Digit Ratio as a Predictor of Risk Taking and Sensation Seeking Personality Traits and Behaviors

Digit ratio is the difference in length between the pointer finger and the ring finger on either hand. Commonly referred to as the 2D:4D ratio, this ratio is determined prior to birth, and serves as an indicator of prenatal hormone exposure. Digit ratio has been found to correlate with fundamental personality and behavior characteristics in adulthood. Digit ratio is also thought to be a determinate of sexual orientation in both men and women, but has been debated in the literature. This study examined multiple 2D:4D relationships. Men who were found to have a more masculinized (ie. lower) digit ratio had significantly higher rates of overall sensation seeking, boredom susceptibility, disinhibition, experience seeking, and lifetime drug behaviors. We found no significant relationships between 2D:4D ratio and behaviors in females. Similarly, we found no relationship between digit ratio and sensation seeking, impulsive, or risky personality traits either. Digit ratio bad no relationship with sexual orientation, nor on number of older brothers. Overall, our findings suggest that there is a significant relationship between a masculinized digit ratio and certain sensation seeking and risk taking behaviors in men

Digit Ratio as a Predictor of Risk Taking and Sensation Seeking Personality Traits and Behaviors

Digit ratio is the difference in length between the pointer finger and the ring finger on either hand. Commonly referred to as the 2D:4D ratio, this ratio is determined prior to birth, and serves as an indicator of prenatal hormone exposure. Digit ratio has been found to correlate with fundamental personality and behavior characteristics in adulthood. Digit ratio is also thought to be a determinate of sexual orientation in both men and women, but has been debated in the literature. This study examined multiple 2D:4D relationships. Men who were found to have a more masculinized (ie. lower) digit ratio had significantly higher rates of overall sensation seeking, boredom susceptibility, disinhibition, experience seeking, and lifetime drug behaviors. We found no significant relationships between 2D:4D ratio and behaviors in females. Similarly, we found no relationship between digit ratio and sensation seeking, impulsive, or risky personality traits either. Digit ratio bad no relationship with sexual orientation, nor on number of older brothers. Overall, our findings suggest that there is a significant relationship between a masculinized digit ratio and certain sensation seeking and risk taking behaviors in men

New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms

Background: Hyperekplexia mutations have provided much information about glycine receptor structure and function. Results: Weidentified and characterized nine new mutations. Dominant mutations resulted in spontaneous activation, whereas recessive mutations precluded surface expression. Conclusion: These data provide insight into glycine receptor activation mechanisms and surface expression determinants. Significance: The results enhance our understanding of hyperekplexia pathology and glycine receptor structure-function. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A

Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study

Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis

Clinical and genetic characteristics of late-onset Huntington's disease

Background: The frequency of late-onset Huntington's disease (&gt;59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P &lt;.001). Overall motor and cognitive performance (P &lt;.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P &lt;.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P &lt;.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P &lt;.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients