Study examining the inhibition of human monoamine oxidase (MAO) by the new psychoactive substance 5-(2-aminopropyl)indole (5-IT). Annex 2 to the “5-(2-Aminopropyl)indole (5-IT): Report on the risk assessment of 5-(2-aminopropyl)indole in the framework of the Council Decision on new psychoactive substances”.

This report forms the basis for a risk assessment, which is convened by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) under auspices of its Scientific Committee and other externally invited experts. Furthermore, the Commission, Europol and the EMA are invited to participate in the risk assessment meetings. The risk assessment takes into account all factors that, according to the 1961 United Nations Single Convention on Narcotic Drugs or the 1971 United Nations Convention on Psychotropic Substances, would warrant the placing of a substance under international control (see http://www.emcdda.europa.eu/html.cfm/index16776EN.html)

Effects of the presence of skins during alcoholic fermentation on the composition of wine volatiles

Der Einfluß des Beerenhautkontaktes während der alkoholischen Gärung auf die Zusammensetzung der WeinaromakomponentenDie Zusammensetzung der flüchtigen und nichtflüchtigen Inhaltsstoffe von Weinen, die aus einem Most der Rebsorte Cencibel unter vier verschiedenen Gärungsbedingungen gewonnen wurden, wird beschrieben. Die Vergärung durch Saccharomyces cerevisiae erfolgte mit oder ohne Beerenhäute und mit oder ohne SO2. Die mittels konventioneller Analysenmethoden und auf gaschromatographischem Wege gewonnenen Daten wurden der Faktoren- und Clusteranalyse unterzogen. Bei einigen Komponenten traten signifikante Konzentrationsunterschiede in Abhängigkeit von den Gärungsbedingungen auf

A revised approach to the ?<i>o</i>F2 long-term trends analysis

International audienceA new approach to extract foF2 long-term trends, which are free to a great extent from solar and geomagnetic activity effects, has been proposed. These trends are insensitive to the phase (increasing/decreasing) of geomagnetic activity, with long-term variations being small and insignificant for such relatively short time periods. A small but significant residual foF2 trend, with the slope Kr = - 2.2 × 10-4 per year, was obtained over a 55-year period (the longest avail-able) of observations at Slough. Such small trends have no practical importance. On the other hand, negative (although insignificant) residual trends obtained at 10 ionosonde stations for shorter periods (31 years) may be considered as a manifestation of a very long-term geomagnetic activity increase which did take place during the 20th century. All of the revealed foF2 long-term variations (trends) are shown to have a natural origin related to long-term variations in solar and geomagnetic activity. There is no indication of any manmade foF2 trends. Key words. Ionosphere (ionosphere-atmosphere interactions, ionospheric disturbances

A handheld diagnostic system for 6LoWPAN networks

The successful deployment of low-power wireless sensor networks (WSNs) in real application environments is a much broader exercise than just the simple instrumentation of the intended monitoring site. Many problems, from node malfunctions to connectivity issues, may arise during commissioning of these networks. These need to be corrected on the spot, often within limited time, to avoid undesired delays in commissioning and yet a fully functional system does not guarantee that no new problems will occur after leaving the site. In this paper we present the first ever (to our knowledge) implementation of a handheld diagnostic system for fast on-site commissioning of low-power IPv6 (6LoWPAN) WSNs as well as troubleshooting of network problems during and after deployment. This system can be used where traditional solutions are insufficient to ascertain the root causes of any problems encountered at no additional complexity in the implementation of the WSN. The embedded diagnosis capability in our system is based on a lightweight decision tree that distills the functioning of communication protocols in use by the network, with a major focus on interoperable IPv6 standards and protocols for low-power WSNs. To show the applicability of our system, we present a set of experiments based on results from a real deployment in a large construction site. Through these experiments, important performance insights are gained that can be used as guidelines for improvement of operation and maintenance of 6LoWPAN networks.This research has been funded by the EPSRC Innovation and Knowledge Centre for Smart Infrastructure and Construction project (EP/K000314/1). The authors wish to thank Costain-Skanska Joint Venture (CSJV) and our industrial partner Crossrail for allowing access and instrumentation of the Paddington site referenced in this paper

