Working Memory Deficits After Lesions Involving the Supplementary Motor Area.

Published: 23 May 2018The Supplementary Motor Area (SMA)—located in the superior and medial aspects of the superior frontal gyrus—is a preferential site of certain brain tumors and arteriovenous malformations, which often provoke the so-called SMA syndrome. The bulk of the literature studying this syndrome has focused on two of its most apparent symptoms: contralateral motor and speech deficits. Surprisingly, little attention has been given to working memory (WM) even though neuroimaging studies have implicated the SMA in this cognitive process. Given its relevance for higher-order functions, our main goal was to examine whether WM is compromised in SMA lesions. We also asked whether WM deficits might be reducible to processing speed (PS) difficulties. Given the connectivity of the SMA with prefrontal regions related to executive control (EC), as a secondary goal we examined whether SMA lesions also hampered EC. To this end, we tested 12 patients with lesions involving the left (i.e., the dominant) SMA. We also tested 12 healthy controls matched with patients for socio-demographic variables. To ensure that the results of this study can be easily transferred and implemented in clinical practice, we used widely-known clinical neuropsychological tests: WM and PS were measured with their respective Wechsler Adult Intelligence Scale indexes, and EC was tested with phonemic and semantic verbal fluency tasks. Non-parametric statistical methods revealed that patients showed deficits in the executive component of WM: they were able to sustain information temporarily but not to mentally manipulate this information. Such WM deficits were not subject to patients’ marginal PS impairment. Patients also showed reduced phonemic fluency, which disappeared after controlling for the influence of WM. This observation suggests that SMA damage does not seem to affect cognitive processes engaged by verbal fluency other than WM. In conclusion, WM impairment needs to be considered as part of the SMA syndrome. These findings represent the first evidence about the cognitive consequences (other than language) of damage to the SMA. Further research is needed to establish a more specific profile of WM impairment in SMA patients and determine the consequences of SMA damage for other cognitive functions.MH was supported by the Ramón y Cajal (RYC-2016-19477) research program (Spanish Ministry of Economy, Industry, and Competitiveness). MH also acknowledges financial support from the Diputación Foral de Gipuzkoa/Gipuzkoako Foru Aldundia (Programa FellowsGipuzkoa de atracción y retención de talento)

Com ensenyar a investigar. Avaluació a traves de mini-articles en un màster de ciències de l'esport. How to teach research evaluation through articles in a mini-master of science of sport

En aquest treball presentem un projecte innovador que planteja l’aprenentatge de la investigació científica de manera molt pragmàtica. Descrivim els objectius que es persegueixenamb els seus continguts, els fonament didàctics en què es basa i les fases en les què es desenvolupa.El projecte, que està dirigit a alumnes d’Educació Física del Màster de Formació del Professorat d’Educació Secundària Obligatòria, Batxillerat, Formació Professional de la Universitat de Lleida, sorgeix de la inquietud docent d’aconseguir convertir l’aprenentatge de la investigació en una activitat suggerent i atractiva

Impact of laser attacks on the switching behavior of RRAM devices

The ubiquitous use of critical and private data in electronic format requires reliable and secure embedded systems for IoT devices. In this context, RRAMs (Resistive Random Access Memories) arises as a promising alternative to replace current memory technologies. However, their suitability for this kind of application, where the integrity of the data is crucial, is still under study. Among the different typology of attacks to recover information of secret data, laser attack is one of the most common due to its simplicity. Some preliminary works have already addressed the influence of laser tests on RRAM devices. Nevertheless, the results are not conclusive since different responses have been reported depending on the circuit under testing and the features of the test. In this paper, we have conducted laser tests on individual RRAM devices. For the set of experiments conducted, the devices did not show faulty behaviors. These results contribute to the characterization of RRAMs and, together with the rest of related works, are expected to pave the way for the development of suitable countermeasures against external attacks.Postprint (published version

Creencias y actitudes de los estudiantes del último curso de magisterio hacia la atención a la diversidad

