The effect of beach nourishment on loggerhead (Caretta caretta) nesting and reproductive success at Sebastian Inlet, Florida

Beach nourishment has become common in Florida and it occurs on beaches that are major loggerhead (Caretta caretta) nesting grounds. Despite efforts to use beach-quality sand, nourishment sand may be different in grain size, moisture content, shear resistance and temperature when compared to native sand. Two main aspects of loggerhead nesting may be affected by nourishment. First, nourishment may reduce nesting success [(female nesting emergences/ female total emergences) X 100] due to physical barriers (i.e., scarps or steep cliffs) that can impede gravid females. Second, nourishment may reduce reproductive success {i.e., hatching success) by altering the nestsand environment. The objective of this study was to compare loggerhead nesting success, nest placement, slopes at nest sites, nest depths, incubation periods, reproductive success and egg fates among an old renourished beach { south ), a recently nourished beach ( treatment ) and a natural beach ( control ) at Sebastian Inlet, Florida in 1996, 1997 and 1998. In all three years, nesting success was significantly different among study sites. After nourishment (1997), nesting success was reduced at the treatment site due to a seaward scarp. A year later (1998), the scarp was leveled and nesting success improved. Nest placement was not significantly different between study sites prior to nourishm_ent of the treatment study site (1996), but it was after nourishment (1997) and one-year post-nourishment (1998). After nourishment, most nests at the treatment beach were placed too close to the water or too close to the dune. There were no significant differences in the slope at nest sites in 1997; suggesting females may have selected similar increases in slope, but at varied cross-shore locations. Nest depths were significantly shallower at the treatment beach after nourishment, probably due to higher compaction of the nourishment sand. In addition, incubation periods were significantly longer on the nourished beaches one year post-nourishment. Loggerhead hatching success was significantly reduced on the nourished beaches in 1996 and 1997. The reduction was seen primarily in a larger proportion of eggs that were arrested early in development. The higher moisture in the nourishment sand may have impeded gas exchange, which resulted in decreased hatching success. One year post-nourishment (1998), there were no significant differences in hatching success. The lack of rainfall in 1998 may have introduced better incubation conditions on the nourished beaches. Researchers at the Florida Institute of Technology continued to show that the nourishment sand exhibited significantly smaller grain size, higher moisture content, lower temperature and higher shear resistance. These attributes were probably responsible for many of the results reported herein. However, other variables such as non-random nest depredation, inlet influences and water table levels may have also contributed to the results

Suivi de patients en physiothérapie à domicile via une application smartwatch

Comment améliorer le suivi d’un patient en traitement physiothérapeutique ? L’objectif de ce travail de Bachelor est de fournir un outil qui permette au patient de saisir aussi souvent que nécessaire des indications sur le niveau de douleur perçu à un instant « t ». Cette prise d’information est effectuée grâce à une « Smartwatch ». En parallèle, une application pour « Smartphone » donne au patient la possibilité de préciser par un commentaire la cause de la variation de douleur. Pour le physiothérapeute, une plateforme web est mise à disposition pour consulter et analyser l’évolution de son patient

First report of Crumillospongia (Demospongea) from the Cambrian of Europe (Murero biota, Spain)

The demosponge genus Crumillospongia, originally described from the Burgess Shale (middle Cambrian of Canada), has only been cited from lower and middle Cambrian localities of North America and China. The taxon is now also described from uppermost lower Cambrian rocks of the Murero Lagerstätte (Zaragoza Province, NE Spain). Crumillospongia mureroensis sp. nov. is a small to medium sized sack-shaped to elongate demosponge characterized by the presence of densely packed pores of three sizes, considerably larger than those in any other species of the genus. The Spanish material represents a link in the chronostratigraphical gap between the Chinese and North American material.Peer reviewe

Measles Virus Fusion Protein: Structure, Function and Inhibition.

