Laserstrahlablation von SiO2-Passivierschichten mit Anwendung auf die RISE-EWT-Solarzelle

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Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice

Accumulation of α-synuclein is observed in neurodegenerative diseases like Parkinson's disease and Multiple System Atrophy. In previous studies with transgenic C57BL/6 mice overexpressing α-synuclein carrying the mutations A53T and A30P found in Parkinson's disease or with a parkin-null background, we reported severe mitochondrial impairments in neurons and to a larger extent in glial cells of the mesencephalon. Neuron death was not observed in the brain. Here we show that the mice show severe motor impairments in behavioral tests. In addition, these mice exhibit astrocytic cell death in the spinal cord, accompanied by extensive gliosis and microglial activation. This is shown by cell death staining and immunohistochemistry. Ultrastructural analyses revealed severe mitochondrial impairments not only in astrocytes, but also in oligodendrocytes and, to a small extent, in neurons. Thus, the transgenic mice show a profound pathology in glial cells of the spinal cord

Development, validation, and application of a fast, simple, and robust SPE-based LC-MS/MS method for quantification of angiotensin I-converting enzyme inhibiting tripeptides Val-Pro-Pro, Ile-Pro-Pro, and Leu-Pro-Pro in yoghurt and other fermented dairy products

Dairy products are an important part of a nutritionally balanced diet as their constituents can affect the human state of health. By inhibiting the angiotensin I-converting enzyme, the tripeptides Val-Pro-Pro, Ile-Pro-Pro, and Leu-Pro-Pro can lower blood pressure. As these peptides are produced during fermentation, they are found in various dairy products like cheese, yoghurt, etc., but except for cheese only little is known about their content. To investigate how other dairy products contribute to a supply of these antihypertensive peptides, we developed and validated a fast and sensitive assay for quantification of the three tripeptides with LC-MS/MS combined with a simple protocol for extraction and SPE-purification from yoghurt, curd, or other products. Finally, the entire method was successfully applied to survey peptide concentrations in samples from local dairies and thus expands our awareness on the content of antihypertensive peptides in our food. (C) 2019 Elsevier Ltd. All rights reserved.Peer reviewe

Охрана окружающей среды при утилизации отходов на реке Емец Тюменской области

В статье рассмотрены основные методы охраны окружающей среди при утилизации отходов на реке Емец Тюменской области.The article considers the main methods of environmental protection in waste management on the Emets river in the Tyumen Region

Fächerübergreifender Projektunterricht - Demokratie als Leitbild für veränderte Rollen Lehrender und Lernender. OSZ Bürowirtschaft und Verwaltung, Berlin

Das Oberstufenzentrum Bürowirtschaft und Verwaltung hat in drei thematisch unterschiedlichen Projekten neue Lern- und Arbeitsformen für Schüler/-innen und Lehrer/-innen entwickelt. Schüler/-innen des 13. Jahrgangs und Lehrer/innen erarbeiteten unterschiedliche und vielfältige Formen selbstständiger Arbeits- und Projektplanung und -organisation, des Zeitmanagements, der Dokumentation und Präsentation der Arbeitsprozesse und -ergebnisse, der Leistungsbewertung und der Evaluation

Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease

Obliterative airway disease (OAD) is the major complication after lung transplantations that limits long term survival (1-7)

Making data centres fit for demand response: introducing GreenSDA and GreenSLA contracts

The power grid has become a critical infrastructure, which modern society cannot do without. It has always been a challenge to keep power supply and demand in balance; the more so with the recent rise of intermittent renewable energy sources. Demand response schemes are one of the counter measures, traditionally employed with large industrial plants. This paper suggests to consider data centres as candidates for demand response as they are large energy consumers and as they are able to adapt their power profile sufficiently well. To unlock this potential, we suggest a system of contracts that regulate collaboration and economic incentives between the data centre and its energy supplier (GreenSDA) as well as between the data centre and its customers (GreenSLA). Several presented use cases serve to validate the suitability of data centers for demand response schemes.Peer ReviewedPostprint (author's final draft

Seasonal study of the Small-Scale Variability of Dissolved Methane in the western Kiel Bight (Baltic Sea) during the European Heat Wave in 2018

