Undergraduate Diversity Scholar Program: A Proactive Approach to Creating an Inclusive and Multicultural Workforce

The University of Kentucky (UK) Libraries approved a statement in September 2013 confirming its commitment to cultivating and encouraging diversity and inclusivity in its personnel policies and in its collections, programs, and services. The library subsequently developed an Undergraduate Diversity Scholar Program to provide two students with a paid internship in the 2014/15 academic year. UK undergraduates interested in diversity issues were encouraged to apply. Applicants were evaluated based on their work experience, volunteer or service activities, recommendations from two referees, and an essay about their belief in the benefits of a diverse society. The successful candidates started the inaugural Program in Fall 2014 and developed and/or led activities and research that promoted the benefits of inclusivity and multicultural awareness in the UK community. They also explored career options in academic librarianship through working in several different library units. Additionally, they received mentoring on building their résumés and preparing for future employment

Indian Monsoon Depression: Climatology and Variability

The monsoon climate is traditionally characterized by large amount of seasonal rainfall and reversal of wind direction (e.g., Krishnamurti 1979). Most importantly this rainfall is the major source of fresh water to various human activities such as agriculture. The Indian subcontinent resides at the core of the Southeast Asian summer monsoon system with the monsoon trough extended from northern India across Indochina to the Western Tropical Pacific (WTP). Large fraction of annual rainfall occurs during the summer monsoon season, i.e., June – August1, with two distinct maxima. One is located over the Bay of Bengal with rainfall extending northwestward into eastern and central India, and the other along the west coast of India where the lower level moist wind meets the Western Ghat Mountains (Saha and Bavardeckar 1976). The rest of the Indian subcontinent receives relatively less rainfall.https://digitalcommons.usu.edu/modern_climatology/1001/thumbnail.jp

Hereditary Colorectal Cancer Syndromes in Hong Kong: a Registry's Perspective

Established in 1995, the Hereditary Gastrointestinal Cancer Registry aimed at cancer prevention due to hereditary colorectal cancer syndromes in Hong Kong through early detection, timely treatment, education and ongoing research. This article details the history, structure and work of the Registry. A summary is also provided on the results of various research work conducted by the Registry which facilitates the clinical management of hereditary colorectal cancer syndromes in Hong Kong Chinese families

Alpha-Linolenic Acid-Enriched Butter Promotes Fatty Acid Remodeling and Thermogenic Activation in the Brown Adipose Tissue

Supplementation with n-3 long-chain (LC) polyunsaturated fatty acids (PUFA) is known to promote thermogenesis via the activation of brown adipose tissue (BAT). Agricultural products that are biofortified with α-linolenic acid (ALA), the precursor of n-3 LC PUFA, have been launched to the market, but their impact on BAT function is unknown. This study aimed to evaluate the effects of ALA-biofortified butter on lipid metabolism and thermogenic functions in the BAT. C57BL/6 mice were fed a high-fat diet containing ALA-biofortified butter (n3Bu, 45% calorie from fat) for ten weeks in comparison with the isocaloric high-fat diets prepared from conventional butter or margarine. The intake of n3Bu significantly reduced the whitening of BAT and increased the thermogenesis in response to acute-cold treatment. Also, n3Bu supplementation is linked with the remodeling of BAT by promoting bioconversion into n-3 LC PUFA, FA elongation and desaturation, and mitochondrial biogenesis. Taken together, our results support that ALA-biofortified butter is a novel source of n-3 PUFA, which potentiates the BAT thermogenic function

Bilingualism and executive functioning in children born very low birth weight and normal birth weight

Research has documented an advantage on executive functioning in bilingual compared to monolingual children, suggesting that bilingual children may develop inhibitory control earlier than their monolingual peers. There are no known studies examining the differences between monolingual and bilingual children who were born very low birth weight (VLBW). Children born VLBW are at greater risk for difficulties with attention and inhibition. Executive functioning abilities were measured at 3-4 years and at 5-7 years. Caregivers reported sociodemographic information. Bilingualism was measured by self-report and observation of unstructured mother-child play. Executive functioning abilities were measured using the Bear Dragon (inhibition and working memory 3-4 years), Memory for Location 2 (working memory 3-4 years), Gift Delay (inhibition 3-4 & 5-7 years), WJ-III Memory for Words (working memory 3-4 & 5-7 years), Color Form (inhibition and task switching 5-7 years), and the DCCS (inhibition and task switching 5-7 years). Children born normal birth weight (NBW) performed significantly better on tasks involving working memory (3-4 years), and inhibition (5-7years). Monolingual children born NBW performed better on tasks of working memory (3-4 years) and inhibition (5-7 years) compared to bilingual children born VLBW. Modest evidence for a bilingual (parent reported but not observational) advantage on one of three inhibition tasks (Gift Delay) emerged at school age (5-7 years). Children born NBW performed better on executive functioning measures beginning at the preschool age (3-4 years). Evidence for developmental differences between these groups helps to provide a broader understanding of the development of early executive processes

Fundamental Elements for Successful Performance of CT Colonography (Virtual Colonoscopy)

There are many factors affecting the successful performance of CT colonography (CTC). Adequate colonic cleansing and distention, the optimal CT technique and interpretation with using the newest CTC software by a trained reader will help ensure high accuracy for lesion detection. Fecal and fluid tagging may improve the diagnostic accuracy and allow for reduced bowel preparation. Automated carbon dioxide insufflation is more efficient and may be safer for colonic distention as compared to manual room air insufflation. CT scanning should use thin collimation of ≤3 mm with a reconstruction interval of ≤1.5 mm and a low radiation dose. There is not any one correct method for the interpretation of CTC; therefore, readers should be well-versed with both the primary 3D and 2D reviews. Polyps detected at CTC should be measured accurately and reported following the "polyp size-based" patient management system. The time-intensive nature of CTC and the limited resources for training radiologists appear to be the major barriers for implementing CTC in Korea

