Case report: Sigmoid schwannoma as the lead point for intussusception in an adult patient with neurofibromatosis

No abstract available

A search for passive protoplanetary disks in the Taurus-Auriga star-forming region

We conducted a 12-month monitoring campaign of 33 T Tauri stars (TTS) in Taurus. Our goal was to monitor objects that possess a disk but have a weak Halpha line, a common accretion tracer for young stars, to determine whether they host a passive circumstellar disk. We used medium-resolution optical spectroscopy to assess the objects' accretion status and to measure the Halpha line. We found no convincing example of passive disks; only transition disk and debris disk systems in our sample are non-accreting. Among accretors, we find no example of flickering accretion, leading to an upper limit of 2.2% on the duty cycle of accretion gaps assuming that all accreting TTS experience such events. Combining literature results with our observations, we find that the reliability of traditional Halpha-based criteria to test for accretion is high but imperfect, particularly for low-mass TTS. We find a significant correlation between stellar mass and the full width at 10 per cent of the peak (W10%) of the Halpha line that does not seem to be related to variations in free-fall velocity. Finally, our data reveal a positive correlation between the Halpha equivalent width and its W10%, indicative of a systematic modulation in the line profile whereby the high-velocity wings of the line are proportionally more enhanced than its core when the line luminosity increases. We argue that this supports the hypothesis that the mass accretion rate on the central star is correlated with the Halpha W10% through a common physical mechanism.Comment: accepted for publication in MNRAS; 26 pages, 9 figures, 3 table

Changing trends in novel benzodiazepine use within Scottish prisons:detection, quantitation, prevalence, and modes of use

Drug use within prisons is increasingly complex and unpredictable. Benzodiazepines are currently one of the most common drugs detected in individuals leaving Scottish prisons; however, understanding illicit benzodiazepine use within prisons and assessing the potential harm to individuals is challenging due to the lack of available analytical data on the substances circulating. Increasingly, materials, such as paper and clothing, infused with novel benzodiazepines have been identified as a smuggling route into Scottish prisons. Methods were developed for the qualitative and quantitative analysis of benzodiazepines using gas chromatography–mass spectrometry (GC–MS) and applied to 495 seized samples from 11 Scottish prisons, including papers, cards, blotters, powders, tablets, and clothing. Evolution in the benzodiazepines being detected was demonstrated, with etizolam being the most prevalent throughout 2020/2021 following which flubromazepam and bromazolam detections increased. Additionally, significant changes in the smuggling methods and drug formats detected occurred over time following policy changes within prisons. These data represent the first reported widescale etizolam quantitation data and demonstrate high levels of variability across all sample types, most notably within tablets (0.34–2.33 mg per tablet). Additionally, concentration mapping of a whole seized card sample revealed the total concentration of drug present (312.5 mg) and demonstrated variability across the surface of the card (1.16–1.87 mg/cm 2). These data highlight the challenges of consistent dosing for individuals and the high risks of unintentional overdose. Increased understanding of the challenge of such drug smuggling and benzodiazepine use will aid in the development of strategies to reduce supply and mitigate harm.</p

The Use of Ebola Convalescent Plasma to Treat Ebola Virus Disease in Resource-Constrained Settings: A Perspective From the Field.

The clinical evaluation of convalescent plasma (CP) for the treatment of Ebola virus disease (EVD) in the current outbreak, predominantly affecting Guinea, Sierra Leone, and Liberia, was prioritized by the World Health Organization in September 2014. In each of these countries, nonrandomized comparative clinical trials were initiated. The Ebola-Tx trial in Conakry, Guinea, enrolled 102 patients by 7 July 2015; no severe adverse reactions were noted. The Ebola-CP trial in Sierra Leone and the EVD001 trial in Liberia have included few patients. Although no efficacy data are available yet, current field experience supports the safety, acceptability, and feasibility of CP as EVD treatment. Longer-term follow-up as well as data from nontrial settings and evidence on the scalability of the intervention are required. CP sourced from within the outbreak is the most readily available source of anti-EVD antibodies. Until the advent of effective antivirals or monoclonal antibodies, CP merits further evaluation

Atomic layer fluorination of 5 V class positive electrode material LiCoPO4 for enhanced electrochemical performance

EJK would like to thank the Alistore ERI for the award of a studentship. The authors thank EPSRC Capital for Great Technologies Grant EP/L017008/1. The authors want to thank the French Research Network on the Electrochemical Energy Storage (RS2E) for YCB’s PhD grant. MD and NL are indebted to the IR-RMN-THC FR3050 CNRS for the spectrometer time access and the financial support of the NMR experiments.The surface fluorination of lithium cobalt phosphate (LiCoPO4, LCP) using a one‐step, room temperature processable, easily up‐scalable and dry surface modification method with XeF2 as fluorine source was developed. After fluorination, fluorine‐rich nanoparticles were observed mainly on the particle surface, which facilitates the improvement of surface stability and electrochemical performance such as cycling stability and rate capability, as the fluorinated LCP can be protected against side reactions with electrolyte or by‐products of electrolyte decomposition at high voltage (5 V). More importantly, the direct surface fluorination proved more efficient than adding a fluorinated electrolyte additive (i. e., FEC). These results suggest that surface fluorination using XeF2 is of great promise for practical applications of high voltage positive materials for lithium‐ion batteries.PostprintPeer reviewe

A Deep 1.2 mm Map of the Lockman Hole North Field

We present deep 1.2 mm continuum mapping of a 566 arcmin^2 area within the Lockman Hole North field, previously a target of the Spitzer Wide-area Infrared Extragalactic (SWIRE) survey and extremely deep 20 cm mapping with the Very Large Array, which we have obtained using the Max-Planck millimeter bolometer (MAMBO) array on the IRAM 30 m telescope. After filtering, our full map has an RMS sensitivity ranging from 0.45 to 1.5 mJy/beam, with an average of 0.75 mJy/beam. Using the pixel flux distribution in a map made from our best data, we determine the shape, normalization, and approximate flux density cutoff for 1.2 mm number counts well below our nominal sensitivity and confusion limits. After validating our full dataset through comparison with this map, we successfully detect 41 1.2 mm sources with S/N > 4.0 and S(1.2 mm)\simeq 2-5 mJy. We use the most significant of these detections to directly determine the integral number counts down to 1.8 mJy, which are consistent with the results of the pixel flux distribution analysis. 93% of our 41 individual detections have 20 cm counterparts, 49% have Spitzer/MIPS 24 micron counterparts, and one may have a significant Chandra X-ray counterpart. We resolve \simeq 3% of the cosmic infrared background (CIB) at 1.2 mm into significant detections, and directly estimate a 0.05 mJy faint-end cutoff for the counts that is consistent with the full intensity of the 1.2 mm CIB. The median redshift of our 17 detections with spectroscopic or robust photometric redshifts is z(median)=2.3, and rises to z(median)=2.9 when we include redshifts estimated from the radio/far-infrared spectral index. By using a nearest neighbor and angular correlation function analysis, we find evidence that our S/N>4.0 detections are clustered at the 95% confidence level.Comment: 40 pages, 25 figures, accepted for publication in Ap