1,081 research outputs found
P35. Intratumoral patterns of clonal evolution in meningiomas
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Notes on Conformal Invisibility Devices
As a consequence of the wave nature of light, invisibility devices based on
isotropic media cannot be perfect. The principal distortions of invisibility
are due to reflections and time delays. Reflections can be made exponentially
small for devices that are large in comparison with the wavelength of light.
Time delays are unavoidable and will result in wave-front dislocations. This
paper considers invisibility devices based on optical conformal mapping. The
paper shows that the time delays do not depend on the directions and impact
parameters of incident light rays, although the refractive-index profile of any
conformal invisibility device is necessarily asymmetric. The distortions of
images are thus uniform, which reduces the risk of detection. The paper also
shows how the ideas of invisibility devices are connected to the transmutation
of force, the stereographic projection and Escheresque tilings of the plane
Synaptic abnormalities in the infralimbic cortex of a model of congenital depression
Multiple lines of evidence suggest that disturbances in excitatory transmission contribute to depression. Whether these defects involve the number, size, or composition of glutamatergic contacts is unclear. This study used recently introduced procedures for fluorescence deconvolution tomography in a well-studied rat model of congenital depression to characterize excitatory synapses in layer I of infralimbic cortex, a region involved in mood disorders, and of primary somatosensory cortex. Three groups were studied: (1) rats bred for learned helplessness (cLH); (2) rats resistant to learned helplessness (cNLH); and (3) control Sprague Dawley rats. In fields within infralimbic cortex, cLH rats had the same numerical density of synapses, immunolabeled for either the postsynaptic density (PSD) marker PSD95 or the presynaptic protein synaptophysin, as controls. However, PSD95 immunolabeling intensities were substantially lower in cLH rats, as were numerical densities of synapse-sized clusters of the AMPA receptor subunit GluA1. Similar but less pronounced differences (comparable numerical densities but reduced immunolabeling intensity for PSD95) were found in the somatosensory cortex. In contrast, non-helpless rats had 25% more PSDs than either cLH or control rats without any increase in synaptophysin-labeled terminal frequency. Compared with controls, both cLH and cNLH rats had fewer GABAergic contacts. These results indicate that congenital tendencies that increase or decrease depression-like behavior differentially affect excitatory synapses
Generation of nonground-state Bose-Einstein condensates by modulating atomic interactions
A technique is proposed for creating nonground-state Bose-Einstein
condensates in a trapping potential by means of the temporal modulation of
atomic interactions. Applying a time-dependent spatially homogeneous magnetic
field modifies the atomic scattering length. An alternating modulation of the
scattering length excites the condensate, which, under special conditions, can
be transferred to an excited nonlinear coherent mode. It is shown that there
occurs a phase-transition-like behavior in the time-averaged population
imbalance between the ground and excited states. The application of the
suggested technique to realistic experimental conditions is analyzed and it is
shown that the considered effect can be realized for experimentally available
condensates.Comment: 6 pages, 2 figures, 1 tabl
Basics of Generalized Unitarity
We review generalized unitarity as a means for obtaining loop amplitudes from
on-shell tree amplitudes. The method is generally applicable to both
supersymmetric and non-supersymmetric amplitudes, including non-planar
contributions. Here we focus mainly on N=4 Yang-Mills theory, in the context of
on-shell superspaces. Given the need for regularization at loop level, we also
review a six-dimensional helicity-based superspace formalism and its
application to dimensional and massive regularizations. An important feature of
the unitarity method is that it offers a means for carrying over any identified
tree-level property of on-shell amplitudes to loop level, though sometimes in a
modified form. We illustrate this with examples of dual conformal symmetry and
a recently discovered duality between color and kinematics.Comment: 37 pages, 10 figures. Invited review for a special issue of Journal
of Physics A devoted to "Scattering Amplitudes in Gauge Theories", R.