Onzenes Jornades de Foment de la Investigació de la FCHS (Any 2005-2006)Considerando la importancia que tiene en la actualidad la atención a la diversidad dentro del entorno educativo, y el riesgo de determinados alumnos de ser excluidos, creemos que es de vital importancia conocer la preparación de los futuros docentes en este campo o más exactamente las creencias y actitudes que presentan hacia la atención a la diversidad, ya que serán los indicadores de su posterior conducta. Para ello hemos centrado nuestra investigación en los estudiantes de 3º curso de todas las especialidades de la titulación de maestro de la Universitat Jaume I de Castellón evaluando sus actitudes a través de un cuestionario elaborado para tal fin. Así, a partir de los datos obtenidos se concluye la no existencia de diferencias entre las cuatro especialidades, entre ambos sexos y entre las personas con experiencia previa con alumnos con necesidades educativas especiales y los que no la poseen. Asimismo se comparan los resultados obtenidos en esta investigación con los obtenidos en una similar en 2001 y se concluye que los estudiantes de la promoción actual parecen mostrar una actitud sensiblemente más positiva que en promociones anteriores

‘Saluda’, a programme to prevent the drug consumption: a evaluation of a new version in Spanish adolescents

En la actualidad se han evaluado numerosas intervenciones preventivas de drogodependencias en el medio escolar. Sin embargo, en España son pocos los estudios que analizan la influencia precisa de cada uno de los componentes específicos a los programas con el fin de determinar cuáles se consideran cruciales para el cambio de conducta de consumo. El objetivo del presente estudio fue evaluar los efectos de una nueva versión del programa de prevención del consumo de drogas Saluda en la que se prescinde del componente fomento del ocio saludable y las tareas para casa. Esta versión reducida fue dirigida a una muestra de 106 escolares (44.6 % chicos) entre 14 y 17 años (M = 15.20; DT = 0.92) de un centro de Educación Secundaria. Se trata de un estudio exploratorio de tipo cuasi experimental y un diseño pre-post de un único grupo. Se realizó diferencia de proporciones mediante la prueba Z y diferencia de medias mediante la prueba T para muestras relacionadas. Los resultados muestran una reducción en el porcentaje de episodios de embriaguez, así como un efecto de mejora significativa sobre las variables protectoras del consumo. Se discuten estos hallazgos y se realizan propuestas para la mejora de futuras intervenciones.In Spain, as in the majority of countries in the world, drug use is a public health problem. Adolescence is considered to be a period at risk for the onset of drug use; thus, it becomes essential to intensify efforts and reduce the demand for drugs. For this purpose, numerous interventions have been evaluated, finding several sources of deficiency: among them, it is worth mentioning the lack of studies that analyzing the most effective components on drug prevention programs. In Spain, only Saluda program provides empirical evidence on the contribution of its components to the program. The objective of this study was to evaluate the effects of a new version of Saluda program on a sample of 106 students (44.6% boys) between 14 and 17 years (M = 15.20, SD = 0.92). A pilot study was conducted, in which the components “healthy leisure promotion” and “homework” were omitted. Concerning intragroup comparisons, analyses of variance on repeated measures and difference of proportions were performed. The results showed a reduction in alcohol consumption and cannabis as well as a significant improving effect on consumption protective variables. These findings were made in order to improve future preventive interventions

Charge effect of a liposomal delivery system encapsulating simvastatin to treat experimental ischemic stroke in rats

[Background and aims]: Although the beneficial effects of statins on stroke have been widely demonstrated both in experimental studies and in clinical trials, the aim of this study is to prepare and characterize a new liposomal delivery system that encapsulates simvastatin to improve its delivery into the brain. [Materials and methods]: In order to select the optimal liposome lipid composition with the highest capacity to reach the brain, male Wistar rats were submitted to sham or transitory middle cerebral arterial occlusion (MCAOt) surgery and treated (intravenous [IV]) with fluorescent-labeled liposomes with different net surface charges. Ninety minutes after the administration of liposomes, the brain, blood, liver, lungs, spleen, and kidneys were evaluated ex vivo using the Xenogen IVIS® Spectrum imaging system to detect the load of fluorescent liposomes. In a second substudy, simvastatin was assessed upon reaching the brain, comparing free and encapsulated simvastatin (IV) administration. For this purpose, simvastatin levels in brain homogenates from sham or MCAOt rats at 2 hours or 4 hours after receiving the treatment were detected through ultra-high-protein liquid chromatography. [Results]: Whereas positively charged liposomes were not detected in brain or plasma 90 minutes after their administration, neutral and negatively charged liposomes were able to reach the brain and accumulate specifically in the infarcted area. Moreover, neutral liposomes exhibited higher bioavailability in plasma 4 hours after being administered. The detection of simvastatin by ultra-high-protein liquid chromatography confirmed its ability to cross the blood-brain barrier, when administered either as a free drug or encapsulated into liposomes. [Conclusion]: This study confirms that liposome charge is critical to promote its accumulation in the brain infarct after MCAOt. Furthermore, simvastatin can be delivered after being encapsulated. Thus, simvastatin encapsulation might be a promising strategy to ensure that the drug reaches the brain, while increasing its bioavailability and reducing possible side effects.The research leading to these results received funding from the European Union’s Seventh Framework Program (FP7/2007-2013) under grant agreements number 201024 and number 202213 (European Stroke Network). Neurovascular Research Laboratory takes part in the Spanish stroke research network INVICTUS (RD12/0014/0005). This study was partially funded by projects FIS 11/0176 on stroke biomarkers research and EC07/90195 on increasing safety and efficacy of simvastatin neuroprotection.Peer Reviewe

