IMECE2003-44104 SIMULATION AND BOGIE TESTING OF A NEW CABLE BARRIER TERMINAL

ABSTRACT Roadside barriers of various designs are extensively used for the purpose of shielding obstacles along the road from impact with errant vehicles. One commonly applied roadside barrier system is a cable system, consisting of three steel cables supported by weak steel posts. Due to an increase in the use of cable systems, a tangent to the roadway, as opposed to flared away from the roadway, crashworthy end terminal has been designed by the Midwest Roadside Safety Facility. The design goal was to effectively disengage the pre-tensioned cables at the end anchor point when impacted on the end by a vehicle, allowing the vehicle to pass through the system virtually unobstructed. It is the objective of this study to help evaluate the new design through bogie testing and nonlinear finite element analysis using LS-DYNA. Based on bogie test results and detailed analysis of the simulation results, it was concluded that the new cable end terminal was ready for full-scale crash testing. INTRODUCTION Roadside barriers of various designs are extensively used for the purpose of shielding obstacles along the road from impact with errant vehicles. One commonly applied roadside barrier system is the 3-strand cable system. This system consists of three steel cables supported by weak steel posts. The steel cables are pre-tensioned with a specified initial load, and are anchored at both ends of the system. When an errant vehicle obliquely impacts the 3-strand cable system, sufficient tension is developed within the cables to redirect the vehicle, effectively shielding the roadside hazard and increasing the safety of the vehicle operator. The weak steel posts supporting the cables offer very little resistance to the impacting vehicle. Due to the likelihood of a longitudinal impact with the end of the 3-strand cable system, a crashworthy end terminal has been designed by the Midwest Roadside Safety Facility (MwRSF). The design goal was to effectively disengage the pre-tensioned cables at the end anchor point upon impact with a vehicle, allowing the vehicle to pass through the system virtually unobstructed. To assist in the development of the 3-strand cable system end terminal, the CTB-4 bogie crash test was conducted. It is the objective of this study to simulate the cable terminal bogie test CTB-4 using LS-DYNA, a nonlinear finite element analysis code (1), and validate the simulation results with that of the physical test

Efficient Code Generation in a Region-based Dynamic Binary Translator

Region-based JIT compilation operates on translation units comprising multiple basic blocks and, possibly cyclic or conditional, control flow between these. It promises to reconcile aggressive code optimisation and low compilation latency in performance-critical dynamic binary translators. Whilst various region selection schemes and isolated code optimisation techniques have been investigated it remains unclear how to best exploit such regions for efficient code generation. Complex interactions with indirect branch tables and translation caches can have adverse effects on performance if not considered carefully. In this paper we present a complete code generation strategy for a region-based dynamic binary translator, which exploits branch type and control flow profiling information to improve code quality for the common case. We demonstrate that using our code generation strategy a competitive region-based dynamic compiler can be built on top of the LLVM JIT compilation framework. For the ARM-V5T target ISA and SPEC CPU 2006 benchmarks we achieve execution rates of, on average, 867 MIPS and up to 1323 MIPS on a standard X86 host machine, outperforming state-of-the-art QEMU-ARM by delivering a speedup of 264%

Tubulin isoform composition tunes microtubule dynamics

Microtubules polymerize and depolymerize stochastically, a behavior essential for cell division, motility and differentiation. While many studies advanced our understanding of how microtubule-associated proteins tune microtubule dynamics in trans, we have yet to understand how tubulin genetic diversity regulates microtubule functions. The majority of in vitro dynamics studies are performed with tubulin purified from brain tissue. This preparation is not representative of tubulin found in many cell types. Here we report the 4.2Å cryo-EM structure and in vitro dynamics parameters of α1B/βI+βIVb microtubules assembled from tubulin purified from a human embryonic kidney cell line with isoform composition characteristic of fibroblasts and many immortalized cell lines. We find that these microtubules grow faster and transition to depolymerization less frequently compared to brain microtubules. Cryo-EM reveals that the dynamic ends of α1B/βI+βIVb microtubules are less tapered and that these tubulin heterodimers display lower curvatures. Interestingly, analysis of EB1 distributions at dynamic ends suggests no differences in GTP cap sizes. Lastly, we show that the addition of recombinant α1A/βIII tubulin, a neuronal isotype overexpressed in many tumors, proportionally tunes the dynamics of α1B/βI+βIVb microtubules. Our study is an important step towards understanding how tubulin isoform composition tunes microtubule dynamics

Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to &lt;90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], &gt;300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of &lt;15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P&lt;0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P&lt;0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Neural correlates of emotional regulation processing: Evidence from ERP and source current density analysis

The neural mechanism of emotion regulation had been widely concerned while still unclear. Therefore, the goal of the present study was to investigate and highlight common neural correlates of emotion regulation in healthy populations. During this task, 51 participants were required to down-regulate their emotion when viewing negative images with reappraisal and expressive suppression strategies. Using ERP and source current density analysis, the present study provided precise time frame and construct destiny sources map to show the temporal unfolding of neural events that occur during emotion regulation processes. Results showed that: (1) Emotion regulation processing starts from early attention selection to late emotion experiences processing, represented by decreased P2 and LPP to negative stimulus during emotion regulation. (2) LPP derived from prefrontal gyrus, with different neural circles involving in reappraisal and suppression emotion regulation. (3) There is conflict between the self-reporting and ERP results, indicating the necessary of using objective research methods in study of emotion regulation. &copy; 2018 Association for Computing Machinery.</p

Loop fusion for clustered VLIW architectures

Embedded systems require maximum performance from a processor within significant constraints in power consumption and chip cost. Using software pipelining, high-performance digital signal processors can often exploit considerable instruction-level parallelism (ILP), and thus significantly improve performance. However, software pipelining, in some instances, hinders the goals of low power consumption and low chip cost. Specifically, the registers required by a software pipelined loop may exceed the size of the physical register set. The register pressure problem incurred by software pipelining makes it difficult to build a high-performance embedded processor with a single, multi-ported register bank with enough registers to support high levels of ILP while maintaining clock speed and limiting power consumption. The large number of ports required to support a single register bank severely hampers access time. The port requirement for a register bank can be reduced via hardware by partitioning the register bank into multiple banks connected to disjoint subsets of functional units, called clusters. Since a functional unit is not directly connected to all register banks, wasted energy and resources can result due to delays incurred when accessing non-local registers. The overhead due to partitioning of the register set can be ameliorated by using high-level compiler loop optimization techniques such as unrolling, unroll-and-jam and fusion. High-level loop optimizations spread data-independent parallelism across clusters that may not require non-local register accesses and can provide work to hide the latency of any such register accesses that are needed. In this paper, we examine the effects of loop fusion on DSP loops run on four simulated, clustered VLIW architectures and the Texas Instruments TMS320C64x. Our experiments show a 1.3 - 2 harmonic mean speedup

Loop Transformations for Architectures with Partitioned Register Banks

Embedded systems require maximum performance from a processor within significant constraints in power consumption and chip cost. Using software pipelining, processors can often exploit considerable instruction-level parallelism (ILP), and thus significantly improve performance, at the cost of substantially increasing register requirements. These increasing register requirements, how ever, make it difficult to build a high-performance embedded processor with a single, multi-ported register file while maintaining clock speed and limiting power consumption. Some digita