Hilando generaciones y moda

El proyecto Hilando Generaciones y Moda tiene como objetivo principal fomentar el intercambio y la convivencia intergeneracional entre jóvenes del ITESO y adultos mayores que acuden al Centro Tapatío de Atención al Adulto Mayor, ubicado en Guadalajara, Jalisco. La problemática que se busca resolver con este proyecto es la falta de interacción y comunicación entre estas dos generaciones, lo que puede llevar a la desconexión y aislamiento social de los adultos mayores, así como a una falta de perspectiva y comprensión por parte de los jóvenes sobre las experiencias y desafíos que enfrentan las personas mayores. El proyecto busca romper con estas barreras mediante la realización de actividades que promuevan la convivencia y el aprendizaje mutuo entre ambas generaciones, permitiendo la integración social y emocional de los adultos mayores, así como el desarrollo de habilidades sociales y empáticas en los jóvenes. A través de la interacción y el diálogo entre ambas generaciones, se espera generar un ambiente de respeto y valoración hacia la sabiduría y experiencia de los adultos mayores, así como una comprensión más profunda de las realidades sociales y culturales que enfrentan. A lo largo del semestre hicimos distintas actividades relacionadas con moda, que fueron propuestas por nosotros mismos. Estos talleres pensados en los adultos mayores nos dejarían productos que reflejaran la identidad de cada adulto y con los que después haremos una exposición final. Nuestras primeras actividades con los adultos fueron hacer un collage y un esqueleto exquisito, en el que hablarían sobre ellos y podríamos conocerlos mejor. Después tuvimos un taller de joyería en el CETAM, donde los adultos crearon dijes personalizados. La siguiente actividad fue un taller de creación y personalización de playeras. Para esta, los adultos nos visitaron en el ITESO, donde compartimos desayuno, baile y creatividad con las pinturas para personalizar cada playera. Este semestre colaboramos con Andrés Moreno, stylist y creador de Vintage Ceremony. Andrés nos asesoró en nuestro camino para nuestra siguiente actividad: una sesión de fotos que buscó resaltar la identidad de cada adulto mayor. En esta sesión de fotos contamos con patrocinio de peinado y maquillaje. Nuestra última actividad será la exposición final, donde mostraremos los resultados de todas las actividades, como prendas hechas por los alumnos de moda (con telas diseñadas por ellos, inspiradas en los adultos).ITESO, A.C

Multicentre, randomised, single-blind, parallel group trial to compare the effectiveness of a Holter for Parkinson's symptoms against other clinical monitoring methods: study protocol

Introduction In recent years, multiple studies have aimed to develop and validate portable technological devices capable of monitoring the motor complications of Parkinson's disease patients (Parkinson's Holter). The effectiveness of these monitoring devices for improving clinical control is not known. Methods and analysis This is a single-blind, cluster-randomised controlled clinical trial. Neurologists from Spanish health centres will be randomly assigned to one of three study arms (1:1:1): (a) therapeutic adjustment using information from a Parkinson?s Holter that will be worn by their patients for 7 days, (b) therapeutic adjustment using information from a diary of motor fluctuations that will be completed by their patients for 7 days and (c) therapeutic adjustment using clinical information collected during consultation. It is expected that 162 consecutive patients will be included over a period of 6 months. The primary outcome is the efficiency of the Parkinson?s Holter compared with traditional clinical practice in terms of Off time reduction with respect to the baseline (recorded through a diary of motor fluctuations, which will be completed by all patients). As secondary outcomes, changes in variables related to other motor complications (dyskinesia and freezing of gait), quality of life, autonomy in activities of daily living, adherence to the monitoring system and number of doctor?patient contacts will be analysed. The noninferiority of the Parkinson's Holter against the diary of motor fluctuations in terms of Off time reduction will be studied as the exploratory objective. Ethics and dissemination approval for this study has been obtained from the Hospital Universitari de Bellvitge Ethics Committee. The results of this study will inform the practical utility of the objective information provided by a Parkinson's Holter and, therefore, the convenience of adopting this technology in clinical practice and in future clinical trials. We expect public dissemination of the results in 2022.Funding This work is supported by AbbVie S.L.U, the Instituto de Salud Carlos III [DTS17/00195] and the European Fund for Regional Development, 'A way to make Europe'

Maternal dietary patterns and acute leukemia in infants: results from a case control study in Mexico

