Characterization of the Immune Response Induced by a Commercially Available Inactivated Bluetongue Virus Serotype 1 Vaccine in Sheep

The protective immune response generated by a commercial monovalent inactivated vaccine against bluetongue virus serotype 1 (BTV1) was studied. Five sheep were vaccinated, boost-vaccinated, and then challenged against BTV1 ALG/2006. RT-PCR did not detect viremia at any time during the experiment. Except a temperature increase observed after the initial and boost vaccinations, no clinical signs or lesions were observed. A specific and protective antibody response checked by ELISA was induced after vaccination and boost vaccination. This specific antibody response was associated with a significant increase in B lymphocytes confirmed by flow cytometry, while significant increases were not observed in T lymphocyte subpopulations (CD4+, CD8+, and WC1+), CD25+ regulatory cells, or CD14+ monocytes. After challenge with BTV1, the antibody response was much higher than during the boost vaccination period, and it was associated with a significant increase in B lymphocytes, CD14+ monocytes, CD25+ regulatory cells, and CD8+ cytotoxic T lymphocytes

Proyecto de mejora del estilo cognitivo

Trata el desarrollo de habilidades que ayuden al alumnado a mejorar su rendimiento a través de ejercicios que potencian la habilidad cognitiva. Pretende fomentar la reflexión e investigación individual y colectiva del profesorado en el aula, modificar en el alumnado el estilo cognitivo impulsivo haciéndoles más reflexivos e influir en la dinámica del aula fomentando las interacciones del alumnado-profesorado. La dinámica de trabajo tiene cuatro fases: identificar el problema y toma de conciencia de lo que exige, centrar la atención en la respuesta que se da a esa pregunta autoformulada, eliminar las alternativas no válidas hasta encontrar la correcta y autoevaluarse y autoesforzarse. Evalua el grado de consecución de los objetivos a partir de la observación y fichas de control.Madrid (Comunidad Autónoma). Consejería de Educación y CulturaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES

El derecho de propiedad y el acceso a la vivienda ante un nuevo escenario inmobiliario: Retos y problemas. Libro de resúmenes del VI Congreso Iberoameriano de Derecho Inmobiliario

