INGESTION OF ENDOPHYTE-INFECTED TALL FESCUE SEED INDUCES PERIPHERAL VASOCONSTRICTION BUT DOES NOT AFFECT CYCLICITY IN NON-PREGNANT MARES, AND A POPULATION OF BIOGENIC AMINE RECEPTORS RELATIVE TO VASOCONSTRICTION IS IDENTIFIED

Three experiments were conducted to explore the effect of fescue toxicosis on vasoconstriction and various parameters of the estrous cycle. In the experiment of Chapter 3, a 2x2 crossover experimental design with repeated measures was implemented to test whether the ingestion of endophyte-infected tall fescue seed would alter blood hormone concentrations of prolactin, progesterone, and estradiol, interovulatory intervals, and corpus luteum blood flow. Also, Doppler ultrasonography was used to assess whether palmar artery and palmar vein lumen diameter, area, circumference, and resistivity index could be altered by the ingestion of endophyte-infected tall fescue seed. Ingestion of endophyte-infected tall fescue seed significantly decreased palmar artery resistivity index, area, and circumference, and palmar artery and palmar vein lumen diameter, but did not alter interovulatory intervals, serum concentrations of prolactin, progesterone, estradiol, or corpus luteum blood flow. Experiments 1 and 2 from Chapter 4 profiled the dopaminergic, serotonergic, and α-adrenergic receptor types and subtypes, as expressed within the equine medial palmar artery, medial palmar vein, and uterine artery transcriptomes. Combined results from Chapters 3 & 4 imply that relative quantity of serotonergic receptor subtypes within a vessel may be related to with the severity of that vessel\u27s vasoconstrictive response to endophyte-infected tall fescue

Facing the soprano : Uncovering a feminist performative “I” through autoethnography

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A NON-MARITAL, ROMANTIC RELATIONSHIP DISSOLUTION STUDY

The present study examines three non-marital, romantic relationship dissolution types: (1) normal dyadic dissolution, (2) fatal attraction dissolution, and (3) social allergen dissolution among a sample of 321 emerging adults, who are between ages eighteen and twenty-nine. Results of an online survey revealed that normal dyadic dissolution occurred in 62%, social allergen dissolution occurred in 27%, and fatal attraction dissolution occurred in 11% of the participants’ relational demises. Results also revealed that there is a surprising amount of overlap between the three dissolution types, and that age is not specifically correlated with a particular dissolution type. However, there are two predicators of dissolution type within an emerging adult population: perceived family support and whether or not the couple cohabitate

Trust in crisis: Conspiracy mentality, lack of trust and religiosity predicted conspiracy beliefs about COVID-19 in a Norwegian sample

Crises are associated with a search for meaning and security. In recent years, they have also been associated with increased attention to conspiracy theories. Such theories about COVID-19 have been many. We have looked at several COVID-specific conspiracy theories and their relation to a number of other factors, including religiosity in a highly educated Norwegian convenience sample (n=1225). Conspiracy mentality, lack of trust, and religiosity were directly associated with conspiracy beliefs about COVID-19, whereas self-reported stress and negative emotions related to the pandemic had only small, indirect effects. Unlike previous research findings, we found no effect of gender or age

The Peripheral Kynurenine Pathway and Psychosomatic Comorbidity in Subjects with Morbid Obesity Undergoing Bariatric Surgery

Background: The Kynurenine pathway (KP) is involved in various disorders, but little is known about the KP and psychosomatic complaints. The aim was to study the peripheral KP and psychosomatic comorbidity in subjects with morbid obesity. Methods: Psychosomatic comorbidity (perceived general health, muscle-skeletal pain, well-being, mood disorders, fatigue, self-esteem, sleepiness, and sense of humour) was registered, and serum samples were collected six months before and after bariatric surgery. Results: A total of 141 subjects (men/women, 116/25) with a mean age of 43.0 (SD 8.7) years and BMI of 42.1 (SD 3.8) kg/m2 were included. No significant associations were seen between the psychosomatic disorders and the KP. There was a significant downregulation of all KP metabolites after surgery, a reduction in CRP, and strong associations between CRP and the KP, particularly with the ratios of Kynurenine/Tryptophan and Quinolinic acid (QA)/Xanthurenic acid (XA). The QA/XA ratio was negatively associated with diabetes. Conclusions: The peripheral KP seemed to be of minor importance for the psychosomatic comorbidity in subjects with morbid obesity. The downregulation of all KP metabolites after bariatric surgery indicated reduced inflammation. The QA/XA ratio seemed to be a marker of insulin sensitivity and favourable glucose control.The Peripheral Kynurenine Pathway and Psychosomatic Comorbidity in Subjects with Morbid Obesity Undergoing Bariatric SurgerypublishedVersio

