All-Solid-State Batteries Using Rationally Designed Garnet Electrolyte Frameworks

Functioning bulk-type all-solid-state batteries in a practical form factor with composite positive electrodes, using Al-substituted Li7La3Zr2O12 (LLZO) as the solid electrolyte, have been demonstrated for the first time. The devices incorporate bilayers composed of dense LLZO membranes and porous LLZO scaffolds infiltrated with LiNi0.6Mn0.2Co0.2O2 and other components as positive electrodes, combined with lithium anodes. The porous scaffolds are prepared using an easily scaled freeze-tape-casting method. The unidirectional pores of the scaffold facilitate infiltration of cathode components and shorten lithium ion diffusion path lengths, while the addition of a soft ionically conductive solid to the scaffold ensures good contact among the components

Elucidating the toxic effect and disease mechanisms associated with Lyso-Gb3 in Fabry disease

Fabry disease stems from a deficiency of alpha-galactosidase and results in the accumulation of globotriaosylceramide (Gb3). However, the production of its deacylated form globotriaosylsphingosine (lyso-Gb3) is also observed and its plasma levels have closer association with disease severity. Studies have shown that lyso-Gb3 directly affects podocytes and causes sensitisation of peripheral nociceptive neurons. However, little is understood of the mechanisms of this cytotoxicity. To study the effect on neuronal cells, we incubated SH-Sy5y cells with lyso-Gb3 at low (20 ng/mL) and high (200 ng/mL) levels, to mimic mild and classical FD serum levels. We used glucosylsphingosine as a positive control to determine specific effects of lyso-Gb3. Proteomic analyses revealed that cellular systems affected by lyso-Gb3 included cell signalling particularly protein ubiquitination and protein translation. To confirm ER/proteasome perturbations, we performed an immune enrichment of ubiquitinated proteins and demonstrated specific increased protein ubiquitination at both doses. The most ubiquitinated proteins observed included the chaperone/heat shock proteins, cytoskeletal proteins and synthesis/translation proteins. To detect proteins that interact directly with lyso-Gb3, we immobilised lyso-lipids, then incubated them with neuronal cellular extracts and identified bound proteins using mass spectrometry. Proteins that specifically bound were chaperones and included HSP90, HSP60 and the TRiC complex. In conclusion, lyso-Gb3 exposure affects pathways involved in protein translation and folding. This response is observed as increased ubiquitination and changes in signalling proteins which may explain the multiple biological processes, particularly cellular remodelling, often associated with FD

Vortices and the entrainment transition in the 2D Kuramoto model

We study synchronization in the two-dimensional lattice of coupled phase oscillators with random intrinsic frequencies. When the coupling $K$ is larger than a threshold $K_E$, there is a macroscopic cluster of frequency-synchronized oscillators. We explain why the macroscopic cluster disappears at $K_E$. We view the system in terms of vortices, since cluster boundaries are delineated by the motion of these topological defects. In the entrained phase ($K>K_E$), vortices move in fixed paths around clusters, while in the unentrained phase ($K<K_E$), vortices sometimes wander off. These deviant vortices are responsible for the disappearance of the macroscopic cluster. The regularity of vortex motion is determined by whether clusters behave as single effective oscillators. The unentrained phase is also characterized by time-dependent cluster structure and the presence of chaos. Thus, the entrainment transition is actually an order-chaos transition. We present an analytical argument for the scaling $K_E\sim K_L$ for small lattices, where $K_L$ is the threshold for phase-locking. By also deriving the scaling $K_L\sim\log N$, we thus show that $K_E\sim\log N$ for small $N$, in agreement with numerics. In addition, we show how to use the linearized model to predict where vortices are generated.Comment: 11 pages, 8 figure

The Free Will Theorem

On the basis of three physical axioms, we prove that if the choice of a particular type of spin 1 experiment is not a function of the information accessible to the experimenters, then its outcome is equally not a function of the information accessible to the particles. We show that this result is robust, and deduce that neither hidden variable theories nor mechanisms of the GRW type for wave function collapse can be made relativistic. We also establish the consistency of our axioms and discuss the philosophical implications.Comment: 31 pages, 6figure

Preliminary data on microcharacters and chromosome number in Tornabenea species (Apiaceae) from Cape Verde islands

