760 research outputs found
Is hepatitis C virus elimination possible among people living with HIV and what will it take to achieve it?
Introduction
The World Health Organization targets for hepatitis C virus (HCV) elimination include a 90% reduction in new infections by 2030. Our objective is to review the modelling evidence and cost data surrounding feasibility of HCV elimination among people living with HIV (PLWH), and identify likely components for elimination. We also discuss the realâworld experience of HCV direct acting antiviral (DAA) scaleâup and elimination efforts in the Netherlands.
Methods
We review modelling evidence of what intervention scaleâup is required to achieve WHO HCV elimination targets among HIVâinfected (HIV+) people who inject drugs (PWID) and men who have sex with men (MSM), review costâeffectiveness of HCV therapy among PLWH and discuss economic implications of elimination. We additionally use the realâworld experience of DAA scaleâup in the Netherlands to illustrate the promise and potential challenges of HCV elimination strategies in MSM. Finally, we summarize key components of the HCV elimination response among PWLH.
Results and discussion
Modelling indicates HCV elimination among HIV+ MSM and PWID is potentially achievable but requires combination treatment and either harm reduction or behavioural risk reductions. Preliminary modelling indicates elimination among HIV+ PWID will require elimination efforts among PWID more broadly. Treatment for PLWH and highârisk populations (PWID and MSM) is costâeffective in highâincome countries, but costs of DAAs remain a barrier to scaleâup worldwide despite the potential low production price ($50 per 12 week course). In the Netherlands, universal DAA availability led to rapid uptake among HIV+ MSM in 2015/16, and a 50% reduction in acute HCV incidence among HIV+ MSM from 2014 to 2016 was observed. In addition to HCV treatment, elimination among PLWH globally also likely requires regular HCV testing, development of lowâcost accurate HCV diagnostics, reduced costs of DAA therapy, broad treatment access without restrictions, close monitoring for HCV reinfection and retreatment, and harm reduction and/or behavioural interventions.
Conclusions
Achieving WHO HCV Elimination targets is potentially achievable among HIVâinfected populations. Among HIV+ PWID, it likely requires HCV treatment scaleâup combined with harm reduction fo
A sustainable biomineralization approach for the synthesis of highly fluorescent ultra-small pt nanoclusters
Herein we report the first example of a facile biomineralization process to produce ultra-small-sized highly fluorescent aqueous dispersions of platinum noble metal quantum clusters (Pt-NMQCs) using a multi-stimulus responsive, biomimetic intrinsically disordered protein (IDP), Rec1-resilin. We demonstrate that Rec1-resilin acts concurrently as the host, reducing agent, and stabilizer of the blue-green fluorescent Pt-NMQCs once they are being formed. The photophysical properties, quantum yield, and fluorescence lifetime measurements of the synthesized Pt-NMQCs were examined using UV-Vis and fluorescence spectroscopy. The oxidation state of the Pt-NMQCs was quantitatively analyzed using X-ray photoelectron spectroscopy. Both a small angle X-ray scattering technique and a modeling approach have been attempted to present a detailed understanding of the structure and conformational dynamics of Rec1-resilin as an IDP during the formation of the Pt-NMQCs. It has been demonstrated that the green fluorescent Pt-NMQCs exhibit a high quantum yield of ~7.0% and a lifetime of ~9.5 ns in aqueous media. The change in photoluminescence properties due to the inter-dot interactions between proximal dots and aggregation of the Pt-NMQCs by evaporation was also measured spectroscopically and discussed.Rajkamal Balu, Robert Knott, Christopher M. Elvin, Anita J. Hill, Namita R. Choudhury and Naba K. Dutt
Fermionic massive modes along cosmic strings
The influence on cosmic string dynamics of fermionic massive bound states
propagating in the vortex, and getting their mass only from coupling to the
string forming Higgs field, is studied. Such massive fermionic currents are
numerically found to exist for a wide range of model parameters and seen to
modify drastically the usual string dynamics coming from the zero mode currents
alone. In particular, by means of a quantization procedure, a new equation of
state describing cosmic strings with any kind of fermionic current, massive or
massless, is derived and found to involve, at least, one state parameter per
trapped fermion species. This equation of state exhibits transitions from
subsonic to supersonic regimes while the massive modes are filled.Comment: 27 pages, 15 figures, uses ReVTeX. Shortened version, accepted for
publication in Phys. Rev.
Equation of state of cosmic strings with fermionic current-carriers
The relevant characteristic features, including energy per unit length and
tension, of a cosmic string carrying massless fermionic currents in the
framework of the Witten model in the neutral limit are derived through
quantization of the spinor fields along the string. The construction of a Fock
space is performed by means of a separation between longitudinal modes and the
so-called transverse zero energy solutions of the Dirac equation in the vortex.
