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Analysis of the Importance of Extension in Accounting for the Post-Carboniferous Subsidence of the North Sea Basin
Post Carboniferous sedimentary deposition in the Central North Sea basins can be separated into three major periods: Permian, Triassic and mid-Jurassic through present. Most efforts to explain the basin within an extensional framework have concentrated on the post mid-Jurassic subsidence. These efforts have ignored the large amount of prior extension required to account for the observed crustal thinning and the substantial Permian and Triassic sediment fill. In addition the models predict a mid-Jurassic through early Cretaceous extension that significantly exceeds estimates of the horizontal displacement observed on high angle faults on multichannel seismic lines. We show in areas of minimal pre-Permian subsidence that adding two earlier phase extensions, one in the late Carboniferous through early Permian and the other in the Triassic produces a nearly horizontal late Carboniferous crustal thickness. The time-dependent extensional model required to account for the three periods of sediment deposition gives an excellent match to the observed subsidence history of the basement. We present an analysis of a recent seismic reflection line nm across the Central Graben in the vicinity of published refraction and well data. We show that the extension required in the third phase of the three phase model is compatible with the observed displacement on the high angle mid-Jurassic through early Cretaceous faults. However, we find no evidence for major extension either in the Triassic or late Carboniferous through early Permian.Institute for Geophysic
Testing Conditional Independence of Discrete Distributions
We study the problem of testing \emph{conditional independence} for discrete
distributions. Specifically, given samples from a discrete random variable on domain , we want to distinguish,
with probability at least , between the case that and are
conditionally independent given from the case that is
-far, in -distance, from every distribution that has this
property. Conditional independence is a concept of central importance in
probability and statistics with a range of applications in various scientific
domains. As such, the statistical task of testing conditional independence has
been extensively studied in various forms within the statistics and
econometrics communities for nearly a century. Perhaps surprisingly, this
problem has not been previously considered in the framework of distribution
property testing and in particular no tester with sublinear sample complexity
is known, even for the important special case that the domains of and
are binary.
The main algorithmic result of this work is the first conditional
independence tester with {\em sublinear} sample complexity for discrete
distributions over . To complement our upper
bounds, we prove information-theoretic lower bounds establishing that the
sample complexity of our algorithm is optimal, up to constant factors, for a
number of settings. Specifically, for the prototypical setting when , we show that the sample complexity of testing conditional
independence (upper bound and matching lower bound) is
\[
\Theta\left({\max\left(n^{1/2}/\epsilon^2,\min\left(n^{7/8}/\epsilon,n^{6/7}/\epsilon^{8/7}\right)\right)}\right)\,.
\
Nonlinear evolution of the magnetized Kelvin-Helmholtz instability: from fluid to kinetic modeling
The nonlinear evolution of collisionless plasmas is typically a multi-scale
process where the energy is injected at large, fluid scales and dissipated at
small, kinetic scales. Accurately modelling the global evolution requires to
take into account the main micro-scale physical processes of interest. This is
why comparison of different plasma models is today an imperative task aiming at
understanding cross-scale processes in plasmas. We report here the first
comparative study of the evolution of a magnetized shear flow, through a
variety of different plasma models by using magnetohydrodynamic, Hall-MHD,
two-fluid, hybrid kinetic and full kinetic codes. Kinetic relaxation effects
are discussed to emphasize the need for kinetic equilibriums to study the
dynamics of collisionless plasmas in non trivial configurations. Discrepancies
between models are studied both in the linear and in the nonlinear regime of
the magnetized Kelvin-Helmholtz instability, to highlight the effects of small
scale processes on the nonlinear evolution of collisionless plasmas. We
illustrate how the evolution of a magnetized shear flow depends on the relative
orientation of the fluid vorticity with respect to the magnetic field direction
during the linear evolution when kinetic effects are taken into account. Even
