121 research outputs found
Cavity sensitivity correction factors for alanine dosimetry in Bruker EMX-micro EPR spectrometers
The CORALIE survey for southern extra-solar planets. X. A Hot Jupiter orbiting HD73256
Recent radial-velocity measurements obtained with the CORALIE spectrograph on
the 1.2-m Euler Swiss telescope at La Silla unveil the presence of a new
Jovian-mass Hot Jupiter around HD 73256. The 1.85-M_Jup planet moves on an
extremely short-period (P=2.5486 d), quasi-circular orbit. The best Keplerian
orbital solution is presented together with an unsuccessful photometric
planetary-transit search performed with the SAT Danish telescope at La Silla.
Over the time span of the observations, the photometric follow-up of the
candidate has nevertheless revealed a P=14-d photometric periodicity
corresponding to the rotational period of the star. This variation as well as
the radial-velocity jitter around the Keplerian solution are shown to be
related to the fair activity level known for HD 73256.Comment: 7 pages, 7 figures. Accepted in A&
Broadband quadrature-squeezed vacuum and nonclassical photon number correlations from a nanophotonic device
We report the first demonstrations of both quadrature squeezed vacuum and
photon number difference squeezing generated in an integrated nanophotonic
device. Squeezed light is generated via strongly driven spontaneous four-wave
mixing below threshold in silicon nitride microring resonators. The generated
light is characterized with both homodyne detection and direct measurements of
photon statistics using photon number-resolving transition edge sensors. We
measure ~dB of broadband quadrature squeezing (~dB inferred
on-chip) and ~dB of photon number difference squeezing (~dB
inferred on-chip). Nearly-single temporal mode operation is achieved, with raw
unheralded second-order correlations as high as measured
(~when corrected for noise). Multi-photon events of over 10 photons
are directly detected with rates exceeding any previous quantum optical
demonstration using integrated nanophotonics. These results will have an
enabling impact on scaling continuous variable quantum technology.Comment: Significant improvements and updates to photon number squeezing
results and discussions, including results on single temporal mode operatio
The CORALIE survey for southern extra-solar planets IX. A 1.3-day period brown dwarf disguised as a planet
In this article we present the case of HD 41004 AB, a system composed of a
K0V star and a 3.7-magnitude fainter M-dwarf companion separated by only 0.5
arcsec. An analysis of CORALIE radial-velocity measurements has revealed a
variation with an amplitude of about 50m/s and a periodicity of 1.3days. This
radial-velocity signal is consistent with the expected variation induced by the
presence a very low mass giant planetary companion to HD 41004 A, whose light
dominates the spectra. The radial-velocity measurements were then complemented
with a photometric campaign and with the analysis of the bisector of the
CORALIE Cross-Correlation Function (CCF). While the former revealed no
significant variations within the observational precision of 0.003-0.004 mag
(except for an observed flare event), the bisector analysis showed that the
line profiles are varying in phase with the radial-velocity. This latter
result, complemented with a series of simulations, has shown that we can
explain the observations by considering that HD 41004 B has a brown-dwarf
companion orbiting with the observed 1.3-day period. If confirmed, this
detection represents the first discovery of a brown dwarf in a very short
period (1.3-day) orbit around an M dwarf. Finally, this case should be taken as
a serious warning about the importance of analyzing the bisector when looking
for planets using radial-velocity techniques.Comment: 16 pages, 17 eps figures, A&A in press (Figure 11 not as in original
version due to size
Cross-polarized photon-pair generation and bi-chromatically pumped optical parametric oscillation on a chip
Nonlinear optical processes are one of the most important tools in modern optics with a broad spectrum of applications in, for example, frequency conversion, spectroscopy, signal processing and quantum optics. For practical and ultimately widespread implementation, on-chip devices compatible with electronic integrated circuit technology offer great advantages in terms of low cost, small footprint, high performance and low energy consumption. While many on-chip key components have been realized, to date polarization has not been fully exploited as a degree of freedom for integrated nonlinear devices. In particular, frequency conversion based on orthogonally polarized beams has not yet been demonstrated on chip. Here we show frequency mixing between orthogonal polarization modes in a compact integrated microring resonator and demonstrate a bi-chromatically pumped optical parametric oscillator. Operating the device above and below threshold, we directly generate orthogonally polarized beams, as well as photon pairs, respectively, that can find applications, for example, in optical communication and quantum optics
Reference dosimetry and small-field dosimetry in external beam radiotherapy: Results from a Danish intercomparison study
A Blue Straggler Binary System with at least Three Progenitors in the Core of a Globular Cluster?
We show that the X-ray source W31 in the core of the globular cluster 47
Tucanae is physically associated with the bright blue straggler BSS-7. The two
sources are astrometrically matched to 0.061\arcsec, with a chance coincidence
probability of less than 1%. We then analyse optical time-series photometry
obtained with the {\em Hubble Space Telescope} (HST) and find that BSS-7
displays a 1.56 day periodic signal in the I band. We also construct a
broad-band (far-ultraviolet through far-red) spectral energy distribution for
BSS-7 and fit this with single and binary models. The binary model is a better
fit to the data, and we derive the corresponding stellar parameters.