As a result, quantization leads to a set of naturally defined state parameters
which are the number densities of particles and anti-particles trapped in the
cosmic string. It is seen that the usual one-parameter formalism for describing
the macroscopic dynamics of current-carrying vortices is not sufficient in the
case of fermionic carriers.Comment: 30 pages, 15 figures, uses ReVTeX, equation of state corrected,
comments and references added. Accepted for publication in Phys. Rev.
The Intentional Use of Service Recovery Strategies to Influence Consumer Emotion, Cognition and Behaviour
Service recovery strategies have been identified as a critical factor in the success of. service organizations. This study develops a conceptual frame work to investigate how specific service recovery strategies influence the emotional, cognitive and negative behavioural responses of . consumers., as well as how emotion and cognition influence negative behavior. Understanding the impact of specific service recovery strategies will allow service providers' to more deliberately and intentionally engage in strategies that result in positive organizational outcomes. This study was conducted using a 2 x 2 between-subjects quasi-experimental design. The results suggest that service recovery has a significant impact on emotion, cognition and negative behavior. Similarly, satisfaction, negative emotion and positive emotion all influence negative behavior but distributive justice has no effect
Measurement of the partial widths of the Z into up- and down-type quarks
Using the entire OPAL LEP1 on-peak Z hadronic decay sample, Z -> qbarq gamma
decays were selected by tagging hadronic final states with isolated photon
candidates in the electromagnetic calorimeter. Combining the measured rates of
Z -> qbarq gamma decays with the total rate of hadronic Z decays permits the
simultaneous determination of the widths of the Z into up- and down-type
quarks. The values obtained, with total errors, were Gamma u = 300 ^{+19}_{-18}
MeV and Gamma d = 381 ^{+12}_{-12} MeV. The results are in good agreement with
the Standard Model expectation.Comment: 22 pages, 5 figures, Submitted to Phys. Letts.
Search for R-Parity Violating Decays of Scalar Fermions at LEP
A search for pair-produced scalar fermions under the assumption that R-parity
is not conserved has been performed using data collected with the OPAL detector
at LEP. The data samples analysed correspond to an integrated luminosity of
about 610 pb-1 collected at centre-of-mass energies of sqrt(s) 189-209 GeV. An
important consequence of R-parity violation is that the lightest supersymmetric
particle is expected to be unstable. Searches of R-parity violating decays of
charged sleptons, sneutrinos and squarks have been performed under the
assumptions that the lightest supersymmetric particle decays promptly and that
only one of the R-parity violating couplings is dominant for each of the decay
modes considered. Such processes would yield final states consisting of
leptons, jets, or both with or without missing energy. No significant
single-like excess of events has been observed with respect to the Standard
Model expectations. Limits on the production cross- section of scalar fermions
in R-parity violating scenarios are obtained. Constraints on the supersymmetric
particle masses are also presented in an R-parity violating framework analogous
to the Constrained Minimal Supersymmetric Standard Model.Comment: 51 pages, 24 figures, Submitted to Eur. Phys. J.
Measurement of the Strong Coupling alpha s from Four-Jet Observables in e+e- Annihilation
Data from e+e- annihilation into hadrons at centre-of-mass energies between
91 GeV and 209 GeV collected with the OPAL detector at LEP, are used to study
the four-jet rate as a function of the Durham algorithm resolution parameter
ycut. The four-jet rate is compared to next-to-leading order calculations that
include the resummation of large logarithms. The strong coupling measured from
the four-jet rate is alphas(Mz0)=
0.1182+-0.0003(stat.)+-0.0015(exp.)+-0.0011(had.)+-0.0012(scale)+-0.0013(mass)
in agreement with the world average. Next-to-leading order fits to the
D-parameter and thrust minor event-shape observables are also performed for the
first time. We find consistent results, but with significantly larger
theoretical uncertainties.Comment: 25 pages, 15 figures, Submitted to Euro. Phys. J.
Measurement of the Hadronic Photon Structure Function F_2^gamma at LEP2
The hadronic structure function of the photon F_2^gamma is measured as a
function of Bjorken x and of the factorisation scale Q^2 using data taken by
the OPAL detector at LEP. Previous OPAL measurements of the x dependence of
F_2^gamma are extended to an average Q^2 of 767 GeV^2. The Q^2 evolution of
F_2^gamma is studied for average Q^2 between 11.9 and 1051 GeV^2. As predicted
by QCD, the data show positive scaling violations in F_2^gamma. Several
parameterisations of F_2^gamma are in agreement with the measurements whereas
the quark-parton model prediction fails to describe the data.Comment: 4 pages, 2 figures, to appear in the proceedings of Photon 2001,
Ascona, Switzerlan
A measurement of the tau mass and the first CPT test with tau leptons
We measure the mass of the tau lepton to be 1775.1+-1.6(stat)+-1.0(syst.) MeV
using tau pairs from Z0 decays. To test CPT invariance we compare the masses of
the positively and negatively charged tau leptons. The relative mass difference
is found to be smaller than 3.0 10^-3 at the 90% confidence level.Comment: 10 pages, 4 figures, Submitted to Phys. Letts.
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