Moderate Alcohol Consumption and Cognitive Functioning in a Zambian Population

Objectives: To investigate the relationship between moderate alcohol consumption and cognitive functioning.Design: A cross-sectional study comprising a sample of 157 (48.5%) males and 167 (51.5%) females, with an age range of between 20 and 50 years. All the participants were conversant with the English language. Their educational range was between 5-19 years of schooling.Measures: The Zambia Neurobehavioural Test Battery was used to measure cognitive functioning. Self-reported alcohol consumption was obtained by means of the Chinese Substance Use Form.Results: Male moderate drinkers have performed better on the Stroop Colour and Word Test, t-score (M=52.78; SD=8.4) than the non-drinking males, (M=48; SD= 10.2). The drinking females however, seemed to perform less well (M= 47.36; SD= 8.2) when compared to the non-drinking females (M=50.68; SD= 9.2) in the area of Verbal Episodic Memory.Conclusion: The male participants seem to benefit from moderate alcohol consumption whereas a seemingly negative outcome in terms of cognitive functioning was observed in the female moderate alcohol consumers. It should be noted, however, that these differences observed though statistically significant are not clinically significant. Therefore, both the drinking and non-drinking groups with similar demographic characteristics are more or less expected to fall with the normal range of performance

A tale of grappling: Performative duoethnography as expanded methodological thinking

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APOE – a genetic marker of comorbidity in subjects with morbid obesity

Background: In population-based studies, the genetic variability of the APOE E alleles have been associated with health outcomes. Health problems are common in subjects with obesity. This study explored associations between the APOE E alleles and comorbidity in subjects with morbid obesity. Methods: The study included consecutive subjects referred for evaluation of bariatric surgery with morbid obesity (defined as BMI > 40 or > 35 kg/m2 with complications related to obesity). The subjects followed a conservative weight loss program for 6 months before surgery and had a follow-up visit 12 months after surgery. Demographic data and a set psychosomatic scores (musculoskeletal pain, WHO-5 Well-Being Index, Rosenberg Self-Esteem Scale, Hopkins Symptom Check-list 10; Epworth Sleepiness Scale, and Fatigue Severity Scale) were collected, and blood samples were analysed for haematological and biochemical parameters and APOE alleles. Results: One hundred and forty subjects (men/women: 32 (23%)/108 (77%) with mean age 43.0 (SD 8.7) years and BMI 42.1 (SD 3.8) kg/m2 were included. One hundred and eight and 92 subjects had data after conservative treatment and 12 months after surgery, respectively. The prevalence of the APOE alleles were: E2E2: 1 (0.7%), E2E3: 13 (9.3%), E2E4: 4 (2.9%), E3E3: 71 (50.7%), E3E4: 47 (33.6%), and E4E4: 4 (2.9%). The prevalence rates were as anticipated in a Norwegian population. The weight loss during conservative treatment and after bariatric surgery was independent of E allele variability. E2 was associated with a significant or clear trend toward improvement of all psychosomatic disorders. There was a significant fall in CRP during the two treatment periods with weight loss. E2 and E4 were significantly associated with high and low CRP, respectively, but no associations were seen between CRP and comorbidity. Conclusions: The most marked finding was the association between E2 and improvement of all psychosomatic disorders. The positive and negative associations between CRP and E2 and E4, respectively, could indicate effects on inflammation and immunological reactions.acceptedVersio