An efficient synthesis of 1,2,4-oxathiazoles from N-acylthiourea derivatives

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Capturing themed evidence, a hybrid approach

The task of identifying pieces of evidence in texts is of fundamental importance in supporting qualitative studies in various domains, especially in the humanities. In this paper, we coin the expression themed evidence, to refer to (direct or indirect) traces of a fact or situation relevant to a theme of interest and study the problem of identifying them in texts. We devise a generic framework aimed at capturing themed evidence in texts based on a hybrid approach, combining statistical natural language processing, background knowledge, and Semantic Web technologies. The effectiveness of the method is demonstrated in a case study of a digital humanities database aimed at collecting and curating a repository of evidence of experiences of listening to music. Extensive experiments demonstrate that our hybrid approach outperforms alternative solutions. We also evidence its generality by testing it on a different use case in the digital humanities

Development of a stochastic computational fluid dynamics approach for offshore wind farms

In this paper, a method for stochastic analysis of an offshore wind farm using computational fluid dynamics (CFD) is proposed. An existing offshore wind farm is modelled using a steady-state CFD solver at several deterministic input ranges and an approximation model is trained on the CFD results. The approximation model is then used in a Monte-Carlo analysis to build joint probability distributions for values of interest within the wind farm. The results are compared with real measurements obtained from the existing wind farm to quantify the accuracy of the predictions. It is shown that this method works well for the relatively simple problem considered in this study and has potential to be used in more complex situations where an existing analytical method is either insufficient or unable to make a good prediction

Proximity-induced quasi-one-dimensional superconducting quantum anomalous Hall state: a promising scalable top-down approach towards localized Majorana modes

In this work, ~100 nm wide quantum anomalous Hall insulator (QAHI) nanoribbons are etched from a two-dimensional QAHI film. One part of the nanoribbon is covered with superconducting Nb, while the other part is connected to an Au lead via two-dimensional QAHI regions. Andreev reflection spectroscopy measurements were performed, and multiple in-gap conductance peaks were observed in three different devices. In the presence of an increasing magnetic field perpendicular to the QAHI film, the multiple in-gap peak structure evolves into a single zero-bias conductance peak (ZBCP). Theoretical simulations suggest that the measurements are consistent with the scenario that the increasing magnetic field drives the nanoribbons from a multi-channel occupied regime to a single channel occupied regime, and that the ZBCP may be induced by zero energy Majorana modes as previously predicted [24]. Although further experiments are needed to clarify the nature of the ZBCP, we provide initial evidence that quasi-1D QAHI nanoribbon/superconductor heterostructures are new and promising platforms for realizing zero-energy Majorana modes

The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial

Background: Allergic rhinitis (AR) is an upper airways chronic inflammatory disease mediated by IgE, which affects 10%–20% of the population. The mainstay for allergic rhinitis nowadays include steroids and antihistamines, but their effects are less than ideal. Many patients therefore seek Chinese medicine for treatment and Yupingfeng Powder is one of the most common formulae prescribed. In this study, we aim to investigate the efficacy and safety of Yupingfeng Powder with variation for the treatment of allergic rhinitis.Study design: This is a double-blind, randomized, placebo-controlled trial. A 2-week screening period will be implemented, and then eligible subjects with allergic rhinitis will receive interventions of either “Yupingfeng Powder with variation” granules or placebo granules for 8 weeks, followed by post treatment visits at weeks 12 and 16. The change in the Total Nasal Symptom Score (TNSS) will be used as the primary outcome.Discussion: This trail will evaluate the efficacy and safety of Yupingfeng Powder in treating allergic rhinitis. The study may provide the solid evidence of Yupingfeng Powder with variation can produce better clinical efficacy than the placebo granules.Trial registration:ClinicalTrials.gov, identifier NCT04976023

Action-based recommendation in pull-request development

Pull requests (PRs) selection is a challenging task faced by integrators in pull-based development (PbD), with hundreds of PRs submitted on a daily basis to large open-source projects. Managing these PRs manually consumes integrators' time and resources and may lead to delays in the acceptance, response, or rejection of PRs that can propose bug fixes or feature enhancements. On the one hand, well-known platforms for performing PbD, like GitHub, do not provide built-in recommendation mechanisms for facilitating the management of PRs. On the other hand, prior research on PRs recommendation has focused on the likelihood of either a PR being accepted or receive a response by the integrator. In this paper, we consider both those likelihoods, this to help integrators in the PRs selection process by suggesting to them the appropriate actions to undertake on each specific PR. To this aim, we propose an approach, called CARTESIAN (aCceptance And Response classificaTion-based requESt IdentificAtioN) modeling the PRs recommendation according to PR actions. In particular, CARTESIAN is able to recommend three types of PR actions: accept, respond, and reject. We evaluated CARTESIAN on the PRs of 19 popular GitHub projects. The results of our study demonstrate that our approach can identify PR actions with an average precision and recall of about 86%. Moreover, our findings also highlight that CARTESIAN outperforms the results of two baseline approaches in the task of PRs selection