133 research outputs found
Is Brain Banking of Psychiatric Cases Valuable for Neurobiological Research?
It is widely accepted that neurobiological abnormalities underlie the symptoms of psychiatric disorders such as schizophrenia and unipolar or bipolar affective disorders. New molecular methods, computer-assisted quantification techniques and neurobiological investigation methods that can be applied to the human brain are all used in post-mortem investigations of psychiatric disorders. The following article describes modern quantitative methods and recent post-mortem findings in schizophrenia and affective disorders. Using our brain bank as an example, necessary considerations of modern brain banking are addressed such as ethical considerations, clinical work-up, preparation techniques and the organization of a brain bank, the value of modern brain banking for investigations of psychiatric disorders is summarized
Анализ возможности использования борсодержащих материалов в транспортных упаковках с РАО
Выпускная квалификационная работа включает в себя: 126 страниц, 43 рисунка, 24 таблицы, 5 приложений.Объектом исследования является тетраборид вольфрама.
Цель работы – проведение многоступенчатого анализа возможности применения тетраборида вольфрама в качестве материала для усиления радиационной защиты контейнеров для транспортировки и хранения РАО.
В процессе исследования были изучены инженерные и программные методы расчёта ослабления потоков радиационных частиц, проанализированы различные защитные материалы с точки зрения ослабления проходящего через них ионизирующего излучения.
В результате исследования получены подробные данные о радиационно-защитных характеристиках тетраборида вольфрама.
Степень внедрения: высокая.
Область применения: ядерная промышленность.Final qualifying work includes: 126 pages, 43 drawings, 24 tables, 5 prilozheniy.Obektom study is tetraborid tungsten.
Purpose - to conduct analysis of the possibility of using multi-tetraborida tungsten as a material for strengthening radiation protection container for transportation and storage of radioactive waste.
During the research were studied engineering and software methods for calculating the attenuation of radiation particles flows analyzed various protective materials from the standpoint of weakening passing through them to ionizing radiation.
The study detailed data on radiation protection characteristics of tungsten tetraborida.
Degree of implementation: high.
Scope: the nuclear industry
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Dont die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
A hallmark of Parkinsons disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are affected to the same extent. Studies revealed that neurons located more ventrally within the substantia nigra pars compacta have a higher prevalence to degenerate than those located in the dorsal tier. The underlying reasons for this selective neuronal vulnerability are still unknown. The aim of the present study was to gain a better understanding of molecular differences between these two neuronal subpopulations that may explain the selective neuronal vulnerability within the human substantia nigra. For this purpose, the neurons from the ventral as well as dorsal tier of the substantia nigra were specifically isolated out of neuropathologically unremarkable human substantia nigra sections with laser microdissection. Following, their proteome was analyzed by data independent acquisition mass spectrometry. The samples were analysed donor-specifically and not pooled for this purpose. A total of 5,391 proteins were identified in the substantia nigra. Of these, 2,453 proteins could be quantified in 100% of the dorsal tier samples. 1,629 could be quantified in 100% of the ventral tier samples. Nine proteins were differentially regulated with a log2 value ≥0.5 and a Qvalue ≤0.05. Of these 7 were higher abundant in the dorsal tier and 2 higher in the ventral tier. These proteins are associated with the cytoskeleton, neuronal plasticity, or calcium homeostasis. With these findings a deeper understanding can be gained of the selective neuronal vulnerability within the substantia nigra and of protective mechanisms against neurodegeneration in specific neuronal subpopulations
Effect of sintering temperature on properties of transparent YSZ-ceramics prepared by spark plasma sintering
Transparent yttria-stabilized zirconia (YSZ) ceramics were sintered with the spark plasma sintering (SPS) method at different temperatures. The influence of sintering temperature (1200-1400°С) on the ceramics microstructure and mechanical properties was investigated and discussed
Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment
The fornix and hippocampus are critical to recollection in the healthy human brain. Fornix degeneration is a feature of aging and Alzheimer's disease. In the presence of fornix damage in mild cognitive impairment ( MCI ), a recognized prodrome of Alzheimer's disease, recall shows greater dependence on other tracts, notably the parahippocampal cingulum ( PHC ). The current aims were to determine whether this shift is adaptive and to probe its relationship to cholinergic signaling, which is also compromised in Alzheimer's disease. Twenty-five human participants with MCI and 20 matched healthy volunteers underwent diffusion MRI, behavioral assessment, and volumetric measurement of the basal forebrain. In a regression model for recall, there was a significant group × fornix interaction, indicating that the association between recall and fornix structure was weaker in patients. The opposite trend was present for the left PHC. To further investigate this pattern, two regression models were generated to account for recall performance: one based on fornix microstructure and the other on both fornix and left PHC. The realignment to PHC was positively correlated with free recall but not non-memory measures, implying a reconfiguration that is beneficial to residual memory. There was a positive relationship between realignment to PHC and basal forebrain gray matter volume despite this region demonstrating atrophy at a group level, i.e., the cognitive realignment to left PHC was most apparent when cholinergic areas were relatively spared. Therefore, cholinergic systems appear to enable adaptation to injury even as they degenerate, which has implications for functional restoration
Perbandingan Pendekatan Tradisional dan Semantic Web untuk Akses Informasi Sebagai Penunjang Pengambilan Keputusan
Pengambilan keputusan pada dunia industry akan membutuhkan data teks, grafik dan juga bentuk data traditional lainnya. Dengan perkembangan teknologi informasi saat ini makasifat dari sumber informasi berkembang sehingga berjumlah sangat besar, keragaman jenis sumber informasi (sintaktik, struktur, semantic) dan data volume data semakin besar serta komplek
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