Optimal time-domain combination of the two calibrated output quadratures of GEO 600

GEO 600 is an interferometric gravitational wave detector with a 600 m arm-length and which uses a dual-recycled optical configuration to give enhanced sensitivity over certain frequencies in the detection band. Due to the dual-recycling, GEO 600 has two main output signals, both of which potentially contain gravitational wave signals. These two outputs are calibrated to strain using a time-domain method. In order to simplify the analysis of the GEO 600 data set, it is desirable to combine these two calibrated outputs to form a single strain signal that has optimal signal-to-noise ratio across the detection band. This paper describes a time-domain method for doing this combination. The method presented is similar to one developed for optimally combining the outputs of two colocated gravitational wave detectors. In the scheme presented in this paper, some simplifications are made to allow its implementation using time-domain methods

Robust vetoes for gravitational-wave burst triggers using known instrumental couplings

The search for signatures of transient, unmodelled gravitational-wave (GW) bursts in the data of ground-based interferometric detectors typically uses `excess-power' search methods. One of the most challenging problems in the burst-data-analysis is to distinguish between actual GW bursts and spurious noise transients that trigger the detection algorithms. In this paper, we present a unique and robust strategy to `veto' the instrumental glitches. This method makes use of the phenomenological understanding of the coupling of different detector sub-systems to the main detector output. The main idea behind this method is that the noise at the detector output (channel H) can be projected into two orthogonal directions in the Fourier space -- along, and orthogonal to, the direction in which the noise in an instrumental channel X would couple into H. If a noise transient in the detector output originates from channel X, it leaves the statistics of the noise-component of H orthogonal to X unchanged, which can be verified by a statistical hypothesis testing. This strategy is demonstrated by doing software injections in simulated Gaussian noise. We also formulate a less-rigorous, but computationally inexpensive alternative to the above method. Here, the parameters of the triggers in channel X are compared to the parameters of the triggers in channel H to see whether a trigger in channel H can be `explained' by a trigger in channel X and the measured transfer function.Comment: 14 Pages, 8 Figures, To appear in Class. Quantum Gra

Stabilization of a Fabry-Perot interferometer using a suspension-point interferometer

A suspension-point interferometer (SPI) is an auxiliary interferometer for active vibration isolation, implemented at the suspension points of the mirrors of an interferometric gravitational wave detector. We constructed a prototype Fabry-Perot interferometer equipped with an SPI and observed vibration isolation in both the spectrum and transfer function. The noise spectrum of the main interferometer was reduced by 40 dB below 1 Hz. Transfer function measurements showed that the SPI also produced good vibration suppression above 1 Hz. These results indicate that SPI can improve both the sensitivity and the stability of the interferometer.Comment: 14 pages, 8 figures; added discussion; to be published in Physics Letters

A closed-loop EKF and multi-failure diagnosis approach for cooperative GNSS positioning

Current cooperative positioning with Global Navigation Satellite System (GNSS) for connected vehicle application mainly uses pseudorange measurements. However the positioning accuracy offered cannot meet the requirements for lane-level positioning, collision avoidance and future automatic driving, which needs real-time positioning accuracy of better than 0.5m. Furthermore, there is an apparent lack of research into the integrity issue for these new applications under emerging driverless vehicle applications. In order to overcome those problems, a new Extended Kalman Filter (EKF) and a multi-failure diagnosis algorithm are developed to process both GNSS pseudorange and carrier phase measurements. We first introduce a new closed-loop EKF with partial ambiguity resolution (PAR) as feedback to address the low accuracy issue. Then a multi-failure diagnosis algorithm is proposed to improve integrity and reliability. The core of this new algorithm includes using Carrier phase based Receiver Autonomous Integrity Monitoring (CRAIM) method for failure detection, and the double extended w-test detectors to identify failure. A cooperative positioning experiment was carried out to validate the proposed method. The results show that the proposed closed-loop EKF can provide highly accurate positioning, and the multi-failure diagnosis method is effective in detecting and identifying failures for both code and carrier phase measurements

Photon pressure induced test mass deformation in gravitational-wave detectors

A widely used assumption within the gravitational-wave community has so far been that a test mass acts like a rigid body for frequencies in the detection band, i.e. for frequencies far below the first internal resonance. In this article we demonstrate that localized forces, applied for example by a photon pressure actuator, can result in a non-negligible elastic deformation of the test masses. For a photon pressure actuator setup used in the gravitational wave detector GEO600 we measured that this effect modifies the standard response function by 10% at 1 kHz and about 100% at 2.5 kHz

