Validation of the effect of mantle inelasticity and latitude dependence through the observed tidal parameters

第2回極域科学シンポジウム/第31回極域地学シンポジウム 11月16日（水） 国立国語研究

Traditional Herbal Medicine, Rikkunshito, Induces HSP60 and Enhances Cytoprotection of Small Intestinal Mucosal Cells as a Nontoxic Chaperone Inducer

Increasing incidence of small intestinal ulcers associated with nonsteroidal anti-inflammatory drugs (NSAIDs) has become a topic with recent advances of endoscopic technology. However, the pathogenesis and therapy are not fully understood. The aim of this study is to examine the effect of Rikkunshito (TJ-43), a traditional herbal medicine, on expression of HSP60 and cytoprotective ability in small intestinal cell line (IEC-6). Effect of TJ-43 on HSP60 expression in IEC-6 cells was evaluated by immunoblot analysis. The effect of TJ-43 on cytoprotective abilities of IEC-6 cells against hydrogen peroxide or indomethacin was studied by MTT assay, LDH-release assay, caspase-8 activity, and TUNEL. HSP60 was significantly induced by TJ-43. Cell necrosis and apoptosis were significantly suppressed in IEC-6 cells pretreated by TJ-43 with overexpression of HSP60. Our results suggested that HSP60 induced by TJ-43 might play an important role in protecting small intestinal epithelial cells from apoptosis and necrosis in vitro

The ITASAT CubeSat Development and Design

Because they are inexpensive platforms for satellites, CubeSats have become a low-cost way for universities and even developing countries to have access to space technology. This paper presents the ITASAT design, particularly the Attitude Determination and Control Subsystem, the Onboard Software, and the Assembly, Integration and Testing program. The ITASAT is a 6U CubeSat nano-satellite in development at the Instituto Tecnologico de Aeronautica, in Sao Jose dos Campos, Brazil. The platform and its subsystems will be provided by industry while the payloads are being designed and developed by the principal investigators. The ITASAT Attitude Determination and Control Subsystem will rely on a 3-axis magnetometer, 6 analog cosine sun sensors, 3-axis MEMS gyroscopes, 3 magnetic torque coils, and 3 reaction wheels. The Attitude Determination and Control Subsystem operating modes, control laws, and embedded software are under the responsibility of the Instituto Tecnologico de Aeronautica. A Kalman filter shall be employed to estimate the quaternion attitude and gyroscope biases from sensor measurements. The Attitude Determination and Control Subsystem operating modes are the nominal mode, with geocentric pointing attitude control and the stabilization mode, in which only the satellite angular velocity is controlled. The nominal mode will be split into 2 sub-modes: reaction wheel control plus magnetic wheel desaturation and 3-axis magnetic attitude control. Simulation results have shown that the attitude can be controlled with 1-degree accuracy in nominal mode with the reaction wheels, but these errors grow as much as 20 degrees or higher with the 3-axis magnetic control.Inst Nacl Pesquisas Espaciais Engn, Sao Jose Dos Campos, SP, BrazilTecnol Espaciais Div Mecan Espacial Control, Sao Jose Dos Campos, SP, BrazilInst Tecnol Aeronaut, Dept Ciencia & Tecnol Aeroespacial, Div Engn Aeronaut, Praca Marechal Eduardo Gomes 50 Vila Acacias, BR-12230901 Sao Jose Dos Campos, SP, BrazilUniv Fed Sao Paulo, Inst Ciencia & Tecnol, Dept Ciencia Computacao, Sao Jose Dos Campos, SP, BrazilUniv Fed Sao Paulo, Inst Ciencia & Tecnol, Dept Engn Computacao, Sao Jose Dos Campos, SP, BrazilInst Tecnol Aeronaut, Dept Ciencia & Tecnol Aeroespacial, Div Engn Eletr & Computacao, Sao Jose Dos Campos, SP, BrazilUniv Fed Sao Paulo, Inst Ciencia & Tecnol, Dept Engn Computacao, Sao Jose Dos Campos, SP, BrazilWeb of Scienc

Correlation of Heat Shock Protein Expression to Gender Difference in Development of Stress-Induced Gastric Mucosal Injury in Rats

