Título: Curso completo de todas las ciencias.

Joseph Vazquez es seud. de José Cadalso.Sign.: A-T4, V2.Port. con grab calc: "G. Schouten, inv. et efec.

Ocios de mi juventud ó poesias liricas

Sign. : A-N4

D. Sancho Garcia, Conde de Castilla : tragedia española original

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Sign.: A-H

Apología del Rey Don Pedro de Castilla, conforme a la crónica verdadera de D. Pedro de Ayala

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Palau lo supone impreso hacia 1780.Marca de imp. en port.Sign.: []1, [sol]2, A-Z2, 2A-2Z2, 3A-3Z2, 4A-4Z2, 5A-5S2, 5T1

Reflexiones criticas del lic. Cosme Berruguete i Maza : sobre el tomo octavo de la Historia Literaria : continuacion á los reparos del bachiller Gil Porras i defensa de Nicolás Antonio sobre las omisiones i yerros que le imputan los R.R. P.P. Mohedanos

Ignacio López de Ayala utilizó los seud.: Cosme Berruguete y Maza, Gil Porras Machuca, Fulgencio de Rajas PeñalosaSign.:A-M4, N1Port. con viñeta xil.Adorno tip. en port. y al principio del text

Experiencias del grupo de creación de nuevos materiales docentes de la UPCT en el desarrollo de libros digitales multimedia e interactivos

[SPA] El empleo de los libros electrónicos (eBook) está proliferando cada vez más en la sociedad actual, así como la existencia de los dispositivos electrónicos que permiten su lectura. Esta situación ha provocado que existan numerosos tipos de formatos para estos libros, entre los que destacan el ePub, iBook y Folio. Una de los objetivos principales del profesorado actual de las Universidades es adaptar y desarrollar nuevo material docente que permita mejorar el proceso de enseñanza-aprendizaje del alumno. Con ese objetivo, el grupo docente de “Creación de nuevos materiales docentes” de la Universidad Politécnica de Cartagena ha llevado a cabo un estudio comparativo de los tipos de formato de eBook más utilizados, a fin de orientar al profesorado a elegir un formato u otro en función de su finalidad y experiencia en este tipo de herramientas. [ENG] The use of electronic books (eBook) is becoming increasingly common in the actual society, as well as the existence of electronic devices that permit reading them. This situation has led to the presence of many types of formats for this eBooks, including ePub, iBook and iFolio. One of the main objectives of the actual Universities teaching staff is to adapt and develop new teaching material that permits to improve the teaching-learning process of the students. With this aim, the teaching group of “Creation of new teaching material” of the Technical University of Cartagena has performed a comparative analysis of the more used types of eBook format in order to give advice the teaching staff about choosing one format or another with regard to the purpose and experience in this type of tools

Ensayos de comidas económicas á la Rumford [Texto impreso]

Hay un ejemplar encuadernado dentro del volumen facticio XVIII/1829Sign. : [asterisco]1

Analysis of FOXP3 gene in children with allergy and autoimmune diseases

Allergy and autoimmunity are important immunological entities underlying chronic diseases in children. In some cases both entities develop simultaneously in the same patient. FOXP3 gene codes for a transcription factor involved in regulation of the immune system. Considering that regulatory T cells are involved in controlling immunological disease development, and the relevant role of FOXP3 in this kind of T cells, the objective of this study was to analyse the FOXP3 gene in the most prevalent autoimmune diseases and/or allergies in childhood in a European population. A total of 255 Caucasian individuals, 95 controls and 160 patients diagnosed with allergic, autoimmune or both diseases were included in this study. The molecular analysis of FOXP3 was performed by DNA sequencing following the recommendations for quality of the European Molecular Genetics Quality Network. Genomic DNA was extracted from peripheral blood of all participants and was amplified using the polymerase chain reaction. After the visualisation of the amplified fragments by agarose gel-electrophoresis, they were sequenced. Thirteen different polymorphisms in FOXP3 gene were found, seven of which had not been previously described. The mutated allele of SNP 7340C>T was observed more frequently in the group of male children suffering from both allergic and autoimmune diseases simultaneously (p=0.004, OR=16.2 [1.34-195.15]). In this study we identified for first time genetic variants of FOXP3 that are significantly more frequent in children who share allergic and autoimmune diseases. These variants mainly affect regulatory sequences that could alter the expression levels of FOXP3 modifying its function including its role in Treg cells

Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19 : a meta-analysis

IMPORTANCE Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm. OBJECTIVE To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes. DATA SOURCES Trials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts. STUDY SELECTION Eligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria. DATA EXTRACTION AND SYNTHESIS In this prospectivemeta-analysis, risk of biaswas assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I-2 statistic. The primary analysis was an inverse variance-weighted fixed-effects meta-analysis of odds ratios (ORs) for 28-day all-cause mortality. MAIN OUTCOMES AND MEASURES The primary outcome measurewas all-cause mortality at 28 days after randomization. There were 9 secondary outcomes including progression to invasive mechanical ventilation or death and risk of secondary infection by 28 days. RESULTS A total of 10 930 patients (median age, 61 years [range of medians, 52-68 years]; 3560 [33%] were women) participating in 27 trials were included. By 28 days, there were 1407 deaths among 6449 patients randomized to IL-6 antagonists and 1158 deaths among 4481 patients randomized to usual care or placebo (summary OR, 0.86 [95% CI, 0.79-0.95]; P =.003 based on a fixed-effects meta-analysis). This corresponds to an absolute mortality risk of 22% for IL-6 antagonists compared with an assumed mortality risk of 25% for usual care or placebo. The corresponding summary ORs were 0.83 (95% CI, 0.74-0.92; P <.001) for tocilizumab and 1.08 (95% CI, 0.86-1.36; P =.52) for sarilumab. The summary ORs for the association with mortality compared with usual care or placebo in those receiving corticosteroids were 0.77 (95% CI, 0.68-0.87) for tocilizumab and 0.92 (95% CI, 0.61-1.38) for sarilumab. The ORs for the association with progression to invasive mechanical ventilation or death, compared with usual care or placebo, were 0.77 (95% CI, 0.70-0.85) for all IL-6 antagonists, 0.74 (95% CI, 0.66-0.82) for tocilizumab, and 1.00 (95% CI, 0.74-1.34) for sarilumab. Secondary infections by 28 days occurred in 21.9% of patients treated with IL-6 antagonists vs 17.6% of patients treated with usual care or placebo (OR accounting for trial sample sizes, 0.99; 95% CI, 0.85-1.16). CONCLUSIONS AND RELEVANCE In this prospectivemeta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality

Mortality after surgery in Europe: a 7 day cohort study

Background: Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe.Methods: We did this 7 day cohort study between April 4 and April 11, 2011. We collected data describing consecutive patients aged 16 years and older undergoing inpatient non-cardiac surgery in 498 hospitals across 28 European nations. Patients were followed up for a maximum of 60 days. The primary endpoint was in-hospital mortality. Secondary outcome measures were duration of hospital stay and admission to critical care. We used χ² and Fisher’s exact tests to compare categorical variables and the t test or the Mann-Whitney U test to compare continuous variables. Significance was set at p&lt;0·05. We constructed multilevel logistic regression models to adjust for the differences in mortality rates between countries.Findings: We included 46 539 patients, of whom 1855 (4%) died before hospital discharge. 3599 (8%) patients were admitted to critical care after surgery with a median length of stay of 1·2 days (IQR 0·9–3·6). 1358 (73%) patients who died were not admitted to critical care at any stage after surgery. Crude mortality rates varied widely between countries (from 1·2% [95% CI 0·0–3·0] for Iceland to 21·5% [16·9–26·2] for Latvia). After adjustment for confounding variables, important differences remained between countries when compared with the UK, the country with the largest dataset (OR range from 0·44 [95% CI 0·19 1·05; p=0·06] for Finland to 6·92 [2·37–20·27; p=0·0004] for Poland).Interpretation: The mortality rate for patients undergoing inpatient non-cardiac surgery was higher than anticipated. Variations in mortality between countries suggest the need for national and international strategies to improve care for this group of patients.Funding: European Society of Intensive Care Medicine, European Society of Anaesthesiology