Woolly hair nevus: case report and review of literature

Woolly hair nevus consists of a patch of curly and hypopigmented hair that is restricted to an area of the scalp. It is usually benign but it can be associated with other systemic findings. Trichoscopy and dermoscopy may be useful when analyzing this entity. The authors describe a case of woolly hair nevus in a 5-year-old boy and present a review of the literature of woolly hair nevus, including classification, histopathology, associated systemic findings, and the recent described genetic mutations

International Year of Soils 2015: oportunity to promote an integrated administration of soils in Portugal?

Resumo: Neste trabalho assinala-se o retrocesso da administração do recurso solo em Portugal ao longo dos últimos 40 anos, em contraponto com a evolução recente a nível europeu (Estratégia Temática para a Protecção do Solo) e a nível global (Parceria Global para o Solo, Dia Mundial do Solo e Ano Internacional dos Solos 2015, AIS-2015). Aproveitando o impulso internacional neste domínio apresenta-se a Parceria Portuguesa para o Solo (PPS), como mais uma iniciativa que procura inverter o processo de regressão e de dispersão de esforços na administração dos solos do país. Correspondendo aos objectivos estratégicos da PPS, também apresentados, propõem-se e justificam-se sumariamente duas acções a mais curto prazo: a harmonização da cartografia de solos do país à escala 1:250.000 ou 1:500.000 e a constituição de um Sistema Nacional de Informação de Solos (SNIS). A Carta Mundial dos Solos, revista em 2015, insta os governos nacionais a desenvolverem uma política nacional do solo, um sistema nacional de informação de solos e uma estrutura institucional para monitorizar os recursos do solo. O AIS-2015 representa uma oportunidade excepcional para despoletar a implementação de uma política (integrada) do solo em Portugal e de um SNIS como ferramenta pivô para essa política. ---------- Abstract: In this work it is pointed out the recession of the administration of soil resources in Portugal in the last 40 years, as opposed to the recent development actions at European level (Thematic Strategy for Soil Protection) and at global level (Global Soil Partnership, World Soil Day and International Year of Soils 2015, IYS-2015). Taking advantage of the international momentum in this field it is presented the Portuguese Soil Partnership (PtSP) as an initiative that aims to reverse the process of regression and the dispersion of efforts in the national administration of the soils. Accordingly with the PtSP's strategic objectives, also presented, two short-term actions are proposed: the harmonization of the country's soil maps at 1: 250,000 or 1: 500,000 scale, and the establishment of a National Soil Information System (NSIS). The World Soil Charter, revised in 2015, strongly recommends that national governments develop a national land policy, a national land information system and an institutional framework to monitor soil resources. The IYS-2015 would be an exceptional opportunity to trigger the implementation of an (integrated) soil policy in Portugal and a NSIS as a pivot tool for this policy

Cellular interactions in the tumor microenvironment: the role of secretome

Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix. These components of the tumor microenvironment and the neoplastic cells interact with each other providing pro and antitumor signals. The tumor-stroma communication occurs directly between cells or via a variety of molecules secreted, such as growth factors, cytokines, chemokines and microRNAs. This secretome, which derives not only from tumor cells but also from cancer-associated stromal cells, is an important source of key regulators of the tumorigenic process. Their screening and characterization could provide useful biomarkers to improve cancer diagnosis, prognosis, and monitoring of treatment responses.Agência financiadora Fundação de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) FAPESP 10/51168-0 12/06048-2 13/03839-1 National Council for Scientific and Technological Development (CNPq) CNPq 306216/2010-8 Fundacao para a Ciencia e a Tecnologia (FCT) UID/BIM/04773/2013 CBMR 1334info:eu-repo/semantics/publishedVersio

Ciência em sala de aula: extraindo DNA

Anais do II Seminário Seminário Estadual PIBID do Paraná: tecendo saberes / organizado por Dulcyene Maria Ribeiro e Catarina Costa Fernandes — Foz do Iguaçu: Unioeste; Unila, 2014Para uma melhor formação educacional dos alunos diante da grade de aulas escolar, é importante a realização de atividades práticas para maior assimilação do conteúdo proposto expositivamente pelos professores. Como exemplo de um tema de grande importância para formação do aluno é sobre a molécula ácido desoxirribonucleico (DNA), molécula com importância de carregar a informação genética das espécies, e que na maioria das vezes é trabalhada em forma de aulas expositivas. Este trabalho tem como enfoque, apresentar em sala de aula, uma aula pratica de extração de DNA, onde será possível ver um aglomerado, e neste aglomerado estar presente o DNA. São apresentados a metodologia e materiais corretos a extrair com eficácia a molécula, além do que, também orientações sobre o experimento e aplicação de uma avaliação na forma de discussão com os alunos para melhor assimilar o conteúd

Direct Application of the Phase Estimation Algorithm to Find the Eigenvalues of the Hamiltonians

The eigenvalue of a Hamiltonian, $\mathcal{H}$, can be estimated through the phase estimation algorithm given the matrix exponential of the Hamiltonian, $exp(-i\mathcal{H})$. The difficulty of this exponentiation impedes the applications of the phase estimation algorithm particularly when $\mathcal{H}$ is composed of non-commuting terms. In this paper, we present a method to use the Hamiltonian matrix directly in the phase estimation algorithm by using an ancilla based framework: In this framework, we also show how to find the power of the Hamiltonian matrix-which is necessary in the phase estimation algorithm-through the successive applications. This may eliminate the necessity of matrix exponential for the phase estimation algorithm and therefore provide an efficient way to estimate the eigenvalues of particular Hamiltonians. The classical and quantum algorithmic complexities of the framework are analyzed for the Hamiltonians which can be written as a sum of simple unitary matrices and shown that a Hamiltonian of order $2^n$ written as a sum of $L$ number of simple terms can be used in the phase estimation algorithm with $(n+1+logL)$ number of qubits and $O(2^anL)$ number of quantum operations, where $a$ is the number of iterations in the phase estimation. In addition, we use the Hamiltonian of the hydrogen molecule as an example system and present the simulation results for finding its ground state energy.Comment: 10 pages, 3 figure

13th FINA World Championships: analysis of swimsuits used by elite male swimmers

The purpose of this study was to describe the distribution of different swimsuits models used by male swimmers during all the finals at the 13th FINA World Championships, being held at Rome in 2009. Simultaneously, it was intended to verify the distribution of the different swimsuits used along the distances of the freestyle finals, and thus to understand the preferences of the top-level swimmers. It were used the results databases from the 13th FINA World Championships, in Rome 2009. Only the male swimmers participating at the finals were analyzed, for a total number of 17 individual swimming events. The wear swimsuit by each swimmer in a given event was observed from video recorded of the television broadcast. Male swimmers participating in the finals limited their choice to seven types of commercial swimsuits, of four different sports brands. Jaked01 Full® was the most used (47.07%), followed by the Powerskin X-Glide Full® (34.56%), the Powerskin X-Glide Pants® (7.35%) and the LZR Racer Full® (5.15%). In freestyle swimming events most of the male swimmers choose to wear full body swimsuits. Jaked01 Full® was predominant in the 50 m event, with 62.50% of swimmers choices. This value decreases to 25.00% when analyzing 100 m event, and remained similar over the longer distances swum. The Powerskin X-Glide Full® was used for 37.50% of the swimmers in 50 m swimming event, and it increases to 62.50% for the 100 m freestyle. These results seem to demonstrate that swimmers have preferences for full swimsuits, and for these two swimsuits, the Powerskin X-Glide Full® and the Jaked01 Full®

Effect of culture time and gender of nuclei donor cells on bovine development produced by nuclear transfer