Saving irrigation water as a tool to increase pomegranate fruit price and enhance the bioactive compound content

The non-climateric character of pomegranate (P. granatum) fruit underlines the importance of determining the optimum harvest time to improve fruit quality. The effect of irrigation withholding during 6, 15, 25 and 36 d before harvest was evaluated in order to clarify whether fruit ripening is critical or non-critical from the yield, fruit characteristics and composition point of view. The results indicated that this phenological period is critical because irrigation is essential during most of this phenological period to achieve maximum yield. However, a 6 d of irrigation restriction at the end of ripening period can be used as a tool to come early harvest time, saves irrigation water, enhances the bioactive compounds (anthocyanins, phenolic compounds, punicalagin and ellagic acid) and increases the price of the fruit without affecting marketable yield and fruit size

The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum

Subjects with sleep apnea-hypopnea syndrome (SAHS) show an increased carotid intima-media thickness. However, no data exist about earlier markers of atheromatous disease, such as the proliferation and expansion of the adventitial vasa vasorum (VV) to the avascular intima in this setting. Our aim was to assess carotid VV density and its relationship with sleep parameters in a cohort of obese patients without prior vascular events. A total of 55 subjects evaluated for bariatric surgery were prospectively recruited. A non-attended respiratory polygraphy was performed. The apnea-hypopnea index (AHI) and the cumulative percentage of time spent with oxygen saturation below 90% (CT90) were assessed. Serum concentrations of soluble intercellular adhesion molecule 1, P-selectin, lipocalin-2 and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured. Contrast-enhanced carotid ultrasound was used to assess the VV density. Patients with SAHS (80%) showed a higher adventitial VV density (0.801±0.125 vs. 0.697±0.082, p = 0.005) and higher levels of sVCAM-1 (745.2±137.8 vs. 643.3±122.7 ng/ml, p = 0.035) than subjects with an AHI lower than 10 events/hour. In addition, a positive association exist between mean VV density and AHI (r = 0.445, p = 0.001) and CT90 (r = 0.399, p = 0.005). Finally, in the multiple linear regression analysis, female sex, fasting plasma glucose and AHI (but not CT90) were the only variables independently associated with the mean adventitial VV density (R2 = 0.327). In conclusion, a high VV density is present in obese subjects with SAHS, and chronic intermittent hypoxia is pointed as an independent risk factor for the development of this early step of atheromatous diseaseThis study was supported by grants from Instituto de Salud Carlos III (Fondo de Investigación Sanitaria PI15/00260), European Union (European Regional Development Fund, Fondo Europeo de Desarrollo Regional, “Una manera de hacer Europa”), Fundación Sociedad Española Endocrinología y Nutrición (FSEEN) and Laboratorios Almirall (“Beca FSEEN de ayuda a la investigación sobre factores de riesgo cardiovascular”, Laboratorio ESTEVE and Menarini Spain S.A. CIBER de Diabetes y Enfermedades Metabólicas Asociadas and CIBER de Enfermedades Respiratorias are initiatives of the Instituto de Salud Carlos III. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors would like to thank Virtudes Maria and Mª del Valle Peña (from the Unit for the Detection and Treatment of Atherothrombotic Diseases), Olga Mínguez and Lidia Pascual (from the Sleep Unit) for their help in the study