El ejercicio de los derechos de la personalidad del adulto protegido

En este trabajo se analiza la protección de los derechos de la personalidad del adulto protegido desde la perspectiva de su ejercicio personal, efectivo y sin discriminaciónIn this paper the protection of the protected adult´s personality rights is analyze from the perspective of this personal and effective exercise and without discriminatio

Portugal ante la Guerra Civil Española

Desde el 17 de julio de 1936 dos naciones de segundo orden, España y Portugal, van a aparecer como protagonistas en el escenarlo internacional de Europa para pernnanecer como constante pesadilla a lo largo de tres años en las relaciones exteriores de las potencias mundiales

CRISPR-Mediated Strand Displacement Logic Circuits with Toehold-Free DNA

[EN] DNA nanotechnology, and DNA computing in particular, has grown extensively over the past decade to end with a variety of functional stable structures and dynamic circuits. However, the use as designer elements of regular DNA pieces, perfectly complementary double strands, has remained elusive. Here, we report the exploitation of CRISPR-Cas systems to engineer logic circuits based on isothermal strand displacement that perform with toehold-free double-stranded DNA. We designed and implemented molecular converters for signal detection and amplification, showing good interoperability between enzymatic and nonenzymatic processes. Overall, these results contribute to enlarge the repertoire of substrates and reactions (hardware) for DNA computing.We thank V. Aragones (IBMCP) for her technical assistance on PAGE. The work was supported by the Spanish Ministry of Economy and Competitiveness grants BFU2015-66894-P (to GR) and BIO2017-83184-R (to JAD) and by the Spanish Ministry of Science, Innovation, and Universities grant PGC2018-101410-B-I00 (to GR); grants cofinanced by the European Regional Development Fund.Montagud-Martínez, R.; Heras-Hernández, M.; Goiriz, L.; Rodrigo Tarrega, G.; Daròs, J. (2021). CRISPR-Mediated Strand Displacement Logic Circuits with Toehold-Free DNA. ACS Synthetic Biology. 10(5):950-956. https://doi.org/10.1021/acssynbio.0c0064995095610

On-design and off-design thermodynamic analysis of a hybrid multi-stage solar thermal tower power plant

[ENConcentrated solar power (CSP) is one challenging renewable technology for the future production of electricity. Within this concept central receiver solar plants combined with gas turbines are being investigated because of their promising efficiencies and reduced water consumption. Hybrid plants incorporate a combustion chamber in such a way that in periods of low solar irradiance power output can be kept approximately constant and so, electricity production is predictable. An integrated, non-complex solar thermodynamic model of a hybrid multi-stage gas turbine solar plant is developed employing a reduced number of parameters with a clear physical meaning. The solar subsystem is modelled in detail, taking into account the main heliostats field losses factors as cosine effect, blocking, or attenuation. The model is implemented in our own software, developed in Mathematica® language, considering as reference Gemasolar solar field (Seville, Spain). First, an on-design analysis is performed for four different working fluids (dry air, nitrogen, carbon dioxide, and helium), for different number of expansion and compression stages, and for recuperative and non-recuperative modes. Moreover, heliostats field configuration is determined for the design point and its associated efficiency is computed. A pre-optimization process is carried out regarding the pressure ratio of the gas turbine for different configurations. Some significant efficiency and power rises can be obtained when pressure ratio is adapted for each specific configuration and working fluid. Three particular plant configurations are chosen for the off-design analysis due to their interesting behaviours. For these configurations, a dynamic study is performed for four representative of each season. Then, efficiencies and solar share are plotted against time. In addition, fuel consumption and greenhouse emissions are computed for all seasons. Heliostats efficiency varying with the season and the solar time is also forecasted. Keywords: Dynamic analysis, On-design pre-optimization, Multi-stage gasJunta de Castilla y León of Spain (project SA017P17

Thermo-economic study of hybrid parabolic dish solar power plants in different regions of Spain

[EN]Small-scale hybrid parabolic dish Concentrated Solar Power (CSP) systems coupled to a micro-gas turbine are a promising option to obtain electrical energy in a distributed manner. During the day, solar energy is used to produce electricity and the absence of sunlight can be overcome with the combustion of a fossil or renewable fuel. This study presents the technical feasibility and thermo-economic model of a hybridized power plant in different regions of Spain, considering the local climatic conditions. The implemented model aims to provide a realistic view of the behaviour of the system, using a reduced number of selected parameters with a clear physical meaning. The irreversibilities taking place in all subsystems (solar part, combustion chamber, micro-gas turbine, and the corresponding heat exchangers) have been considered in the model, developed in Mathematica® language. The model considers the instant solar irradiance and ambient temperature dynamically, providing an estimation of the power output, the associated fuel consumption, and the most relevant pollutant emissions (CO2, CH4 and NO2) linked to combustion, for hybrid and combustion only operating modes at selected geographical locations in Spain. The considered power output ranges between 7 to 30 kWe which is achieved by varying the design specifications. The levelized cost of electricity (LCoE) indicator is estimated as a function of investment, interest rate, maintenance and fuel consumption actual costs in Spain. The electricity costs from hybrid parabolic dish are between 22% and 27% lower compared to pure combustion power plant, while specific fuel consumption and therefore CO2 emissions can be reduced up to 33%. This model shows the potential of hybrid solar dishes to become cost-competitive against non-renewable ones from the point of view of electricity costs and significant reduction in gas emission levels in regions with high solar radiation and low water resources.Junta de Castilla y Leó