if we found that small scale processes differ between the different models, we
show that the feedback from small, kinetic scales to large, fluid scales is
negligable in the nonlinear regime. This study show that the kinetic modeling
validates the use of a fluid approach at large scales, which encourages the
development and use of fluid codes to study the nonlinear evolution of
magnetized fluid flows, even in the colisionless regime
Inhibition of human prolyl oligopeptidase activity by the Cyclotide Psysol 2 isolated from Psychotria solitudinum
Cyclotides are head-to-tail cyclized peptides comprising a stabilizing cystine-knot motif. To date, they are well known for their diverse bioactivities such as anti-HIV and immunosuppressive properties. Yet little is known about specific molecular mechanisms, in particular the interaction of cyclotides with cellular protein targets. Native and synthetic cyclotide-like peptides from Momordica plants are potent and selective inhibitors of different serine-type proteinases such as trypsin, chymotrypsin, matriptase, and tryptase-beta. This study describes the bioactivity-guided isolation of a cyclotide from Psychotria solitudinum as an inhibitor of another serine-type protease, namely, the human prolyl oligopeptidase (POP). Analysis of the inhibitory potency of Psychotria extracts and subsequent fractionation by liquid chromatography yielded the isolated peptide psysol 2 (1), which exhibited an IC50 of 25 μM. In addition the prototypical cyclotide kalata B1 inhibited POP activity with an IC50 of 5.6 μM. The inhibitory activity appeared to be selective for POP, since neither psysol 2 nor kalata B1 were able to inhibit the proteolytic activity of trypsin or chymotrypsin. The enzyme POP is well known for its role in memory and learning processes, and it is currently being considered as a promising therapeutic target for the cognitive deficits associated with several psychiatric and neurodegenerative diseases, such as schizophrenia and Parkinson's disease. In the context of discovery and development of POP inhibitors with beneficial ADME properties, cyclotides may be suitable starting points considering their stability in biological fluids and possible oral bioavailability
Continuous catalytic hydrodeoxygenation of guaiacol over Pt/SiO₂ and Pt/H-MFI-90
Hydrodeoxygenation of guaiacol in the presence of 1-octanol was studied in a fixed-bed reactor under mild conditions (50-250 °C) over platinum particles supported on silica (Pt/SiO2) and a zeolite with framework type MFI at a Si/Al-ratio of 45 (Pt/H-MFI-90). The deoxygenation selectivity strongly depended on the support and the temperature. Both guaiacol and octanol were rapidly deoxygenated in the presence of hydrogen over Pt/H-MFI-90 at 250 °C to cyclohexane and octane, respectively. In contrast, Pt/SiO2 mostly showed hydrogenation, but hardly any deoxygenation activity. The acidic sites of the MFI-90 support lead to improved deoxygenation performance at the mild temperature conditions of this study. Significant conversions under reaction conditions applied already occurred at temperatures of 200 °C. However, during long-term stability tests, the Pt/H-MFI-90 catalyst deactivated after more than 30 h, probably due to carbon deposition, whereas Pt/SiO2 was more stable. The catalytic activity of the zeolite catalyst could only partly be regained by calcination in air, as some of the acidic sites were lost
Spherical harmonic representation of the gravitational potential of discrete spherical mass elements
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73812/1/j.1365-246X.1991.tb01157.x.pd
ARTEMIS Science Objectives
NASA's two spacecraft ARTEMIS mission will address both heliospheric and planetary research questions, first while in orbit about the Earth with the Moon and subsequently while in orbit about the Moon. Heliospheric topics include the structure of the Earth's magnetotail; reconnection, particle acceleration, and turbulence in the Earth's magnetosphere, at the bow shock, and in the solar wind; and the formation and structure of the lunar wake. Planetary topics include the lunar exosphere and its relationship to the composition of the lunar surface, the effects of electric fields on dust in the exosphere, internal structure of the Moon, and the lunar crustal magnetic field. This paper describes the expected contributions of ARTEMIS to these baseline scientific objectives
Solar Wind Turbulence and the Role of Ion Instabilities
International audienc
MULTIPLE CURRENT SHEET SYSTEMS IN THE OUTER HELIOSPHERE: ENERGY RELEASE AND TURBULENCE
Accepted for publication in The Astrophysical Journal, March 21, 201
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