Resúmenes del VI Congreso Iberoamericano de Derecho Inmobiliario celebrado del 29 de septiembre al 1 de octubre de 2021 en Madrid organizado por la Cátedra UC3M - UCEN de Derecho Inmobiliario y la Universidad Francisco de Vitoria.Grabación de la primera jornada 29 septiembre 2021: https://www.youtube.com/watch?v=PD98tXgvMwI .-- Gabración de la segunda jornada 30 septiembre 2021: https://www.youtube.com/watch?v=Wo0dlkzHFQE . -- Grabación de la tercera jornada 1 octubre 2021: https://www.youtube.com/watch?v=hJigjXBB04YEl trabajo "La propiedad superficiaria, la propiedad temporal y la propiedad compartida como formas alternativas para la adquisición de vivienda" de Chantal Moll de Alba forma parte del Proyecto de investigación financiado por el Ministerio de Ciencia, Innovación y Universidades “Consumidor y vivienda: acceso, financiación y resolución de conflictos” (2019-2021) PGC2018-096260-B-C21.El fenómeno de la okupación en Chile / Francisco Javier Talep Pardo (p. 9). -- El Derecho Civil en la encrucijada: la progresiva influencia de los derechos fundamentales y humanos en la "okupación de viviendas" / Héctor Simón Moreno (p. 10- ). -- Ocupación y desahucios. Problemática procesal civil y propuestas de Lege Ferenda / Alejandro Fuentes-Lojo Ríus (p. 11). -- El papel del registro de la propiedad ante la "okupación" / José Blas Pau Echave-Sustaeta (p. 12). -- Régimen jurídico del suelo y expropiación en España / Antonio Descalzo González (pp. 14-15). -- Unicidad vs estanqueidad. La unicidad de valores como criterio justo y coherente en las valoraciones para la Administración: principio general de la buena fe / Antonio Eduardo Humero Martín (p. 16). -- La permuta real forzosa como medio indirecto de expropiación / Gilberto Mendoza de Maestro (p. 17). -- El tratamiento de la ocupación ilegal en la ejecución sobre bienes inmuebles: la experiencia española / Antonio Martínez Santos (p. 19). -- Límites a la propiedad inmobiliaria en las leyes sobre vivienda. (La función social de la vivienda) / Remedios Aranda Rodríguez (pp. 20-21). -- Propiedad, propiedades y su afectación por la función social / Mónica Muñoz-Alonso López (p. 22). -- Las comunidades de propietarios ante la ocupación ilegal de una vivienda / María Rosario Martín Briceño (p. 24). -- El fenómeno "okupa" y la vulneración de los derechos fundamentales / Carmen Iglesias Martín (pp. 25-26). -- Propiedad privada y derecho natural en la Escuela Kantiana / Jesús Miguel Santos Román (p. 27). -- La Administración Pública ante los casos de ocupación ilegal de inmuebles. Procedimientos de recuperación posesoria / Elena Sánchez Utrilla (p. 28). -- El alquiler social / Emilio Murcia Quintana (p. 31). -- Modelos de gestión de vivienda social en clave europea / Nuria Lambea Llop (p. 32). -- La protección del arrendamiento de vivienda y el registro de propiedad / Pilar Verdejo García (p. 33). -- La posesión sin título habilitante en el DL. 2695 de 1979 en Chile / Santiago Zárate González (p. 35). -- Diáspora habitacional en el entorno rural / Manuel Ignacio Feliú Rey (p. 36). -- La propiedad superficiaria, la propiedad temporal y la propiedad compartida como formas alternativas para la adquisición de vivienda / Chantal Moll de Alba (pp. 37-38). -- Soluciones habitacionales en derecho comparado / Ana María de la Encarnación (p. 39). -- El derecho de propiedad y vivienda: perfiles constitucionales legales / Ángel Juárez Torrejón (pp. 41-42). -- Medidas fiscales y vivienda: una perspectiva comparada / Sofía Borgia Sorrosal (p. 43). -- Creando un mercado para la eficiencia energética de los edificios: medidas tributarias de apoyo / Zulema Calderón Corredor (p. 44). -- El fideicomiso inmobiliario como instrumento para mitigar el déficit habitacional en Iberoamérica / Maridalia Rodríguez-Padilla (pp. 46-47). -- Fomento del alquiler residencial: medidas de incentivo y garantías al propietario arrendador / Beatriz Sáenz de Jubera Higuero (pp. 48-49). -- Derecho de propiedad y normativa urbanística en relación con el patrimonio arquitectónico rural andaluz / Elena Romero Cañabate y Gema Ramírez Pacheco (p. 50). -- Registro de la propiedad y nuevas tecnologías / Javier Gómez Gálligo (pp. 52-53). -- El documento electrónico notarial / Marco Antonio Sepúlveda Larroucau (p. 55). -- Tokenización y activos físicos inmobiliarios / Jesús Sieira y Jimena Campuzano (p. 56). -- La contratación inmobiliaria en plataformas / Teresa Rodríguez de las Heras Ballell (p. 57). -- La financiación de la actividad inmobiliaria a través de plataformas de crowdfunding inmobiliario / Teresa Asunción Jiménez París (p. 59). -- El fideicomiso como mecanismo para la mitigación de riesgo en el crowdfunding inmobiliario en México / Eduardo Rocha Núñez (p. 60). -- Transmisión propiedad inmobiliaria y nuevas tecnologías / María Goñi Rodríguez de Almeida (p. 62). -- La garantía funcional de los edificios inteligentes / Alejandro Zornoza Somolinos (p. 63). -- Ciudades inteligentes y la tributación al desarrollo / Diego Bisi Almada (p. 65). -- Blockchain y tokenización para la inversión inmobiliaria / Pedro Barreda García y Gema Ramírez Pacheco (p. 66). -- El futuro de la valoración inmobiliaria. Big data y modelos AVM / Andrea San José Cabrero (p. 67). -- Reflexiones sobre la contratación con plataformas digitales intermediarias en el sector inmobiliario / Pastora de Artíñano Marra (pp. 68)

Down syndrome as risk factor for respiratory syncytial virus hospitalization : A prospective multicenter epidemiological study

Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection. In a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (±1 week) and were followed up to 1 year of age and during a complete RSV season. The hospitalization rate for all acute respiratory infection was significantly higher in the DS cohort than in the non-DS cohort (44.1% vs 7.7%, P<.0001). Hospitalizations due to RSV were significantly more frequent in the DH cohort than in the non-DS cohort (9.7% vs 1.5%, P=.03). RSV prophylaxis was recorded in 33 (35.5%) infants with DS. The rate of hospitalization according to presence or absence of RSV immunoprophylaxis was 3.0% vs 15%, respectively. Infants with DS showed a higher rate of hospitalization due to acute lower respiratory tract infection and RSV infection compared to non-DS infants. Including DS infants in recommendations for immunoprophylaxis of RSV disease should be considered

Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

International audienc

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P &lt; 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)

Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study

Item does not contain fulltextOBJECTIVES: To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection. DESIGN: A retrospective analysis of the Extended Prevalence of Infection in the ICU Study (EPIC II). Demographic, physiological, infection-related and therapeutic data were collected. Patients were grouped as having Candida, Gram-positive, Gram-negative, and combined Candida/bacterial bloodstream infection. Outcome data were assessed at intensive care unit and hospital discharge. SETTING: EPIC II included 1265 intensive care units in 76 countries. PATIENTS: Patients in participating intensive care units on study day. INTERVENTIONS: None. MEASUREMENT AND MAIN RESULTS: Of the 14,414 patients in EPIC II, 99 patients had Candida bloodstream infections for a prevalence of 6.9 per 1000 patients. Sixty-one patients had candidemia alone and 38 patients had combined bloodstream infections. Candida albicans (n = 70) was the predominant species. Primary therapy included monotherapy with fluconazole (n = 39), caspofungin (n = 16), and a polyene-based product (n = 12). Combination therapy was infrequently used (n = 10). Compared with patients with Gram-positive (n = 420) and Gram-negative (n = 264) bloodstream infections, patients with candidemia were more likely to have solid tumors (p < .05) and appeared to have been in an intensive care unit longer (14 days [range, 5-25 days], 8 days [range, 3-20 days], and 10 days [range, 2-23 days], respectively), but this difference was not statistically significant. Severity of illness and organ dysfunction scores were similar between groups. Patients with Candida bloodstream infections, compared with patients with Gram-positive and Gram-negative bloodstream infections, had the greatest crude intensive care unit mortality rates (42.6%, 25.3%, and 29.1%, respectively) and longer intensive care unit lengths of stay (median [interquartile range]) (33 days [18-44], 20 days [9-43], and 21 days [8-46], respectively); however, these differences were not statistically significant. CONCLUSION: Candidemia remains a significant problem in intensive care units patients. In the EPIC II population, Candida albicans was the most common organism and fluconazole remained the predominant antifungal agent used. Candida bloodstream infections are associated with high intensive care unit and hospital mortality rates and resource use

Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study

To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection. DESIGN: A retrospective analysis of the Extended Prevalence of Infection in the ICU Study (EPIC II). Demographic, physiological, infection-related and therapeutic data were collected. Patients were grouped as having Candida, Gram-positive, Gram-negative, and combined Candida/bacterial bloodstream infection. Outcome data were assessed at intensive care unit and hospital discharge. SETTING: EPIC II included 1265 intensive care units in 76 countries. PATIENTS: Patients in participating intensive care units on study day. INTERVENTIONS: None. MEASUREMENT AND MAIN RESULTS: Of the 14,414 patients in EPIC II, 99 patients had Candida bloodstream infections for a prevalence of 6.9 per 1000 patients. Sixty-one patients had candidemia alone and 38 patients had combined bloodstream infections. Candida albicans (n = 70) was the predominant species. Primary therapy included monotherapy with fluconazole (n = 39), caspofungin (n = 16), and a polyene-based product (n = 12). Combination therapy was infrequently used (n = 10). Compared with patients with Gram-positive (n = 420) and Gram-negative (n = 264) bloodstream infections, patients with candidemia were more likely to have solid tumors (p < .05) and appeared to have been in an intensive care unit longer (14 days [range, 5-25 days], 8 days [range, 3-20 days], and 10 days [range, 2-23 days], respectively), but this difference was not statistically significant. Severity of illness and organ dysfunction scores were similar between groups. Patients with Candida bloodstream infections, compared with patients with Gram-positive and Gram-negative bloodstream infections, had the greatest crude intensive care unit mortality rates (42.6%, 25.3%, and 29.1%, respectively) and longer intensive care unit lengths of stay (median [interquartile range]) (33 days [18-44], 20 days [9-43], and 21 days [8-46], respectively); however, these differences were not statistically significant. CONCLUSION: Candidemia remains a significant problem in intensive care units patients. In the EPIC II population, Candida albicans was the most common organism and fluconazole remained the predominant antifungal agent used. Candida bloodstream infections are associated with high intensive care unit and hospital mortality rates and resource use