Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Acceso a productos electrónicos en una red local: soluciones en la biblioteca de la Universidad de Castilla-La Mancha

There are large numbers in the market of digital resources on CD-ROM or by economic issues, or lack of online versions of the same, we have to keep subscriptions in local hardware. Allowing access to these resources for all users within a network, including avoiding duplication in the acquisition, supposed to resolve several problems. It exposes how has been solved in the UCLM, multicampus University of very complex structure, to provide access through both the website and in the OPACs of libraries

Análisis de la gestión de los residuos sanitarios de titularidad privada en el municipio de Alcobendas

En el artículo se analiza la gestión de los residuos sanitarios que llevan a cabo las clínicas privadas del municipio de Alcobendas, con el fin de conocer la situación real y plantear actividades de mejora

Proyecto AMIDA

Primera herramienta de teleformación creada para la ESO, Bachillerato y Ciclos Formativos. La innovación ha consistido en crear la plataforma y permitir a todos los centros subir material interactivo para usar en sus clases y llevar un control de las tareas realizadas y no realizadas por los alumnos. Elaborar páginas de teoría y ejercicios para trabajar con los alumnos, labor de la que se encargan los profesores especialistas de cada asignatura que construyen páginas de teoría y ejercicios clasificados por niveles de dificultad..Consejería de Educación, Formación y Empleo. Director General de Promoción Educativa e InnovaciónMurciaConsejería de Educación, Formación y Empleo. Servicio de Publicaciones; Avda. de la Fama, 15; 30006 Murcia; Tel. +34968279685; Fax +34968279835; [email protected]

Educational platforms adapted to university teaching II: Mentimeter or Kahoot!?

Referencias Ros Velasco, J., Hernández Yáñez, L., Yousef Sandoval, L., González Pascual, C., Fragio Gistau, A., Zaragoza Bernal, J. M., Köwitz García, J., Cifuentes Matanza, A., Cervigón Rückauer, C., Manero Iglesias, J. B., Torregroza Lara, E. J., Jiménez Alcázar, J. F., Seguró Mendlewicz, M., Barros García, B., Esteban Nebot, V., García Villar, C., Sánchez San José, I., Jiménez Avedaño, D., Fernández Zavagno, J. P., Eljaiek Rodríguez, A. M., Hernández Albarracín, J. D., Moya Arriagada, I., Márquez Romero, M. Á., Garzón Costumero, X., Kalil el Aazzaoui, O., de Todo Orellana, R., Gómez Aliendres, K. A. y Mínguez Vicente, L. (2023). Plataformas educativas adaptadas a la enseñanza universitaria: ¿Mentimeter o Kahoot!?. Docta Complutense. Ros Velasco, J., Yousef Sandoval, L., González Pascual, C. y Köwitz García, J. (2024a). Preferencias del profesorado y el alumnado universitario en el uso de Mentimeter y Kahoot! Resultados de un estudio empírico comparativo. En Estrategias para la Transferencia de Conocimiento y la Innovación Educativa: Usos y aplicaciones de tecnologías innovadoras en la docencia (pp. 31-64). Dykinson. Ros Velasco, J., Yousef Sandoval, L., González Pascual, C. y Köwitz García, J. (2024b, en prensa). Seguridad e inclusividad en las apps Mentimeter y Kahoot! Comunicación & Métodos. Ros Velasco, J., Yousef Sandoval, L., González Pascual, C. y Köwitz García, J. (2024c, en prensa). Preferencias del profesorado y el alumnado en el uso de Mentimeter y Kahoot! Resultados de un estudio empírico en la enseñanza universitaria. En Innovación, investigación y transferencias ante la era de las Inteligencias Artificiales. Libro de resúmenes del congreso Internacional Nodos del Conocimiento 2023. Egregius Editorial.Memoria final del proyecto "Plataformas educativas adaptadas a la enseñanza universitaria II: ¿Mentimeter o Kahoot!?" (Nº 70), que es la continuación del proyecto "Plataformas educativas adaptadas a la enseñanza universitaria: ¿Mentimeter o Kahoot!?" (Nº 82, 2022-2023, https://hdl.handle.net/20.500.14352/87378). En esta secuela 1) seguimos recabando datos a través de la realización de experimentos con las apps Mentimeter y Kahoot! y 2) ejecutamos el plan de presentación/difusión de los resultados del proyecto Nº 82.Final report of the project "Educational platforms adapted to university teaching II: Mentimeter or Kahoot!?" (No. 70), which is the continuation of the project "Educational platforms adapted to university teaching: Mentimeter or Kahoot!?" (No. 82, 2022-2023, https://hdl.handle.net/20.500.14352/87378). In this sequel, we 1) continue collecting data by carrying out experiments with the Mentimeter and Kahoot! apps, and 2) execute the dissemination plan for the results of project No. 82.Vicerrectorado de Calidad, Proyectos de Innovación 2022-2024 Innova-Docencia UCMEuropean Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 847635Depto. de Filosofía y SociedadFac. de FilosofíaFALSEsubmittedAPC financiada por la UC

Role of age and comorbidities in mortality of patients with infective endocarditis.

The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups: A total of 3120 patients with IE (1327  There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in th

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective