DYNAMICAL CHARACTERISTICS OF SPEECH APPARATUS IN HUNTINGTON’S DISEASE

This paper presents new approach to measuring dynamical characteristics of the articulation and phonation apparatus in Huntington's disease (HD). This study utilizes the rhythm task in unusual way. Each repetition of the syllable is explored as unique measurement of dynamical characteristics of speech apparatus. The evaluation of dynamical characteristics was implemented into fully automatic algorithm. The database is gender balanced and consists of 43 Czech native participants including 20 healthy control (HC) and 23 HD subjects. The evaluation is based on recently designed segmentation method with very high accuracy of syllable detection and set of 6 descriptive features. All features of the set showed significant statistical difference (p<0.05) between HC and HD group. Longer duration of syllables and longer volume increase time reflect the decline of coordination of vocal and articulatory muscles. Higher instability in volume increase time and instability of reproduction are related to ataxic movements of vocal muscles in HD. Instability of duration of syllables and pauses corresponds with all motor manifestations in HD include vocal, articulatory and respiratory system dysfunction

Design and Diagnostic of Electromagnetic Actuator

Tato práce se zabývá návrhem elektromagnetického aktuátoru s více cívkami, jeho numerickým řešením ve výpočtovém programu Agros2D a ověřením jeho funkčnosti na experimentálním zařízení.Katedra elektromechaniky a výkonové elektronikyObhájenoThis work deal with a proposal of electromagnetic actuator with more coils, numerical solution of actuator in computational program Agros2D and verification of actuator on the experimental equipment

Headset microphone pre-amplifier

Předkládaná bakalářská práce je zaměřena na návrh obvodového řešení předzesilovače a zdroje napětí mikrofonní kapsle.Katedra aplikované elektroniky a telekomunikacíObhájenoThe presented bachelor thesis ?Headset microphone pre-amplifier? focuses on the design of the preamplifier circuitry and the power supply for the microphone capsule

Information architecture for e-shop and video game repository

This bachelor thesis deals with the issue of information architecture for e-shops and digital video game repositories. The thesis explores current trends in web design, including UX (User Experience) and UI (User Interface) design, and applies these findings to the design of a prototype web interface that provides users with a clear and functional platform for purchasing and archiving video games. The thesis also discusses the principles of digital repository design and its key role in ensuring reliable access to digital data and its long-term sustainability. Through analysis of player surveys, the thesis identifies the growing public interest in preserving the cultural value of video games. The web design is presented as a functional solution to these needs, laying the groundwork for a new type of information system focused on the video game industry in the Czech Republic.Tato bakalářská práce se zabývá problematikou informační architektury pro e-shopy a digitální repozitáře videoher. Práce zkoumá současné trendy v oblasti webového designu, včetně UX (User experience) a UI (User interface) designu, a aplikuje tyto poznatky na návrh prototypu webového rozhraní, které poskytuje uživatelům přehlednou a funkční platformu pro nákup a archivaci videoher. Práce také diskutuje principy tvorby digitálních repozitářů a jejich klíčovou roli při zajištění spolehlivého přístupu k digitálním datům a jejich dlouhodobé udržitelnosti. Prostřednictvím analýzy dotazníků mezi hráči práce zjišťuje rostoucí zájem veřejnosti o zachování kulturní hodnoty videoher. Návrh webu je prezentován jako funkční řešení těchto potřeb, čímž vytváří základy pro nový typ informačního systému zaměřeného na videoherní průmysl v České republice

Possibilities of distribution system reconfiguration with regard to a circulating current

Tato diplomová práce se zabývá rozborem a stanovením bezpečných spínacích podmínek při rekonfiguraci sítí 22 kV a 110 kV distribuční soustavy, v závislosti na rozdílovém úhlu fázorů spínaných napětí. Práce obsahuje rozbor závislosti rozdílového úhlu fázorů spínaných napětí na zatížení vývodů 22 kV a lokální výrobě v těchto sítích. Dále predikci rozkladu vyrovnávacího proudu v sítích 110 kV, která je podložená měřením v rozvodně 110 kV Veselí. Výstupem práce je nástroj pro predikci rozkladu vyrovnávacího proudu v síti 110 kV, pro spínání v rozvodnách 110 kV Tábor, Pacov, Veselí a Hradec. Práce vznikla za podpory společnosti E.ON Česká republika, s.r.o.ObhájenoThe diploma thesis deals with the study of 22 kV and 110 kV network reconfiguration with respect of voltage phasor angle difference between switched substations. This thesis describes dependence of voltage phasor angle on load of middle voltage lines and local production. Next part is focused on prediction of circulating current distribution between HV power lines. This prediction is based on measurement in substation 110 kV Veselí. Output of this thesis is tool (in program Microsoft Excel 2010), which predicts decomposition of circulating current in high voltage lines, for switching in substations Tábor, Pacov, Veselí and Hradec. This work was made in cooperation with company E.ON Czech Republic