Bayesian parameter estimation in the second LISA Pathfinder Mock Data Challenge

A main scientific output of the LISA Pathfinder mission is to provide a noise model that can be extended to the future gravitational wave observatory, LISA. The success of the mission depends thus upon a deep understanding of the instrument, especially the ability to correctly determine the parameters of the underlying noise model. In this work we estimate the parameters of a simplified model of the LISA Technology Package (LTP) instrument. We describe the LTP by means of a closed-loop model that is used to generate the data, both injected signals and noise. Then, parameters are estimated using a Bayesian framework and it is shown that this method reaches the optimal attainable error, the Cramer-Rao bound. We also address an important issue for the mission: how to efficiently combine the results of different experiments to obtain a unique set of parameters describing the instrument.Comment: 14 pages, 4 figures, submitted to PR

Physical instrumental vetoes for gravitational-wave burst triggers

We present a robust strategy to \emph{veto} certain classes of instrumental glitches that appear at the output of interferometric gravitational-wave (GW) detectors.This veto method is `physical' in the sense that, in order to veto a burst trigger, we make use of our knowledge of the coupling of different detector subsystems to the main detector output. The main idea behind this method is that the noise in an instrumental channel X can be \emph{transferred} to the detector output (channel H) using the \emph{transfer function} from X to H, provided the noise coupling is \emph{linear} and the transfer function is \emph{unique}. If a non-stationarity in channel H is causally related to one in channel X, the two have to be consistent with the transfer function. We formulate two methods for testing the consistency between the burst triggers in channel X and channel H. One method makes use of the \emph{null-stream} constructed from channel H and the \emph{transferred} channel X, and the second involves cross-correlating the two. We demonstrate the efficiency of the veto by `injecting' instrumental glitches in the hardware of the GEO 600 detector. The \emph{veto safety} is demonstrated by performing GW-like hardware injections. We also show an example application of this method using 5 days of data from the fifth science run of GEO 600. The method is found to have very high veto efficiency with a very low accidental veto rate.Comment: Minor changes, To appear in Phys. Rev.

Rapid and inexpensive purification of adenovirus vectors using an optimised aqueous two-phase technology.

Adenoviruses (AdVs) are used as gene therapy vectors to treat human diseases and as vaccines against COVID-19. AdVs are produced by transfecting human embryonic kidney 239 (HEK293) or PER.C6 virus producer cells with AdV plasmid vectors or infecting these cells withcell lysates containing replication-defective AdV. Cell lysates can be purified further by caesium chloride or chromatographic protocols to research virus seed stocks (RVSS) for characterisation to high quality master virus seed stocks (MVSS) and working virus seed stocks (WVSS) before downstream production of pure, high titre AdV. Lysates are poorly infectious, block filtration columns and have limited storage capability. Aqueous two-phase systems (ATPS) are an alternative method for AdV purification that rapidly generates cleaner RVSS for characterisation to MVSS. After testing multiple ATPS formulations, an aqueous mixture of 20 % PEG 600 and 20 % (NH4)2SO4 (w/w) was found most effective for AdV partitioning, producing up to 97+3% yield of high-titre virus that was devoid of aggregates both effective in vitro and in vivo with no observable cytotoxicity. Importantly, AdV preparations stored at −20 °C or 4 °C show negligible loss of titre and are suitable for downstream processing to clinical grade to support the need for AdV vaccines

Fibrosis in the kidney: is a problem shared a problem halved?

Fibrotic disorders are commonplace, take many forms and can be life-threatening. No better example of this exists than the progressive fibrosis that accompanies all chronic renal disease. Renal fibrosis is a direct consequence of the kidney's limited capacity to regenerate after injury. Renal scarring results in a progressive loss of renal function, ultimately leading to end-stage renal failure and a requirement for dialysis or kidney transplantation

Triple Michelson Interferometer for a Third-Generation Gravitational Wave Detector

The upcoming European design study `Einstein gravitational-wave Telescope' represents the first step towards a substantial, international effort for the design of a third-generation interferometric gravitational wave detector. It is generally believed that third-generation instruments might not be installed into existing infrastructures but will provoke a new search for optimal detector sites. Consequently, the detector design could be subject to fewer constraints than the on-going design of the second generation instruments. In particular, it will be prudent to investigate alternatives to the traditional L-shaped Michelson interferometer. In this article, we review an old proposal to use three Michelson interferometers in a triangular configuration. We use this example of a triple Michelson interferometer to clarify the terminology and will put this idea into the context of more recent research on interferometer technologies. Furthermore the benefits of a triangular detector will be used to motivate this design as a good starting point for a more detailed research effort towards a third-generation gravitational wave detector.Comment: Minor corrections to the main text and two additional appendices. 14 pages, 6 figure