Long-distance structure of the X(3872)

We investigate heavy quark symmetries for heavy meson hadronic molecules, and explore the consequences of assuming the X(3872) and $Z_b(10610)$ as an isoscalar $D\bar D^*$ and an isovector $B\bar B^*$ hadronic molecules, respectively. The symmetry allows to predict new hadronic molecules, in particular we find an isoscalar $1^{++}$ $B\bar B^*$ bound state with a mass about 10580 MeV and the isovector charmonium partners of the $Z_b(10610)$ and the $Z_b(10650)$ states. Next, we study the $X(3872) \to D^0 \bar D^0\pi^0$ three body decay. This decay mode is more sensitive to the long-distance structure of the X(3872) resonance than its $J/\psi\pi\pi$ and $J/\psi3\pi$ decays, which are mainly controlled by the short distance part of the X(3872) molecular wave function. We discuss the $D^0 \bar D^0$ final state interactions, which in some situations become quite important. Indeed in these cases, a precise measurement of this partial decay width could provide precise information on the interaction strength between the $D^{(*)}\bar D^{(*)}$ charm mesons.Comment: Talk presented at the "XI International Conference on Hyperons, Charm and Beauty Hadrons (BEACH 2014)", Birmingham (U.K.), July 201

Discrete Fracture Model with Anisotropic Load Sharing

A two-dimensional fracture model where the interaction among elements is modeled by an anisotropic stress-transfer function is presented. The influence of anisotropy on the macroscopic properties of the samples is clarified, by interpolating between several limiting cases of load sharing. Furthermore, the critical stress and the distribution of failure avalanches are obtained numerically for different values of the anisotropy parameter $\alpha$ and as a function of the interaction exponent $\gamma$. From numerical results, one can certainly conclude that the anisotropy does not change the crossover point $\gamma_c=2$ in 2D. Hence, in the limit of infinite system size, the crossover value $\gamma_c=2$ between local and global load sharing is the same as the one obtained in the isotropic case. In the case of finite systems, however, for $\gamma\le2$, the global load sharing behavior is approached very slowly

Diffuse Ionized Gas in the Dwarf Irregular Galaxy DDO 53

The spectral characteristics throughout the dwarf irregular galaxy DDO 53 are studied. The results are very similar to those for other irregular galaxies: high excitation and low values of the [SII]/Halpha ratio. The most likely ionization source is photon leakage from the classical HII regions, without any other source, although the interstellar medium of the galaxy is quite perturbed. Moreover, the physical conditions throughout the galaxy do not change very much because both the photon leakage percentage and the ionization temperature are very similar. In addition, the determined metal content for two HII regions indicates that DDO 53 is a low-metallicity galaxy.Comment: 32 pages, 9 figures, 7 tables. AJ, in pres

DNA binding shifts the redox potential of the transcription factor SoxR

Electrochemistry measurements on DNA-modified electrodes are used to probe the effects of binding to DNA on the redox potential of SoxR, a transcription factor that contains a [2Fe-2S] cluster and is activated through oxidation. A DNA-bound potential of +200 mV versus NHE (normal hydrogen electrode) is found for SoxR isolated from Escherichia coli and Pseudomonas aeruginosa. This potential value corresponds to a dramatic shift of +490 mV versus values found in the absence of DNA. Using Redmond red as a covalently bound redox reporter affixed above the SoxR binding site, we also see, associated with SoxR binding, an attenuation in the Redmond red signal compared with that for Redmond red attached below the SoxR binding site. This observation is consistent with a SoxR-binding-induced structural distortion in the DNA base stack that inhibits DNA-mediated charge transport to the Redmond red probe. The dramatic shift in potential for DNA-bound SoxR compared with the free form is thus reconciled based on a high-energy conformational change in the SoxR–DNA complex. The substantial positive shift in potential for DNA-bound SoxR furthermore indicates that, in the reducing intracellular environment, DNA-bound SoxR is primarily in the reduced form; the activation of DNA-bound SoxR would then be limited to strong oxidants, making SoxR an effective sensor for oxidative stress. These results more generally underscore the importance of using DNA electrochemistry to determine DNA-bound potentials for redox-sensitive transcription factors because such binding can dramatically affect this key protein property

A dynamic network approach for the study of human phenotypes

The use of networks to integrate different genetic, proteomic, and metabolic datasets has been proposed as a viable path toward elucidating the origins of specific diseases. Here we introduce a new phenotypic database summarizing correlations obtained from the disease history of more than 30 million patients in a Phenotypic Disease Network (PDN). We present evidence that the structure of the PDN is relevant to the understanding of illness progression by showing that (1) patients develop diseases close in the network to those they already have; (2) the progression of disease along the links of the network is different for patients of different genders and ethnicities; (3) patients diagnosed with diseases which are more highly connected in the PDN tend to die sooner than those affected by less connected diseases; and (4) diseases that tend to be preceded by others in the PDN tend to be more connected than diseases that precede other illnesses, and are associated with higher degrees of mortality. Our findings show that disease progression can be represented and studied using network methods, offering the potential to enhance our understanding of the origin and evolution of human diseases. The dataset introduced here, released concurrently with this publication, represents the largest relational phenotypic resource publicly available to the research community.Comment: 28 pages (double space), 6 figure

