Views of healthcare professionals to linkage of routinely collected healthcare data : a systematic review

Peer reviewedPublisher PD

Advanced Gas Turbine (AGT) powertrain system

A 74.5 kW(100 hp) advanced automotive gas turbine engine is described. A design iteration to improve the weight and production cost associated with the original concept is discussed. Major rig tests included 15 hours of compressor testing to 80% design speed and the results are presented. Approximately 150 hours of cold flow testing showed duct loss to be less than the design goal. Combustor test results are presented for initial checkout tests. Turbine design and rig fabrication is discussed. From a materials study of six methods to fabricate rotors, two have been selected for further effort. A discussion of all six methods is given

Linked health data for pharmacovigilance in children : Perceived legal and ethical issues for stakeholders and data guardians

Peer reviewedPublisher PD

The analgesic effect of electroacupuncture on acute thermal pain perception-a central neural correlate study with fMRI

Abstract Background Electrical acupuncture (EA) has been utilized in acute pain management. However, the neuronal mechanisms that lead to the analgesic effect are still not well defined. The current study assessed the intensity [optimal EA (OI-EA) vs. minimal EA (MI-EA)] effect of non-noxious EA on supraspinal regions related to noxious heat pain (HP) stimulation utilizing an EA treatment protocol for acute pain and functional magnetic resonance imaging (fMRI) with correlation in behavioral changes. Subjects underwent five fMRI scanning paradigms: one with heat pain (HP), two with OI-EA and MI-EA, and two with OI-EA and HP, and MI-EA and HP. Results While HP resulted in activations (excitatory effect) in supraspinal areas known for pain processing and perception, EA paradigms primarily resulted in deactivations (suppressive effect) in most of these corresponding areas. In addition, OI-EA resulted in a more robust supraspinal sedative effect in comparison to MI-EA. As a result, OI-EA is more effective than MI-EA in suppressing the excitatory effect of HP in supraspinal areas related to both pain processing and perception. Conclusion Intensities of EA plays an important role in modulating central pain perception

Modeling the ballistic-to-diffusive transition in nematode motility reveals variation in exploratory behavior across species

A quantitative understanding of organism-level behavior requires predictive models that can capture the richness of behavioral phenotypes, yet are simple enough to connect with underlying mechanistic processes. Here we investigate the motile behavior of nematodes at the level of their translational motion on surfaces driven by undulatory propulsion. We broadly sample the nematode behavioral repertoire by measuring motile trajectories of the canonical lab strain $C. elegans$ N2 as well as wild strains and distant species. We focus on trajectory dynamics over timescales spanning the transition from ballistic (straight) to diffusive (random) movement and find that salient features of the motility statistics are captured by a random walk model with independent dynamics in the speed, bearing and reversal events. We show that the model parameters vary among species in a correlated, low-dimensional manner suggestive of a common mode of behavioral control and a trade-off between exploration and exploitation. The distribution of phenotypes along this primary mode of variation reveals that not only the mean but also the variance varies considerably across strains, suggesting that these nematode lineages employ contrasting ``bet-hedging'' strategies for foraging.Comment: 46 pages, 18 figures, 6 table

Revealing Knowledge Networks From Computer Mediated Communication in Organizations

In today’s knowledge driven economy, knowledge is considered to be the key factor in defining the success of an organization. We have learned that knowledge is residing in the informal network of the organization. Hence, to improve performance, it is the informal knowledge network that should be examined and developed. For this purpose, social network analysis is increasingly applied in business contexts. This is, however, a new domain, which is still in development. This paper aims to aid in this development by researching how representative knowledge networks can be revealed in organizations. While surveying is a common first option to capture an organizational network, this technique may not always be suitable. Communication sources (e.g. e-mail) may provide an alternative, however, we do not know to what extent these sources can represent the actual knowledge network. This paper examines a Dutch IT services organization. Here, a web-survey among the employees baselines the knowledge network, which is compared to 3 communication networks from the same organization, captured by means of e-mail, telephone and SMS (Short Message Service) communication (also known as text messaging or texting). A comparison is made by means of correlating the network matrices and by comparing essential network properties. Findings show that only the e-mail network is significantly representative for the baselined knowledge network. This exercise is exploratory in nature as only one organization is examined, but comprehensive with regard to the richness of data that is available for examination. From our findings we gain insight in the extent to which networks, captured from e-mail, telephone and SMS archives can represent an organizational knowledge network

