El servicio comunitario, una experiencia de innovación educativa en Venezuela

ResumenEl servicio comunitario del estudiante de educación superior se estableció por decisión de la asamblea nacional de la república bolivariana de Venezuela en el año 2005, con la intención de integrar a la universidad con los miembros de la comunidad, mediante la participación activa y protagónica del sector estudiantil y del sector profesoral en la búsqueda de soluciones a los problemas nacionales, a través del diseño y ejecución de proyectos sociales. Utiliza el aprendizaje-servicio como una metodología que promueve el desarrollo de competencias a través de actividades educativas de servicio a la comunidad, basándose en la convicción de que puede ser un factor de transformación de la realidad social. El contenido de la conferencia se referirá a las bases legales del servicio, a los aspectos metodológicos implementados a través de cursos de los inducción y al impacto social, político y económico de la ejecución de algunos proyectos en la realidad nacional venezolana.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Release of antioxidant peptides from the body wall proteins of the sea cucumber Isostichopus fuscus

Proteases from the tentacles of the sea cucumber Isostichopus fuscus were partially purified and used to produce antioxidant peptides from body wall proteins of this marine species. Three proteins (105, 68, and 39 kDa) were identified by SDS-PAGE in the proteolytic extract of the tentacles. Protein hydrolyzates were generated with gelatin and crude protein substrates from body wall, and peptidic fractions lower and higher than 3 kDa were obtained to evaluate their oxygen radical scavenging capacity (ORAC). The 3 kDa-fraction obtained from the crude protein hydrolyzate showed the highest ORAC value (0.92 ± 0.04 μmol Trolox equivalent/mg protein). This fraction was selected to purify peptides potentially responsible for the activity that might be used as ingredients for development of functional foods.A.C.H.-S thanks the National Council of Science and Technology (CONACYT, Mexico) for a graduate scholarship and the “Universidad Autónoma Metropolitana” for giving the marine organisms. B.H.-L. thanks the Ministry of Economy and Competitiveness (MINECO) and the Spanish National Research Council (CSIC) for her “Ramón y Cajal” postdoctoral contract.Peer Reviewe

Lunasin: A Novel Cancer Preventive Seed Peptide

Cancer is one of the leading causes of deaths in the Western world. Approximately one-third of these deaths are preventable by lifestyle factors, including modification of nutritional habits. Studies have demonstrated that adequate nutrition with certain types of foods containing bioactive compounds might offer significant protection against carcinogenesis. Soybeans contain a variety of phytochemicals with demonstrated anticancer activity, including isoflavones, protease inhibitors, and more recently lunasin, a novel cancer preventive seed peptide. Initially isolated from soybean, lunasin has also been reported in barley and wheat. The purpose of this review is to summarize the most recent evidence on the possible benefits of lunasin for cancer prevention

Three-dimensional aspects of fluid flows in channels. II. Effects of Meniscus and Thin Film regimes on Viscous Fingers

We perform a three-dimensional study of steady state viscous fingers that develop in linear channels. By means of a three-dimensional Lattice-Boltzmann scheme that mimics the full macroscopic equations of motion of the fluid momentum and order parameter, we study the effect of the thickness of the channel in two cases. First, for total displacement of the fluids in the channel thickness direction, we find that the steady state finger is effectively two-dimensional and that previous two-dimensional results can be recovered by taking into account the effect of a curved meniscus across the channel thickness as a contribution to surface stresses. Secondly, when a thin film develops in the channel thickness direction, the finger narrows with increasing channel aspect ratio in agreement with experimental results. The effect of the thin film renders the problem three-dimensional and results deviate from the two-dimensional prediction.Comment: 9 pages, 10 figure

Growth saturation of unstable thin films on transverse-striped hydrophilic-hydrophobic micropatterns

