What triggers a microcrack in printed engineering parts produced by selective laser sintering on the first place?

The proximity of un-melted particles within Selective Laser Sintered (SLS) printed engineering parts made of Nylon-12 is found as a major triggering effect for cracking and ultimately failure. The numerical investigation, by means of the eXtended Finite Element Method (XFEM), was performed over samples with different arrangements of un-melted particles obtained experimentally. The onset and propagation of microcracks was simulated. This included inherently how the degree of particle melt (DPM) in SLS parts affects and controls both crack initiation and propagation. The results evidenced that a microcrack started invariably between the two closest un-melted particles in all numerical tests performed considering different arrangements of un-melted particles

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.

Data for: Steering the propagation direction of a non-linear acoustic wave in a solid material

Ultrasonic data from non-collinear wave mixing experiments

Data for: Steering the propagation direction of a non-linear acoustic wave in a solid material

Ultrasonic data from non-collinear wave mixing experiments

Data for: Steering the propagation direction of a non-linear acoustic wave in a solid material

Ultrasonic data from non-collinear wave mixing experiments.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Data for: Steering the propagation direction of a non-linear acoustic wave in a solid material

Ultrasonic data from non-collinear wave mixing experiments.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Interaction with goats in estrus maintain intense sexual behavior of bucks during the sexual rest

International audienc

Maternal selectivity suppression through peripheral anosmia affects neither overall nursing frequency and duration, nor lactation performance in ewes

International audienc

La conducta de amamantamiento en cabras, es influenciada por la época de parto y el tamaño de la camada

International audienc

Exposing lactating subtropical goats to artificially long days during autumn prolongs post-partum anovulation period and reduces milk protein content

International audienc