Tornabenea is a small Apiaceae genus that is endemic to the Cape Verde Islands. Its species differentiation is based just on a few macromorphological characters: leaf shape, number and shape of umbel bracts and mericarp ribs. These characters vary within each species and show high plasticity. Thus, in recent taxonomic data of the genus, there are different viewpoints as to the number of species. Here, in order to improve the taxonomy of the genus, microcharacters of the vegetative and reproductive structures of three taxa—T. insularis, T. annua and T. tenuissima—have been examined. The shape and arrangement of hairs on the surface of the mericarps, and the presence and structure of starch grains are the only different microcharacters noted in T. insularis and T. annua. Chromosome number of the latter two species is 2n¼18. Our preliminary results disagree with the existing classifications of the genus Tornabenea. In fact, they do not lead to a clear separation between T. insularis and T. annua. By contrast, it is easy to distinguish between these species and T. tenuissima, which possesses more peculiar microcharacter

Sub-Sets of Cancer Stem Cells Differ Intrinsically in Their Patterns of Oxygen Metabolism

PMCID: PMC3640080This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

A Strong Jet Signature in the Late-Time Lightcurve of GW170817

We present new 0.6-10 GHz observations of the binary neutron star merger GW170817 covering the period up to 300 days post-merger, taken with the Karl G. Jansky Very Large Array, the Australia Telescope Compact Array, the Giant Metrewave Radio Telescope and the MeerKAT telescope. We use these data to precisely characterize the decay phase of the late-time radio light curve. We find that the temporal decay is consistent with a power-law slope of t^-2.2, and that the transition between the power-law rise and decay is relatively sharp. Such a slope cannot be produced by a quasi-isotropic (cocoon-dominated) outflow, but is instead the classic signature of a relativistic jet. This provides strong observational evidence that GW170817 produced a successful jet, and directly demonstrates the link between binary neutron star mergers and short-hard GRBs. Using simple analytical arguments, we derive constraints on the geometry and the jet opening angle of GW170817. These results are consistent with those from our companion Very Long Baseline Interferometry (VLBI) paper, reporting superluminal motion in GW170817.Comment: 11 pages, 3 figures, 3 tables. Accepted for publication in ApJ Letter

High-velocity OH megamasers in IRAS 20100-4156: Evidence for a Supermassive Black Hole

We report the discovery of new, high-velocity narrow-line components of the OH megamaser in IRAS 20100-4156. Results from the Australian Square Kilometre Array Pathfinder (ASKAP)'s Boolardy Engineering Test Array (BETA) and the Australia Telescope Compact Array (ATCA) provide two independent measurements of the OH megamaser spectrum. We found evidence for OH megamaser clumps at $-$409 and $-$562 km/s (blue-shifted) from the systemic velocity of the galaxy, in addition to the lines previously known. The presence of such high velocities in the molecular emission from IRAS 20100$-$4156 could be explained by a ~50 pc molecular ring enclosing an approximately 3.8 billion solar mass black hole. We also discuss two alternatives, i.e. that the narrow-line masers are dynamically coupled to the wind driven by the active galactic nucleus or they are associated with two separate galactic nuclei. The comparison between the BETA and ATCA spectra provides another scientific verification of ASKAP's BETA. Our data, combined with previous measurements of the source enabled us to study the variability of the source over a twenty-six year period. The flux density of the brightest OH maser components has reduced by more than a factor of two between 1988 and 2015, whereas a secondary narrow-line component has more than doubled in the same time. Plans for high-resolution VLBI follow-up of this source are discussed, as are prospects for discovering new OH megamasers during the ASKAP early science program.Comment: Accepted to MNRAS. Seven pages, three figure

Existential Contextuality and the Models of Meyer, Kent and Clifton

It is shown that the models recently proposed by Meyer, Kent and Clifton (MKC) exhibit a novel kind of contextuality, which we term existential contextuality. In this phenomenon it is not simply the pre-existing value but the actual existence of an observable which is context dependent. This result confirms the point made elsewhere, that the MKC models do not, as the authors claim, ``nullify'' the Kochen-Specker theorem. It may also be of some independent interest.Comment: Revtex, 7 pages, 1 figure. Replaced with published versio

Discourse and identity in a corpus of lesbian erotica

This article uses corpus linguistic methodologies to explore representations of lesbian desires and identities in a corpus of lesbian erotica from the 1980s and 1990s. We provide a critical examination of the ways in which “lesbian gender,” power, and desire are represented, (re-)produced, and enacted, often in ways that challenge hegemonic discourses of gender and sexuality. By examining word frequencies and collocations, we critically analyze some of the themes, processes, and patterns of representation in the texts. Although rooted in linguistics, we hope this article provides an accessible, interdisciplinary, and timely contribution toward developing understandings of discursive practices surrounding gender and sexuality