Universal insulating-to-metallic crossover in tight-binding random geometric graphs

Within the scattering matrix approach to electronic transport, the scattering and transport properties of tight-binding random graphs are analyzed. In particular, we compute the scattering matrix elements, the transmission, the channel-to-channel transmission distributions (including the total transmission distribution), the shot noise power, and the elastic enhancement factor. Two graph models are considered: random geometric graphs and bipartite random geometric graphs. The results show an insulating to a metallic crossover in the scattering and transport properties by increasing the average degree of the graphs from small to large values. Also, the scattering and transport properties are shown to be invariant under a scaling parameter depending on the average degree and the graph size. Furthermore, for large connectivity and in the perfect coupling regime, the scattering and transport properties of both graph models are well described by the random matrix theory predictions of electronic transport, except for bipartite graphs in particular scattering setups.Comment: 13 pages, 16 figure

Emergence of good conduct, scaling and Zipf laws in human behavioral sequences in an online world

We study behavioral action sequences of players in a massive multiplayer online game. In their virtual life players use eight basic actions which allow them to interact with each other. These actions are communication, trade, establishing or breaking friendships and enmities, attack, and punishment. We measure the probabilities for these actions conditional on previous taken and received actions and find a dramatic increase of negative behavior immediately after receiving negative actions. Similarly, positive behavior is intensified by receiving positive actions. We observe a tendency towards anti-persistence in communication sequences. Classifying actions as positive (good) and negative (bad) allows us to define binary 'world lines' of lives of individuals. Positive and negative actions are persistent and occur in clusters, indicated by large scaling exponents alpha~0.87 of the mean square displacement of the world lines. For all eight action types we find strong signs for high levels of repetitiveness, especially for negative actions. We partition behavioral sequences into segments of length n (behavioral `words' and 'motifs') and study their statistical properties. We find two approximate power laws in the word ranking distribution, one with an exponent of kappa-1 for the ranks up to 100, and another with a lower exponent for higher ranks. The Shannon n-tuple redundancy yields large values and increases in terms of word length, further underscoring the non-trivial statistical properties of behavioral sequences. On the collective, societal level the timeseries of particular actions per day can be understood by a simple mean-reverting log-normal model.Comment: 6 pages, 5 figure

Is the solar spectrum latitude dependent? An investigation with SST/TRIPPEL

Context: In studies of the solar spectrum relative to spectra of solar twin stars, it has been found that the chemical composition of the Sun seems to depart systematically from those of the twins. One possible explanation is that the effect is due to the special aspect angle of the Sun when observed from Earth, as compared with the aspect angles of the twins. Thus, a latitude dependence of the solar spectrum, even with the heliocentric angle constant, could lead to effects of the type observed. Aim: We explore a possible variation in the strength of certain spectral lines, used in the comparisons between the composition of the Sun and the twins, at loci on the solar disk with different latitudes but at constant heliocentric angle. Methods: We use the TRIPPEL spectrograph at the Swedish 1-m Solar Telescope on La Palma to record spectra in five spectral regions in order to compare different locations on the solar disk at a heliocentric angle of 45 deg. Equivalent widths and other parameters are measured for fifteen different lines representing nine atomic species. Results: The relative variations in equivalent widths at the equator and at solar latitude 45 deg are found to be less than 1.5 % for all spectral lines studied. Translated to elemental abundances as they would be measured from a terrestrial and a hypothetical pole-on observer, the difference is estimated to be within 0.005 dex in all cases. Conclusion: It is very unlikely that latitude effects could cause the reported abundance difference between the Sun and the solar twins. The accuracy obtainable in measurements of small differences in spectral line strengths between different solar disk positions is very high.Comment: 9 pages, 10 figures, accepted by Astronomy & Astrophysic

Factor V Leiden and prothrombin G20210A among Chilean patients with venous and arterial thrombosis

Iván Palomo. Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud. Universidad de Talca, Talca, Chile. Casilla 747,Talca, Chile.Factor V Leiden and G20210A mutation of prothrombin gene are two important genetic polymorphisms associated with an increased risk for thrombosis. Aim: To establish the prevalence of factor V Leiden and prothrombin G20210A mutation in the Chilean population and their association to venous and arterial thromboembolism. Material and methods: A case-control study was conducted where 149 patients with thrombosis (87 with arterial and 62 with venous thrombosis) confirmed by CAT-scan, electrocardiogram and cardiac enzymes or Doppler depending on the case, and 160 healthy blood donors were genetically analyzed for the presence of both polymorphisms. Results: Factor V Leiden mutation was found in 5.4% of patients and in 1.3% of healthy controls (p=0.04). Heterozygosity for G20210A prothrombin mutation was found in 5.4% of patients and in 2.5% of the control group (p=NS). When arterial and venous thrombosis were considered as separate entities, 4.6% of patients with arterial thrombosis and 6.5% with venous thrombosis presented factor V Leiden (p=NS). Likewise, 8.1% of patients with venous thrombosis and 3.5% of patients with arterial thrombosis had G20210A prothrombin mutation (p=NS). Conclusions: In non selected consecutive Chilean patients with arterial and venous thrombosis the frequency of factor V Leiden and prothrombin G20210A is less than we could expect from their prevalence in the general populatio