Measles virus (MeV), a highly contagious member of the Paramyxoviridae family, causes measles in humans. The Paramyxoviridae family of negative single-stranded enveloped viruses includes several important human and animal pathogens, with MeV causing approximately 120,000 deaths annually. MeV and canine distemper virus (CDV)-mediated diseases can be prevented by vaccination. However, sub-optimal vaccine delivery continues to foster MeV outbreaks. Post-exposure prophylaxis with antivirals has been proposed as a novel strategy to complement vaccination programs by filling herd immunity gaps. Recent research has shown that membrane fusion induced by the morbillivirus glycoproteins is the first critical step for viral entry and infection, and determines cell pathology and disease outcome. Our molecular understanding of morbillivirus-associated membrane fusion has greatly progressed towards the feasibility to control this process by treating the fusion glycoprotein with inhibitory molecules. Current approaches to develop anti-membrane fusion drugs and our knowledge on drug resistance mechanisms strongly suggest that combined therapies will be a prerequisite. Thus, discovery of additional anti-fusion and/or anti-attachment protein small-molecule compounds may eventually translate into realistic therapeutic options

Policies for ecological intensification of crop production

Ecological intensification aims to increase crop productivity by enhancing biodiversity and associated ecosystem services, while minimizing the use of synthetic inputs and cropland expansion. Policies to promote ecological intensification have emerged in different countries, but they are still scarce and vary widely across regions. Here, we propose ten policy targets that governments can follow for ecological intensification

A Preliminary Survey of Interprofessional Education

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153603/1/jddj002203372006704tb04096x.pd

Simulating Z2\mathbb{Z}_2 lattice gauge theory on a quantum computer

The utility of quantum computers for simulating lattice gauge theories is currently limited by the noisiness of the physical hardware. Various quantum error mitigation strategies exist to reduce the statistical and systematic uncertainties in quantum simulations via improved algorithms and analysis strategies. We perform quantum simulations of $1+1d$ $\mathbb{Z}_2$ gauge theory with matter to study the efficacy and interplay of different error mitigation methods: readout error mitigation, randomized compiling, rescaling, and dynamical decoupling. We compute Minkowski correlation functions in this confining gauge theory and extract the mass of the lightest spin-1 state from fits to their time dependence. Quantum error mitigation extends the range of times over which our correlation function calculations are accurate by a factor of six and is therefore essential for obtaining reliable masses.Comment: 20 Pages, 18 Figure

The CEA/CD3-Bispecific Antibody MEDI-565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA

MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with cancers expressing carcinoembryonic antigen (CEA). MEDI-565 binds CEA on cancer cells and CD3 on T cells to induce T-cell mediated killing of cancer cells. To understand the molecular basis of human CEA recognition by MEDI-565 and how polymorphisms and spliced forms of CEA may affect MEDI-565 activity, we mapped the epitope of MEDI-565 on CEA using mutagenesis and homology modeling approaches. We found that MEDI-565 recognized a conformational epitope in the A2 domain comprised of amino acids 326–349 and 388–410, with critical residues F326, T328, N333, V388, G389, P390, E392, I408, and N410. Two non-synonymous single-nucleotide polymorphisms (SNPs) (rs10407503, rs7249230) were identified in the epitope region, but they are found at low homozygosity rates. Searching the National Center for Biotechnology Information GenBank® database, we further identified a single, previously uncharacterized mRNA splice variant of CEA that lacks a portion of the N-terminal domain, the A1 and B1 domains, and a large portion of the A2 domain. Real-time quantitative polymerase chain reaction analysis of multiple cancers showed widespread expression of full-length CEA in these tumors, with less frequent but concordant expression of the CEA splice variant. Because the epitope was largely absent from the CEA splice variant, MEDI-565 did not bind or mediate T-cell killing of cells solely expressing this form of CEA. In addition, the splice variant did not interfere with MEDI-565 binding or activity when co-expressed with full-length CEA. Thus MEDI-565 may broadly target CEA-positive tumors without regard for expression of the short splice variant of CEA. Together our data suggest that MEDI-565 activity will neither be impacted by SNPs nor by a splice variant of CEA