Roiban(ed), M. Spradlin(ed), A. Volovich(ed
Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions
Altered glucocorticoid receptor (GR) signaling is a postulated mechanism for the pathogenesis of major depression. To mimic the human situation of altered GR function claimed for depression, we generated mouse strains that underexpress or overexpress GR, but maintain the regulatory genetic context controlling the GR gene. To achieve this goal, we used the following: (1) GR-heterozygous mutant mice (GR+/-) with a 50% GR gene dose reduction, and (2) mice overexpressing GR by a yeast artificial chromosome resulting in a twofold gene dose elevation. GR+/- mice exhibit normal baseline behaviors but demonstrate increased helplessness after stress exposure, a behavioral correlate of depression in mice. Similar to depressed patients, GR+/- mice have a disinhibited hypothalamic-pituitary-adrenal (HPA) system and a pathological dexamethasone/corticotropin-releasing hormone test. Thus, they represent a murine depression model with good face and construct validity. Overexpression of GR in mice evokes reduced helplessness after stress exposure, and an enhanced HPA system feedback regulation. Therefore, they may represent a model for a stress-resistant strain. These mouse models can now be used to study biological changes underlying the pathogenesis of depressive disorders. As a first potential molecular correlate for such changes, we identified a downregulation of BDNF protein content in the hippocampus of GR+/- mice, which is in agreement with the so-called neurotrophin hypothesis of depression
Hopf algebras, coproducts and symbols: an application to Higgs boson amplitudes
We show how the Hopf algebra structure of multiple polylogarithms can be used
to simplify complicated expressions for multi-loop amplitudes in perturbative
quantum field theory and we argue that, unlike the recently popularized
symbol-based approach, the coproduct incorporates information about the zeta
values. We illustrate our approach by rewriting the two-loop helicity
amplitudes for a Higgs boson plus three gluons in a simplified and compact form
involving only classical polylogarithms.Comment: 46 page
C-axis lattice dynamics in Bi-based cuprate superconductors
We present results of a systematic study of the c axis lattice dynamics in
single layer Bi2Sr2CuO6 (Bi2201), bilayer Bi2Sr2CaCu2O8 (Bi2212) and trilayer
Bi2Sr2Ca2Cu3O10 (Bi2223) cuprate superconductors. Our study is based on both
experimental data obtained by spectral ellipsometry on single crystals and
theoretical calculations. The calculations are carried out within the framework
of a classical shell model, which includes long-range Coulomb interactions and
short-range interactions of the Buckingham form in a system of polarizable
ions. Using the same set of the shell model parameters for Bi2201, Bi2212 and
Bi2223, we calculate the frequencies of the Brillouin-zone center phonon modes
of A2u symmetry and suggest the phonon mode eigenvector patterns. We achieve
good agreement between the calculated A2u eigenfrequencies and the experimental
values of the c axis TO phonon frequencies which allows us to make a reliable
phonon mode assignment for all three Bi-based cuprate superconductors. We also
present the results of our shell model calculations for the Gamma-point A1g
symmetry modes in Bi2201, Bi2212 and Bi2223 and suggest an assignment that is
based on the published experimental Raman spectra. The
superconductivity-induced phonon anomalies recently observed in the c axis
infrared and resonant Raman scattering spectra in trilayer Bi2223 are
consistently explained with the suggested assignment.Comment: 29 pages, 13 figure
Spectral Parameters for Scattering Amplitudes in N=4 Super Yang-Mills Theory
49 pages, 20 figures; v2: typos fixedPlanar N=4 Super Yang-Mills theory appears to be a quantum integrable four-dimensional conformal theory. This has been used to find equations believed to describe its exact spectrum of anomalous dimensions. Integrability seemingly also extends to the planar space-time scattering amplitudes of the N=4 model, which show strong signs of Yangian invariance. However, in contradistinction to the spectral problem, this has not yet led to equations determining the exact amplitudes. We propose that the missing element is the spectral parameter, ubiquitous in integrable models. We show that it may indeed be included into recent on-shell approaches to scattering amplitude integrands, providing a natural deformation of the latter. Under some constraints, Yangian symmetry is preserved. Finally we speculate that the spectral parameter might also be the regulator of choice for controlling the infrared divergences appearing when integrating the integrands in exactly four dimensions.Peer reviewe
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