BackgroundChildhood cancer is the leading cause of disease-related mortality among children aged 5–14 years in Mexico, with acute leukemia being the most common cancer among infants. Examining the overall dietary patterns allows for a comprehensive assessment of food and nutrient consumption, providing a more predictive measure of disease risk than individual foods or nutrients. This study aims to evaluate the association between maternal dietary patterns during pregnancy and the risk of acute leukemia in Mexican infants.MethodsA hospital-based case–control study was conducted, comparing 109 confirmed acute leukemia cases with 152 age-matched controls. All participants (≤24 months) were identified at hospitals in Mexico City between 2010 and 2019. Data on a posteriori dietary patterns and other relevant variables were collected through structured interviews and dietary questionnaires. Multivariate logistic regression was employed to estimate the association between maternal dietary patterns during pregnancy and the risk of acute leukemia in infants.ResultsThe “Balanced & Vegetable-Rich” pattern, characterized by a balanced consumption of various food groups and higher vegetable intake, exhibited a negative association with acute leukemia when compared to the “High Dairy & Cereals” Pattern (adjusted odds ratio [OR] = 0.51; 95% confidence interval [CI]: 0.29, 0.90). We observed that mothers who gave birth to girls and adhered to a healthy dietary pattern during pregnancy exhibited significantly lower odds of their children developing AL compared to those who gave birth to boys [OR = 0.32 (95% CI 0.11, 0.97)]. Our results underscore the significance of maternal nutrition as a modifiable factor in disease prevention and the importance of prenatal health education

Mineralización en suelos con incorporación de residuos orgánicos en los altos de Chiapas, México

Atributos criticos de la region Altos de Chiapas son el relieve abrupto, suelos con baja disponibilidad de nutrientes y acidez, la intensificacion de su uso y el crecimiento de la superficie agropecuaria a expensas de los bosques. El objetivo del estudio fue conocer el efecto del estiercol de bovino, la cascarilla de cacao y la composta, incorporados a suelos Acrisol humico y Feozem haplico, cultivados o forestales, en la mineralizacion de la materia organica y su potencial para aumentar su fertilidad. La variable utilizada fue la tasa de mineralizacion, como dioxido de carbono formado en mezclas de suelo mas residuo organico, incubadas durante 10 dias. Se utilizo un diseno completamente al azar, con un arreglo factorial 4x4 y cuatro repeticiones. Ambos suelos cultivados, comparados con los forestales, disminuyeron 24 y 39% su contenido de materia organica e incrementaron 21 y 23% su densidad aparente. En los sitios cultivado y forestal, la incorporacion del estiercol, en el Acrisol humico tuvo tasas medias de mineralizacion de 180 y 146 ¿Êg CO2 g.1d.1 y en el Feozem haplico, 245 y 359 ¿Êg CO2 g.1d.1 respectivamente. Estas fueron mas altas (ANDEVA; F=3.33; p=0.0031) que sus controles y mezclas con cascarilla o composta. La incorporacion del estiercol mostro mayor potencial para restituir y aumentar su fertilidad. Este residuo incorporado al Acrisol humico cultivado incremento 164% la tasa de mineralizacion. Este incremento fue el mas alto de todos los sitios comparados con sus respectivos controles

Reactive oxygen species mediate the down-regulation of mitochondrial transcripts and proteins by tumour necrosis factor-a in L929 cells

11 pages, 10 figures.In this study, we show that reactive oxygen species production induced by tumour necrosis factor a (TNF-a) in L929 cells was associated with a decrease in the steady-state mRNA levels of the mitochondrial transcript ATPase 6-8. Simultaneously, the transcript levels of two nuclear-encoded glycolytic enzymes, glyceraldehyde- 3-phosphate dehydrogenase (GAPDH) and phosphofructokinase, were increased. These changes were associated with decreased protein levels of the ATPase subunit a (encoded by the mitochondrial ATPase 6 gene) and cytochrome c oxidase subunit II, and increased protein levels of phosphofructokinase. Since TNF-a had no effect on the amount of mitochondrial DNA, the results suggested that TNF-a acted at the transcriptional and/or post-transcriptional level. Reactive oxygen species scavengers, such as butylated hydroxianisole and butylated hydroxytoluene, blocked the production of free radicals, prevented the down-regulation of ATPase 6-8 transcripts, preserved the protein levels of ATPase subunit a and cytochrome c oxidase subunit II, and attenuated the cytotoxic response to TNF-a, indicating a direct link between these two phenomena.This work has been partially supported by the Spanish Direccion General de Ensen4 anza Superior grant no. PB98-0329-C02-01 and Fondo de Investigación Sanitaria (FIS 00/373).Peer reviewe

Reactive oxygen species mediate the down-regulation of mitochondrial transcripts and proteins by tumour necrosis factor-alpha in L929 cells.

In this study, we show that reactive oxygen species production induced by tumour necrosis factor alpha (TNF-alpha) in L929 cells was associated with a decrease in the steady-state mRNA levels of the mitochondrial transcript ATPase 6-8. Simultaneously, the transcript levels of two nuclear-encoded glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphofructokinase, were increased. These changes were associated with decreased protein levels of the ATPase subunit a (encoded by the mitochondrial ATPase 6 gene) and cytochrome c oxidase subunit II, and increased protein levels of phosphofructokinase. Since TNF-alpha had no effect on the amount of mitochondrial DNA, the results suggested that TNF-alpha acted at the transcriptional and/or post-transcriptional level. Reactive oxygen species scavengers, such as butylated hydroxianisole and butylated hydroxytoluene, blocked the production of free radicals, prevented the down-regulation of ATPase 6-8 transcripts, preserved the protein levels of ATPase subunit a and cytochrome c oxidase subunit II, and attenuated the cytotoxic response to TNF-alpha, indicating a direct link between these two phenomena