Recent studies have indicated that heat shock proteins (HSPs), which function as molecular chaperones, play important roles in cellular responses to stress-related events. However, the gender difference in the expression of HSP in the gastric mucosa remains unclear. In order to understand the mechanism of gender difference in the prevalence or severity of gastric mucosal lesions, the expression level of HSP and the correlation of estrogen to HSP induction in the gastric mucosa were evaluated in this study. The basal expression levels of HSP60 and HSP90 in the gastric mucosa were significantly higher in females than those in males. The gastric ulcer index was significantly higher in male rats compared to female rats observed after 12 h water immersion stress exposure. At this time point, the expression levels of HSP60 and HSP90 in the gastric mucosa were significantly higher in females than those in males. An estrogen-treatment significantly induced the expression of HSP60, HSP70 and HSP90 in the gastric mucosa. Inversely, an ovariectomy dramatically reduced the expression of HSP60, HSP70 and HSP90 in the gastric mucosa. Our results suggested that estrogen might play an important role in gastric mucosal protection with the induction of gastric mucosal HSPs

Five years’ gravity observation with the superconducting gravimeter OSG#058 at Syowa Station, East Antarctica: gravitational effects of accumulated snow mass

Continuous gravimetric observations have been made with three successive generations of superconducting gravimeter over 20 yr at Syowa Station (E, [Math Processing Error]S), East Antarctica. The third-generation instrument, OSG#058, was installed in January 2010 and was calibrated by an absolute gravimeter during January and February, 2010. The estimated scale factor was −73.823 ± 0.053 μGal V−1 (1 μGal = 10−8 m s−2). The first 5 yr of OSG#058 data from 2010 January 7 to 2015 January 10 were decomposed into tidal waves (M3 to Ssa) and other non-tidal components by applying the Bayesian tidal analysis program BAYTAP. Long-term non-tidal gravity residuals, which were obtained by subtracting annual and 18.6 year tidal waves and the predicted gravity response to the Earth\u27s variable rotation, showed significant correlation with the accumulated snow depth measured at Syowa Station. The greatest correlation occurred when the gravity variations lagged the accumulated snow depth by 21 d. To estimate the gravitational effect of the accumulated snow mass, we inferred a conversion factor of 3.13 ± 0.08 μGal m−1 from this relation. The accumulated snow depth at Syowa Station was found to represent an extensive terrestrial water storage (the snow accumulation) around Syowa Station, which was estimated from the Gravity Recovery and Climate Experiment satellite gravity data. The snow accumulation around Syowa Station was detectable by the superconducting gravimeter

Long-term continuous operation of superconducting gravimeter (OSG#058)

第3回極域科学シンポジウム/第32回極域地学シンポジウム 11月29日（木） 統計数理研究所 ３階セミナー

Monitoring of changes in the geosphere with the geodetic techniques at Syowa Station, Antarctica during the JARE-52 overwintering

第3回極域科学シンポジウム/第32回極域地学シンポジウム 11月29日（木） 国立極地研究所 ３階ラウン

Clinical Study A Randomized Prospective Study of Bowel Preparation for Colonoscopy with Low-Dose Sodium Phosphate Tablets versus Polyethylene Glycol Electrolyte Solution

Optimal bowel preparation is essential for the safety and outcome of colonoscopy. A solution containing polyethylene glycol (PEG) is often used as a bowel cleansing agent, but some patients are intolerant of PEG, and this may lead to discontinuation of colonoscopy. Sodium phosphates (NaP) tablets are designed to improve patient acceptance and compliance. The objective of this study was to compare bowel preparation efficiency and patient acceptance of a 30 NaP tablet preparation (L-NaP) and a 2 L PEG preparation. Patients were randomized into either the L-NaP or PEG group. The primary endpoint was the efficiency of colon cleansing as assessed by a validated four-point scale according to the Aronchick scale by endoscopists and was verified by blinded investigators. The secondary endpoints were patients' tolerability and acceptance. Colon-cleansing efficiency was not significantly different between the two preparations. However, patients' overall judgment was significantly in favor of L-NaP, reflecting better acceptance of L-NaP than PEG. Additionally, more patients favored L-NaP over PEG in a hypothetical future occasion requiring colonoscopy

The ITASAT – The Lessons Learned from the Mission Concept to the Operation

The ITASAT Project was initiated as an effort of the Brazilian Space Agency (AEB), the Technological Institute of Aeronautics (ITA) and the National Institute of Space Research (INPE) to train human resources to the Aerospace sector due to the lack of experience of the students in practical projects in the aerospace segment in Brazil. In this effort students were challenged to design, build and operate a satellite in a hands-on project. Along the project years several changes happened on the satellite configuration, going through a 100 kg satellite to a 6U CubeSat and this last configuration was designed, assembled and tested. In December ITASAT was launched and since its launch has been tracked and operated by the ground operation team. In this paper we will discuss the lessons learned during the project, since the decision to change the satellite size and re-thinking the scope of the project objectives, focusing on system engineering, Assembly Integration and Testing (AIT), Verification and Validation (V&V) and ground operations. The paper will present the challenges of the group of students in this hands-on project, the mistakes and hits along the project phases