Enhanced hemangioblast generation and improved vascular repair and regeneration from embryonic stem cells by defined transcription factors

SummaryThe fetal liver kinase 1 (FLK-1)+ hemangioblast can generate hematopoietic, endothelial, and smooth muscle cells (SMCs). ER71/ETV2, GATA2, and SCL form a core transcriptional network in hemangioblast development. Transient coexpression of these three factors during mesoderm formation stage in mouse embryonic stem cells (ESCs) robustly enhanced hemangioblast generation by activating bone morphogenetic protein (BMP) and FLK-1 signaling while inhibiting phosphatidylinositol 3-kinase, WNT signaling, and cardiac output. Moreover, etsrp, gata2, and scl inhibition converted hematopoietic field of the zebrafish anterior lateral plate mesoderm to cardiac. FLK-1+ hemangioblasts generated by transient coexpression of the three factors (ER71-GATA2-SCL [EGS]-induced FLK-1+) effectively produced hematopoietic, endothelial, and SMCs in culture and in vivo. Importantly, EGS-induced FLK-1+ hemangioblasts, when codelivered with mesenchymal stem cells as spheroids, were protected from apoptosis and generated functional endothelial cells and SMCs in ischemic mouse hindlimbs, resulting in improved blood perfusion and limb salvage. ESC-derived, EGS-induced FLK-1+ hemangioblasts could provide an attractive cell source for future hematopoietic and vascular repair and regeneration

Study protocol for "Moving bright, eating smart"- a phase 2 clinical trial on the acceptability and feasibility of a diet and physical activity intervention to prevent recurrence in colorectal cancer survivors

Background: Colorectal cancer is the second most common cancer and cancer-killer in Hong Kong with an alarming increasing incidence in recent years. The latest World Cancer Research Fund report concluded that foods low in fibre, and high in red and processed meat cause colorectal cancer whereas physical activity protects againstcolon cancer. Yet, the influence of these lifestyle factors on cancer outcome is largely unknown even though cancer survivors are eager for lifestyle modifications. Observational studies suggested that low intake of a Western-pattern diet and high physical activity level reduced colorectal cancer mortality. The Theory of PlannedBehaviour and the Health Action Process Approach have guided the design of intervention models targeting a wide range of health-related behaviours.Methods/design: We aim to demonstrate the feasibility of two behavioural interventions intended to improve colorectal cancer outcome and which are designed to increase physical activity level and reduce consumption of a Western-pattern diet. This three year study will be a multicentre, randomised controlled trial in a 2x2 factorialdesign comparing the “Moving Bright, Eating Smart” (physical activity and diet) programme against usual care. Subjects will be recruited over a 12-month period, undertake intervention for 12 months and followed up for a further 12 months. Baseline, interim and three post-intervention assessments will be conducted. Two hundred and twenty-two colorectal cancer patients who completed curative treatment without evidence of recurrence will be recruited into the study. Primary outcome measure will be whether physical activity and dietary targets are met at the end of the 12-month intervention. Secondary outcome measures include the magnitude andmechanism of behavioural change, the degree and determinants of compliance, and the additional health benefits and side effects of the intervention.Discussion: The results of this study will establish the feasibility of targeting the two behaviours (diet and physical activity) and demonstrate the magnitude of behaviour change. The information will facilitate the design of a further larger phase III randomised controlled trial with colorectal cancer outcome as the study endpoint to determine whether this intervention model would reduce colorectal cancer recurrence and mortality

Crepuscular Rays from the Highly Inclined Active Galactic Nucleus in IC 5063

On Earth near sunset, the sun may cast "crepuscular rays" such that clouds near the horizon obscure the origin of light scattered in bright rays. In principle, AGN should be able to produce similar effects. Using new Hubble Space Telescope (HST) near-infrared and optical observations, we show that the active galaxy IC 5063 contains broad radial rays extending to $\gtrsim$11 kpc from the nucleus. We argue that the bright rays may arise from dusty scattering of continuum emission from the active nucleus, while the dark rays are due to shadowing near the nucleus, possibly by a warped torus. We also consider alternative AGN-related and stellar origins for the extended light.Comment: Accepted for publication to ApJ Letters. 13 pages, 5 figures. Facilitated by Twitter discussion (see https://twitter.com/SpaceGeck/status/1201350966945017856). This version corrects figure labels and includes other more minor update

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease). An essential feature of AD pathology is the presence of BACE1 (β-site amyloid precursor protein-cleaving enzyme 1), which regulates production of toxic amyloid peptides. However, whether BACE1 also plays a role in glucose homoeostasis is presently unknown. We have used transgenic mice to analyse the effects of loss of BACE1 on body weight, and lipid and glucose homoeostasis. BACE1−/− mice are lean, with decreased adiposity, higher energy expenditure, and improved glucose disposal and peripheral insulin sensitivity than wild-type littermates. BACE1−/− mice are also protected from diet-induced obesity. BACE1-deficient skeletal muscle and liver exhibit improved insulin sensitivity. In a skeletal muscle cell line, BACE1 inhibition increased glucose uptake and enhanced insulin sensitivity. The loss of BACE1 is associated with increased levels of UCP1 (uncoupling protein 1) in BAT (brown adipose tissue) and UCP2 and UCP3 mRNA in skeletal muscle, indicative of increased uncoupled respiration and metabolic inefficiency. Thus BACE1 levels may play a critical role in glucose and lipid homoeostasis in conditions of chronic nutrient excess. Therefore strategies that ameliorate BACE1 activity may be important novel approaches for the treatment of diabetes