Aiguèze – Grotte aux Points

Date de l'opération : 1994 (SU) Inventeur(s) : Galant Philippe (SDA) ; Colomer Albert (SRA) ; Chauvet Jean-Marie ; Deschamps Eliette ; Hillaire Christian C'est au cours d'un travail d'inventaire systématique des cavités naturelles des gorges de l'Ardèche, que Jean-Marie Chauvet, Éliette Deschamps et Christian Hillaire ont constaté la présence de signes peints à l'ocre rouge, dans une partie profonde de la grotte aux Points (Aiguèze). Il s'agit d'une grotte qui se présente sous la forme d'un ..

Clay mineral signature of the NW Atlantic Boundary Undercurrent

Surface sediments were sampled along 2 transects, across the Iceland and Irminger basins and in the Labrador Sea. Clay mineral assemblages (deduced from X-ray analyses of the carbonate-free <2 mu m fraction) are largely dominated by smectites (about 60%) in the Iceland and Irminger basins. In the Labrador Sea, smectites are present along the Greenland Slope, but absent or rare in sediments from the Labrador Slope. They may, however, represent up to 50% of the clay fraction at depths between 2800 and 3400 m along both margins of the Labrador Sea, i.e., along the axis of the Western Boundary Undercurrent (WBUC). A detrital supply from the adjacent continents is unlikely. The WBUC is thought to be responsible for erosion and transport of fine particles from the smectite-rich Irminger and Iceland Basins, then for their redeposition in the Labrador Sea. These results suggest that clay minerals can be used as paleocurrent indicators in the Northwest Atlantic

Parkinsonian Patients Requiring Proteasome Inhibitors for Multiple Myeloma: Exceptional Circumstances Call for Extra Caution

Feedback on the management of patients with both Parkinson’s disease (PD) and multiple myeloma (MM) is not common in the literature, and we would like to report an original possible adverse event (AE) of MM chemotherapy: an increased PD severity induced by ixazomib. The patient, a 68-year-old man with PD (Hoehn and Yahr (HY) stage 3) was effectively and stably treated for 14 years with dopaminergic therapy (levodopa equiva25 lent daily dose (LEDD) 1275 mg). His symptomatic MM was first treated by lenalidomide (25 mg) with dexamethasone (Rd protocol) for 19 months. Then, a second-line therapy combined the proteasome inhibitor (PI) ixazomib (4 mg) with lenalidomide (20 mg) and dexamethasone (IRd protocol, 4-week cycle) due to MM progression

A stable isotope toolbox for water and inorganic carbon cycle studies

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Changes in the Western Boundary Undercurrent outflow since the Last Glacial Maximum, from smectite/illite ratios in deep Labrador Sea sediments

High-resolution mineralogical studies were performed on late glacial and deglacial sediments from two deep piston cores from the Labrador Sea, located at the inlet (SW Greenland Rise) and outlet (Labrador Rise) of the Western Boundary Undercurrent (WBUC) gyre. At the two sites, smectites transported from the eastern Iceland and Irminger basins by the WBUC are observed. Clay mineral changes are used as proxies for the paleointensity reconstruction of the WBUC. On the Greenland Rise, a clay mineral index (smectite/illite (S/I) ratio) is defined. A S/I ratio of similar to 1 characterized the Last Glacial Maximum. It increased after similar to 17 ka, and reached a maximum value of 4 during the early Holocene, The mineralogical changes are gradual and do not show any reversal during the Younger Dryas, This pattern, which is confirmed by first-order estimations of smectite and illite fluxes, suggests gradually increasing sedimentary fluxes and WBUC intensity since the Last Glacial Maximum, A peak in the velocity of the WBUC at similar to 9 ka, as recorded by clay assemblages, is consistent with other regional studies based on pollen, foraminifera, or grain-size measurements, A massive dilution of smectites by illite and chlorite (S/I approximate to 3) occurs at similar to 8.5 ka. It corresponds to a period of rapid sediment accumulation and reflects an intensified illite-rich detrital supply by meltwaters from the southern Greenland Ice Margin. On the Labrador Rise, the smectite content varies between 20 and 60% with no obvious trend through time. The mineralogical composition is strongly influenced by ice-rafted deposition and by the abundance of fast deposit units (cf, Heinrich layers in the North Atlantic) which contain abundant detrital carbonates spilled-over from the North-West Atlantic Mid-Ocean Channel. In such layers, smectites are present but are diluted by the addition of illites, chlorites, and kaolinites. This provides evidence for a discrete and continuous WBUC supply of fine particles from the Irminger and Iceland Basins as far as the southeastern part of the Labrador Basin, Early deglacial smectite-rich layers (up to 60%) are also observed at this site, They indicate an increase in the outflow of the WBUC at similar to 13.5 ka, (Bolling-Allerod), as previously reported from grain size or foraminiferal assemblage studies

Preclinical research in Rett syndrome: setting the foundation for translational success

In September of 2011, the National Institute of Neurological Disorders and Stroke (NINDS), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the International Rett Syndrome Foundation (IRSF) and the Rett Syndrome Research Trust (RSRT) convened a workshop involving a broad cross-section of basic scientists, clinicians and representatives from the National Institutes of Health (NIH), the US Food and Drug Administration (FDA), the pharmaceutical industry and private foundations to assess the state of the art in animal studies of Rett syndrome (RTT). The aim of the workshop was to identify crucial knowledge gaps and to suggest scientific priorities and best practices for the use of animal models in preclinical evaluation of potential new RTT therapeutics. This review summarizes outcomes from the workshop and extensive follow-up discussions among participants, and includes: (1) a comprehensive summary of the physiological and behavioral phenotypes of RTT mouse models to date, and areas in which further phenotypic analyses are required to enhance the utility of these models for translational studies; (2) discussion of the impact of genetic differences among mouse models, and methodological differences among laboratories, on the expression and analysis, respectively, of phenotypic traits; and (3) definitions of the standards that the community of RTT researchers can implement for rigorous preclinical study design and transparent reporting to ensure that decisions to initiate costly clinical trials are grounded in reliable preclinical data

Early Hepatocellular Carcinoma Detection Using Magnetic Resonance Imaging Is Cost-Effective in High-Risk Patients with Cirrhosis

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