1,872 research outputs found
Age of second language acquisition affects nonverbal conflict processing in children : an fMRI study
Background: In their daily communication, bilinguals switch between two languages, a process that involves the selection of a target language and minimization of interference from a nontarget language. Previous studies have uncovered the neural structure in bilinguals and the activation patterns associated with performing verbal conflict tasks. One question that remains, however is whether this extra verbal switching affects brain function during nonverbal conflict tasks.
Methods: In this study, we have used fMRI to investigate the impact of bilingualism in children performing two nonverbal tasks involving stimulus-stimulus and stimulus-response conflicts. Three groups of 8-11-year-old children - bilinguals from birth (2L1), second language learners (L2L), and a control group of monolinguals (1L1) - were scanned while performing a color Simon and a numerical Stroop task. Reaction times and accuracy were logged.
Results: Compared to monolingual controls, bilingual children showed higher behavioral congruency effect of these tasks, which is matched by the recruitment of brain regions that are generally used in general cognitive control, language processing or to solve language conflict situations in bilinguals (caudate nucleus, posterior cingulate gyrus, STG, precuneus). Further, the activation of these areas was found to be higher in 2L1 compared to L2L.
Conclusion: The coupling of longer reaction times to the recruitment of extra language-related brain areas supports the hypothesis that when dealing with language conflicts the specialization of bilinguals hampers the way they can process with nonverbal conflicts, at least at early stages in life
Aligning physical elements with persons' attitude: an approach using Rasch measurement theory
Affective engineering uses mathematical models to convert the information obtained from persons' attitude to physical elements into an ergonomic design. However, applications in the domain have not in many cases met measurement assumptions. This paper proposes a novel approach based on Rasch measurement theory to overcome the problem. The research demonstrates that if data fit the model, further variables can be added to a scale. An empirical study was designed to determine the range of compliance where consumers could obtain an impression of a moisturizer cream when touching some product containers. Persons, variables and stimulus objects were parameterised independently on a linear continuum. The results showed that a calibrated scale preserves comparability although incorporating further variables
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The use of large animals to facilitate the process of MSC going from laboratory to patientââbench to bedsideâ
Abstract: Large animal models have been widely used to facilitate the translation of mesenchymal stem cells (MSC) from the laboratory to patient. MSC, with their multi-potent capacity, have been proposed to have therapeutic benefits in a number of pathological conditions. Laboratory studies allow the investigation of cellular and molecular interactions, while small animal models allow initial âproof of conceptâ experiments. Large animals (dogs, pigs, sheep, goats and horses) are more similar physiologically and structurally to man. These models have allowed clinically relevant assessments of safety, efficacy and dosing of different MSC sources prior to clinical trials. In this review, we recapitulate the use of large animal models to facilitate the use of MSC to treat myocardial infarctionâan example of one large animal model being considered the âgold standardâ for research and osteoarthritisâan example of the complexities of using different large animal models in a multifactorial disease. These examples show how large animals can provide a research platform that can be used to evaluate the value of cell-based therapies and facilitate the process of âbench to bedsideâ
Recommended from our members
The use of large animals to facilitate the process of MSC going from laboratory to patientââbench to bedsideâ
Abstract: Large animal models have been widely used to facilitate the translation of mesenchymal stem cells (MSC) from the laboratory to patient. MSC, with their multi-potent capacity, have been proposed to have therapeutic benefits in a number of pathological conditions. Laboratory studies allow the investigation of cellular and molecular interactions, while small animal models allow initial âproof of conceptâ experiments. Large animals (dogs, pigs, sheep, goats and horses) are more similar physiologically and structurally to man. These models have allowed clinically relevant assessments of safety, efficacy and dosing of different MSC sources prior to clinical trials. In this review, we recapitulate the use of large animal models to facilitate the use of MSC to treat myocardial infarctionâan example of one large animal model being considered the âgold standardâ for research and osteoarthritisâan example of the complexities of using different large animal models in a multifactorial disease. These examples show how large animals can provide a research platform that can be used to evaluate the value of cell-based therapies and facilitate the process of âbench to bedsideâ