Methane (CH4) is a climate-relevant atmospheric trace gas which is emitted to the atmosphere from coastal areas such as the Baltic Sea. The oceanic CH4 emission estimates are still associated with a high degree of uncertainty partly because the temporal and spatial variability of the CH4 distribution in the ocean surface layer is usually not known. In order to determine the small-scale variability of dissolved CH4 we set up a purge-and-trap system with a significantly improved precision for the CH4 concentration measurements. We measured the distribution of dissolved CH4 in the water column of the western Kiel Bight and Eckernförde Bay in June and September 2018. The top 1 m was sampled in high-resolution to determine potential small-scale CH4 concentration gradients within the mixed layer. CH4 concentrations throughout the water column of the western Kiel Bight and Eckernförde Bay were generally higher in September than in June. The increase of the CH4 concentrations in the bottom water was accompanied by a strong decrease in O2 concentrations which led to anoxic conditions favorable for microbial CH4 production in September. In summer 2018, northwestern Europe experienced a pronounced heatwave. However, we found no relationship between the anomalies of water temperature and excess CH4 in both the surface and the bottom layer at the site of the Boknis Eck Time-Series Station (Eckernförde Bay). Therefore, the 2018 European heatwave most likely did not affect the observed increase of the CH4 concentrations in the western Kiel Bight from June to September 2018. The high-resolution measurements of the CH4 concentrations in the upper 1 m of the water column were highly variable and showed no uniform decreasing or increasing gradients with water depth. Overall, our results show that the CH4 distribution in the water column of the western Kiel Bight and Eckernförde Bay is strongly affected by both large-scale temporal (i.e. seasonal) and small-scale spatial variabilities which need to be considered when quantifying the exchange of CH4 across the ocean/atmosphere interface

Driver Persistence, Safety and Older Adult Self-efficacy: Addressing Driving Challenges Using Innovative Multimodal Communication Concepts

New assisted driving technology provides a solution to enabling driver persistence while also addressing older adult fitness to drive issues. The proposed driver assistance system follows a detailed literature review, an analysis of secondary data, and the specification of a solution using human machine interaction (HMI) design methods. Overall, the assisted driving concept follows from a principled/ethical perspective in relation to promoting self-efficacy and enablement for older adults. The system is conceptualized as a supportive friend or ‘co-pilot’. It is argued that the use of new car-based sensors, along with machine learning intelligence and novel multimodal HMI communication methods will enable driver persistence while also promoting older adult self-efficacy and positive ageing

Geophysical analysis of an area affected by subsurface dissolution - case study of an inland salt marsh in northern Thuringia, Germany

The subsurface dissolution of soluble rocks can affect areas over a long period of time and pose a severe hazard. We show the benefits of a combined approach using P-wave and SH-wave reflection seismics, electrical resistivity tomography, transient electromagnetics, and gravimetry for a better understanding of the dissolution process. The study area, "Esperstedter Ried"in northern Thuringia, Germany, located south of the Kyffhäuser hills, is a large inland salt marsh that developed due to dissolution of soluble rocks at approximately 300 m depth. We were able to locate buried dissolution structures and zones, faults and fractures, and potential fluid pathways, aquifers, and aquitards based on seismic and electromagnetic surveys. Further improvement of the model was accomplished by analyzing gravimetry data that indicates dissolution-induced mass movement, as shown by local minima of the Bouguer anomaly for the Esperstedter Ried. Forward modeling of the gravimetry data, in combination with the seismic results, delivered a cross section through the inland salt marsh from north to south. We conclude that tectonic movements during the Tertiary, which led to the uplift of the Kyffhäuser hills and the formation of faults parallel and perpendicular to the low mountain range, were the initial trigger for subsurface dissolution. The faults and the fractured Triassic and lower Tertiary deposits serve as fluid pathways for groundwater to leach the deep Permian Zechstein deposits, since dissolution and erosional processes are more intense near faults. The artesian-confined saltwater rises towards the surface along the faults and fracture networks, and it formed the inland salt marsh over time. In the past, dissolution of the Zechstein formations formed several, now buried, sagging and collapse structures, and, since the entire region is affected by recent sinkhole development, dissolution is still ongoing. From the results of this study, we suggest that the combined geophysical investigation of areas prone to subsurface dissolution can improve the knowledge of control factors, hazardous areas, and thus local dissolution processes