Atlas van de trekvaarten in Zuid-Holland

Review of a book written by Marca Bultink, Jacques Moerman, Marloes Wellenberg en Ad van der Zee (eds.)Bespreking van een boek van Marca Bultink, Jacques Moerman, Marloes Wellenberg en Ad van der Zee (red.

Het landschap bewaard: Natuur en erfgoed bij Natuurmonumenten

Book review of a book by Michiel PurmerBoekbespreking van een boek van Michiel Purme

Hollands erfgoed: De stand van het onderzoek naar de geschiedenis van architectuur, stedenbouw en cultuurlandschap

In its recent publication Erfgoedbalans, the new National Service for Archaeology, Cultural Landscape and Built Heritage (RACM) provides a national overview of its three areas of responsibility: built heritage, manmade landscape and archaeological heritage.1 A general introductory chapter on heritage and heritage conservation is followed by chapters on the heritage stock in the Netherlands and the state of its conservation. The fourth chapter is about the present state of knowledge and gaps in it, while the fifth discusses education and public relations. This is followed by a chapter on spatial trends and another about policy. The final chapter discusses a number of specific topical themes, such as the consequences of the Malta Convention, the Belvedere Plan, the reuse and preservation of historical buildings and structures, and funding issues. The volume closes with an atlas section with a number of thematic maps for each province. This article will not summarize the entire content of the Erfgoedbalans. Given the theme of the journal OverHolland, we shall focus on the state of research on the history of architecture, urban planning and the manmade landscape, especially in the provinces of North and South Holland, within the wider context of the Netherlands. A brief review of the background that led to the Erfgoedbalans will be followed by a section on the heritage stock − that is, the buildings, sites and landscapes that are considered to be of value, whether or not these enjoy protected status, before considering the state of research on this heritage. Onlangs verscheen de Erfgoedbalans, waarin de Rijksdienst voor Archeologie, Cultuurlandschap en Monumenten (RACM) een overzicht op nationale schaal geeft van de drie thema’s waarmee de nieuw gevormde rijksdienst zich bezighoudt: gebouwd erfgoed, cultuurlandschap en archeologisch erfgoed.1 Na een algemeen inleidend hoofdstuk over erfgoed en erfgoedzorg volgen hoofdstukken over de voorraad en de staat van het erfgoed in Nederland. Het vierde hoofdstuk gaat over kennis en kennislacunes, het vijfde over publiek en educatie. Daarna volgen een hoofdstuk over ruimtelijke ontwikkelingen en een over beleid. In het laatste hoofdstuk komen enkele specifieke actuele thema’s aan de orde, zoals de effecten van het verdrag van Malta, Belvedere, herbestemming en instandhouding van monumenten en de financiering daarvan. De balans sluit af met een atlasdeel, waarin per provincie een aantal thema’s in kaarten is weergegeven. In dit artikel geven we geen samenvatting van de complete inhoud van de Erfgoedbalans. Gezien de thematiek van OverHolland spitsen we het toe op de stand van het onderzoek naar de geschiedenis van architectuur, stedenbouw en cultuurlandschap, in het bijzonder in de provincies Noord en Zuid-Holland, binnen de context van heel Nederland. Nadat we kort de voorgeschiedenis van de Erfgoedbalans hebben belicht, wijden we een paragraaf aan de voorraad, waarmee (al dan niet beschermde) waardevolle gebouwen, gezichten en landschappen worden bedoeld, om vervolgens in te gaan op de stand van onderzoek naar die voorraad

Clearance of influenza virus from the lung depends on migratory langerin+CD11b− but not plasmacytoid dendritic cells

Although dendritic cells (DCs) play an important role in mediating protection against influenza virus, the precise role of lung DC subsets, such as CD11b− and CD11b+ conventional DCs or plasmacytoid DCs (pDCs), in different lung compartments is currently unknown. Early after intranasal infection, tracheal CD11b−CD11chi DCs migrated to the mediastinal lymph nodes (MLNs), acquiring co-stimulatory molecules in the process. This emigration from the lung was followed by an accumulation of CD11b+CD11chi DCs in the trachea and lung interstitium. In the MLNs, the CD11b+ DCs contained abundant viral nucleoprotein (NP), but these cells failed to present antigen to CD4 or CD8 T cells, whereas resident CD11b−CD8α+ DCs presented to CD8 cells, and migratory CD11b−CD8α− DCs presented to CD4 and CD8 T cells. When lung CD11chi DCs and macrophages or langerin+CD11b−CD11chi DCs were depleted using either CD11c–diphtheria toxin receptor (DTR) or langerin-DTR mice, the development of virus-specific CD8+ T cells was severely delayed, which correlated with increased clinical severity and a delayed viral clearance. 120G8+ CD11cint pDCs also accumulated in the lung and LNs carrying viral NP, but in their absence, there was no effect on viral clearance or clinical severity. Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus

The CHeriScape project, 2014-2016 : key messages from CHeriScape : cultural solutions for cultural problems

publishedVersio

Brief cognitive behavioral therapy compared to general practitioners care for depression in primary care: a randomized trial

<p>Abstract</p> <p>Background</p> <p>Depressive disorders are highly prevalent in primary care (PC) and are associated with considerable functional impairment and increased health care use. Research has shown that many patients prefer psychological treatments to pharmacotherapy, however, it remains unclear which treatment is most optimal for depressive patients in primary care.</p> <p>Methods/Design</p> <p>A randomized, multi-centre trial involving two intervention groups: one receiving brief cognitive behavioral therapy and the other receiving general practitioner care. General practitioners from 109 General Practices in Nijmegen and Amsterdam (The Netherlands) will be asked to include patients aged between 18-70 years presenting with depressive symptomatology, who do not receive an active treatment for their depressive complaints. Patients will be telephonically assessed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) to ascertain study eligibility. Eligible patients will be randomized to one of two treatment conditions: either 8 sessions of cognitive behavioral therapy by a first line psychologist or general practitioner's care according to The Dutch College of General Practitioners Practice Guideline (NHG- standaard). Baseline and follow-up assessments are scheduled at 0, 6, 12 and 52 weeks following the start of the intervention. Primary outcome will be measured with the Hamilton Depression Rating Scale-17 (HDRS-17) and the Patient Health Questionnaire-9 (PHQ-9). Outcomes will be analyzed on an intention to treat basis.</p> <p>Trial Registration</p> <p>ISRCTN65811640</p

ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): ASL pipeline inventory

Purpose: To create an inventory of image processing pipelines of arterial spin labeling (ASL) and list their main features, and to evaluate the capability, flexibility, and ease of use of publicly available pipelines to guide novice ASL users in selecting their optimal pipeline. Methods: Developers self‐assessed their pipelines using a questionnaire developed by the Task Force 1.1 of the ISMRM Open Science Initiative for Perfusion Imaging. Additionally, each publicly available pipeline was evaluated by two independent testers with basic ASL experience using a scoring system created for this purpose. Results: The developers of 21 pipelines filled the questionnaire. Most pipelines are free for noncommercial use (n = 18) and work with the standard NIfTI (Neuroimaging Informatics Technology Initiative) data format (n = 15). All pipelines can process standard 3D single postlabeling delay pseudo‐continuous ASL images and primarily differ in their support of advanced sequences and features. The publicly available pipelines (n = 9) were included in the independent testing, all of them being free for noncommercial use. The pipelines, in general, provided a trade‐off between ease of use and flexibility for configuring advanced processing options. Conclusion: Although most ASL pipelines can process the common ASL data types, only some (namely, ASLPrep, ASLtbx, BASIL/Quantiphyse, ExploreASL, and MRICloud) are well‐documented, publicly available, support multiple ASL types, have a user‐friendly interface, and can provide a useful starting point for ASL processing. The choice of an optimal pipeline should be driven by specific data to be processed and user experience, and can be guided by the information provided in this ASL inventory

A Large-Scale Full GBA1 Gene Screening in Parkinson's Disease in the Netherlands

Background: The most common genetic risk factor for Parkinson’s disease known is a damaging variant in the GBA1 gene. The entire GBA1 gene has rarely been studied in a large cohort from a single population. The objective of this study was to assess the entire GBA1 gene in Parkinson’s disease from a single large population. Methods: The GBA1 gene was assessed in 3402 Dutch Parkinson’s disease patients using nextgeneration sequencing. Frequencies were compared with Dutch controls (n = 655). Family history of Parkinson’s disease was compared in carriers and noncarriers. Results: Fifteen percent of patients had a GBA1 nonsynonymous variant (including missense, frameshift, and recombinant alleles), compared with 6.4% of c