Bloodstream form trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes

Trypanosoma brucei possesses five metacaspase genes. Of these, MCA2 and MCA3 are expressed only in the mammalian bloodstream form of the parasite, whereas MCA5 is expressed also in the insect procyclic form. Triple RNAi analysis showed MCA2, MCA3 and MCA5 to be essential in the bloodstream form, with parasites accumulating pre-cytokinesis. Nevertheless, triple null mutants (Δmca2/3Δmca5) could be isolated after sequential gene deletion. Thereafter, Δmca2/3Δmca5 mutants were found to grow well both in vitro in culture and in vivo in mice. We hypothesise that metacaspases are essential for bloodstream form parasites, but they have overlapping functions and their progressive loss can be compensated for by activation of alternative biochemical pathways. Analysis of Δmca2/3Δmca5 revealed no greater or lesser susceptibility to stresses reported to initiate programmed cell death, such as treatment with prostaglandin D2. The metacaspases were found to colocalise with RAB11, a marker for recycling endosomes. However, variant surface glycoprotein (VSG) recycling processes and the degradation of internalised anti-VSG antibody were found to occur similarly in wild type, Δmca2/3Δmca5 and triple RNAi induced parasites. Thus, the data provide no support for the direct involvement of T. brucei metacaspases in programmed cell death and suggest that the proteins have a function associated with RAB11 vesicles that is independent of known recycling processes of RAB11-positive endosomes

Barriers to HIV Services among MSM in Rural Georgia

Using information gathered from men who have sex with men (MSM) and service providers in four rural Georgia health districts (Valdosta, Rome, Gainesville, Waycross), this presentation will examine how predisposing, enabling and need characteristics (as described in the Andersen Healthcare Utilization Model) affect access and utilization of HIV prevention and treatment services among rural MSM in Georgia

Reverse Khas'minskii condition

The aim of this paper is to present and discuss some equivalent characterizations of p-parabolicity in terms of existence of special exhaustion functions. In particular, Khas'minskii in [K] proved that if there exists a 2-superharmonic function k defined outside a compact set such that $\lim_{x\to \infty} k(x)=\infty$, then R is 2-parabolic, and Sario and Nakai in [SN] were able to improve this result by showing that R is 2-parabolic if and only if there exists an Evans potential, i.e. a 2-harmonic function $E:R\setminus K \to \R^+$ with \lim_{x\to \infty} \E(x)=\infty. In this paper, we will prove a reverse Khas'minskii condition valid for any p>1 and discuss the existence of Evans potentials in the nonlinear case.Comment: final version of the article available at http://www.springer.co

Hydrological simulation of extreme flood scenarios for operational flood management at the Middle Elbe river

Operational flood management at the Middle Elbe river requires comprehensive knowledge about the magnitude and characteristics of possible extreme flood events. Since these events are not sufficiently included in available historical records, an extended sample of extreme flood events was generated by hydrological scenario simulation. Present paper emphasises simulations in the German part of the catchment of the Middle Elbe river and introduces the stochastic-conceptual precipitation-runoff model which was developed for this task. After validation of this model and its coupling with the weather forecast model COSMO and hydraulic-numerical models, a set of 25 flood scenarios could be simulated and provided for a planning of flood protection measures. Analysis of simulated scenarios reveal that extreme flood events at the Mulde and Middle Elbe rivers may have a wide spectrum of characteristics and may considerably exceed the magnitude of past flood events (e.g., those of August 2002)