549 research outputs found

    Genetic Susceptibility to Graves’ Ophthalmopathy

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    Isolated Iliac Artery Aneurysm

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    Mélancolie postcoloniale : relecture de la mémoire collective et du lieu d'appartenance identitaire chez Patrick Chamoiseau et Émile Ollivier

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    La présente thèse vise à analyser le thème de la mélancolie postcoloniale et son utilisation stratégique dans huit romans de Patrick Chamoiseau (Solibo Magnifique, Texaco, Biblique des derniers gestes et Un dimanche au cachot) et d’Émile Ollivier (Mère-Solitude, Passages, Les urnes scellées et La Brûlerie). Sous l’éclairage de la psychanalyse et de la critique postcoloniale, nous définissons cette notion fondamentale comme suit : un psychisme ambivalent entraîné par la perte ou le manque de certains objets d’attachement ––– objets qui sont en l’occurrence la mémoire collective et/ou le lieu d’appartenance identitaire. Comment et pourquoi ce thème se manifeste-t-il dans notre corpus ? Notre hypothèse est que l’utilisation dudit thème serait plus le résultat de leur choix stratégique que l’effet de leur état psychique. C’est afin d’examiner leurs propres problématiques des construction et perception identitaires dans le contexte postcolonial que ces écrivains mettent en récit une telle situation de manque mnémonique et spatial à travers l’écriture romanesque. Afin de mieux élucider la manifestation textuelle de ce thème, nous divisons celui-ci en deux motifs : la « non-histoire » et le « non-lieu ». En nous appuyant principalement sur les réflexions d’Édouard Glissant, de Takayuki Nakamura et de Marc Augé, nous définissons ces concepts comme deux aspects de la mélancolie postcoloniale : situation de manque de la mémoire collective et celle du lieu d’appartenance identitaire. Nos analyses de ces deux motifs sur un plan stylistique, narratologique, structurel et théorique permettent d’examiner de plus près les points de convergence et de divergence entre l’écriture romanesque de Chamoiseau et celle d’Ollivier. En nous fondant sur les quatre études dans la deuxième partie concernant la mise en récit de la non-histoire, nous analysons les utilisations stratégiques de ce motif afin de voir la mise en récit de la « vision prophétique du passé » (É. Glissant). Nous élucidons ensuite en quoi consiste cette vision temporelle paradoxale : choix de genres littéraires tels que le récit policier (Mère-Solitude et Solibo Magnifique) et le récit du retour au pays natal (Les urnes scellées et Bibliques des derniers gestes). Ce choix narratif se réfère toujours à ce que nous nommons la méthode inductive de la narration. La troisième partie, composée encore de quatre études, éclaire les stratégies de la description du lieu. Nous en déduisons une modalité sui generis de la description spatiale que nous appelons, d’après Marc Augé, l’« évocation prophétique d’espaces ». Cette stratégie descriptive se représente notamment par la spatialisation métaphorique de l’identité créole (Texaco et Un dimanche au cachot) ou migrante (Passages et La Brûlerie). En conclusion, nous résumons ces analyses pour en extraire les points communs et divergents entre les utilisations stratégiques de la mélancolie postcoloniale chez Chamoiseau et Ollivier. Entre autres aspects, nous constatons que la mise en récit de la vulnérabilité due à la mélancolie postcoloniale constitue leur positionnement esthétique et éthique afin qu’ils puissent réfléchir aux constructions et perception identitaires au sein du monde actuel devenu plus que jamais flou et fluide.The purpose of this doctoral thesis is to analyse the theme of postcolonial melancholia and that strategic utilization in eight novels of Patrick Chamoiseau (Solibo Magnifique, Texaco, Biblique des derniers gestes et Un dimanche au cachot) et Émile Ollivier (Mère-Solitude, Passages, Les urnes scellées et La Brûlerie). From the perspective of psychoanalysis and postcolonial criticism, we define this fundamental notion in the following manner : an ambivalent psychology produced by the loss or lack of some objects of attachement ― objects which in this instance are the collective memory and/or the place of belonging. How and why does this theme manifeste itself in our corpus ? Our hypotheses is that the utilization of this theme would be their strategic choice rather than their psychological condition. It is in order to dissect their own problematics of identity construction and perception in the postcolonial contexte that these authors put into narrative form such situations of mnemonic and spatial lack through the writing of these novels. For the purpose of better clarifying the textual appearance of this theme, we divide it into two motifs : the « non-history (non-histoire) » and the « non-place (non-lieu) ». According to the reflections of Édouard Glissant, Takayuki Nakamura and Marc Augé, we define these concepts as being respectively one of the aspects of the postcolonial melancholia : a situation of lack of the collective memory and of the place of belonging. Our analyses of these two motifs from the stylistic, narratological, structural and theorical perspectives make it possible to examine with meticulous care the points of convergence and divergence of the novel writing between Chamoiseau and Ollivier. Based on four studies in the second part which concerns putting in narrative form of the non-history, we deduce that their strategic utilizations of this motif are actualized by « prophetic vision of past » in the glissantian meaning. We clarify subsequently what this paradoxal vision of time consists in : a choice of the literary genres such as the detective novel (Mère-Solitude et Solibo Magnifique) and the return to the native land (Les urnes scellées et Biblique des derniers gestes). This narrative choice is always supported by what we call the inductive method of narrating. The third part, composed again of four individual studies, throws light on strategies of spatial description. We abstract from these studies a way sui generis of the spatial description which we call, in Augé’s words, the « prophetic evocation of spaces ». This descriptive strategy is represented notably by the metaphorical spatialization of creole identity (Texaco et Un dimanche au cachot) or migrant identity (Passages et La Brûlerie). In conclusion, we summarize these eight studies to extract the points of convergence and divergence between the stratégic utilizations of the postcolonial melancholia in Chamoiseau and Ollivier. Prominently, we notice that the work of putting into narrative form the vulnerability due to the postcolonial melancholia constitutes their aesthétical and ethical standpoints so that they can reflect the identity construction and perception within the today’s world which is more blurred and fluid than ever before

    Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus

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    We previously reported in randomized controlled trials that maoto, a traditional herbal medicine, showed clinical and virological efficacy for seasonal influenza. In this study, a culturing system for influenza was used to test the effect of maoto. A549 cells in the culture were infected with influenza virus A (PR8) and followed after treatment with maoto; the virus titers in the culture supernatant, intracellular viral proteins, and viral RNA were determined. When infected cells were cultured with maoto for 24 hr, the virus titer and protein were significantly reduced compared with medium only. Other subtypes, A/H3N2, H1N1pdm, and B, were also inhibited by maoto. Proliferation of viral RNA in a 6 hr culture was inhibited by maoto in the early phase, especially in the first 30 min. Focusing on the entry step of the influenza virus, we found that endosomal pH, regulated by vacuolar-type H+ ATPase (V-ATPase) located in the membrane, was increased when treated with maoto. We also found that uncoating of influenza viruses was also inhibited by maoto, resulting in the increase of the number of virus particles in endosomes. These results strongly suggest that the inhibition of endosomal acidification by maoto results in blocking influenza virus entry to cytoplasm, probably through the inhibition of V-ATPase. The present study provides evidence that supports the clinical use of maoto for the treatment of influenza

    Hematuria Secondary to an Internal Iliac Artery Aneurysm

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    We report a case of macroscopic hematuria secondary to an aneurysm of the internal iliac artery. An 84-year-old male presented to our department with a 12-hour history of painless gross hematuria. Cystoscopy showed decreased expansion suggesting compression from outside the bladder. At the point of compression, increased vascularization was noted in the bladder mucosa without evidence of active bleeding. No trace of blood was identified coming from the ureteric orifices, the bladder neck, or the prostate. There was no evidence of intra-vesicular masses or other inflammatory changes. The abdominal computed tomography scan revealed left-sided hydronephrosis and an abdominal aortic aneurysm involving the aortic bifurcation and both internal iliac arteries. There was no evidence of rupture. An aneurysm of the internal iliac artery is a rare cause of macroscopic hematuria that can be fatal. Awareness of this as a possible cause of hematuria may assist in immediate diagnosis and appropriate treatment
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