Silicone Applicator Cleaning Improvement

Silicone is curing inside the applicator tips due to process not being standardized. Due to silicone curing inside the tips, the employees are having to repeat the cleaning process resulting in added labor expenses

Silicone Applicator Cleaning Improvement

Cardinal Glass is a residential glass manufacturer for doors and windows. Cardinal glass was first founded in 1962 by a man named M.L. Gordon. Today, they employ 6,000 employees across 37 manufacturing plants throughout the United States. The Greenfield, Iowa, plant distributes to local large window manufacturers. Cardinal Glass is separated into five divisions. They are as followed:FG- Float & High Volume Tempered Glass; CT- Custom Tempered Glass; LG- Laminated Glass; CG- coated glass and optical mirrors; and IG- Insulating Glass. The Client is experiencing problems with silicone curing in applicator tips due to lack of a better process. The silicone cured tips are causing re-work that is costing the company thousands of dollars in labor

The Ability of the Landing Error Scoring System to Detect Changes in Landing Mechanics: A Critically Appraised Topic

Clinical Question: Is there evidence to suggest that the Landing Error Scoring System (LESS) is able to detect functional changes in landing mechanics in healthy individuals after participation in an injury prevention program (IPP)? Clinical Bottom Line: In a healthy, physically active population, there is strong evidence to support the use of the LESS as an outcome measure for changes in landing mechanics after the implementation of IPPs. Clinicians should consider the LESS as an evaluative tool for measuring the efficacy of IPPs in clinical practice

Harmful Elements in Estuarine and Coastal Systems

Estuaries and coastal zones are dynamic transitional systems which provide many economic and ecological benefits to humans, but also are an ideal habitat for other organisms as well. These areas are becoming contaminated by various anthropogenic activities due to a quick economic growth and urbanization. This chapter explores the sources, chemical speciation, sediment accumulation and removal mechanisms of the harmful elements in estuarine and coastal seawaters. It also describes the effects of toxic elements on aquatic flora and fauna. Finally, the toxic element pollution of the Venice Lagoon, a transitional water body located in the northeastern part of Italy, is discussed as a case study, by presenting the procedures adopted to measure the extent of the pollution, the impacts on organisms and the restoration activities

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Silicone Applicator Cleaning Improvement

Silicone is curing inside the applicator tips due to process not being standardized. Due to silicone curing inside the tips, the employees are having to repeat the cleaning process resulting in added labor expenses.</p

Silicone Applicator Cleaning Improvement

Cardinal Glass is a residential glass manufacturer for doors and windows. Cardinal glass was first founded in 1962 by a man named M.L. Gordon. Today, they employ 6,000 employees across 37 manufacturing plants throughout the United States. The Greenfield, Iowa, plant distributes to local large window manufacturers. Cardinal Glass is separated into five divisions. They are as followed:FG- Float & High Volume Tempered Glass; CT- Custom Tempered Glass; LG- Laminated Glass; CG- coated glass and optical mirrors; and IG- Insulating Glass. The Client is experiencing problems with silicone curing in applicator tips due to lack of a better process. The silicone cured tips are causing re-work that is costing the company thousands of dollars in labor.</p

Regularity of unit length boosts statistical learning in verbal and nonverbal artificial languages

Humans have remarkable statistical learning abilities for verbal speech-like materials and for nonverbal music-like materials. Statistical learning has been shown with artificial languages (AL) that consist of the concatenation of nonsense word-like units into a continuous stream. These ALs contain no cues to unit boundaries other than the transitional probabilities between events, which are high within a unit and low between units. Most AL studies have used units of regular lengths. In the present study, the ALs were based on the same statistical structures but differed in unit length regularity (i.e., whether they were made out of units of regular vs. irregular lengths) and in materials (i.e., syllables vs. musical timbres), to allow us to investigate the influence of unit length regularity on domain-general statistical learning. In addition to better performance for verbal than for nonverbal materials, the findings revealed an effect of unit length regularity, with better performance for languages with regular- (vs. irregular-) length units. This unit length regularity effect suggests the influence of dynamic attentional processes (as proposed by the dynamic attending theory; Large & Jones (Psychological Review 106: 119-159, 1999)) on domain-general statistical learning

Evaluation of habitat use by adult plaice (Pleuronectes platessa L.) using underwater video survey techniques

Large-scale spatial surveys of fish species in relation to habitat have tended to focus on depth, sediment type and temperature as descriptors of fish habitats. At a smaller scale, habitat parameters such as the relief of the sea floor, the presence of structuring fauna and prey availability may have a large influence on fish distribution, but often are not considered. In the present study we used video survey techniques to study habitat components in areas of the English Channel that were known to support consistently high densities of adult plaice. Habitat features were quantified and related to the density of adult plaice caught within the same study areas. To focus the study on habitat components other than sediment type all sites chosen had sandy substrata. The scale and spatial distribution and heterogeneity of physical and biological structures were quantified for each site and correlated to plaice densities. Plaice densities correlated with the abundance of benthic fauna recorded. In particular the emergent tube-dwelling polychaetes Lanice conchilega and Cheatopterus spp., that are a valuable food source for plaice dominated some sites. Abiotic habitat features and habitat heterogeneity showed no clear relationships with respect to plaice densities at the scale of our surveys. This indicated that prey availability might be the driving force for habitat selection of adult plaice within sandy habitats and that other habitat descriptors assume lesser importance at smaller spatial scales