Using three-dimensional numerical simulations, we demonstrate the growth saturation of an unstable thin liquid film on micropatterned hydrophilic-hydrophobic substrates. We consider different transverse-striped micropatterns, characterized by the total fraction of hydrophilic coverage and the width of the hydrophilic stripes. We compare the growth of the film on the micropatterns to the steady states observed on homogeneous substrates, which correspond to a saturated sawtooth and growing finger configurations for hydrophilic and hydrophobic substrates, respectively. The proposed micropatterns trigger an alternating fingering-spreading dynamics of the film, which leads to a complete suppression of the contact line growth above a critical fraction of hydrophilic stripes. Furthermore, we find that increasing the width of the hydrophilic stripes slows down the advancing front, giving smaller critical fractions the wider the hydrophilic stripes are. Using analytical approximations, we quantitatively predict the growth rate of the contact line as a function of the covering fraction, and predict the threshold fraction for saturation as a function of the stripe width.Comment: 11 pages, 5 figure

Obras completas. Tomo I. Poemas

Port. a dos tintasAntep.Enc. rúst

1997-2012: Fifteen Years of Research on Peptide Lunasin

Publisher under CC BY 3.0 license.Peer Reviewe

Maxillomandibular giant osteosclerotic lesions

Giant Osteosclerotic Lesions (GOLs) are a group of rarely reported intraosseous lesions. Their precise diagnosis is important since they can be confused with malignant neoplasms. Objective: This retrospective study aimed to record and analyze the clinical and radiographic Giant Osteosclerotic Lesions (GOLs) detected in the maxillomandibular area of patients attending to our institution. Materials and Methods: Informed consent from the patients was obtained and those cases of 2.5 cm or larger lesions with radiopaque or mixed (radiolucid-radiopaque) appearance located in the maxillofacial bones were selected. Assessed parameters were: age, gender, radiographic aspect, shape, borders, size, location and relations to roots. Lesions were classified as radicular, apical, interradicular, interradicular-apical, radicular-apical or located in a previous teeth extraction area. Additionally, several osseous and dental developmental alterations (DDAs) were assessed. Results: Seventeen radiopacities in 14 patients were found and were located almost exclusively in mandible and were two types: idiopathic osteosclerosis and condensing osteitis. GOLs were more frequent in females, and in the anterior and premolar zones. 94.2% of GOLs were qualified as idiopathic osteosclerosis and one case was condensing osteitis. All studied cases showed different osseous and dental developmental alterations (DDAs). The most common were: Microdontia, hypodontia, pulp stones, macrodontia and variations in the mental foramina. Conclusions: GOLs must be differentiated from other radiopaque benign and malignant tumors. Condensing osteitis, was considered an anomalous osseous response induced by a chronic low-grade inflammatory stimulus. For development of idiopathic osteosclerosis, two possible mechanisms could be related. The first is modification of the normal turnover with excessive osseous deposition. The second mechanism will prevent the normal bone resorption, arresting the osseous breakdown process

Péptidos antihipertensivos derivados de proteínas lácteas

La leche es una excelente fuente de nutrientes. Mas allá de su bien documentada función nutricional, la leche ejerce un amplio rango de actividades biológicas que influyen sobre el sistema digestivo y metabólico, el crecimiento y desarrollo de los órganos y la resistencia a diversos trastornos y enfermedades. Estas actividades han sido atribuidas principalmente a las proteínas y péptidos secretados en la leche por la glándula mamaria. Sin embargo, algunas de las actividades biológicas de las proteínas lácteas se encuentran en un estado latente y requieren de procesos de proteolisis para su liberación.Este trabajo ha sido realizado en el marco del Proyecto CYTED XI.24. También se agradece a los Proyectos Consolider 2010 CS-063 y CM-S0505 -AGR-0153 y AGL- 2007 065035. Blanca Hernández-Ledesma disfruta de un contrato post-doctoral Marie-Curie de la Comisión Europea coordinado por el Consejo Superior de Investigaciones Científicas. María del Mar Contreras disfruta de una beca DANONE.Peer Reviewe