On the Localized superluminal Solutions to the Maxwell Equations

In the first part of this article the various experimental sectors of physics in which Superluminal motions seem to appear are briefly mentioned, after a sketchy theoretical introduction. In particular, a panoramic view is presented of the experiments with evanescent waves (and/or tunneling photons), and with the "Localized superluminal Solutions" (SLS) to the wave equation, like the so-called X-shaped waves. In the second part of this paper we present a series of new SLSs to the Maxwell equations, suitable for arbitrary frequencies and arbitrary bandwidths: some of them being endowed with finite total energy. Among the others, we set forth an infinite family of generalizations of the classic X-shaped wave; and show how to deal with the case of a dispersive medium. Results of this kind may find application in other fields in which an essential role is played by a wave-equation (like acoustics, seismology, geophysics, gravitation, elementary particle physics, etc.). This e-print, in large part a review, was prepared for the special issue on "Nontraditional Forms of Light" of the IEEE JSTQE (2003); and a preliminary version of it appeared as Report NSF-ITP-02-93 (KITP, UCSB; 2002). Further material can be found in the recent e-prints arXiv:0708.1655v2 [physics.gen-ph] and arXiv:0708.1209v1 [physics.gen-ph]. The case of the very interesting (and more orthodox, in a sense) subluminal Localized Waves, solutions to the wave equations, will be dealt with in a coming paper. [Keywords: Wave equation; Wave propagation; Localized solutions to Maxwell equations; Superluminal waves; Bessel beams; Limited-dispersion beams; Electromagnetic wavelets; X-shaped waves; Finite-energy beams; Optics; Electromagnetism; Microwaves; Special relativity]Comment: LaTeX paper of 37 pages, with 20 Figures in jpg [to be processed by PDFlatex

Wireless link evaluation of a dielectric resonator nanoantenna

Optical antennas/nanoantennas are optical elements that have gained highlight in this decade and have potential application in several branches of photonics/plasmonics, such as, optical sensors, lasers, solid state lighting, photovoltaics, microscopy, etc. Additionally, the dipole nanoantennas have been the antennas elements mostly studied in proposals for those applications and, in special, for free-space communication based on plasmonic circuits. Here we report some advantages of dielectric resonator nanoantennas (DRNAs) as elements for coupling light to plasmonic-based circuits. Fundamental antenna parameters such as reflection coefficient, gain, efficiency, among others, are evaluated and its advantages are highlighted for nanophotonics applications. A study about an optical link for circuits based on metal-dielectric-metal-dielectric (MDMD) nanostrip waveguides operating at the central wavelength of λ0 = 1.55 μm is evaluated. We studied the coupling of near- and far-fields of a DRNA matched to an MDMD nanostrip waveguide. The results show the advantage of it as an element for optical coupling from/to free-space as well as to establish a wireless optical link for inter-chip communication10924SPIE OPTO - Optical Interconnects XI

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic low-grade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Magnetless optical circulator based on an iron garnet with reduced magnetization saturation

A three-port circulator for optical communication systems comprising a photonic crystal slab made of a magneto-optical material in which an magnetizing element is not required to keep its magnetic domains aligned is suggested for the first time. By maximizing the incorporation of europium to its molecular formula, the magneto-optical material can remain in the saturated magnetic state even in the absence of an external DC magnetic field. Two-and three-dimensional simulations of the device performed with full-wave electromagnetic solvers based on the finite element method demonstrate that, at the 1550 nm wavelength, the insertion loss, isolation, and reflection levels are equal to or better than −1 dB, −14 dB, and −20 dB, respectively. Since its operation does not require an electromagnet or a permanent magnet, the suggested circulator is much more compact, being able to reach footprints in the range of three orders of magnitude smaller, when compared to other circulator designs referred to in the literature and the presented results can be useful for the design of other nonreciprocal devices with reduced dimensions for optical communication systems

Non-diffractive waves

This continuation and extension of the successful book ""Localized Waves"" by the same editors brings together leading researchers in non-diffractive waves to cover the most important results in their field and as such is the first to present the current state.The well-balanced presentation of theory and experiments guides readers through the background of different types of non-diffractive waves, their generation, propagation, and possible applications. The authors include a historical account of the development of the field, and cover different types of non-diffractive waves, including Air