Czech Sleep Norms

StudyThe CzechSleepNorms.exe is a graphical user interface for the Czech Sleep Norms described in the publication:J. Nepožitek, S. Dostálová, J. Hlavnička, J. Košťálová, E. M. Horvat, T. Vorlová, V. Ibarburu, L. Račanská, P. Peřinová, K. Šonka (2024). Evolution of sleep in aging: a polysomnographic study stratified over five decades.RequirementsOperating system: Windows 11, Windows 10 (version 1909 or higher), Windows Server 2019Processor: Any Intel or AMD x86-64 processor (minimum), any Intel or AMD x86-64 processor with four logical cores and AVX2 instruction set support (recommended)RAM: 4 GB minimumMATLAB Runtime is free and will be downloaded and installed during installationStorage: 3 MB max (after installation), ~750 MB including MATLAB RuntimeDatabaseSeventy-six healthy individuals with no history of sleep disorders or neurological diseases were included in the study. Five equal-sized age brackets balanced in gender were created: 20-30, 30-40, 40-50, 50-60, and 60-70 years. The study protocol consisted of polysomnography and questionnaires assessing insomnia, sleepiness, depression, and state/trait anxiety.AbbreviationsBMI = body mass indexBDI-II = Beck Depression Inventory, second editionSTAI X1 = State-Trait Anxiety Inventory, state anxietySTAI X2 = State-Trait Anxiety Inventory, trait anxietyESS = Epworth Sleepiness ScaleISI = Insomnia Severity IndexTST = total sleep timeSL = sleep latencySE = sleep efficiencyREM = rapid eye movement sleepN1, N2, N3 = non-rapid eye movement sleep stage 1, 2, 3AHI = apnoea-hypopnoea indexODI = oxygen desaturation indexT90 = time under 90% oxygen saturationPLMI = periodic limb movements indexEFM = excessive fragmentary myoclonusOSA = obstructive sleep apnoeaPLMS = periodic limb movements in sleepHow to UninstallPlease find the CzechSleepNorms in the Start menu and select Uninstall after right click. A new window "Programs and Features" pops up. Please select the CzechSleepNorms and click Uninstall. You can also remove the Matlab Runtime if you do not need it for other apps.Another way is to go to Windows Settings and click on Apps. You can find the CzechSleepNorms in the list and click on Uninstall.</p

Speech Biomarkers in Rapid Eye Movement Sleep Behavior Disorder and Parkinson Disease.

International audienceObjective: This multilanguage study used simple speech recording and high-end pattern analysis to provide sensitive and reliable noninvasive biomarkers of prodromal versus manifest α-synucleinopathy in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) and early-stage Parkinson disease (PD).Methods: We performed a multicenter study across the Czech, English, German, French, and Italian languages at 7 centers in Europe and North America. A total of 448 participants (337 males), including 150 with iRBD (mean duration of iRBD across language groups 0.5-3.4 years), 149 with PD (mean duration of disease across language groups 1.7-2.5 years), and 149 healthy controls were recorded; 350 of the participants completed the 12-month follow-up. We developed a fully automated acoustic quantitative assessment approach for the 7 distinctive patterns of hypokinetic dysarthria.Results: No differences in language that impacted clinical parkinsonian phenotypes were found. Compared with the controls, we found significant abnormalities of an overall acoustic speech severity measure via composite dysarthria index for both iRBD (p = 0.002) and PD (p < 0.001). However, only PD (p < 0.001) was perceptually distinct in a blinded subjective analysis. We found significant group differences between PD and controls for monopitch (p < 0.001), prolonged pauses (p < 0.001), and imprecise consonants (p = 0.03); only monopitch was able to differentiate iRBD patients from controls (p = 0.004). At the 12-month follow-up, a slight progression of overall acoustic speech impairment was noted for the iRBD (p = 0.04) and PD (p = 0.03) groups.Interpretation: Automated speech analysis might provide a useful additional biomarker of parkinsonism for the assessment of disease progression and therapeutic interventions. ANN NEUROL 2021;90:62-75

Spoken language alterations can predict phenoconversion in isolated REM sleep behavior disorder: a multicentric study.

OBJECTIVE This study assessed the relationship between speech and language impairment and outcome in a multicenter cohort of isolated/idiopathic rapid eye movement sleep behavior disorder (iRBD). METHODS Patients with iRBD from 7 centers speaking Czech, English, German, French, and Italian languages underwent a detailed speech assessment at baseline. Story-tale narratives were transcribed and linguistically annotated using fully automated methods based on automatic speech recognition and natural language processing algorithms, leading to the 3 distinctive linguistic and 2 acoustic patterns of language deterioration and associated composite indexes of their overall severity. Patients were then prospectively followed and received assessments for parkinsonism or dementia during follow-up. The Cox proportional hazard was performed to evaluate the predictive value of language patterns for phenoconversion over a follow-up period of 5 years. RESULTS Of 180 patients free of parkinsonism or dementia, 156 provided follow-up information. After a mean follow-up of 2.7 years, 42 (26.9%) patients developed neurodegenerative disease. Patients with higher severity of linguistic abnormalities (hazard ratio [HR = 2.35]) and acoustic abnormalities (HR = 1.92) were more likely to develop a defined neurodegenerative disease, with converters having lower content richness (HR = 1.74), slower articulation rate (HR = 1.58), and prolonged pauses (HR = 1.46). Dementia-first (n = 16) and parkinsonism-first with mild cognitive impairment (n = 9) converters had higher severity of linguistic abnormalities than parkinsonism-first with normal cognition converters (n = 17). INTERPRETATION Automated language analysis might provide a predictor of phenoconversion from iRBD into synucleinopathy subtypes with cognitive impairment, and thus can be used to stratify patients for neuroprotective trials. This article is protected by copyright. All rights reserved