Code smells survival analysis in web apps

Web applications are heterogeneous, both in their target platform (split across client and server sides) and on the formalisms they are built with, usually a mixture of programming and formatting languages. This heterogeneity is perhaps an explanation why software evolution of web applications (apps) is a poorly addressed topic in the literature. In this paper we focus on web apps built with PHP, the most widely used server-side programming language. We analyzed the evolution of 6 code smells in 4 web applications, using the survival analysis technique. Since code smells are symptoms of poor design, it is relevant to study their survival, that is, how long did it take from their introduction to their removal. It is obviously desirable to minimize their survival. In our analysis we split code smells in two categories: scattered smells and localized smells, since we expect the former to be more harmful than the latter. Our results provide some evidence that the survival of PHP code smells depends on their spreadness. We have also analyzed whether the survival curve varies in the long term, for the same web application. Due to the increasing awareness on the potential harm-fulness of code smells, we expected to observe a reduction in the survival rate in the long term. The results show that there is indeed a change, for all applications except one, which lead us to consider that other factors should be analyzed in the future, to explain the phenomenon.info:eu-repo/semantics/acceptedVersio

Asymptotic expansions of the solutions of the Cauchy problem for nonlinear parabolic equations

Let $u$ be a solution of the Cauchy problem for the nonlinear parabolic equation $$\partial_t u=\Delta u+F(x,t,u,\nabla u) \quad in \quad{\bf R}^N\times(0,\infty), \quad u(x,0)=\varphi(x)\quad in \quad{\bf R}^N,$$ and assume that the solution $u$ behaves like the Gauss kernel as $t\to\infty$. In this paper, under suitable assumptions of the reaction term $F$ and the initial function $\varphi$, we establish the method of obtaining higher order asymptotic expansions of the solution $u$ as $t\to\infty$. This paper is a generalization of our previous paper, and our arguments are applicable to the large class of nonlinear parabolic equations

Self-similarity and long-time behavior of solutions of the diffusion equation with nonlinear absorption and a boundary source

This paper deals with the long-time behavior of solutions of nonlinear reaction-diffusion equations describing formation of morphogen gradients, the concentration fields of molecules acting as spatial regulators of cell differentiation in developing tissues. For the considered class of models, we establish existence of a new type of ultra-singular self-similar solutions. These solutions arise as limits of the solutions of the initial value problem with zero initial data and infinitely strong source at the boundary. We prove existence and uniqueness of such solutions in the suitable weighted energy spaces. Moreover, we prove that the obtained self-similar solutions are the long-time limits of the solutions of the initial value problem with zero initial data and a time-independent boundary source

Introducing a new breed of wine yeast: interspecific hybridisation between a commercial Saccharomyces cerevisiae wine yeast and Saccharomyces mikatae

Interspecific hybrids are commonplace in agriculture and horticulture; bread wheat and grapefruit are but two examples. The benefits derived from interspecific hybridisation include the potential of generating advantageous transgressive phenotypes. This paper describes the generation of a new breed of wine yeast by interspecific hybridisation between a commercial Saccharomyces cerevisiae wine yeast strain and Saccharomyces mikatae, a species hitherto not associated with industrial fermentation environs. While commercially available wine yeast strains provide consistent and reliable fermentations, wines produced using single inocula are thought to lack the sensory complexity and rounded palate structure obtained from spontaneous fermentations. In contrast, interspecific yeast hybrids have the potential to deliver increased complexity to wine sensory properties and alternative wine styles through the formation of novel, and wider ranging, yeast volatile fermentation metabolite profiles, whilst maintaining the robustness of the wine yeast parent. Screening of newly generated hybrids from a cross between a S. cerevisiae wine yeast and S. mikatae (closely-related but ecologically distant members of the Saccharomyces sensu stricto clade), has identified progeny with robust fermentation properties and winemaking potential. Chemical analysis showed that, relative to the S. cerevisiae wine yeast parent, hybrids produced wines with different concentrations of volatile metabolites that are known to contribute to wine flavour and aroma, including flavour compounds associated with non-Saccharomyces species. The new S. cerevisiae x S. mikatae hybrids have the potential to produce complex wines akin to products of spontaneous fermentation while giving winemakers the safeguard of an inoculated ferment.Jennifer R. Bellon, Frank Schmid, Dimitra L. Capone, Barbara L. Dunn, Paul J. Chamber