A Bell Inequality Analog in Quantum Measure Theory
One obtains Bell's inequalities if one posits a hypothetical joint
probability distribution, or {\it measure}, whose marginals yield the
probabilities produced by the spin measurements in question. The existence of a
joint measure is in turn equivalent to a certain causality condition known as
``screening off''. We show that if one assumes, more generally, a joint {\it
quantal measure}, or ``decoherence functional'', one obtains instead an
analogous inequality weaker by a factor of . The proof of this
``Tsirel'son inequality'' is geometrical and rests on the possibility of
associating a Hilbert space to any strongly positive quantal measure. These
results lead both to a {\it question}: ``Does a joint measure follow from some
quantal analog of `screening off'?'', and to the {\it observation} that
non-contextual hidden variables are viable in histories-based quantum
mechanics, even if they are excluded classically.Comment: 38 pages, TeX. Several changes and added comments to bring out the
meaning more clearly. Minor rewording and extra acknowledgements, now closer
to published versio
Simulating causal collapse models
We present simulations of causal dynamical collapse models of field theories
on a 1+1 null lattice. We use our simulations to compare and contrast two
possible interpretations of the models, one in which the field values are real
and the other in which the state vector is real. We suggest that a procedure of
coarse graining and renormalising the fundamental field can overcome its
noisiness and argue that this coarse grained renormalised field will show
interesting structure if the state vector does on the coarse grained scale.Comment: 18 pages, 8 fugures, LaTeX, Reference added, discussion of
probability distribution of labellings correcte
Causal Sets: Quantum gravity from a fundamentally discrete spacetime
In order to construct a quantum theory of gravity, we may have to abandon
certain assumptions we were making. In particular, the concept of spacetime as
a continuum substratum is questioned. Causal Sets is an attempt to construct a
quantum theory of gravity starting with a fundamentally discrete spacetime. In
this contribution we review the whole approach, focusing on some recent
developments in the kinematics and dynamics of the approach.Comment: 10 pages, review of causal sets based on talk given at the 1st MCCQG
conferenc
The structure of causal sets
More often than not, recently popular structuralist interpretations of
physical theories leave the central concept of a structure insufficiently
precisified. The incipient causal sets approach to quantum gravity offers a
paradigmatic case of a physical theory predestined to be interpreted in
structuralist terms. It is shown how employing structuralism lends itself to a
natural interpretation of the physical meaning of causal sets theory.
Conversely, the conceptually exceptionally clear case of causal sets is used as
a foil to illustrate how a mathematically informed rigorous conceptualization
of structure serves to identify structures in physical theories. Furthermore, a
number of technical issues infesting structuralist interpretations of physical
theories such as difficulties with grounding the identity of the places of
highly symmetrical physical structures in their relational profile and what may
resolve these difficulties can be vividly illustrated with causal sets.Comment: 19 pages, 4 figure
Quantum Histories and Quantum Gravity
This paper reviews the histories approach to quantum mechanics. This
discussion is then applied to theories of quantum gravity. It is argued that
some of the quantum histories must approximate (in a suitable sense) to
classical histories, if the correct classical regime is to be recovered. This
observation has significance for the formulation of new theories (such as
quantum gravity theories) as it puts a constraint on the kinematics, if the
quantum/classical correspondence principle is to be preserved. Consequences for
quantum gravity, particularly for Lorentz symmetry and the idea of "emergent
geometry", are discussed.Comment: 35 pages (29 pages main body), two figure
A Study of the Soft X-Ray Emission Lines in NGC 4151. I. Kinematic Properties of the Plasma Wind
We present our analysis of the narrow emission lines produced in the plasma regions within the bright active galactic nucleus of NGC 4151, from an ORBYTS research-with-schools public engagement project. Our goal was to test whether the properties of these plasma regions changed between XMM-Newton observations spanning 15 yr from 2000 to 2015, by measuring the outflow velocities and distances. From this study, we found that NGC 4151 has at least two to three plasma regions. There is no evidence of the outflowing wind properties changing as the velocities and distances are consistent throughout the observations
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