Asymmetric transmission of linearly polarized light at optical metamaterials

We experimentally demonstrate a three-dimensional chiral optical metamaterial that exhibits an asymmetric transmission for forwardly and backwardly propagating linearly polarized light. The observation of this novel effect requires a metamaterial composed of three-dimensional chiral metaatoms without any rotational symmetry. Our analysis is supported by a systematic investigation of the transmission matrices for arbitrarily complex, lossy media that allows deriving a simple criterion for asymmetric transmission in an arbitrary polarization base. Contrary to physical intuition, in general the polarization eigenstates in such three-dimensional and low-symmetry metamaterials do not obey fxed relations and the associated transmission matrices cannot be symmetrized

Virtual Reality as a Tool for Studying Diversity and Inclusion in Human-Robot Interaction: Advantages and Challenges

This paper investigates the potential of Virtual Reality (VR) as a research tool for studying diversity and inclusion characteristics in the context of human-robot interactions (HRI). Some exclusive advantages of using VR in HRI are discussed, such as a controllable environment, the possibility to manipulate the variables related to the robot and the human-robot interaction, flexibility in the design of the robot and the environment, and advanced measurement methods related e.g. to eye tracking and physiological data. At the same time, the challenges of researching diversity and inclusion in HRI are described, especially in accessibility, cyber sickness and bias when developing VR-environments. Furthermore, solutions to these challenges are being discussed to fully harness the benefits of VR for the studying of diversity and inclusion.Comment: 4 page

Intrahistiocytic Storage of Clofazimine Crystals in a Cat

A 13-year-old castrated male Maine coon cat with a 5-year history of atypical mycobacteriosis was euthanized and submitted for necropsy. The cat had been kept in clinical remission since diagnosis using a combination of the antimycobacterial drug clofazimine and additional multimodal antimicrobial therapy. Grossly, tissues were diffusely discolored red-brown to yellow. Histologically, the myocardial interstitum was expanded by numerous, often multinucleated cells, which were distended by uniformly shaped acicular cytoplasmic spaces. These cells were immunopositive for CD18 and immunonegative for desmin, suggesting a histiocytic rather than muscular origin. Macrophages in other tissues contained similar acicular spaces. Ultrastructurally, the spaces were surrounded by 2 lipid membranes, resembling an autophagosome. Based on the clinical history and histologic, immunohistochemical, and ultrastructural data, we diagnosed clofazimine crystal storage. To our knowledge, this is the first report of clofazimine storage in a cat or within myocardial interstitial macrophages

Contribution of the magnetic resonance to the third harmonic generation from a fishnet metamaterial

We investigate experimentally and theoretically the third harmonic generated by a double-layer fishnet metamaterial. To unambiguously disclose most notably the influence of the magnetic resonance, the generated third harmonic was measured as a function of the angle of incidence. It is shown experimentally and numerically that when the magnetic resonance is excited by pump beam, the angular dependence of the third harmonic signal has a local maximum at an incidence angle of {\theta} \simeq 20{\deg}. This maximum is shown to be a fingerprint of the antisymmetric distribution of currents in the gold layers. An analytical model based on the nonlinear dynamics of the electrons inside the gold shows excellent agreement with experimental and numerical results. This clearly indicates the difference in the third harmonic angular pattern at electric and magnetic resonances of the metamaterial.Comment: 7 pages, 5 figure

Определение эффективности нейтронного детектора из пластического сцинтиллятора o100?200 мм

Рассчитывается и экспериментально проверяется эффективность детектора. к нейтронам сверхвысоких (десятки и сотни МэВ) энергий

Quasicrystal metamaterials: A route to optical isotropy

We introduce a novel class of metamaterials with quasicrystalline meta-atom arrangements and study their properties in comparison with periodic and disordered metamaterials. We show that quasicrystalline metamaterials exhibit isotropic optical propertie

Optical metamaterials with quasicrystalline symmetry: Symmetry-induced optical isotropy

We apply the concept of quasicrystals to metamaterials and experimentally demonstrate metasurfaces with isotropic properties and high resonance strength. By comparing quasicrystalline, periodic, and amorphous metasurfaces we quantify the impact of symmet

Open innovation at the Abbe School of Photonics

The Abbe School of Photonics (ASP) provides and coordinates the optics and photonics education of graduate and doctoral students at the Friedrich Schiller University in Jena, Germany. The internationalized Master's degree program is the key activity in training students in the optical sciences. The program is designed to provide them with the skills necessary to fill challenging positions in industry and academia. Here, an essential factor is ASP's close collaboration with more than 20 German photonics companies. To sustain these partners' future economic development, the availability of highly qualified employees is constantly required. Accordingly, these industrial partners, the European Union, the local state and the federal German government are strongly involved in the sustainable development of ASP's curriculum by both conceptual and financial engagements. The main goal is to promote the students' academic careers and job experience in the photonics industry as well as in academia. To open up the program to students from all over the world, all ASP lectures and courses are taught in English. ASP's qualification strategy is fully research-oriented and based on the principles of academic freedom, competitive research conditions and internationalization at all levels. The education program is complemented by a structured doctoral student support and a prestigious guest professorship program. Recently, ASP and partners have started a project to build an open photonics laboratory in order to foster innovative and co-creative processes. The idea follows well-established open innovation schemes e.g. in electronics. This Photon Garage (German: "Lichtwerkstatt") will bring together professionals and interested laymen from different backgrounds to approach pertinent challenges in photonics. Here, we will share our latest insights into the potentials and opportunities offered by this novel educative approach

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)