All of our findings are consistent with BSS-7 being a detached binary
consisting of a blue straggler primary with an X-ray-active,
upper-main-sequence companion. The formation of such a system would necessarily
involve at least three stars, which is consistent with recent N-body models in
which blue stragglers often form via multiple encounters that can involve both
single and binary stars. However, we cannot yet entirely rule out the
possibility that BSS-7 descended directly from a binary system via mass
transfer. The system parameters needed to distinguish definitively between
these scenarios may be obtainable from time-resolved spectroscopy.Comment: 19 pages, 3 figures, accepted for publication in ApJ; revised version
includes a discussion of an alternative 2-progenitor binary evolution
scenario, and an appendix discussing other probable/possible BSS/X-ray
matches in globular clusters and related source
Absolute dimensions of solar-type eclipsing binaries : NY Hya: a test for magnetic stellar evolution models
Funding: Europlanet 2024 RI has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 871149. N.P.’s work was supported by Fundação para a Ciência e a Tecnologia (FCT) through the research grants UIDB/04434/2020 and UIDP/04434/2020. U.G.J. acknowledges funding from the Novo Nordisk Foundation Interdisciplinary Synergy Programme grant no. NNF19OC0057374 and from the European Union H2020-MSCA-ITN-2019 under Grant no. 860470 (CHAMELEON). J.V. acknowledges support from the Grant Agency of the Czech Republic (GACR 22-34467S). J.C.M. acknowledges financial support by Spanish grants PID2021-125627OBC31 funded by MCIU/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, PGC2018-098153-B-C33 funded by MCIU/AEI, by the programme Unidad de Excelencia María de Maeztu CEX2020-001058-M, and by the Generalitat de Catalunya/CERCA programme. P.L.P. was partly funded by Programa de Iniciación en Investigación-Universidad de Antofagasta. INI-17-03.The binary star NY Hya is a bright, detached, double-lined eclipsing system with an orbital period of just under five days with two components each nearly identical to the Sun and located in the solar neighbourhood. The objective of this study is to test and confront various stellar evolution models for solar-type stars based on accurate measurements of stellar mass and radius. We present new ground-based spectroscopic and photometric as well as high-precision space-based photometric and astrometric data from which we derive orbital as well as physical properties of the components via the method of least-squares minimisation based on a standard binary model valid for two detached components. Classic statistical techniques were invoked to test the significance of model parameters. Additional empirical evidence was compiled from the public domain; the derived system properties were compared with archival broad-band photometry data enabling a measurement of the system's spectral energy distribution that allowed an independent estimate of stellar properties. We also utilised semi-empirical calibration methods to derive atmospheric properties from Str\"{o}mgren photometry and related colour indices. Data was used to confront the observed physical properties with classic and magnetic stellar evolution models.Peer reviewe
On-chip generation of high-dimensional entangled quantum states and their coherent control
Optical quantum states based on entangled photons are essential for solving questions in fundamental physics and are at the heart of quantum information science1. Specifically, the realization of high-dimensional states (D-level quantum systems, that is, qudits, with D > 2) and their control are necessary for fundamental investigations of quantum mechanics2, for increasing the sensitivity of quantum imaging schemes3, for improving the robustness and key rate of quantum communication protocols4, for enabling a richer variety of quantum simulations5, and for achieving more efficient and error-tolerant quantum computation6. Integrated photonics has recently become a leading platform for the compact, cost-efficient, and stable generation and processing of non-classical optical states7. However, so far, integrated entangled quantum sources have been limited to qubits (D = 2)8, 9, 10, 11. Here we demonstrate on-chip generation of entangled qudit states, where the photons are created in a coherent superposition of multiple high-purity frequency modes. In particular, we confirm the realization of a quantum system with at least one hundred dimensions, formed by two entangled qudits with D = 10. Furthermore, using state-of-the-art, yet off-the-shelf telecommunications components, we introduce a coherent manipulation platform with which to control frequency-entangled states, capable of performing deterministic high-dimensional gate operations. We validate this platform by measuring Bell inequality violations and performing quantum state tomography. Our work enables the generation and processing of high-dimensional quantum states in a single spatial mode
Potent Anti-Tumor Effect Generated by a Novel Human Papillomavirus (HPV) Antagonist Peptide Reactivating the pRb/E2F Pathway
Human papillomavirus type 16 (HPV16) E7 is a viral oncoprotein believed to play a major role in cervical cancer. In this study, an antagonist peptide against HPV16E7 protein was first identified from screening the c7c phage display peptide library. The binding specificity and affinity of the selected peptide to HPV16E7 were tested by competitive enzyme-linked immunosorbent assay (ELISA). The antagonist peptide showed obvious anti-tumor efficacy both in cell lines and animal tumor models. Significant cell proliferation inhibition with high specificity was noted when HPV16-positive cells were treated with the peptide. This anti-tumor efficacy was resulted from overriding the activities of HPV16E7 and reactivating the pRb/E2F pathway, as shown by a series of experiments. Flow cytometry analysis revealed that the selected peptide induced G1 arrest in a dose-dependent manner. Competitive ELISA, pull down, and Co-IP experiments indicated that the selected peptide disrupted the interaction between HPV16E7 and pRb proteins both in vitro and in vivo. Luciferase reporter assay verified that transcription activities of E2F were suppressed by the peptide through restoration of pRb. RT-PCR and Western blot revealed that it reduced cyclins A, D1, and E1 expression, and led to HPV16E7 protein degradation, but pRb protein stabilization. The current study suggests that this specific peptide may serve as a potential therapeutic agent for HPV16-positive cervical cancer
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