domains. In the theories where inflation occurs near a local extremum of the effective potential corresponding to a metastable state, the Universe looks like de Sitter space surrounding islands of thermalized phase. A similar picture appears even if the state $\phi = 0$ is unstable but the effective potential has a discrete symmetry $\phi \to =-\phi$. In this case the Universe becomes divided into domains containing different phases. These domains will be separated from each other by domain walls. However, unlike ordinary domain walls, these domain walls will inflate, and their thickness will exponentially grow. In the theories with continuous symmetries inflation generates exponentially expanding strings and monopoles surrounded by thermalized phase. Inflating topological defects will be stable, and they will unceasingly produce new inflating topological defects. This means that topological defects may play a role of indestructible seeds for eternal inflation.Comment: 21 pages, 17 figures (not included), Stanford University preprint SU--ITP--94--

Constraining the Power Spectrum using Clusters

(Shortened Abstract). We analyze a redshift sample of Abell/ACO clusters and compare them with numerical simulations based on the truncated Zel'dovich approximation (TZA), for a list of eleven dark matter (DM) models. For each model we run several realizations, on which we estimate cosmic variance effects. We analyse correlation statistics, the probability density function, and supercluster properties from percolation analysis. As a general result, we find that the distribution of galaxy clusters provides a constraint only on the shape of the power spectrum, but not on its amplitude: a shape parameter 0.18 < \Gamma < 0.25 and an effective spectral index at 20Mpc/h in the range [-1.1,-0.9] are required by the Abell/ACO data. In order to obtain complementary constraints on the spectrum amplitude, we consider the cluster abundance as estimated using the Press--Schechter approach, whose reliability is explicitly tested against N--body simulations. We conclude that, of the cosmological models considered here, the only viable models are either Cold+Hot DM ones with \Omega_\nu = [0.2-0.3], better if shared between two massive neutrinos, and flat low-density CDM models with \Omega_0 = [0.3-0.5].Comment: 37 pages, Latex file, 9 figures; New Astronomy, in pres

A process calculus with finitary comprehended terms

We introduce the notion of an ACP process algebra and the notion of a meadow enriched ACP process algebra. The former notion originates from the models of the axiom system ACP. The latter notion is a simple generalization of the former notion to processes in which data are involved, the mathematical structure of data being a meadow. Moreover, for all associative operators from the signature of meadow enriched ACP process algebras that are not of an auxiliary nature, we introduce variable-binding operators as generalizations. These variable-binding operators, which give rise to comprehended terms, have the property that they can always be eliminated. Thus, we obtain a process calculus whose terms can be interpreted in all meadow enriched ACP process algebras. Use of the variable-binding operators can have a major impact on the size of terms.Comment: 25 pages, combined with arXiv:0901.3012 [math.RA]; presentation improved, mistakes in Table 5 correcte

Linear-T scattering and pairing from antiferromagnetic fluctuations in the (TMTSF)_2X organic superconductors

An exhaustive investigation of metallic electronic transport and superconductivity of organic superconductors (TMTSF)_2PF_6 and (TMTSF)_2ClO_4 in the Pressure-Temperature phase diagram between T=0 and 20 K and a theoretical description based on the weak coupling renormalization group method are reported. The analysis of the data reveals a high temperature domain (T\approx 20 K) in which a regular T^2 electron-electron Umklapp scattering obeys a Kadowaki-Woods law and a low temperature regime (T< 8 K) where the resistivity is dominated by a linear-in temperature component. In both compounds a correlated behavior exists between the linear transport and the extra nuclear spin-lattice relaxation due to antiferromagnetic fluctuations. In addition, a tight connection is clearly established between linear transport and T_c. We propose a theoretical description of the anomalous resistivity based on a weak coupling renormalization group determination of electron-electron scattering rate. A linear resistivity is found and its origin lies in antiferromagnetic correlations sustained by Cooper pairing via constructive interference. The decay of the linear resistivity term under pressure is correlated with the strength of antiferromagnetic spin correlations and T_c, along with an unusual build-up of the Fermi liquid scattering. The results capture the key features of the low temperature electrical transport in the Bechgaard salts