Objetivou-se com este trabalho avaliar o efeito do número da passagem e do sexo das células doadoras de núcleo no desenvolvimento embrionário e fetal após transferência nuclear. Para isso, oócitos bovinos foram maturados, enucleados e reconstruídos com células somáticas de animal adulto. Após a fusão e ativação química, os zigotos reconstituídos foram cultivados em Charles Rosenkranz 2 (CR2) com monocamada de células da granulosa a 38,8ºC em atmosfera umidificada a 5% de CO2 em ar, durante sete dias, e transferidos para receptoras sincronizadas. As taxas de clivagem e desenvolvimento a blastocisto de embriões reconstruídos com células cultivadas por tempo maior foram inferiores às obtidas com os demais tempos de cultivo. Além disso, os blastocistos produzidos não resultaram no desenvolvimento de uma gestação a termo. Embora a taxa de clivagem em embriões fêmeas tenha sido maior, o número de embriões que atingiram o estádio de blastocisto foi maior nos embriões machos. No período gestacional, fêmeas apresentaram maior taxa de aborto entre 90 e 120 dias de gestação. Esses resultados indicam que células doadoras de núcleos cultivados por longos períodos dificultam a produção de blastocistos e aumentam as chances de perdas durante a gestação. Embriões clonados machos têm maior competência para se desenvolver a blastocisto e resultam em menor taxa de perda gestacional.The objective of this study was to evaluate the effects of culture time and sex of nuclei donor cells on embryo and fetal development after nuclear transfer. Thus, bovine oocytes were matured, enucleated and reconstructed with somatic cells from an adult animal. After fusion and chemical activation, the reconstituted zygotes were cultured in Charles Rosenkranz 2 (CR2) on a granular monolayer cell at 38.8ºC in a humidified atmosphere 5% CO2 in air for seven days, and transferred to synchronized receptors. Cleavage rates and development to blastocyst of embryo reconstructed with cells cultured for a longer time were lower than rates obtained with other culture times. Moreover, these produced blastocysts did not result in the development of full term pregnancy. Although cleavage rates were higher in female embryos, the number of embryos that reached blastocyst stage was higher in male embryos. During gestation period, females showed higher abortion rates from 90 to 120 days of gestation. These results indicate that cells donnors of nuclei cultured for long periods make the production of blastocysts difficult and increase the chances of losses during pregnancy. Cloned male embryos are more succesful in becoming blastocysts and result in lower gestational loss rate.À Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

L'acquisition de procédures scientifiques auprès de lycéens brésiliens

El estudio tuvo como objetivo identificar la comprensión por parte de los estudiantes, que han participado de un proyecto de Iniciación Científica Junior, sobre aspectos referentes a los procedimientos en Ciencias como la identificación del problema a ser investigado, elaboración de un plan de trabajo para resolución de un problema, obtención y organización de los datos. El proyecto de iniciación Científica Junior fue realizado entre la escuela y una universidad. Los resultados señalaron que dichos alumnos presentaron más dificultades en elaborar un plan de trabajo para resolver el problema e identificar evidencias; por otra parte, presentaron mejor comprensión en la manera de registrar los datos. Esas informaciones contribuyeron para orientar las actividades de Iniciación Científica proporcionando a los alumnos mejor entendimiento de los procedimientos utilizados en Ciencia.The objective of this study was to identify the understanding of students who participated in a Jr Initiative Project, in relation to aspects related to the procedures in Sciences, such as identification of the problem to be investigated, elaboration of a work plan for problem solving, organization of the data. The Jr Scientific initiation project was conducted between the school and a university. The results indicated that these students had more difficulties in developing a work plan to solve the problem and to identify evidence, on the other hand, they presented a better understanding of how to record the data. This information provided elements to guide the activities of Scientific Initiation to provide students with a better understanding of the procedures used to establish scientific knowledge.L'objectif de cette étude était d'identifier la compréhension des étudiants qui ont participé à un projet d'initiative Jr, en relation avec des aspects liés aux procédures en sciences, comme l'identification du problème à étudier, l'élaboration d'un plan de travail pour la résolution de problèmes, organisation des données. Le projet d'initiation Jr Scientific a été mené entre l'école et une université. Les résultats indiquaient que ces étudiants avaient plus de difficultés à élaborer un plan de travail pour résoudre le problème et identifier les preuves, d'autre part, ils ont présenté une meilleure compréhension de la façon d'enregistrer les données. Cette information a fourni des éléments pour guider les activités de l'Initiation Scientifique afin de fournir aux élèves une meilleure compréhension des procédures utilisées pour établir les connaissances scientifiques