On-design pre-optimization and off-design analysis of hybrid Brayton thermosolar tower power plants for different fluids and plant configurations

[EN]A working fluid performs a Brayton cycle that is fed by a heat input from a solar power tower and from a combustion chamber, which burns natural gas. This hybrid system is described by a complete model that includes all the main losses and irreversibility sources (optical and thermodynamic). Numerical implementation and validation is performed based on a Spanish commercial plant. On-design computations are carried out varying the pressure ratio for four working fluids (dry air, nitrogen, carbon dioxide, and helium), for different number of stages and for recuperative and non-recuperative configurations. When adjusting the pressure ratio, an improvement of about 7% in overall thermal efficiency is predicted for a dry air single-stage recuperative configuration with respect to a standard commercial gas turbine. A study about the main energy losses in each plant subsystem for some particular plant layouts is accomplished. A two-compression and expansion stages recuperative Brayton cycle working with air is expected to give overall thermal efficiencies about 0.29 at design conditions, which is about a 47% increase with respect to the simplest single-stage configuration. It is stressing that fuel consumption from the reheaters maybe higher than that of the main combustion chamber for multi-stage layouts. Off-design hourly curves of output records for the four seasons throughout a day are analyzed. Greenhouse emissions are also analyzed. Specific carbon dioxide emissions are smaller for helium than for dry air, when they both work in a single-stage non-recuperative configurationJunta de Castilla y León SA017P1

Aplicaciones de las nuevas herramientas de visualización de modelos 3D y realidad virtual en Internet a la docencia de la conservación y restauración del patrimonio, el diseño, y las bellas artes

Depto. de Diseño e ImagenFac. de Bellas ArtesFALSEsubmitte

Alternativas al Trabajo Fin de Master: el juego de empresas. Proyecto de Innovación y Mejora de la Calidad Docente Convocatoria 2014. Nº 279

El business game o juego de empresas es una actividad que cumple los objetivos que se señalan para un Trabajo Fin de Master y que, en opinión del grupo de trabajo de este proyecto, aporta más valor formativo para el alumno que un TFM convencional y a facilitar la finalización de la titulación dentro del curso académico

Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet

Funding: This research was funded by the Ministry of Economy and Competitivity of Spain, partly with Fondo Europeo de Desarrollo Regional FEDER funds [BFU2014-57736-P, AGL2014-58883-R, SAF2017-88457-R, AGL2017-85270-R] and by Junta de Andalucía [CTS235, CTS164]. MTG, RGB and CHC were supported by fellowships from the Ministry of Education. CIBERehd is funded by Instituto de Salud Carlos III. Institutional Review Board Statement: The study was conducted according to the guidelines of the Guide for the Care and Use of Laboratory Animals, and approved by the Animal Welfare Committee of the University of Granada (registry number: CEEA 01/03/2017–029). Informed Consent Statement: Not applicable for studies not involving humans. Acknowledgments: We gratefully acknowledge the assistance of Mercedes González and the rest of the group.The liver expresses tissue-nonspecific alkaline phosphatase (TNAP), which may participate in the defense against bacterial components, in cell regulation as part of the purinome or in bile secretion, among other roles. We aimed to study the role of TNAP in the development of hepatosteatosis. TNAP+/− haplodeficient and wild type (WT) mice were fed a control diet (containing 10% fat w/w) or the same diet deficient in methionine and choline (MCD diet). The MCD diet induced substantial weight loss together with hepatic steatosis and increased alanine aminotransferase (ALT) plasma levels, but no differences in IL-6, TNF, insulin or resistin. There were no substantial differences between TNAP+/− and WT mice fed the MCD diet. In turn, TNAP+/− mice receiving the control diet presented hepatic steatosis with alterations in metabolic parameters very similar to those induced by the MCD diet. Nevertheless, no weight loss, increased ALT plasma levels or hypoglycemia were observed. These mice also presented increased levels of liver TNF and systemic resistin and glucagon compared to WT mice. The phenotype of TNAP+/− mice fed a standard diet was normal. In conclusion, TNAP haplodeficiency induces steatosis comparable to that produced by a MCD diet when fed a control diet.Ministry of Economy and Competitivity of SpainEuropean Commission BFU2014-57736-P AGL2014-58883-R SAF2017-88457-R AGL2017-85270-RJunta de Andalucia CTS235 CTS164Ministry of EducationInstituto de Salud Carlos III European Commissio